Your Choices of OTC Pain Relievers and your reasons

the pressure here is down, the wind is blowing blizzard conditions and our first good snow of the seaso here.  Temperature finally up to 14F  pressure down to 28.92 .  And although I a snug as a bug in a rug (to quote my Mother)the wind is noisey, I cannot sleep and generalized aching is setting in.

My ususal style to to stick it out but I am wondering if taking and OTC medicaton chold be helpful.   I know there have been some discussions regarding peoples preferences.  Naproxene Sodium, Ibuprofen and Lightly coated simple asprin are my available sources with the weather promissing to hold me up till at least Tuesday morning. 

I was hoping to get some feedback for gueses as to which of this anti-inflamatiories might possibly effect my liver inflamation as well as taking care of this generalized aching and stiffness.

Any thoughts woud be welcome.  I rarely have to take mediation for pain these days so that is a pluse.

Thanks Louise 

Well there are certainly a lot of typographical errors in that post. 

To ask again:  does anyone have a suggestion regarding the NSAD's of choice that might be helpful to  decrease liver inflammationi as well as for general muscular effect,  in theory only of course!  Louise

  • CAPi(TiniOnly): 06/07-02/09 for CFSi<
  • MethylationProtocolSupplements: Started08/08
  • Intermtnt CAP: 02/09-02/10
  • Full MethylProtocol & LDNi 02/09
  • Off CAP: 02/10, cont LDN & MethlyProtocol support
  • <

Hello Louise...

There was a link previously that had some good info.. perhaps this will help Laughing

 (hey ... why is my "linK' button disabled????)

 

http://www.cpnhelp.org/stopping_inflammation_whi<

 

Information on NSAID half<

Submitted by farandwide< on Sat, 2008-11-22 13:16.

Information on NSAID half lives...

The information I have found is sketchy in my opinion, not as reliable as more scientific information.  But still, it's information to start from.

My understanding of the half lives of NSAIDSi<i< is that they remain in blood plasma a shorter time then in humna tissues.  To me this poses a problem with vitamin Di<i<.  Here is some information I've found and where I got it from.

From http://arthritis.about.com/cs/nsaids/a/factsofnsaids.htm< I found...

  • Pain< and inflammation< sometimes occur in a circadian rhythm (daily rhythmic cycle based on a 24 hour interval). Therefore NSAIDs may be more effective at certain times.
  • NSAIDs can be divided into two groups: those with plasma (blood) half-lives less than 6 hours (i.e. aspirin, diclofenac, ibuprofen) and those with half-lives greater than 10 hours (i.e. diflunisal, piroxicam, and sulindac). Since it takes three to five half-lives to stabilize blood levels, NSAIDs with longer half-lives require a loading dose to be given (large dose given initially). The "half-life" is the time it takes a drug to go down to half of its initial level.
  • Prostaglandins, which are inhibited by NSAIDs, function in the body to protect the stomach lining, promote clotting of the blood, regulate salt and fluid balance, and maintain blood flow to the kidneys when kidney function is reduced. By decreasing prostaglandins, NSAIDs can cause stomach irritation, bleeding, fluid retention, and decreased kidney function.
  • Synovial fluid (joint fluid) concentrations are 60% of plasma concentrations regardless of type of NSAID or its half-life. Synovial fluid is mostly the site of action of NSAIDs.
  • NSAIDs are 95% albumin (protein) bound. The unbound fraction of the NSAID is increased in patients with low albumin concentrations such as in active rheumatoid arthritis< and the elderly.

From http://www.medicineau.net.au/clinical/palliative/NSAIDS.html< I found...

Drug Half-life (hr)

Short half-life

  • Aspirin 0.25 0.03
  • Diclofenac 1.1 0.2
  • Flufenamic acid 1.4;9.0
  • Ibuprofen 2.1 0.3
  • Indomethacin 4.6 0.7
  • Ketoprofen 1.8 0.4
  • Tiaprofenic acid 3.0 0.2

Long half-life

  • Diflunisal 13 2
  • Naproxen 14 2
  • Phenylbutazone 68 25
  • Piroxicam 57 22
  • Salicylate 2 - 15
  • Suldinac (sulfide) 14 8
  • Tenoxicam 60 11

This information is good but only addresses blood plasma half life and not tissue half life.  So, it's only partially there.  I've been trying to find the tissue half life but my guess is that it isn't out there.  How does a researcher known how long a drug remains in the brain/spine or heart/lungs?  I haven't a clue how that works.

___________________________________________________________

all my best

John

RRMSi<i</EDSSi<i< was 4.5, 5, now 6 on Wheldon Protocol (naci<, doxycycline, azithromycin, metronidazolei<i<) since 04/12/2006. Added Rifampin 2x150mg/daily 08/19/2007. Added INHi< 300mg/daily 03/17/2008 stopped 05/08

 

 

JeanneRoz ~ DXi'd w/ CPNi 4/2007; 6/07 -"officially" dx'd w/CFIDSi/FM; also: HHV6, EBVi, IBSi-C, 100 Doxyi:BIDi<; 500 mg Biaxin BIDi; Tindamax Pulses, B12 shots, ERFA Dessicated Thyroid,Cortef, Iodoral 25 mg, Vit D-6,000 uni

Thanks Jeannroz, what I am really looking for is info about an anti-inflamation effects comparison of Asprin, Naproxen Sodium and Ibuprofen not duration of the individual substances but the mechanisms by which they work which theoretically make one more useful in my case of liver cell inflamation.   I know that some are better for different tissues of inflamation (the location of the pain is that is what it is being used for.)   I know I could just pick one and take it until my next lab study however I would like to make a more educated selection.  Louise
  • CAPi(TiniOnly): 06/07-02/09 for CFSi<
  • MethylationProtocolSupplements: Started08/08
  • Intermtnt CAP: 02/09-02/10
  • Full MethylProtocol & LDNi 02/09
  • Off CAP: 02/10, cont LDN & MethlyProtocol support
  • <

 Found this open access study.  Have not read it but want to keep track of what I find for myself so here is the link:

http://jpet.aspetjournals.org/cgi/reprint/jpet.107.128264v1< 

my search is entitled cox-s inhibitors effect on hepatic inflammationi.

http://www.fasebj.org/cgi/content/full/19/9/1120<

  • CAPi(TiniOnly): 06/07-02/09 for CFSi<
  • MethylationProtocolSupplements: Started08/08
  • Intermtnt CAP: 02/09-02/10
  • Full MethylProtocol & LDNi 02/09
  • Off CAP: 02/10, cont LDN & MethlyProtocol support
  • <
What do the numbers with the double decimal points mean?  Maybe I'm dense, but are they minutes?  Is the half life of asprin 25 minutes and 3/100 of a second?

In pursuit of ABX<

Don't Allow What You Know To Get In The Way Of What Might Be

I was wondering about that interpretation as well.  Maybe a miss type?
  • CAPi(TiniOnly): 06/07-02/09 for CFSi<
  • MethylationProtocolSupplements: Started08/08
  • Intermtnt CAP: 02/09-02/10
  • Full MethylProtocol & LDNi 02/09
  • Off CAP: 02/10, cont LDN & MethlyProtocol support
  • <

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