Vitamin D Induction of the Human Antimicrobial Peptide Cathelicidin in the Urinary Bladder

Swedish researchers investigate that vitamin Di supplementation is useful from preventative reasons for UTIi

http://www.plosone.org/article/info:doi/10.1371/journal.pone.0015580<

"In light of the emerging resistance to antibioticsi used against UTIi [33], new treatment strategies are needed. Our data suggest that vitamin D can stimulate an increased production of the antimicrobial peptide cathelicidin. By inducing and activating cathelicidin with vitamin D, a local rather than a systemic effect can be achieved. This could offer selective and site-specific treatment of pathogens without perturbing commensal microbes elsewhere in the body. Likewise, systemic effects of 25D3 treatment secondary to cathelicidin induction seem unlikely. This could make 25D3 an effective and safe way of activating the endogenous antimicrobial response locally at the site of infection. Determining the vitamin D status of individuals with a history of UTI may be of importance to evaluate their ability to fend off intruding bacteria. Supplementation to restore proper vitamin D levels may therefore help preparing the bladder epithelium to mount a stronger and faster immunei response once bacteria enter the bladder"

Lala, You are really on top of this topic as is Red thank you for sharing your findings.  We have not had a single cold or any other acute infection since getting our Vit D levels up and we continue to take high Dose Vit D3 and also continue with testing myself and partner levels with the self testing option through the Vitamin Di Counsel and ZRT Laboratory at least twice a year as we are wanting to maintain a maximum yet safe level to take advantage of the Defensin effect of Vit D3, it seems to be working well for us.  I have been off CAPi for the past two years, pulsing several times without problem.

I see that this article is expressing the 25-OHD (D3) in the nmol/L expression which is a constant confusion for the lay reader I believe.

Would you be able to post the ng/L expression conversion? 

For those in the USA where nmol/L is not commonly used it would be helpful to review that information.   As you know it changes the the numbers and is a constant cause of confusion.       I would do it but I must say that personally, I lose the conversion factor in my memory bank all to frequently.   Thanks if you or someone else can add this.       Louise

  • CAPi(TiniOnly): 06/07-02/09 for CFSi<
  • MethylationProtocolSupplements: Started08/08
  • Intermtnt CAP: 02/09-02/10
  • Full MethylProtocol & LDNi 02/09
  • Off CAP: 02/10, cont LDN & MethlyProtocol support
  • <

Hi Louise, here is tab with conversion factors, scroll down to Vitamin Di.

http://www.unc.edu/~rowlett/units/scales/clinical_data.html 

Stratton/Wheldon protocol 02/2006 - 10/11 for CFSi and many problems 30 years

Thanks Lala,

http://www.unc.edu/~rowlett/units/scales/clinical_data.html< 

  • CAPi(TiniOnly): 06/07-02/09 for CFSi<
  • MethylationProtocolSupplements: Started08/08
  • Intermtnt CAP: 02/09-02/10
  • Full MethylProtocol & LDNi 02/09
  • Off CAP: 02/10, cont LDN & MethlyProtocol support
  • <

Lala, A lot of good research coming out of Scandanavian countries. 

Wonder who funds research there?  Studying Vit D3 certainly is to no advantage to drug companies here is theUSA.  

Since Sweden has a a health care system that charges no one and I know that because when my husband had business there about 10 years ago he got a sore throat, he is very dramatic and I took him to a clinic for a strep screen to ease his mind.  He was seen it was negative and we were never charged for the visit, they just waved us out the door! 

Of course the doctors there refuse to accept CAPi as a treatment protocol which we know from a number of posters from Sweden here, every approach has its problems!

Seems that just under 50 ng/mL would be effective as a preventative for UTIi , from the results of this study.   When will the US get onboard with the rest of the globe in these matters of data expression, they have been supposed to be going there for the past 40 years!

  • CAPi(TiniOnly): 06/07-02/09 for CFSi<
  • MethylationProtocolSupplements: Started08/08
  • Intermtnt CAP: 02/09-02/10
  • Full MethylProtocol & LDNi 02/09
  • Off CAP: 02/10, cont LDN & MethlyProtocol support
  • <

Thanks Lala!

 

Louise, that research was publicly funded:

"Funding: This work was supported by grants from the Swedish Research Council (no. 56X-20356), ALF Project Funding, and the Karolinska Institutet. O.H. has a Karolinska Institutet funded postgraduate position. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript."

The Swedish health care system does have it flaws, especially for the chronically ill, and it's not entirely without charge (but the contribution is capped at a ridiculouly low level, not good). That is before getting into the the particularities of how chronic infectionsi, like Cpni, Borrelia&co, are dealt with in Scandinavia. Doctors refusing to accept Cap is to put it mildly, I'd say.

Other countries have better (or less faulty) systems for health care financing.

That you were not charged was likely not "by the book" (rather another sign of how efficiency slips away when "it's payed by taxes anyway"), it has happend to others, too, but is not according to the regulations.

 Sorry for the sourly sounding note, but thank you for helping maintaining Cpnhelp!

Borrelia/Cpni arthritis: joint, skin, eye, CNSi, respiratory, UG involvment; fatigue. Borrelia Elisa&WB IgGi, and CPn IgG and IgA pos, HLA-B27 neg. CAPi 5/9/2010 -> 3/2016 2017: some signs and symptoms returning, Borrelia?

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