Vitamin D3, Defensins, and Infection


Studies seem to suggest that Vitamin D3 plays an important role in production of  Defensins<, just is it apparently does with the more widely discussed antimicrobial peptides, Cathelicidins (LL-37<):


While less discussed than their antimicrobial "cousins", cathelicidins, studies suggest that Alpha and Beta Defensins also play an important role in host defense.   Here are a few such studies:


Alpha Defensins (also knowns as Neutrophil Defensins):


Beta Defensins:



Here's an excellent article on the various currently identified defensins and their molecular mechanisms of action:




Studies suggest that in addition to their antimicrobial effects, defensins may also play an important role in regulating immunei responses and inflammationi, as well as in wound repair: