Interesting:
Vitamin Di(2) Potentiates Axon Regeneration.
Neurobiologie des Interactions Cellulaires et Neurophysiopathologie (CNRS UMR 6184), Université de la Méditerranée (Aix-Marseille II), Faculté de Médecine Nord, Institut Fédératif de Recherche Jean Roche (IFR11), Marseille, France., Services de Chirurgie de la Main, Chirurgie Plastique et Réparatrice des Membres, Assistance Publique, Hopitaux de Marseille, Marseille, France.
Abstract To date, the use of autograft tissue remains the "gold standard" technique for repairing transected peripheral nerves. However, the recovery is suboptimal, and neuroactive molecules are required. In the current study, we focused our attention on vitamin D, an FDA-approved molecule whose neuroprotective and neurotrophic actions are increasingly recognized. We assessed the therapeutic potential of ergocalciferol-the plant-derived form of vitamin D, named vitamin D(2)-in a rat model of peripheral nerve injury and repair. The left peroneal nerve was cut out on a length of 10 mm and immediately autografted in an inverted position. After surgery, animals were treated with ergocalciferol (100 IU/kg/day) and compared to untreated animals. Functional recovery of hindlimb was measured weekly, during 10 weeks post-surgery, using a walking track apparatus and a numerical camcorder. At the end of this period, motor and sensitive responses of the regenerated axons were calculated and histological analysis was performed. We observed that vitamin D(2) significantly (i) increased axogenesis and axon diameter; (ii) improved the responses of sensory neurons to metabolites such as KCl and lactic acid; and (iii) induced a fast-to-slow fiber type transition of the Tibialis anterior muscle. In addition, functional recovery was not impaired by vitamin D supplementation. Altogether, these data indicate that vitamin D potentiates axon regeneration. Pharmacological studies with various concentrations of the two forms of vitamin D (ergocalciferol vs. cholecalciferol) are now required before recommending this molecule as a potential supplemental therapeutic approach following nerve injury.
PMID: 18986226 [PubMed - as supplied by publisher
Vitamin D(2) Potentiates Axon Regeneration.
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Red- I can't let this
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CAPi for Cpni 11/04. Dx: 25yrs CFSi & FMSi. Currently: 150mg BID Roxithromycin, Doxycycline 100mg BID, Tinii 1000mg/day pulses; Vit D2000 units, T4 & T3
This is amazing. After
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dx msi 1996. started capi 10/05. Started with tinii pulses switched to flagyli pulses. Now almost on continous 500mg flagyl but do need breaks. On minoi 100mg/day biaxin 1000mg day and NACi 600mg. ldni 2.0mg.
one more thing about
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Prague, The Czech Republic, On Wheldon protocol since 02/18/2006, CFSi and many problems 30 years (cpni and mycoplasma), 3rd year on protocol- doxyi, azi, tinii pulses
Thanks for posting this
Thanks for posting this Red. And what is all over the news this week? The study on breast cancer and D where the researchers used 400 iu.and got no positive results. Duh.........
Here it is:
http://tinyurl.com/554vgm
Raven
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Feeling 98% well and going for 100! Still testing + for Cpni since June '08.CAPi since 8-05 for Cpn and Mycoplasma P. for MSi and/or CFSi. Also EBVi and HHV6 NACi, Iodoral, T3, BHRT, Methylcobalamin injections, Nitro patch, LDNi and Methylation supplementsi
Hi Raven,Kind of crazy,
Hi Raven,
Kind of crazy, isn't it?
Meanwhile, more informed (IMHOi) researchers continue their work. Here's an interesting recommendation from Dr Vieth and a panel of experts who have submitted a warning about the toxicity of Cod Liver Oil in the current edition of the Annals of Otology, Rhinology & Laryngology:
"In addition to warning about the consumption of cod liver oil, the above experts recommended healthy children take 1,000 IU/day of vitamin Di for every 25 pounds of body weight. In some cases this is more than ten times current recommendations for children by the government and professional organizations. "
Medical News today: Dangers of Cod Liver Oil
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Treatment for Rosaceai
More on Vit D3 and its
More on Vit D3 and its effects on the nervous system:
New clues about vitamin D functions in the nervous system.
Pharmacological modulation of nerve growth factor synthesis: a mechanistic comparison of vitamin D receptor and beta(2)-adrenoceptor agonists.
A vitamin D(3) derivative (CB1093) induces nerve growth factor and prevents neurotrophic deficits in streptozotocin-diabetic rats.
1,25-Dihydroxyvitamin D3 regulates the expression of VDR and NGF gene in Schwann cells in vitro.
Effect of calcitriol in combination with corticosterone, interleukin-1beta, and transforming growth factor-beta1 on nerve growth factor secretion in an astroglial cell line.
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Treatment for Rosaceai
Red, what a fabulous paper!
Red, what a fabulous paper! Thank you so much for posting it. It is great news
Raven as for the paper with the 400IU, such "researchers" ought to be laughing stocks. It is patently absurd for them to not take the time to understand current research and build on that rather than doing something stupid like wasting money on a 400 IU study. The choice of 400IU is totally random obviously based on the old RDA which as been proven inadequate. And these people are the hope of patients everywhere??? God help us all
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On CAPi since Sept '05 for MSi, RAi, Asthmai, sciatica. EDSSi at start 5.5.(early cane) Now 6 (cane full time) Originally on: Doxyi 200, Azith 3x week, Tinii cont. over summer '07, Revamp of protocol in Summer '08 by Stratton due to functional loss; clarithromy
More studies from as early
More studies from as early as 1991:
1,25-dihydroxyvitamin D3 regulates the synthesis of nerve growth factor in primary cultures of glial cells.
MC903, an analogue of 1,25-dihydroxyvitamin D3, increases the synthesis of nerve growth factor.
1,25-Dihydroxyvitamin D3 is a potent inducer of nerve growth factor synthesis
I know I sound like a broken record, and I'm certainly no expert, but have you taken your Vit D3 today? If we use the recommendations from above for children from the panel of experts, amounts of 1,000IU for each 25 pounds of body weight and even more may be required if you are ill (or more specifically, IMHOi, if Vit D3 is being used in larger amounts by your body to combat infectionsi, rebuild bone loss, regenerate nerves, etc)...
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Treatment for Rosaceai
Wow, fantastic article,
Wow, fantastic article, Red, thank you so much! (And no, you don't sound like a broken record, and even if you did please don't stop!)
Also - I had not heard of the Vit D link with regard to autism ("the group recommended that "children with chronic illness such as autism, diabetes, ... may need to take even more vitamin Di"). I have a friend whose grandson has some form of autism, I will send this information along to her.
And unfortunately, no I have not taken my Vitamin D3 today but thanks to you I am going to be much more faithful about taking it, as well as ramping up the amount to match body weight plus compensate for illness!
Kelly
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Diagnosed FMSi Feb '07. 2x/day: 600 mg NACi, 100 mg Doxyi, 500 mg Amoxicillini. 250 mg Azi M/W/F. Flagyl pulses every 3-4 weeks.