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Karem,  the critical one CPNⁱ- IgGⁱ, IgA look normal as do the EBVⁱ IgM's and I do not see HHV-6. Are there strong signs of improvement from two years ago as maybe the immuneⁱ system is already back to normal.  Any spinal tap issues?  Have you used this lab before and found positive results with these, some labs may not detect as well as others?

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Cpnⁱ, Mycoplasma, Chronic EBVⁱ, M.S.(MRI, Spinal Tap-greater than 5 oligoclonal bands and VEP), PANDAS(OCD). Wheldon CAPⁱ (started 12/08), Azithromycin/Clarithromycin(12/09), Lithium, Lamictal, NACⁱ(2.4g/day), D3(12,000IU/day)

 It's RRMSⁱ and the patient had an attack like episode while she was on CAPⁱ. Her CPNⁱ titers were always negative. Borrelial, mycoplasmal and viral titers were tested for the first time.

 What's the meanings of

  1-High CMV IgGⁱ

  2-positive EBVⁱ IgG PROFİLE

  3-positive Mycoplasma IgG titer

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KEREM'S TAKECARER;

Suspıcıon of MSⁱ (transient nystagmus during conjugated gaze on february 2008, blepharospazms and some optic complaints on february 2009-no plaque on MRI), Vit D3 started 400 IU and elevated to 2000 ıu ın 40 days.

Elevated EBNA-1 is common with M.S..  Mycoplasma seems to show up with Cpnⁱ, high IgGⁱ means past or current exposure. 

Take a Tetanus Anti-toxoid test if you can, it is good for tracking the immuneⁱ system response and the results are not in titers which makes it easier to interpret.  All my doctors I have use it as a marker for problems and here the typical value is 1 and the range is .05-7, mine has been up to 6.5 and now at 4.5, both very high.

Is this lab reliable for others you have checked for Cpn?  What were the spinal tap results?

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Cpnⁱ, Mycoplasma, Chronic EBVⁱ, M.S.(MRI, Spinal Tap-greater than 5 oligoclonal bands and VEP), PANDAS(OCD). Wheldon CAPⁱ (started 12/08), Azithromycin/Clarithromycin(12/09), Lithium, Lamictal, NACⁱ(2.4g/day), D3(12,000IU/day)

 No spinal tap was applied. Tests were done in famous labs. in Turkey but I believe that still there is a possiblity of false negative result for CPNⁱ.

 What will we learn from tetanus antitoxoid test result. What will it mean if it's high, if it's low or  if it's in normal range?

 yılmaz

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KEREM'S TAKECARER;

Suspıcıon of MSⁱ (transient nystagmus during conjugated gaze on february 2008, blepharospazms and some optic complaints on february 2009-no plaque on MRI), Vit D3 started 400 IU and elevated to 2000 ıu ın 40 days.

A high response, value, from a Tetanus Antitoxoid test hints at a tilt toward a strong Th2 reponse from the immuneⁱ system.  An unbalanced condition of the Th1/Th2 cells.  This can be used for a marker of an on going infection.  The more you use it the better feel you will have.  With Cpnⁱ it is known to tilt the immune system towards a Th2 response by changing the interleukin levels.

In my case the value is high and also decades old antibody levels have shown up abnormally high such as Whooping Cough, German Measles, Measles, etc.. 

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Cpnⁱ, Mycoplasma, Chronic EBVⁱ, M.S.(MRI, Spinal Tap-greater than 5 oligoclonal bands and VEP), PANDAS(OCD). Wheldon CAPⁱ (started 12/08), Azithromycin/Clarithromycin(12/09), Lithium, Lamictal, NACⁱ(2.4g/day), D3(12,000IU/day)

The CMV looks the most obviously out of line....perhaps investigation should go along that path.

For info on mycoplasma pneumonia, google search "joel baseman mycoplasma pneumonia" and you will find some info.

I'm not familiar with a.a. profiles.

It would be a good idea to test for HHV-6, as that has been linked to MSⁱ too.

Best, Timaca

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Dx  lyme disease 3/05. Dx HHV-6, EBVⁱ, VZV, and HSV1 6/07. Dx with CPnⁱ 5/08 and enterovirus 2/09. On antibioticsⁱ for 2+ years, Valcyte (antiviral drug) for 9 months. On 100 mg doxyⁱ bidⁱ for Cpn, acyclovir for viruses, oxymatrine for enterovirus

Kerem,

 The Elisa test for Borrelia is useless.  The patient would have a better chance of testing postive for Borrelia with a Western Blot from Igenex or Clongen - especially since he/she has been on antibioticsⁱ.  But please keep in mind that even the Western Blot misses most cases of Borrelia, and it should be a clinical diagnosis.  Babesia and Bartonella are two other infectionsⁱ that can hamper antibiotic treatment of those with tick-borne disease.  My daughter has tested positive for Borrelia, Babesia, Bartonella, Cpnⁱ, and Mycoplasma Pn - and the Bartonella has been the toughest to treat during the last 2 years.  Bactrim has been the best antibiotic for the Bartonella.

Best,

Kathryn

 

  Moxy, thank you for suggestions. MSⁱ is known as TH1 disease, so I would expect a low tetanus antitoxoid test in MS patients. Is this the case?

  Timaca, thanks for your suggestions also. I will make the google research that you suggest.

  Kathryn, thank you for suggestions. I wonder the story of your sister.( I have a 5 years old son who might have lyme. Western blot results from Igenex say that he has 1 double starred  band, 3 single starred  band and 1 indetermined band. It was reported as negative- they report as positive if a patient has 2 double starred band- but they recommend retest for once more. He had some neurological symptoms which may be related to MS). So I wonder how old your daughter is, which antibioticsⁱ does she take and how did she respond the therapy.

  yılmaz

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KEREM'S TAKECARER;

Suspıcıon of MSⁱ (transient nystagmus during conjugated gaze on february 2008, blepharospazms and some optic complaints on february 2009-no plaque on MRI), Vit D3 started 400 IU and elevated to 2000 ıu ın 40 days.

Kerem, Tetanus is an extra-cellular bacteria so with a high response to it, Th2, would suggest a low Th1 response or low intra-cellular.  Cpnⁱ and Mycoplasma are intra-cellular.  Th2/Th1 tilt in other words.  Post what you find I am curious.

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Cpnⁱ, Mycoplasma, Chronic EBVⁱ, M.S.(MRI, Spinal Tap-greater than 5 oligoclonal bands and VEP), PANDAS(OCD). Wheldon CAPⁱ (started 12/08), Azithromycin/Clarithromycin(12/09), Lithium, Lamictal, NACⁱ(2.4g/day), D3(12,000IU/day)

  Moxy, can we say there are enough evidence showing MSⁱ patients have low response to tetanus antitoxoid test.

 yılmaz.

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KEREM'S TAKECARER;

Suspıcıon of MSⁱ (transient nystagmus during conjugated gaze on february 2008, blepharospazms and some optic complaints on february 2009-no plaque on MRI), Vit D3 started 400 IU and elevated to 2000 ıu ın 40 days.

I have M.S. and have a high value reported on the Tetanus Antitoxoid tests for many years, almost ten now.  It was mentioned not as a test for M.S. but used for a first line test hinting for any infection, fishing for an unknown tool.  Seems to be a good marker for that and after the first test a very good baseline test to show change as the results are measured in a linear fashion not incremental as in titers.  It is cheap so try a few known healthy immuneⁱ systems and then those in question to get a sense of the lab and see if it works for you.  My docs find it useful and I take it every three months now to watch for a drop from my CAPⁱ.  It is just a tool that may help you.

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Cpnⁱ, Mycoplasma, Chronic EBVⁱ, M.S.(MRI, Spinal Tap-greater than 5 oligoclonal bands and VEP), PANDAS(OCD). Wheldon CAPⁱ (started 12/08), Azithromycin/Clarithromycin(12/09), Lithium, Lamictal, NACⁱ(2.4g/day), D3(12,000IU/day)

Moxy

Please reply only if you're comfortable.I noticed in your signature that you're on lithium.What is the rationale for its usage?Is it related to your msⁱ diagnosis and/or mycoplasma, epstein-barr , VEP(not sure what that is)? Hope you can help me out?

Loulou

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diagnosed MSⁱ Jan.2000 ,  chronic neurological lyme disease Nov.2002.

doxyⁱ 100 mg. 1BID. roxyⁱ.150 mg.? BIDⁱ,adding rifampin soon, pulsed tiniⁱ. every 3 weeks, as of oct.17/08, rifampin,naltrexone (LDNⁱ),NACⁱ, nystatin, major wheldon supplemrnts daily,

I am bipolar and have been since a teenager, also OCD.  The OCD is mild and is the genetic immuneⁱ system type, see PANDAS-Swedo in a search engine.  I have the D8/17 PANDAS antibody as verified from a blood test, abnormal levels also.  The bipolar is caused I believe from the neurotoxin from Cpnⁱ as it interferes with serotonin, HSP60.  Lithium helps the bipolar swings and lithium may play a role with the immune system as it is known to help fight infection.  I believe the M.S. is genetic in my case as the antibodies generated to fight Cpn also attack the nerves in my body.  My immune system is very overactive and has been for decades.

http://www.ncbi.nlm.nih.gov/pubmed/17287092

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Cpnⁱ, Mycoplasma, Chronic EBVⁱ, M.S.(MRI, Spinal Tap-greater than 5 oligoclonal bands and VEP), PANDAS(OCD). Wheldon CAPⁱ (started 12/08), Azithromycin/Clarithromycin(12/09), Lithium, Lamictal, NACⁱ(2.4g/day), D3(12,000IU/day)

Thanks Moxy. The lithium seems to be working for you and that is good.

Your research has been good. I think I also have OCD. It is becoming so common and readily diagnosed in the world in which we live.

All of us with MS have overactive immuneⁱ systems or so I've been told. The geneticsⁱ are there for me as well, even though this is speculative. My father died  26 years ago of ALS. No other ALS or MS in my family both immediate and extended.

Thus I continue on the cpnⁱ route with much hope.

 

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diagnosed MSⁱ Jan.2000 ,  chronic neurological lyme disease Nov.2002.

doxyⁱ 100 mg. 1BID. roxyⁱ.150 mg.? BIDⁱ,adding rifampin soon, pulsed tiniⁱ. every 3 weeks, as of oct.17/08, rifampin,naltrexone (LDNⁱ),NACⁱ, nystatin, major wheldon supplemrnts daily,