Tovaxin, the vaccine for MSi in trials, has failed to help people with MS in a stage II/III trial.
Quickly, it was supposed to work like this; The company devised some proteins sequences to mimic myelini. Since MS is 'your body attacking myelin', if they could just get rid of those attackers, you would be home free, right? So they take some of your blood and see if you are making t-cells that attack the myelin like sequences they created by putting them in a lab dish together. If your cells go nuts attacking the 'myelin', then you were considered a candidate for treatment. `they then irradiated the t cells they had isolated as myelin reactive ones and gave them back to you in a shot. From then on, your body recognizes these particular bad guys and kills them before they damage the brain . so the theory goes...
But several things turned out to be true, first not that many people even make MRTC --myelin reactive tcells. second it did not help to eliminate them even if you did.
for many on TIMS, and people everywhere with MS in the autoimmune camp, this is devastating news. If you believe the autoimmune theory this is a real blow because they had great hope for it as a really targeted way to treat MS. It was targeted right at the heart of autoimmunity as it is thought to be.
my personal thought had been it might have been a good 'suspenders and belt' strategy for us because it was so targeted and does not wipe out immunity generally.
Having MS for 17 years and watching promising autoimmune approach after approach fail against all excitement and expectations, i am amazed at the relative dearth of literature seriously questioning the autoimmune theory's viability. I also find it incredible that we continue to be viewed as nuts for trying something else, when standard medicine keeps giving us these relatively ineffective treatments.
ugh.
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On CAPii since Sept '05 for MSi, RAii, Asthmaii, sciatica. EDSSii at start 5.5.(early cane) Now 6 (cane full time) Originally on: Doxyi 200, Azith 3x week, Tinii cont. over summer '07, Revamp of protocol in Summer '08 by Stratton due to functional loss; clarithromy
Just more grist to the
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Michèle (UK) GFAi: Wheldon CAPi 1st May 2006. Daily Doxyi, Azi MWF, metroi pulse. Zoo keeper for Ella, RRMSi, At worse EDSSi 9, 3 months later 7 now 6.5 Wheldon CAP 16th March 2006
Marie, These are my
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On Wheldon protocol for MSi since April, 2006. doxyi 200 mgs daily, zithromax 250 mgs 3x/ week , Flagyli Pulses start end Sept., LDNi 2004. Gad-enhanced MRI of brain and spine shows NO NEW DISEASE ACTIVITY and one lesion diminishing in size on 9/30. Ma
Surprise, surprise,
An Itinerary in Light and Shadow
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Autoimmune diseasesi and
Autoimmune diseasesi and idiopathic illnesses... sounds like idiocy to me. I've heard this all my life with psoriasis and nearly every other symptom and illness I have and have had. You'd think someone would "get it" by now... geez.
Oh, wait... SOMEONE did get it! That would be Drs Stratton, Wheldon and Powell!
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NACi 2.4g, Zithi 250mg/MWF, minoi 200mg, Tinii 5day/1g/5 pulses, Valcyte
Don't believe everything you think!Iodoral 12.5mg, Supps, CFIDSi/FMSi, Hashimoto's, Psoriasis, PA, IBSi, Sec Addisons
LOL, exactly! There is a
LOL, exactly! There is a group understanding and questioning the autoimmune dogma, thank goodness.
And Sarah I wish people who've failed these things would post their experiences more prominently. If you go to TIMS and look at individual boards there are occassional 'failed treatment' entries, but they are rare and the person kind of moves on. What I have wondered is if these people actually do worse than average untreated MS patients....fom 2 to 7 is a huge, huge loss. most MSers take years and years to see that kind of shift, yet i seem to have noticed that the ones who fail these things perhaps to do so dramatically in that way. I wonder if she knew if she was on the drug or placebo?
OTOH, the-pharma involved would undoubtedly explain that they have no way ofscreening out people with the rare form of ms where people get those severe fast worsenings, so would not attribute it to the drug but rather to a person with 'bad ms'.
Wiggy, we are all in the same camp! I haven't had a dramatic turn around, yet, but it does not matter. This just makes more sense.
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On CAPi since Sept '05 for MSi, RAi, Asthmai, sciatica. EDSSi at start 5.5.(early cane) Now 6 (cane full time) Originally on: Doxyi 200, Azith 3x week, Tinii cont. over summer '07, Revamp of protocol in Summer '08 by Stratton due to functional loss; clarithromy
That's right, Michelle.
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Wheldon Protocol for rrmsi since Oct '05. Added LDN 4.5mg qhs Oct '07. All supp's. Positive IGGi's for Lyme Disease,Babesia, & Erlichiosis Sept. 2008. Currently: Mepron 750mg bid and Azithromycin 250mg qd for Babesia.