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Body response, often an immune/cytokine response, to infection or other foriegn agent.

Understanding Chronic Inflammation and its potential role in cancer

Here's a link to a great article DW mentioned in Scientific American on chronic inflammation and its potential role in cancer. The article is very easy to read, and I believe, an important article to understand:

A Malignant Flame<

Cpn triggering Reactive Arthritis

For 3 months I've had terrible swelling primarily in my hands, calves, and feet - believed to be Reactive Arthritis triggered by Cpni. I am HLA-B27 negative, but positive for Cpn. I have been Doxycyline 50 mg twice a day now for one week.

Does anyone have any applicable experience or advice here?



CAP ear ~ What to do

If your Cpni history includes acute ear infections or sinusitis with stopped-up ears, the Cpn die-off while on the CAPi may cause considerable ear inflammation. This can be caused by endotoxins released from the killed Cpn and the immune response to those endotoxins. Subsequently, it can be caused by the immune system's clean-up response to apoptosisi. Ear inflammation should not be taken lightly, as your hearing and balance are dependent on the good working order of your ears. Also, ear inflammation can cause or worsen tinnitusi.

travelling hives

Hi everyone,

a very good friend of mine, male, late 30's, is having these horrible bouts of hives, big patches & the colonies move from place to place.  He has been bounced around from MD's to specialist and they cannot pin down the cause.  They have put him on some powerful antihistamines & at the moment things have calmed down.

Has anyone here heard of this type of reaction that could be blamed on Cpni?  I appreciate your comments.



Pinky's News

Checking through recent post I found this from Pinky, and as Mac commented it might not get the attention it deserves in the place in which she posted it.

"It has been a long time since I have checked the site. Dr. P took me off Flagyli<i</zithro right away because of the extreme die off. Now I am on Vit D (5,000 per day) and the assortment of liver//kidney saving drugs. The last time I went in I bought the Infrared Light, but must confess I have not used it faithfully. I have been getting PT in a warm pool (92) and it has done more for the pain that anything in 15 years.

Continuous Treatment

I haven't blogged my treatment for a while, as I've been waiting to see if I would stick with a shift in protocol. So far, still with it, so thought it might be time to report in and get other's thoughts. New folks, please read this as informational only. It does help clarify Dr. Stratton's use of the continuous rather than pulsed protocol, but the rest of the hypotheses here are presented as my own speculations, not scientific fact.

Jaw trouble?


I know that everyone here has very specific diseasesi and everyone is different. But when my interstitial cystitisi symptoms began, so did this incredible jaw discomfort that I have. It isn't really like TMJ becaues it doesn't hurt when I chew, it just feels that my jaw is tightened up all the time and I have to crack it. It also is accompanied by ear pain and dizziness. Is this a symptom anyone has experienced and is it something that CPNi can be implicated in?


Pulse #4 - I made it!

Hi Everyone!

I've made it past 3 days on pulse #4!  It's all very exciting!  I haven't gone crazy nor have I freaked out.  I am going to go for day 4 and day 5.

I am however only taking about 300mg. of Flagyli per day.  A little over half of a 500 mg. tablet.

Last night, my neck, throat, ear and groin throbbed.  All of the areas where I have enlarged lymph nodes. I am a teeny bit twitchy but I'm working through it.  I also had some aches again in my right lung and ribcage.  I'm having a little bit of a hard time falling asleep, and I sleep a little crazy (move a lot).  I still have a ton of mucus coming from my lungs, sinuses and even my eustachian tubes.

This morning I awoke at 7 a.m. (after going to bed at about midnight), I had enough energy to clean the kitchen (my own kitchen test - haha), wake my children up and make chocolate chip pancakes for them before we started our schoolwork.  My husband didn't wake up until about 10 a.m. and he was just thrilled to see that I'd been up and happy. (he hasn't started his pulses yet, he's still dealing with the Zithi and T3 and he works the late shift because he can't get up in the a.m.).

Antibodies Finally

Well today was my doctor's appointment.  I saw Michael at Dr. Powell's office.

Now, apparently, I have thyroid antibodies all over the place.  Michael is pretty sure I have Hashimotos with an elevated TPO at 412 (normal is <30).  However, I also had very slightly elevated Graves antibodies.  I have a thyroid ultrasound tomorrow (because it is still quite large and painful) and I have a referral to see an endocrinologist.  While I thought I had the perfect dose of propranolol, Michael wrote me a new prescription nearly doubling my dosage.  He said he wants my heartrate under 100 at all times and preferably around 80 bpm.

Because I'm having quite a bit of endotoxic reactions (I shivered and fevered all week), we lowered my daily Valtrex to 500mg instead of 1000 mg.  I'm to keep up everything else and apparently I've been managing my pulses quite well.  I'm just about ready to start another one.  I'm also going to begin taking Ursodial for my liver.

Doctor's Appt. Anxiety

I have a doctor's appointment tomorrow morning and I am scared to go.  I am posting this because I am trying to deal with my pre-doc appt. anxiety.  Maybe in a year I won't feel this way.  It's awful and it makes me procrastinate.

So why exactly am I afraid?  Well, my thyroid is still swollen, it hurts and itches, I'm still on the propranolol and have a high heartrate.  Maybe they'll want to take my thyroid out?  Maybe my latest antibody tests came back positive for something like Graves disease and they'll want to radiate my thyroid.

I always have this fear of doc's not listening to me too because of all the terrible experiences I've had of being in so much pain and referred to a psychiatrist for it.  That was probably the lowest point in my life. I know Dr. Powell's office is different, but all those feelings and experiences still hang around.

The Puffies

Hi All,

After my last 2 day pulse I hit the ground and wound up taking several days off of everything except the vits and supps.

Interestingly, a couple days into my med break, I woke up very puffy.  Swollen joints in my fingers, pillow lines on my puffy face, ridges in my ankles from my socks and feeling like my head was going to explode.

This happened about 3 days in a row, along with headaches.  More interesting is that the puffiness came when the post pulse hunger subsided

My thoughts are that when the killing stops, the body goes into major clean up mode and tries to remove all the debris.  If this is actually what happens wouldn't it make a case for taking a short break every so often from all abxi?  Just wondering.  I'm back to the Zithi tomorrow.

Five Ways of Feeling Lousy

 Dr. David Wheldoni's succinct summary of the different reactions to Cpni and its treatment helps in sorting out the different responses and what to do about them. I've moved this from his comment in another members blog post to a page of it's own here in the Cpn Treatment Handbook.

Jim K (Editor in Chief) 

Five Ways of Feeling Lousy

I am inclined to think that there are five major mechanisms behind those unpleasant side effects of chronic large-load infection with C pneumoniae which worsen in the short-term with antichlamydial treatment.

a) Lipid peroxidation may likely get worse in the short-term as bacterial products are released both by breaking down EBs and by apoptosisi< of infected cells. Antioxidantsi<i< and B vitaminsi< (including B12) may help with this. I find melatonin">i<i< at night helpful.

Only 2 days!

So I only made it two days on my pulse.  I reached yesterday evening and for the life of me - I could not take another pill.

The right side of my face around my ear hurts and burns badly, as does the right side of my neck, right shoulder and down the right side of my back.  This has me distracted so badly I am hardly functional.

Other crazy things that happened are the twitchy witchies on my left eye and lots of breakouts all over the back of my neck, forehead, chin, my back and even down the front of my chest in between my breasts.  I understand that I have lymph nodes on my chest there and that they may be infected...hence the breakouts.

I don't feel so bad about the breakouts, my husband looks like a teenager again with them all over the sides of his face and down his neck, and he hasn't even done a pulse!

Update -- Chain Ganger Chris

Hi CPNers -- It’s been 29 days since I began treatment for CPN – Biaxin 500 mg every other day.   6 days ago I began Doxycycline 100 mg every day and I continue to take Biaxin.  I’ve been treated for fibromyalgiai with injections of Gamma Globulin – nothing much else but a heating pad and lots of Flexall – I felt like fumes were arising from me…I could almost see them.  At this point I’m really feeling pretty good.  I don’t have that sick feeling with CPN and fibro that I had for weeks, not as much brain fog, not nearly as much exhaustion – that only happens when I get up at 4 a.m. and work on the computer all day without a break, and of course then I’m asleep by 8 p.m.  The fibro has pretty well let up, especially my painful mid back which was killing me.  It’s my lucky day that I don’t smell of Flexall anymore.  I still have pain in my left upper arm, but that’s not much, comparatively.  I’ve been drinking lots of liquids – zero calorie artificially sweetened clear soda.  I guess if I don’t drink water, it’s better than nothing.  I’ve been taking prescribed supplementsi.  Been a good girl.  So, things are looking up. Do you think I’m being too hopeful?  

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