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Jim’s Story- Chlamydia Pneumoniae and Chronic Fatigue/Fibromyalgia

Submitted by Jim K on Sat, 2005-09-17 19:56.

The Tunnel of Illness

I want to update my story on the front end so readers know even before reading the "agony post" how much benefit I've gotten from the treatment. It is August 26th, 2006. Coming up on two years I've been on the Combined Antibiotic Protocol (CAPi) for Chlamydia pneumoniae (Cpni). A recent forum poster asked if anyone with CFSi has improved on the CAP. My response:

Damned right I'm getting better!When I started the CAP I was in a 2 year slide after 25 years of CFS, then added FMSi. For many years I'd struggled and somehow maintained a semblance of a life. Then over 2 years my pain, brain fog, restricted functioning, etc. slid to a point where I had to stop traveling and could for the first time see the possibility that I would become bedridden eventually.

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Case Reports from the Mitchell, Stratton et al patent

Submitted by Jim K on Wed, 2007-08-22 21:06.
patent 6,838,552 
                             TABLE 11
    Serological and PCRi Responses to Combination Antibiotic Therapy
                                   Months of
                                  Combination
    Pa-                 Titer     Antibiotic
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Five Ways of Feeling Lousy

Submitted by D W on Thu, 2006-12-21 08:22.

 Dr. David Wheldoni's succinct summary of the different reactions to Cpni and its treatment helps in sorting out the different responses and what to do about them. I've moved this from his comment in another members blog post to a page of it's own here in the Cpn Treatment Handbook.

Jim K (Editor in Chief) 

Five Ways of Feeling Lousy

I am inclined to think that there are five major mechanisms behind those unpleasant side effects of chronic large-load infection with C pneumoniae which worsen in the short-term with antichlamydial treatment.

a) Lipid peroxidation may likely get worse in the short-term as bacterial products are released both by breaking down EBs and by apoptosisi of infected cells. Antioxidantsii and B vitaminsi (including B12) may help with this. I find melatoninii at night helpful.

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And one more serology paper

Submitted by paron on Wed, 2006-01-11 12:24.

 According to http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=145278

Clin Diagn Lab Immunol. 2003 January

Measurement of Chlamydia pneumoniae-Specific Immunoglobulin A (IgA) Antibodies by the Microimmunofluorescence (MIF) Method: Comparison of Seven Fluorescein-Labeled Anti-Human IgA Conjugates in an In-House MIF Test Using One Commercial MIF and One Enzyme Immunoassay Kit

 

"...The diagnosis of acute Chlamydia pneumoniae infection is usually based on the demonstration of at least a fourfold increase in immunoglobulin G (IgGi) antibody levels in serum samples between the acute phase and the convalescent phase or the presence of IgM antibodies in any serum sample..."

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PCR Analysis

Submitted by mrhodes40 on Wed, 2005-09-07 15:56.

Here is a link to a detailed and technical paper on PCRi analysis that evaluates and outlines the problem with culturing CPn and the variations in abilities in different labs. It also talks about the results of split samples and concordance between some PCR approaches and discordance with others. Though this is highly technical, it answers the question of how can it be that there are still some researchers producing papers saying, for example, that they tested patients with MSi for CPn and found the incidence to be no higher than controls, such as this article here but note that this one used antibody tests, a ridiculously ineffective way of looking for CPn in cryptic form in the brain.

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