Charles Stratton

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Main researcher/physician at Vanderbilt University whose fundamental science and research, along with his colleagues, has formulated the combination antibiotic approach to treat Chlamydiae pneumoniae

Anticipating Number 20

Anticipating number 20 Flagyli.  Only at the beginning was the cure worse than the disease, but now with eyes wide open,  I march into battle with the knowledge of the gloom to be   I think that is KK2's perfectly chosen description.

Last installment the feeling was just beginning to return to the right  side of my torso after 10 years of at least 90% numbness.  I have done my sit-ups and push-ups most days in hopes of helping this and it must have been doing some good because  very suddenly I can feel my abdominal muscles.  Consequently, more  movement is more under my control and my walking is better.   I feel a little more like me.

 This  last round of Flagyl has dramatically demonstrated the flat "gloom" brought on by it.  The whole week after, and really probably 10 days, I think I am coming back, but this is Tuesday and I am only now leveling out and I begin all over again on Sat.  I think once you know that you are not whirling into an emotionless, bottomless depression you are better equipped and can hold on to the fact that this is a passing part of the treatment.  My mind was apparently very affected by this disease (mostly past tense) which may account for my extreme fog.  I cannot believe how far back I have come, particularly in the 4 or 5 days before the next Flagyl -  "blue sky days" in Macks words, I think. 

Initial and Following Blood Tests in CAP's Treatment

Initial and following blood work is not just a matter of Cpni related indicators, but also relevant to your particular history and case, as determined by your doctor. Suggestions drawn from experts treating Cpn in a variety of conditions include the following.

Initial blood work can be obtained for the following tests:

  1. CBC & Differential
  2. Liver function tests
  3. Uric acid
  4. Serum iron studies (typically depleted by Cpn: low iron levels are more diagnostic, and are not necessariy indicators to supplement, which may actually increase Cpn infection-- see references below).
  5. Red blood cell ALA dehydratase
  6. Red blood cell PBG deaminase
  7. Vitamin B-12 level
  8. Homocysteinei levels
  9. Serum methymalonate level.
  10. Vitamin Di levels
  11. Thyroid panels (standard plus free T4, free T3, revers T3) [Endocrine disturbances common in Cpn and associated diseasesi]
  12. Creatinine
  13. AST
  14. ALT
  15. 24-hour urine and 24-hour stool specimens for porphyrins

Dr Stratton has noted relative to porphyrins:

supplement table ?

Is it my brain fog or is there no B vitaminsi on the supplement list?


Dr. Stratton Cautions on Protecting the Liver

In recent correspondence, Dr. Stratton has been discussing reports in the medical literature that certain antibiotic agents can cause liver damage or failure. Noting that these agents are typically the most potent anti-chlamydials, he has drawn some important hypotheses from this that anyone on an antibiotic protocol should know about.

His cautionary note is that use of some of the new, powerful agents against Cpni must be carefully monitored, and that a more gradual treatment for many is advisable. His observations also affirm the importance of supplementsi in their liver-protective role.

Dr. Stratton notes:
"A recent report of Ketek causing liver failure has crystallized some thoughts that I have had for some time. Cpn can infect the liver and the kidney, but in particular the liver is a target due to the Kupfer cells. Any drug that acts against Cpn (including statins) will therefore in some patients cause hepatic damage or even hepatic failure. The better the activity against Cpn of the agent (or combination of agents), the more likely the liver damage. Even penicillamine can cause liver damage, as does Augmentin.

Stratton Combination Antibiotic Protocol Update: February 2006

Dr. Charles Stratton writes: 

As far as the ideal Cpni Antimicrobial Regimen is concerned, my thoughts (as of 2/06) are as follows:

Yes indeed, I have improved!

In an email to me, one of our new members noted how long I'd been on the protocol and asked me if I'd improved on it. It was a legitimate question, and one that on a day to day basis is not always clear to me, since I continue to have symptoms, and the slope of my improvement has been very gradual. As has been said elsewhere on this site by experts, the longer you've had Cpni, the more systems involved, the higher the bacterial load and so on, the longer and more arduous is the treatment. My CFSi diagnosis means that it's been a chronic condition- underline the C in FS.

So I wanted to report my assessment of this based on some recent experience.

Yes, the protocol has indeed helped. I've had this bug seriously (undiagnosed) for at least 20 years, so my tissue loadi was very high to begin with, and I had to go very gradually to get at it. As you can read in my Patient Story, I was not feeling very patient about the whole thing, wanting to push up doses too fast, suffering more because of that, and so on.  The longer you have had it, the harder to treat, the more reactions to treatment, etc. Certainly so for me. And the slope on the curve of improvement is also very low in such cases.

I've reported other changes in my Patient Story and in previous blogs, but had a very clear reference point recently as to how much I've improved. I travel and teach workshops overseas. By Spring 2004 I could no longer tolerate the travel and feel I could deliver quality teaching. I stopped traveling for a year and started treatment in fall of 2004.

MRI Reading

Like Beethoven, MRIs are even better the second time.  With the 1st MRI from Aug, 2002 missing (!), the local radiologist read the  films 2 through 5 and gave a verdict of overall improvement.  We will attempt to find the mysterious missing 1st film because it IS 1st and probably worst, having been taken because I was having so much trouble.  However,  3 through 5  were all done after beginning abxi Sept, 2004.   No. 2 was Jan 2004 before starting abxi, then Jan 2005, then June 2005, and finally Jan. 2006.   No new lesions and the existent ones are not as bright, especially in the latest.  I have no intention of sitting and waiting a probable year for the next but to get up every morning possible and do whatever needs doing at an ever-increasing speed.  Within reason, of coiurse! 

Highest Order Swamp-Dweller

Taking Marie's admonition to heart I am reporting while measurable achievements are fresh.  That sentence being one of them to compare to a year ago.  Day 1 of my 18th pulse I began my daily pushups (only 10) and situps again.   I stopped these last year due to lack of interest and inability. I can only manage 10 situps but I'll get back to my old 25 soon I hope.   My run/walk was suspended for a few days (still suspended)..  Early in this pulse (day 2 or 3) I could only do 5/8 of a mile instead of a mile, and it took 20 minutes or so.  Now, on day 5 I am wobbly (to borrow a phrase) and not sleeping well in spite of taking 1 1/2 melatonin">i (I believe these are 300mcg pills) last night.  There is no doubt that for about 10 days my body is at war and my mind is fuzzy - as opposed to foggy.  In other words, do not be alarmed at regression during pulses- the rewards are huge but not instantaneous.

MRI Results

Results from MRI no. 5 Jan. 21.2006   -  "no worse- stable- WOW" This was on the report from my doctor.  I spoke only to the nurse.   This is 6 months after no. 4  and is news that any PPMSi patient of 10 years would probably be thrilled to hear but I admit to hoping for a really earthshattering statement but this is good progress and we should all be satisfied that an important marker is noted.    For myself I must remember that Sarah went 2 years, I believe, before  HER earthshattering marker.   The main thing is physical progress which goes by mostly forward bounds with a good dampening  during Flagyli.  We will likely accept the offer of the local radiologist (he is actually a rotating radio.) to examine all 5 and see if he embellishes any.  Apparently not even this happens in PPMS cases like mine.    Remember, last month my neuroi said MS lesions never go away.  Sarah has already proven that is wrong.  I would appreciate any comments David has.

OK, supplements then. Diet as well.

My doctor's completed his research for the time being. Conclusions: I am to follow the Stratton Protocol (V.7), as far as diet/supplementsi, skip Wed's Zithi, and take Friday's.

Added a scrip for xanax -- I said when asked that I felt anxious when I couldn't breathe right. Well, that's natural, right? I wonder how many people say, "Oh, no, I love it when I can't get my breath." Useless question.

 Dianna, though, agrees with the Dr. -- it's really that I don't breathe right when I feel anxious. Took a xanax last night; couldn't tell any difference, but I might not -- how do you know what might have been?

Anyway, as a gustatory experience it's right up there in the Flagyli class. I need to get some big capsules to stick the pill inside -- great suggestion, Jim!

Pleased with my Doctor.

I am; he called me today and asked me to give him a little time to research before he recommended a course of action (following the wierdness of my 2nd dose of Zithi.) He said I could decide for myself, take the next dose or not.

I know, in a perfect world, he'd have the research all done. Of course, in a perfect world, we wouldn't need Doctors at all, would we?

It's great that:

  • he didn't try to snow me; he just went to get some more information
  • he allowed me to be a part of the decision process
  • he doesn't think he has to know everything about everything; but he's willing to find out
  • he's willing to try something out of the mainstream
  • he's actually interested in this whole problem 

It's so nice to find a Doctor that's willing to partner up like that.

Raise the Flag (yl)

This is a short blog entry about being under the influence of Flagyli.  The first 2 days when I measured my 1 mile run/walk it  was a thing of beauty!  My time was 4 minutes for each lap of 700 feet- today it was more than 5 for the 1st lap and I was VERY tired after 3 laps and 17 minutes and stopped.  I ran not 1 step!  It was only 8 hours after my 1st dose and 1 1/2 after my 2nd.  I have to write this now because at this rate I will forget how to write by tomorrow!!  See you later......


patent question

I just read Dr. S patent material. Can someone please explain to me in brain fog terms what this invention is.  That is if any of us have a non brain fog moment.

Stratton/Mitchell & Siram Case Reports

Does it work?

It has been noted that most users of the combination antibiotic protocolsi commenting here have not been on the treatment long enough to give a big enough pool of reports to feel assured of the efficacy of this approach. I had asked Drs. Stratton, Wheldon, and Powell to perhaps tally up at least some basic numbers from their case experience to help us out with this problem, but this would involve problems of confidentiality and use of private data, etc.  

Then, I suddenly realized that we already have a good list of anecdotal reports of response to treatment reported data available to us... right in the Stratton/Mitchell patent materials! (Sheepish, embarrassed grin). So I took it as a project to summarize this data by disease treated. Occasionally I have used the exact wording from the patent materials as they were brief and descriptive. We have the full text referenced in our treatment and links if you want to see more detail.

All reported had with positive serologyi for Cpni using the highly sensitive tests developed by Stratton/Mitchell. I left out a few whose diagnosis was not clear to me, you can see them in the patent materials #6,884,784
All on some form of the combination antibiotic therapy protocol.

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