Charles Stratton

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Main researcher/physician at Vanderbilt University whose fundamental science and research, along with his colleagues, has formulated the combination antibiotic approach to treat Chlamydiae pneumoniae

Sarah's Illustrated Blog......................

Nov. 17th 2005  -  A New Life for 2006
To start my blog, I thought I would add three pictures, so that people can see I am a real person and not just a figment of someone's imagination.  The first two little black and white ones are the only ones that remain of a horrible period of my life, dating from 1999 until late 2003.  I destroyed all the others.  By the second one, taken a few months before my diagnosis, I was looking particularly ill.  This was when my memory was starting to go but I was convinced I was getting better.  The colour one, me and two recently finished watercolours  was taken today.

 

Comparing the Antibiotic Regimens

As people get into more of the information about the combination antibiotic (abxi) protocols on this site, confusion can arise about what medications are used with which protocol, and even which version. In the interests of clarity, I will try to summarize and compare the 7th Stratton/Vanderbilt protocol (published on this site), the most recent version of it represented by the interview with Dr. A, and David Wheldoni's most current regimen. Drs. Stratton and Wheldon have graciously replied with their overviews of protocol variations.

Wheldon Regimen:

  1. Doxycycline 200mg once a day (working up to this dose as the patient can manage)
  2. Then adding Roxithromycin (not avail in USA) 150mg twice a day OR Rifamcini 300mg twice per day OR Azithromycin 250mg three times per week (working up to this dose as the patient can manage)
  3. After 2-3 months or when the patient experiences little reaction from this dual abxi combo metronidazolei (Flagyl) is added (tinidazole may also be used if better tolerated). First a single 400mg (it comes in 500mg in the USA) is tried for the first pulse. Then every 3-6 weeks depending on tolerance a pulse of this is done working up over time to 400mg three times a day for 5 days.

When metronidazole pulses yeild no further reactions or improvements, the goal is to do 2 week courses of the abx, with days 5-9 being also Flagyl pulses. 

Content update

Protocols Compared< updated 10/28/05

 Comment by Dr. Stratton added to Stratton/Vanderbilt protocol page< 10/25/05

Stratton and colleagues, complete publications listing

This is a complete list of all publications written or co-authored by Charles Stratton. We've not had time to cull out only Cpni related references, but interested readers can scan for themselves. All we can say is.... he's been a very busy boy!

LABORATORY RESEARCH PUBLICATIONS

1. Stratton, C.W., Reller, L.B.: Serum dilution test for bactericidal activity. I. Selection of a physiologic diluent. J. Infect. Dis. 136:187-195, 1977.

2. Reller, L.B., Stratton, C.W.: Serum dilution test for bactericidal activity. II. Standardization and correlation with antimicrobial assays and susceptibility tests. J. Infect. Dis. 136:196-204, 1977.

3. McKee, K.T., Wright, P.F., Gregg, C.R., Stratton, C.W.: Initial evaluation of kinetics and efficacy of moxalactam (LY 127935) in neonatal systemic gram-negative bacterial disease. Current Ther. Research 28:603-610, 1980.

Research by Stratton, et al

The absolute, complete list of references can be found here<. The following is a more selected set of references:
  • Sriram S, Stratton CW, Yao S, Tharp A, Bannan JD, Ding L, Mitchell WM. Chlamydia pneumoniae infection of the central nervous system in multiple sclerosis. Annals of Neurology, 46:6-14, 1999.
  • Alberts GL, Mitchell WM, Stratton CW, Franke JJ. Interstitial cystitisi: can Chlamydia pneumoniae be a cause?. Infectionsi in Urology, 16, 19-21, 2003
  • Sams HH, Mitchell WM, Stratton CW, King LE. Culture and immunhistochemical evidence of Chlamydia pneumoniae in pyoderma gangrenosum. Journal of the American Academy of Dermatology, 48, 966-969, 2003
  • Sriram S, Yao S, Mitchell WM, Calibresi P, Stratton CW, Ikejima H, Yamamoto Y. Comparative study of the presence of Chlamydia pneumoniae in cerebrospinal fluid from clinically definite and monosympomatic muliple sclerosis patinets. Clinical and Diagnostic Laboratory Immunology, 9, 1332-1337, 2003
  • Earlier Version of the Vanderbilt Protocol: Stratton, et al.

    Please note: this is an earlier version of the Vanderbilt protocol developed by Dr. Stratton and his colleagues. It is here because it contains useful treatment info for reference. Please see Dr. Stratton's current protocol in the Cpn Handbbook. <

     

    Vanderbilt University has some of the world's experts on Cpn, and has been testing antibiotic treatment especially with MSi. The Mitchell/Stratton, et al patent has highly detailed information about the testing and treatment they have developed, and can be found at this link<.

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