Lab testing

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Laboratory tests for Cpn

Testing available in Hong Kong?

I am wondering if anyone can give a me the name of a doctor in Hong Kong who can arrange for someone to be tested for cPni or a lab where a preliminary blood test for cPn can be sent from Hong Kong? This information can be sent to me privately, if need be.  Also helpful would be any doctor who is able to test for a panel of the various stealth infectionsi. I believe she was tested for Lyme and that came back negative.

I am trying to help a girl who was in the UK for 5 or 6 years going to school but has now been taken back to Hong Kong by her parents.  She has been very ill for the past five years with CFSi,  extreme exhaustion, disturbed sleep cycles, migraines and fibromyalgiai, weakness in legs, extreme brain fog and inability to concentrate.  I believe her problems began after a flu-like episode.  Since Dec. of 2000, she has been taken to the ER with complete exhaustion a couple of times in the UK, and has had brain scans, lots of blood work, adrenal function testing, etc. She has gone to many doctors in the UK including some who specialize in chronic fatigue, has volumes of test results, most of which look "normal". 

Mycoplasma - Diagnosis?

I have let Mycoplasma pneumonia been tested in sputum, it was PCRi and was negative.

What I do not know: Is it usually still present in sputum after multiple antibiotic treatments when it is resistant to most of them? Or does it "hide" so that one cannot find it with usual methods?

May Mycoplasma hominis also make symtoms like they are described here? I found no lab which performs tests on it.

How have you performed your Mycoplasma tests?

Wilsons Syndrome and Chl Pneumoniae

blood work

I had the normal blood work ran last week. All is normal except a slightly elevated white blood cell count. In the beginning of my illness my wbc count was very elevated.  It always remaind elevated to a lesser degree since. Has anyone else had this?

CPn Tx and my recent labs...(Attn: Bio nerds and CFIDS folks...)

I would love any help, suggestions or advice regarding the following:

1. My most recent labs show Vitamin Di way under normal (despite supplementation with cholecalciferol). My result was 15 where 20-200 is normal. Does CPni treatment *deplete* Vitamin D or increase the need for Vitamin D in some way I don't understand?

2. I also compared my most recent labs to some from pre-CPn treatment. The counts of neutrophils and monocytes have dropped significantly, they went from normal to very low normal.  My absolute monocyte count has dropped in half and my absolute neutrophil count has dropped by about 60%.

I'm not getting any colds, flus, or immunei-related problems as of yet; in fact I have had a reduction in such since beginning the CAPi, but these labs are distressing- if they are meaningful in any way, which I am certainly not sure of.

Chat on HYPERCOAGULATION @ 9 EST

http://www.rheumaticsupport.net/<

There will be a Dr. present to answer questions

And one more serology paper

 According to http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=145278<

Clin Diagn Lab Immunol. 2003 January

Measurement of Chlamydia pneumoniae-Specific Immunoglobulin A (IgA) Antibodies by the Microimmunofluorescence (MIF) Method: Comparison of Seven Fluorescein-Labeled Anti-Human IgA Conjugates in an In-House MIF Test Using One Commercial MIF and One Enzyme Immunoassay Kit

 

"...The diagnosis of acute Chlamydia pneumoniae infection is usually based on the demonstration of at least a fourfold increase in immunoglobulin G (IgG) antibody levels in serum samples between the acute phase and the convalescent phase or the presence of IgM antibodies in any serum sample..."

Astute question from my wife

Dianna asks, "Could you detect the CPni for sure by testing during the Flagyli pulse? That breaks up the organism, would the DNA fragments be in the bloodstream then?"

It's beyond me; any comments? I thought it sounded plausible, at least.

Ron 

Testing vs diagnosis

<Testing vs diagnosis

Physicians are enamored of blood tests, as are patients. They seem so clear and unequivocal. But any good doctor knows that blood results do not a diagnosis make. Diagnosis is a complex, multivariate consideration. In the case of infection, serologyi can contribute significantly to making a diagnosis, but many factors go into whether serology is accurate or not.

In the case of Chlamydia pnemoniae, there are significant difficulties in obtaining accurate tests. In addition to the accuracy issue, individual's may not respond antigenically. All of this means that having a negative blood test for Cpni does not mean that you don't have Cpn infection. Tests can be inaccurate for the following, and other, reasons:

  • The test may not be sensitive enough. Antigen tests for Cpn are said to be relatively inaccurate. PCRi tests are the most sensitive, but dependent on the particular primers used, whether the dna used by the test matches the particular strain of Cpn one has, whether the test used accounts for the type of sample well (blood, sputum, cerebrospinal fluid, etc), the accuracy of the technician (PCR is particularly trickey in a technical sense), and so on.
  • If the infection is predominantly in cryptic phase, there is no serology evident.
  • If the patient's immunei system is significantly depleted, they will not show positive antigens for the organism infecting them (they are immuno-incompetant). 

Since many asymptomatic persons show existing antibodies to Cpn, and many with symptoms show no positive Cpn serology, blood tests are not the last word in diagnosis. Diagnosis requires a physician to put together the whole symptom picture: the suggestive evidence of infectious involvement, serology and other tests, to diagnose and treat a condition.

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