Summary Chart of Different CAP Protocols

We have been preparing this for an eventual overhaul of the Handbook, but there have been a number of requests, especially by new folks, to help clear up confusion.

Combination Antibiotic Protocolsi-
These charts are presented to give the brain-fogged an overview of protocols to understand the general approach, and why you may read of people on www.cpnhelp.org as using differing combinations of meds. These charts are meant for clarification only and should not be used as a starting point for doing a CAPi protocol. Everyone’s case is different, and requires individual considerations. Also, understanding the many facets of Cpn and treatment reactions is crucial before engaging in treatment. Don’t start any of these without reading further in the Cpn Handbook.

 

Summary chart of different CAP protocols

Note:

Jim, I'm sorry not to have read this sooner, but you appear to be making a mistake about David's regime.  You don't mention NACi until way down the list and the first alternative is given appears to be azithromycini by itself, which is incorrect as can be seen here:

http://www.davidwheldon.co.uk/ms-treatment1.html

A schedule of treatment.

This is one schedule which strikes all stages of the organism's life-cycle. Other equally good schedules are possible. It is preferable that a committed care-giver (for instance, spouse, partner or parent) should ensure that medication is given, and swallowed, consistently.)

N-acetyl cysteine (NAC) 600mg - 1,200mg twice a day, should be taken continuously. This is a commonly-taken dietary supplement, available at health-food stores. It is an acetylated sulphur-containing amino-acid, and may be expected to cause chlamydial EBs to open prematurely, exposing them to starvation; more on this and other benefits on page 4. This should be started at the lower dose of 600mg twice a day; the dose should be doubled when well-tolerated. NAC offers liver protection; this may be useful, as rapid bacterial die-off may compromise hepatic function.

When NAC is well tolerated, Doxycyclinei 100mg once daily is added. It is taken with plenty of water.

When the two above are well tolerated, Azithromycin 250mg orally, three times a week should be added. (Roxithromycini, 150mg twice daily, is an alternative.)

When all three agents are well tolerated, the dose of Doxycycline is increased to 200mg daily.

The reason for this slow, step-wise introduction of antichlamydials is to minimize any reactions caused by bacterial die-off. These can be unpleasant. NOTE: in rapidly progressive MSi it may be prudent to offset the benefits of stopping progression against the risk of reactions, giving full doses of azithromycin and doxicycline from the beginning.

This combination is taken continuously.

Also, The implication might be taken by some people that metronidazoleii and tinidazolei are taken during a five day break fro the bacteristatics an this also applies to the Stratton Protocol.  This would seem to answer my query as to why so many newbies were asking me this question..........Sarah  

 

Jim,  Thanks for doing

Jim,  Thanks for doing this.  Now...if people will only refer to it and read it.... 

Joyce~caregiver-advocate in Dallas for Steve J (SPMS).  CAPi since August 06, antivirals, heavy metals chelation, LDNi, Metanx, Lunesta, GF/CF diet, Lauricidin, oral IgGi/lactoferrin/IGF-1 booster, astaxanthin, gamma oryzanol.

Thanks Jim, This is

Thanks Jim, This is excellent! On Wheldon protocol for MSi since April, 2006.  doxyi 200 mgs daily, zithromax 250 mgs 3x/ week , Flagyli Pulses start end Sept., LDNi 2004

Very good addition Jim. 

Very good addition Jim.  I've wanted to compare protocolsi and see their differences and commonalities, and this chart brings it home.  Good work! 

all my best

John

RRMS/EDSSi was 4.5, now 4.??? on Wheldon Protocol (naci, doxycycline, azithromycin, metronidazolei) since 04/12/2006

  Jim, I'm sorry not to

 

Jim, I'm sorry not to have read this sooner, but you appear to be making a mistake about David's regime.  You don't mention NACi until way down the list and the first alternative is given appears to be azithromycin by itself, which is incorrect as can be seen here:

http://www.davidwheldon.co.uk/ms-treatment1.html

A schedule of treatment.

This is one schedule which strikes all stages of the organism's life-cycle. Other equally good schedules are possible. It is preferable that a committed care-giver (for instance, spouse, partner or parent) should ensure that medication is given, and swallowed, consistently.)

N-acetyl cysteine (NAC) 600mg - 1,200mg twice a day, should be taken continuously. This is a commonly-taken dietary supplement, available at health-food stores. It is an acetylated sulphur-containing amino-acid, and may be expected to cause chlamydial EBs to open prematurely, exposing them to starvation; more on this and other benefits on page 4. This should be started at the lower dose of 600mg twice a day; the dose should be doubled when well-tolerated. NAC offers liver protection; this may be useful, as rapid bacterial die-off may compromise hepatic function.

When NAC is well tolerated, Doxycycline 100mg once daily is added. It is taken with plenty of water.

When the two above are well tolerated, Azithromycin 250mg orally, three times a week should be added. (Roxithromycin, 150mg twice daily, is an alternative.)

When all three agents are well tolerated, the dose of Doxycycline is increased to 200mg daily.

The reason for this slow, step-wise introduction of antichlamydials is to minimize any reactions caused by bacterial die-off. These can be unpleasant. NOTE: in rapidly progressive MS it may be prudent to offset the benefits of stopping progression against the risk of reactions, giving full doses of azithromycin and doxicycline from the beginning.

This combination is taken continuously.

Also, The implication might be taken by some people that metronidazolei and tinidazole are taken during a five day break fro the bacteristatics an this also applies to the Stratton Protocol.  This would seem to answer my query as to why so many newbies were asking me this question..........Sarah  

  
An Itinerary in Light and Shadow  
Stratton/Wheldon regime since August 2003, for aggressive secondary progressive MS.  Intermittent therapy after one year. 2007 still take this two weeks every three months. Still slowly improving with no exacerbation since starting. EDSSi was 7, now 2

 Rats! To change it will

 Rats! To change it will require a bit of time, as I had to convert the Word chart to an image to insert it.

CAPi for Chlamydia pneumonia since 11/04. 25yrs CFSi & FMSi- Currently: 300mg INHi, 200 Doxycycline, 500mg MWF Azithromycin, 1000mg Tinii daily (Taking a break from continuous protocol)

Jim, how about moving my

Jim, how about moving my comment to imediately below the chart until you have the time?..........Sarah  

An Itinerary in Light and Shadow 
Stratton/Wheldon regime since August 2003, for aggressive secondary progressive MSi.  Intermittent therapy after one year. 2007 still take this two weeks every three months. Still slowly improving with no exacerbation since starting. EDSSi was 7, now 2

Thanks Jim!  Now if I get

Thanks Jim!  Now if I get less mail on the subject, it'll prove that people have read the update...........Sarah

Greetings  :-) I have just

Greetings  :-)

I have just begun the Wheldon Protocol today. This would never have been possible without being able to persuade my doctor to allow this....which was 100% based on the information found on this site. To say I am very appreciative is as much of an understatement as it is to say that I sorta' hope my symptoms improve now.  Ha!   Thank you to everyone here!

My question relates to the order in which to introduce each component of the Protocol. Specifically, my question relates to something Sarah said here:

Also, The implication might be taken by some people that metronidazoleiii and tinidazoleii are taken during a five day break fro the bacteristatics an this also applies to the Stratton Protocol.  This would seem to answer my query as to why so many newbies were asking me this question..........Sarah 

Assuming everything else is well tolerated as added, at what point should we begin to add the Flagyl pulses? And once that phase (Flagyl pulses) has begun, is a separate component (i.e. one that we would be taking at the time Flagyl is added) supposed to be reduced, suspended, or eliminated....and if so, is it then restarted when we rae not active in a Flagyl pulse?

 

CHEERS!

D

Hello D, welcome to the

Hello D, welcome to the madhouse!
Easy answer:  I started metronidazolei three months after the bacteristatic abxi, but you never, ever stop taking these whilst taking metronidazole (flagyl)........Sarah
An Itinerary in Light and Shadow  
Finished Stratton/Wheldon regime for aggressive secondary progressive MSi in June 2007, after four years, three of which intermittent.   Still slowly improving with no exacerbation since starting. EDSSi was 7, now 2, less on a good day.

Sarah.....I love your reply

Sarah.....I love your reply because it is so "unvague".  Lol!!  Thank you. :-)

CHEERS!

D

This is an easy one. Start

This is an easy one. Start doxyi, when tolerated, add azith to the doxy. Azith is only taken on Mon, Weds, Fri. When both of those are well-tolerated, take a five-day long hit of metronidazolei every fourth week, while still taking the other antibiotics. You may be confused by the people here who occasionally have to cut back on their abxi, due to overwhelming die-off reactions. That is not the norm, nor is it the way the protocol is laid out. It's simply an accommodation that might need to be made for those who are having too hard a time of it. Congratulations on starting! We're here to help you through it. I'll be sending you the 'official' welcome letter, so look for it in your private mailbox here.

The difference between what we do and what we are capable of doing would suffice to solve most of the world’s problems.  Mohandas Gandhi

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