Summary Chart of Different CAP Protocols
We have been preparing this for an eventual overhaul of the Handbook, but there have been a number of requests, especially by new folks, to help clear up confusion.
Combination Antibiotic Protocolsi-
These charts are presented to give the brain-fogged an overview of protocols to understand the general approach, and why you may read of people on www.cpnhelp.org as using differing combinations of meds. These charts are meant for clarification only and should not be used as a starting point for doing a CAPi protocol. Everyone’s case is different, and requires individual considerations. Also, understanding the many facets of Cpn and treatment reactions is crucial before engaging in treatment. Don’t start any of these without reading further in the Cpn Handbook.

Note:
Jim, I'm sorry not to have read this sooner, but you appear to be making a mistake about David's regime. You don't mention NACi until way down the list and the first alternative is given appears to be azithromycini by itself, which is incorrect as can be seen here:
http://www.davidwheldon.co.uk/ms-treatment1.html
A schedule of treatment.
This is one schedule which strikes all stages of the organism's life-cycle. Other equally good schedules are possible. It is preferable that a committed care-giver (for instance, spouse, partner or parent) should ensure that medication is given, and swallowed, consistently.)
N-acetyl cysteine (NAC) 600mg - 1,200mg twice a day, should be taken continuously. This is a commonly-taken dietary supplement, available at health-food stores. It is an acetylated sulphur-containing amino-acid, and may be expected to cause chlamydial EBs to open prematurely, exposing them to starvation; more on this and other benefits on page 4. This should be started at the lower dose of 600mg twice a day; the dose should be doubled when well-tolerated. NAC offers liver protection; this may be useful, as rapid bacterial die-off may compromise hepatic function.
When NAC is well tolerated, Doxycyclinei 100mg once daily is added. It is taken with plenty of water.
When the two above are well tolerated, Azithromycin 250mg orally, three times a week should be added. (Roxithromycini, 150mg twice daily, is an alternative.)
When all three agents are well tolerated, the dose of Doxycycline is increased to 200mg daily.
The reason for this slow, step-wise introduction of antichlamydials is to minimize any reactions caused by bacterial die-off. These can be unpleasant. NOTE: in rapidly progressive MSi it may be prudent to offset the benefits of stopping progression against the risk of reactions, giving full doses of azithromycin and doxicycline from the beginning.
This combination is taken continuously.
Also, The implication might be taken by some people that metronidazolei and tinidazolei are taken during a five day break fro the bacteristatics an this also applies to the Stratton Protocol. This would seem to answer my query as to why so many newbies were asking me this question..........Sarah
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Comments
Jim, Thanks for doing this. Now...if people will only refer to it and read it....
Joyce~caregiver-advocate in Dallas for Steve J (SPMSi). CAPi since August 06, antivirals, heavy metals chelation, LDNi, Metanx, Lunesta, GF/CF diet, Lauricidin, oral IgGi/lactoferrin/IGF-1 booster, astaxanthin, gamma oryzanol.
Joyce~caregiver-advocate in Dallas for Steve J (SPMS). CAP since August 06, Cpn, Mpn, B. burgdorferi, systemic candidiasis, EBV, CMV & other herpes family viral infectionsi, elevated heavy metals, gluten+casein sensitivity.
5oo mgs Ceftin 2 x/day, 500 mgs biaxin, 500 mgs 2 x tinii pulses,100 mg diflucan, 4.5 ldni; Wheldon protocol for MSi April, 2006 to May 2008. 2008 MRI shows NO NEW DISEASE ACTIVITY, 2012 MRI no new disease activity.
Very good addition Jim. I've wanted to compare protocolsi and see their differences and commonalities, and this chart brings it home. Good work!
all my best
John
RRMSi/EDSSi was 4.5, now 4.??? on Wheldon Protocol (naci, doxycycline, azithromycin, metronidazole) since 04/12/2006
best, John
RRMSi/EDSSi was 4.5, 5, 6, 6.5, 6.9999, 6.5 on Wheldon/Stratton Protocol beginning 04/12/2006
naci 4x600 mg/day
doxycycline 2x100mg/day
azithromycin 3x250mg/day MWF
metronidazole 3x400mg/day then 3x500mg/day
Jim, I'm sorry not to have read this sooner, but you appear to be making a mistake about David's regime. You don't mention NACi until way down the list and the first alternative is given appears to be azithromycin by itself, which is incorrect as can be seen here:
http://www.davidwheldon.co.uk/ms-treatment1.html
A schedule of treatment.
This is one schedule which strikes all stages of the organism's life-cycle. Other equally good schedules are possible. It is preferable that a committed care-giver (for instance, spouse, partner or parent) should ensure that medication is given, and swallowed, consistently.)
N-acetyl cysteine (NAC) 600mg - 1,200mg twice a day, should be taken continuously. This is a commonly-taken dietary supplement, available at health-food stores. It is an acetylated sulphur-containing amino-acid, and may be expected to cause chlamydial EBs to open prematurely, exposing them to starvation; more on this and other benefits on page 4. This should be started at the lower dose of 600mg twice a day; the dose should be doubled when well-tolerated. NAC offers liver protection; this may be useful, as rapid bacterial die-off may compromise hepatic function.
When NAC is well tolerated, Doxycycline 100mg once daily is added. It is taken with plenty of water.
When the two above are well tolerated, Azithromycin 250mg orally, three times a week should be added. (Roxithromycin, 150mg twice daily, is an alternative.)
When all three agents are well tolerated, the dose of Doxycycline is increased to 200mg daily.
The reason for this slow, step-wise introduction of antichlamydials is to minimize any reactions caused by bacterial die-off. These can be unpleasant. NOTE: in rapidly progressive MS it may be prudent to offset the benefits of stopping progression against the risk of reactions, giving full doses of azithromycin and doxicycline from the beginning.
This combination is taken continuously.
Also, The implication might be taken by some people that metronidazole and tinidazole are taken during a five day break fro the bacteristatics an this also applies to the Stratton Protocol. This would seem to answer my query as to why so many newbies were asking me this question..........Sarah
An Itinerary in Light and Shadow Stratton/Wheldon regime since August 2003, for aggressive secondary progressive MS. Intermittent therapy after one year. 2007 still take this two weeks every three months. Still slowly improving with no exacerbation since starting. EDSSi was 7, now 2Rats! To change it will require a bit of time, as I had to convert the Word chart to an image to insert it.
CAPi for Chlamydia pneumonia since 11/04. 25yrs CFSi & FMSi- Currently: 300mg INHi, 200 Doxycycline, 500mg MWF Azithromycin, 1000mg Tinii daily (Taking a break from continuous protocol)
CAPi for Cpni 11/04. Dxi: 25+yrs CFSi & FMSi. Currently: 250 aithromycin mwf, doxycycline 100mg BIDi, restarted Tinii pulses; Vit D2000 units, T4 & T3, 6mg Iodoral
Jim, how about moving my comment to imediately below the chart until you have the time?..........Sarah
An Itinerary in Light and Shadow Stratton/Wheldon regime since August 2003, for aggressive secondary progressive MSi. Intermittent therapy after one year. 2007 still take this two weeks every three months. Still slowly improving with no exacerbation since starting. EDSSi was 7, now 2Greetings :-)
I have just begun the Wheldon Protocol today. This would never have been possible without being able to persuade my doctor to allow this....which was 100% based on the information found on this site. To say I am very appreciative is as much of an understatement as it is to say that I sorta' hope my symptoms improve now. Ha! Thank you to everyone here!
My question relates to the order in which to introduce each component of the Protocol. Specifically, my question relates to something Sarah said here:
Also, The implication might be taken by some people that metronidazoleii and tinidazoleii are taken during a five day break fro the bacteristatics an this also applies to the Stratton Protocol. This would seem to answer my query as to why so many newbies were asking me this question..........Sarah
Assuming everything else is well tolerated as added, at what point should we begin to add the Flagyl pulses? And once that phase (Flagyl pulses) has begun, is a separate component (i.e. one that we would be taking at the time Flagyl is added) supposed to be reduced, suspended, or eliminated....and if so, is it then restarted when we rae not active in a Flagyl pulse?
CHEERS!
D
CHEERS!
D
CFSi, Hypothyroid, Started CAPi 10/01/07 Doxyi 200 daily, NACi 2400 daily, Azithro 250 M-W-F, T3&T4 250mcg daily, opti-frickin-mistic!
An Itinerary in Light and Shadow
Sarah.....I love your reply because it is so "unvague". Lol!! Thank you. :-)
CHEERS!
D
CHEERS!
D
CFSi, Hypothyroid, Started CAPi 10/01/07 Doxyi 200 daily, NACi 2400 daily, Azithro 250 M-W-F, T3&T4 250mcg daily, opti-frickin-mistic!
The difference between what we do and what we are capable of doing would suffice to solve most of the world’s problems. Mohandas Gandhi
The difference between what we do and what we are capable of doing would suffice to solve most of the world’s problems. Mohandas Gandhi
Is there any reason not to take the doxyi, NACi, and azyth all at the same time? I just started the doxy and azith today and downed all three at once wiht a cracker and plenty of water.... was that a bad idea in general??
thanks
Melissa
Melissa
HIGH EBV 2/08,card/resp sxi,numb hand,musc twitch/pains,neg for msi/lupus,scans hd 2 toe, abd/jnt/lymph pain, dizzy/fatigue, lymph swelling, lyme susp 9/08- igx-1 ++, cd57 52, CMV+, HHV6, MYCO-CAP11/08 NACi,Dxy,Zithi MWF+sups
The difference between what we do and what we are capable of doing would suffice to solve most of the world’s problems. Mohandas Gandhi
NACi 2.4g, Zithi 250mg/MWF, minoi 200mg, Tinii 5day/1g/5 pulses, Valcyte
Don't believe everything you think!Supplementsi, CFIDSi/FMSi, Hashimoto's, Psoriasis, PA, IBSi, Sec Addisons
Brian
The difference between what we do and what we are capable of doing would suffice to solve most of the world’s problems. Mohandas Gandhi
Thanks guys:)
I guess my internalist is the gung ho type:) because he had me on amoxycillin and NACi and then adding doxyi and azyth at the same time right on... I have made the personal decision to get off the amox since the NAC is doing the same thing and already my stomach feels better and less bloated- after almost 3 months of amoxycillin. yeah:) Also-- not really having hte same reactions that i had with the NAC - of course this is only day 2 on the doxy so-- we will see:) NOt much pain or weird feelings-- but it took a while with the NAC and the amox too and then it all came back like a mini series of all of the previous symptoms almost....
Those have subsided alot thankfully- ache/pains/etc
Blessings all
Melissa
Melissa
HIGH EBV 2/08,card/resp sxi,numb hand,musc twitch/pains,neg for msi/lupus,scans hd 2 toe, abd/jnt/lymph pain, dizzy/fatigue, lymph swelling, lyme susp 9/08- igx-1 ++, cd57 52, CMV+, HHV6, MYCO-CAP11/08 NACi,Dxy,Zithi MWF+sups
Bumping this up for reference to recent forum question.
Great bump Louise! Thank you. This should really be on the front page somewhere.
pc
Diagnosed w/ MSi in 2006. 3/15/12 I tested positive for CPni and started doxycycline & azithromycin. 2,400 mg of NACi daily.