Short Vid on Chalmydia survival strategies
Came across this short but very interesting video on how chlamydia survives in the cell. This is one tricky organism:
http://uk.youtube.com/watch?v=kpUzSbM4klg
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CAPi for Cpni 11/04. Dxi: 25+yrs CFSi & FMSi. Currently: 250 aithromycin mwf, doxycycline 100mg BIDi, restarted Tinii pulses; Vit D2000 units, T4 & T3, 6mg Iodoral
Progressive MSi dx2006. LDNi & CAPi: Wheldon version. All supps. Doxyi 200mg. Zithi 250mg. Metroi 400mg.Now Tinii. Pulses #52...I can because I think I can.
Thanks guys. Where else can you learn about Chlamydia's needle-like type-3 secretion system, its hijacking of the cell's golgi apparatusi to cloak itself and have an impersonation of a hispanic Ned Flanders thrown in for good measure? All in just over 2 minutes. That's what I call bang for buck.
Here are some choice quotes:
"Usually within a cell, lysosome fuses with an entry vacuole harbouring foreign intruders. But because of a needle-like projection called a type-3 secretion apparatus the bacteria may inject some of their own proteins into the outer membrane of the entry vacuole. These proteins physically block the lysosomes assualt."
"Chlamydia can also hide from lysosomes by refurbishing their entry vacuole with molecules they divert from the host cell's lipid distribution centre, otherwise known as the golgi apparatus. These stolen lipids make the vacuole virtually indistinguishable from the cell's own organelles."
"Buenos ding-dong-diddly-dias senior!"
"And this is why chlamydia is so hard to stop."
Required viewing for everyone I think. Is there some way in which we can preserve this for future use... Its fun, short and informative.
As for the training of new doctors, they will need to read the comments below also or they will think this refers only the Ct.
Michèle (UK) GFA: Wheldon CAP 1st May 2006. Daily Doxyi, Azi MWF, metroi pulse.
3/9 Symptoms returning. Began 5 abxi protocol 5/9 Rifampin 600, Amox 1000, Doxyi 200, MWF Azith 250, flagyli 1000 daily. Began Sept 04 PPMSi EDSSi 6.7 Now good days EDSS 1 Mind, like parachute, work only when open. Charlie Chan In for the duration.
Michele- I've got this saved just in case it gets dumped from Youtube. You might put a reference link to this in the Getting Started, or maybe it's better in the Handbook?
I particularly like the Homer Simpson "Oo, forbidden donuts" and "Doh!" for the lysosome sounds!
CAPi for Cpni 11/04. Dxi: 25+yrs CFSi & FMSi. Currently: 250 aithromycin mwf, doxycycline 100mg BIDi, restarted Tinii pulses; Vit D2000 units, T4 & T3, 6mg Iodoral