Here's one thing on cathelicidins and germs in general Notice the endotoxini angle.........marie Cathelicidin Peptides as Candidates for a Novel Class of Antimicrobials Authors: Zanetti, M.; Gennaro, R.; Skerlavaj, B.; Tomasinsig, L.; Circo, R. Source: Current Pharmaceutical Design, Volume 8, Number 9, 1 April 2002 , pp. 779-793(15) Abstract: Cathelicidin peptides are a numerous group of mammalian cationic antimicrobial peptides. Despite a common evolutionary origin of their genesi, peptides display a remarkable variety of sizes, sequences and structures. Their spectra of antimicrobial activity are varied and cover a range of organisms that includes bacteria, fungi and enveloped viruses. In addition, they bind to and neutralize the effects of endotoxin. These features make this family of peptides good candidates in view of a therapeutic use. The most promising ones are currently under evaluation as leads for the development of novel anti-infectives, and synthetic variants are in an advanced stage of development for specific clinical applications. This review focuses on recent studies on the structure and in vitro and in vivo biological activities of these peptides. On CAPi since Sept '05 for MS, RA, Asthmai, sciatica. EDSSi at start 5.5. Currently on: Doxyi 200, Azith 3x week, Tinii cont. since April '07, all supplementsi. "Color out side the lines!"

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On CAPi since Sept '05 for MSi, RAi, Asthmai, sciatica. EDSSi at start 5.5.(early cane) Now 6 (cane full time) Originally on: Doxyi 200, Azith 3x week, Tinii cont. over summer '07, Revamp of protocol in Summer '08 by Stratton due to functional loss; clarithromy

Hi Ron,

One of the members posted this study on one of the rosaceai boards, and while I'm certainly no expert, here an edit version of my reply:

 

 

I did read the article, and found it interesting too. But other than the discussion about the stratum corneum tryptic enzymes, the findings are actually not all that new as Dr Gallo has previously reported finding an excess amount of kallikrein activated cathelicidins in rosaceai:

Innate immunity: Role in rosacea?

Is Rosacea Like an Allergy?

 

Also, my personal opinion (uneducated as it may be) is that the finding of elevated activated cathelicidins makes it even clearer that there is an underlying infection going on in rosacea, and I've discussed this in the page I put together discussing a potential link between rosacea and C. pneumoniae (which btw has been shown via previous studies to induce activated cathelicidins in large quantities):

http://www.cpnhelp.org/chlamydia_pneumoniae_an_0

Finally, apparently stratum corneum tryptic enzyme (SCTE) is actually one of the kallikreins, kallikrein 5 specifically:

Kallikrein-mediated proteolysis regulates the antimicrobial effects of cathelicidins in skin

So, this new article just seems to be adding just a little more detail (naming at least one of the kallikreins found to activate the cathelicidins) to the previous articles discussing Dr Gallo's and team's findings of elevated kallikrein activated cathelicidins in rosacea...

On Combined Antibiotic Protocol for Cpn in Rosacea since 01/06

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Treatment for Rosaceai

• CAPi:  01/06 - 07/07
• High-Dose Vit D3, NACi & FIRi Sauna Only:  07/07 - 11/08
• Intermittent CAP, High-Dose Vit D3:  11/08 - Present