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On CAPii since Sept '05 for MSi, RAi, Asthmaii, sciatica. EDSSii at start 5.5.(early cane) Now 6 (cane full time) Originally on: Doxyii 200, Azith 3x week, Tiniii cont. over summer '07, Revamp of protocol in Summer '08 by Stratton due to functional loss; clarithromy
Role of tryptophan supplementation in the treatment of chlamydia
Submitted by mrhodes40 on Mon, 2007-08-06 10:10. Med Hypotheses. 2007;68(2):278-80. Epub 2006 Oct 11.
Role of Tryptophan supplementation in the treatment of Chlamydia.Singla M.
Department of Pediatrics, University of Illinois, 840 S. Wood St., CSB Chicago, IL 60612, USA. msingla@uic.edu
Chlamydia trachomatis, an intracellulari pathogen, is the leading cause of preventable blindness and sexually transmitted infectionsi in the world. Infection of epithelial cells with Chlamydia results in the production of antigeni-specific IFN-gamma -secreting CD4+ and CD8+ T cells. IFN-gamma activates indoleamine 2,3-dioxygenase (IDO), an enzyme that degrades tryptophan in the host cell. This IDO mediated tryptophan starvation is known to activate genesi for persistencei in the Chlamydia, which renders antibioticsi ineffectiveness against it. Tryptophan supplementation causes reactivation of Chlamydia from persistent into metabolically active forms and then the antibiotics easily eradicate these active forms of Chlamydia. Therefore treating the chronic Chlamydia infection with antibiotics and tryptophan together may lead to better clearance of Chlamydia infection, and may be a better therapeutic approach in the future.
PMID: 17045416 [PubMed - indexed for MEDLINE
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Marie, May I assume that
Marie, May I assume that you are working on a comment about the fallacy of this strategy for the benefit of newbies?
Joyce~caregiver-advocate in Dallas for Steve J (SPMSi). CAPi since August 06, antivirals, heavy metals chelation, LDNi, Metanx, Lunesta, GF/CF diet, Lauricidin, oral IgGi/lactoferrin/IGF-1 booster, astaxanthin, gamma oryzanol.
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Joyce~caregiver-advocate in Dallas for Steve J (SPMSi). CAPi since August 06, Cpni, Mpn, B. burgdorferi, systemic candidiasis, EBVi, CMV & other herpes family viral infectionsi, elevated heavy metals, gluten+casein sensitivity.
The problem with this
The problem with this hypothesis is that tryptophan starvation is not the only stimulus that induces persistance (transformation to cryptic state): antibioticsi will do this also. This means that you are still inducing persistant forms by the antibiotic treatment while feeding the replication phase with tryptophan. Remember, the authors of this hypothesis are basing their attempt to defeat the well known persistencei factor in Chlamydia still within the mono-antibiotic model. The microbiological world, as well as the medical world, remains ignorant of the Vanderbilt findings about Flagyli killing the cryptic formi, as this was never published in a scientific journal.
Now, maybe there's a possible strategy here (inducing more EBi to convert to RB by tryptophan supplementation while inhibiting replication, and knocking out the cryptic persistent forms with Flagyl pulses) but I'd like to hear a micribiologist comment on this before I'd experiment with it myself.
CAPi for Chlamydia pneumonia since 11/04. 25yrs CFSi & FMSi- Currently: 300mg INH, 200 Doxycycline, 500mg MWF Azithromycin,
1000mg Tinii daily(Taking a break from continuous protocol)___________________________________________________________
CAPi for Cpni 11/04. Dxi: 25yrs CFSi & FMSi. Currently: 250 aithromycin mwf, doxycycline 100mg BIDi, Tinii 1000mg/day pulses; Vit D2000 units, T4 & T3, 12mg Iodoral
AH Jim you beat me to it.
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On CAPi since Sept '05 for MSi, RAi, Asthmai, sciatica. EDSSi at start 5.5.(early cane) Now 6 (cane full time) Originally on: Doxyi 200, Azith 3x week, Tinii cont. over summer '07, Revamp of protocol in Summer '08 by Stratton due to functional loss; clarithromy
I tried tryptophan along
I tried tryptophan along with antibioticsi about 2 years ago. It was an interesting time, and i did not continue long with tryptophan. I cannot say I felt more dieoff or anything but the hormone effect was quite intense, and put me out of sync. I suspected that the cpni had depleated my reserves of tryptophan and was a possible cause of poor sleep. The effect was like walking around half asleepin a dream, and with a very wierd head.
Diagnoised 98 with ReA (reactive arthritis), Cpn found in eyes! after2 years of study and some trials with Cipro and Biaxin ReA passed. since then colon complications. Did lamisil and fungizone for one year recently, big improvement. Yet still colon probl
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Diagnoised 98 with ReA (reactive arthritis), Cpni found in eyes! after2 years of study and some trials with Cipro and Biaxin ReA passed. since then colon complications. Did lamisil and fungizone for one year recently, big improvement. Yet still colon probl