Resistance to AB

I ate AB for half year and symptoms were gone  but then i felt symptoms as Ab finish to work. Who knows is it a temporary resistance to AB or for alwyas?

Well m2m2m222, what disease are you taking the antibioticsi for?  To treat something caused by a chronic Cpni infection, you have to take the stuff for at least a year before you can say that you might be cured.  You might be just going through a period of 'one step forward and two steps back.'  It happened to all of us!..........................Sarah

Completed Stratton/Wheldon regime for aggressive secondary progressive MSi in June 2007, after four years, three of which intermittent.   Still improving bit by bit and no relapses since finishing treatment.

it's cpni. dows anybody knows is the chlamydia resistance to klacid and doxyi for always or it will dissapear in a big periid of time. Coz it' s like that wuth chlamydia chtrahomatis

m2m2m222, how much metronidazolei (flagyl) have you taken yet?  After six months I had done three pulses of it, but I carried on for much longer.

You say you felt better after six months, then got worse again: I think you just hadn't taken enough metronidazole, because that is what finally kills the pathogen.....................Sarah

Completed Stratton/Wheldon regime for aggressive secondary progressive MSi in June 2007, after four years, three of which intermittent.   Still improving bit by bit and no relapses since finishing treatment.

i took it some times 2 grams at one time, but not like CAPi pulses/ The point is that i ate Ab klaicid and doxyi 2 times a day and symptoms were going under AB. i stopped AB therapy. I think it is chlamydia resistance to AB. Who knows is this resistance for alwyas or it can go away as it is in chalmydia trachomatis. People tried to cure it like that - they give 6 months without Ab and after 1,5-2 months of 2 AB(macrolide + doxy). I read forums on chlamydia trachomatis and there were people who cured like that

Look, you don't just stop the antibioticsi because you think you are getting better: you should follow the instructions given here by professional, hard-working doctors.  It is very unlikely that doxycycline is resistant to C pn because C pn is an intracellulari organism.   I suggest that you either follow the instructions given here, or ask your own doctor why your medication has suddenly stopped working....................Sarah

Completed Stratton/Wheldon regime for aggressive secondary progressive MSi in June 2007, after four years, three of which intermittent.   Still improving bit by bit and no relapses since finishing treatment.

sarah! the cpni from 2017  is very different from cpn in 1990. it became much more resistant to AB. I think if your cpn is resistant to AB than you just have to die using opiat drugs for less pain or use pentobarbital. if smb has other conclusions about resistance please write it 

I think you had better read this: http://www.davidwheldon.co.uk/ms-treatment.html<

I was only treated in 2003, not 1990, and I got perfectly well.  Try it!..................Sarah

Completed Stratton/Wheldon regime for aggressive secondary progressive MSi in June 2007, after four years, three of which intermittent.   Still improving bit by bit and no relapses since finishing treatment.

i meant that you got your cpni in 90's. i got mine in 2015 and azytromicin didnt work at all

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3075073/<

here is information on resistance to AB

I am not a pig and neither are you: read the paper correctly!  Pulse metronidazolei to get better.  Goodbye! Sarah

Completed Stratton/Wheldon regime for aggressive secondary progressive MSi in June 2007, after four years, three of which intermittent.   Still improving bit by bit and no relapses since finishing treatment.

Norman, if you're around, could you address this study, pls?

The difference between what we do and what we are capable of doing would suffice to solve most of the world’s problems. Mohandas Gandhi

hi Sarah can you advise where you got your abxi, i currently get mine from India via Canadian online,can you advise if they are the cheapest?, many thanks Robert

Robert, I last bought abxi in 2010 for a friend and companies come and go.  The company I used was in India but is no longer online....................Sarah

Completed Stratton/Wheldon regime for aggressive secondary progressive MSi in June 2007, after four years, three of which intermittent.   Still improving bit by bit and no relapses since finishing treatment.

I would think the first sentence of the abstract is sufficient: "There are few documented reports of antibiotic resistance in Chlamydia and no examples of natural and stable antibiotic resistance in strains collected from humans."

Chlamydia pneumoniae is a host cell dependent bacterium and so does not naturally encounter antibacterial compounds elaborated by fungi e.g. tetracycline. Over time unused genetic material tends to be lost — and indeed C. pneumoniae has a depleted genome compared with free-living Gram negatives. One could therefore speculate that C. pneumoniae would lose the mechanisms necessary to mount resistance to antibioticsi.

D W - [Myalgia and hypertension">i (typically 155/95.) Began (2003) taking doxycycline and macrolide and later adding metronidazolei. No medication now. Morning BP typically 110/75]

Thank you Norman and David!.......................Sarah

Completed Stratton/Wheldon regime for aggressive secondary progressive MSi in June 2007, after four years, three of which intermittent.   Still improving bit by bit and no relapses since finishing treatment.

the resistance grows not so fast in the begining you dont feel sypmtoms while you on AB and then day by day you feel growing symptoms until the AB dont work at all. it can be several months. that's how it was in mine case

i stopped taking AB not immediately after i felt they start not working. Several month's past. then i waited 4 months not taking AB and tried to take klacid and i felt it didnt work at all. a got both pcri and antibodies iggi igm positive for cpni. i dont have anything else except cpn. my symptoms is eyes, heartburn, snue and sometimes FMSi. and now 1 year passed i didnt take AB. 

On chlamydia trachomatis sites people waited 6 month's between Ab treatments and they won. Ab treatment was 1-1,5 month of doxyi+macrolide. One guy won using sparfloxacin in double dosages 1 month. what i found is that cpn can live without symptoms in organism untill a trigger and then it starts to desseminate. The trigger can be using of alcohol

it looks like chlamydia trahomatis resistance can go away for time (6 months). but cpn can not. your ideas?

M2m2m222,

you ask questions but you have the answers you think to those questions already but you still want to provoke an answer from members here.

you repeat those questions again even though DW and Norman gave you their thoughts and answers to that question including that paper you posted.

you joined this site over a year ago, never once asked a question or posted a remark until now.

you refer to another website and the Information you obtained and viewed on that site!

I find myself that if something isn’t working you move on to something else, and that includes information. So if the antibioticsi are not working for you then try something else but then this website will be of no use to you then!

goodluck

regards

D

The Greatest Risk of all is Not taking the Risk...

You're not the first person to report that clarithromycin (aka klacid) worked at first but then stopped working.  Russell Farris (main author of The Potbelly Syndrome) also reported that as his own experience.  I don't think he had any real explanation for why.  In any case, it's not one of the antibioticsi recommended on this site.

norman clarythromicin has the lowest minimal inhibitory concentration for chlamydia. if it is resistant to clarythromicin than it will be resistant to all others AB

azythtromicin didnt work at all from the very begining, it worked very weak

m2m,  

There's a difference between 'ineffective' and 'resistant'.

If you want advice on using the antibiotic protocoal to eradicate your cpni infection, please read the cpn Handbook and the Getting Started sections (tabs are at the top of each page here).

Then, use the RECOMMENDED antibioticsi.  You have NOT used the correct medications and you have NOT used them for the proper length of time.  

The difference between what we do and what we are capable of doing would suffice to solve most of the world’s problems. Mohandas Gandhi

Plus you have not answered my first question as to what disease you have. The answer is not I have C pn: that causes the the disease. Do you have MSi,  chronic fatigue, asthmai, heart trouble or something else?.........Sarah 

Completed Stratton/Wheldon regime for aggressive secondary progressive MSi in June 2007, after four years, three of which intermittent.   Still improving bit by bit and no relapses since finishing treatment.

i wrote that i have heart pain, sometimes fmsi and eyes

so my main question is the resistance of cpni to AB is temporary or it's for always?

Nonsense.  Resistance to one antibiotic doesn't mean resistance to others.  It's common to see cross-resistance inside a class of antibioticsi (resistance to all tetracyclines, for instance), but even that doesn't always happen.  Different antibiotics work in different ways, so bacteria that have become resistant to one antibiotic are usually still susceptible to others.

norman i ate all AB that exist. doxyi, ofloxacin and macroldes azytro, klacid, macropen, roxyi. rifampicin i ate also it didnt work at all.

resistance to one AB will lead to resistance to the whole group. that's for sure. plus i think that if chlamydia gets resistance to ftorquuinolones or macrolides it's for sure will have resistance to doxy.

The reason I'm not terminating this thread is because I think it's important for people to understand there's a protocol (not a do-it-yourself haphazard approach), and the protocol needs to be followed (not riffed on), and there's a minimum length of time to follow it (no, not a few weeks whenever you feel like it).

So, please continue reading the thread everyone, because there's a lot to be learned when someone posits baseless theories and illogical thinking.

The difference between what we do and what we are capable of doing would suffice to solve most of the world’s problems. Mohandas Gandhi

mac, you are right. but i didnt know that i have cpni almost 8 month's from date i was infected. it started like urethritis after blowjob. all tests for sexually transmitted diseasesi were negative. i thought it was trachomatis and the doctors told me to eat AB for 10 days. i ate 10 days then symptoms came again, i ate other courses and so on . that is why the resistance came. when i understood that i have cpn and found this website it was too late. the AB did not help anymore.

so my question to people who had same story as mine! if you wait some time maybe years without AB will the resistance go away or not. if it's not  better to prepare to die.

p.s. metronidazolei, ornidazol, tinidazole, nimorazol i ate in huge quantities as well

Grow up, please.  Nobody has eaten "all antibioticsi that exist".  And if you really have tried a lot of them, maybe your problem is not infection, or at least not bacterial infection.  There are quite a lot of diseasesi out there, and your presentation is not something that is typical of Cpni.  Just having a positive test for it doesn't mean that it's causing all your problems, or even the biggest ones.  Find a doctor who will really test all the possibilities.

As for your main question, asking whether resistance is permanent is like asking how long a piece of string is.  There are lots of different resistance mechanisms.  At one end of the spectrum is Cpn's ability to go into a cryptic state, where it mostly shuts down so that antibiotics don't kill it; then it re-emerges from that state as soon as the antibiotics go away.  At the other end are genetic changes to bacterial chromosomal DNA that change its biochemistry so that an antibiotic no longer affects it.  The extreme of that is if those genetic changes don't impose any cost in the absence of antibiotics.  (I'm not sure if that extreme has ever been observed.)  In between those extremes, there are things like resistance plasmidsi and efflux pumps.

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