wiggy, I didn't want to know this, but if it's true, knowing is better than ignorant oblivion. Rats! Rats! Rats! Thanks for posting it.

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Joyce~caregiver-advocate in Dallas for Steve J (SPMSi [6]).  CAPi [7] since August 06, Cpni [8], Mpn, B. burgdorferi, systemic candidiasis, EBVi [9], CMV & other herpes family viral infectionsi [10], elevated heavy metals, gluten+casein sensitivity. 

OOPS! I'm guilty of negative mis-remembering. The Rebif Steve injected for a year is Interferon beta-1a, not Interferon alpha. Thank you Lord. Now, it's time to look into EBVi [9] treatment beyond Valtrex!

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Joyce~caregiver-advocate in Dallas for Steve J (SPMSi [6]).  CAPi [7] since August 06, Cpni [8], Mpn, B. burgdorferi, systemic candidiasis, EBVi [9], CMV & other herpes family viral infectionsi [10], elevated heavy metals, gluten+casein sensitivity. 

Yes Joyce, We may have more bugs to kill :(

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On Wheldon protocol for MSi [2] since April, 2006.  doxyi [3] 200 mgs daily, zithromax 250 mgs 3x/ week , Flagyli [4] Pulses start end Sept., LDNi [5] 2004. Gad-enhanced MRI of brain and spine shows NO NEW DISEASE ACTIVITY and one lesion diminishing in size on 9/30. Ma

But all the time we are killing the bugs we can kill we are giving our bodies a chance to hunt the others down more efficiently.

 

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Michèle (UK) GFAi [12]: Wheldon CAPi [7] 1st May 2006. Daily Doxyi [3], Azi MWF, metroi [4] pulse. Zoo keeper for Ella, RRMSi [13], At worse EDSSi [14] 9, 3 months later 7 now 5.5 Wheldon CAP 16th March 2006

If I am reading the link right, the problem is not in our bugs, but in ourselves.

HERV-K18 is a gene in the human body, which we inherit along with eye color and tongue-rolling. Various infectionsi [10] activate this gene, which stays activated and does some of the damage. That's if I am reading it correctly.

What this implies for treatment is anyone's guess. If we eliminate the activating bugs will the gene de-activate? Or, will we need to eat deactivating herbs, or dip ourselves seven times in the Jordan, or just what to shut the dumb gene off again? Who knows, but letting the activating bugs have the run of our bodies can't help, so I'm staying with the CAPi [7], and watching the Valtrex trials with interest.

This over-activation would also explain why CFSi [15] is 'the cold to end all colds.' That gene stays switched on, which hypes up the immunei [16] system, and so we don't get colds, but we do suffer from hyped-up immune systems.

 Also: 75% of MS patients meet "the" criteria for CFS?  (As if there were only one set of criteria.)  I am truly sorry to hear that, folks.

Excellent find, though, wiggy. Thanks for posting it.

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Ron

On CAPi [7] for CFSi [15] starting 01/06 (NE Ohio, USA)

Currently: doxyi [3] & zithi [17] -- continuous; metronidazolei [4] -- 5 days on, 9 days off.

Get the research results you paid for: support Open Access

 

Well, my eyes are blue and I can roll my tongue but I don't know whether I carry any of these genesi [18].  I do know, though, that my immunei [16] system was overactivated but has now righted itself and I don't think MSi [2] is an autoimmune disease until VERY late on and only with some people.  Therefore, I would posit that they are maybe barking up the wrong tree.........Sarah

An Itinerary in Light and Shadow

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PPMSi [19]-misdiagnosed 2001-diagnosed 2006. Also maybe csf and Lyme -- who knows?! Minocycline 7 mos.- resulting bronchitis 5 months. Deserted by Hopkins neurology dept. and going to private md. out-of-plan. Wheldon CAPi [7] 3/2/07 - 200 doxyi [3]; azith MWF. 5 pulses.

Sarah,

I don't think MSi [2] is autoimmune, either, but I am not sure that is what the authors were getting at.  As the term is ordinarily used, 'autoimmune disease' implies the body attacking its own tissues.

 I got the impression that they meant an overactive immune system is damaging to the body in the way that overuse of any body system is damaging -- more analogous to tachycardia or something.  In autoimmune disease the model seems to be an immune system that is misdirected, not just overactivated.

However, your experience is evidence that, if the activating bacteria is removed, the overactivated immune system will right itself -- like a boat when the passengers settle down. So, even if the immune response is "abnormal" or "maladaptive," when the stimulus is removed, it normalizes eventually.  Whereas the usual explanation of autoimmune disease seems to ignore causation altogether. Using immune suppressant therapies for 'autoimmune disease' seems to be analogous to putting a brick on the relief valve instead of turning down the heat.

 

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Ron

On CAPi [7] for CFSi [15] starting 01/06 (NE Ohio, USA)

Currently: doxyi [3] & zithi [17] -- continuous; metronidazolei [4] -- 5 days on, 9 days off.

Get the research results you paid for: support Open Access

Sorry to post this in the wrong thread but I am having constant problems trying to post.  I can't finish my blog or post in the thread about website problems, every time I try to open other threads the site crashes.  Any ideas why?  I gave up yesterday but it's as bad again this morning.

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Elinor ..... from England  on CAPi [7], doxyi [3]/roxi/tini  for ME/CFSi [15]/lyme borreliosis, positive Cpni [8] and borrelia. Started Aug05, stopped Jan06, started again Sept 06.

And I can roll my tongue. Put us together and....

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Berkshire, UK. Diagnosed RRMSi [13] Feb 4th 2008.

NACi [20] 2400mg. All supps. Doxyi [3] 200mg. Zithi [17] 250mg. Metroi [4] 400mg.
No GP/Neuroi [21] support. Self medicating with help from David Wheldoni [22].
Started CAPi [7] 20th April 2008. First pulse June 2008

 

Ron, putting a brick on the relief valve is an excellent descriptor of the use of autoimmune suppressers and I also was not quite sure what the authors were getting at.  I found turning down the heat was much the better option.

Nancy, does that mean you can roll your tongue a well?  I get a crimp in the middle of the roll.  By the way, I'm still working on a proper reply for your installations email.  I just keep getting waylaid............Sarah

An Itinerary in Light and Shadow

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I can roll my tongue, too. Maybe we need to take a poll.

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Combined Antibiotic Protocol minocycline, azithromycin, metronidazolei [4] for muscle pain, insomnia, interstitial cystitisi [23], sinus, disphonia, dry eyes, stiff neck, veins, thyroid, TMJ.

Thanks, Sarah

 I went back and forth between the brick on the relief valve and this one:

 Using immunei [16] suppressant therapies for 'autoimmune disease' seems to be analogous to slowing your car down by shooting out the tires instead of taking your foot off the accelerator.

 Just for variety!

 

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Ron

On CAPi [7] for CFSi [15] starting 01/06 (NE Ohio, USA)

Currently: doxyi [3] & zithi [17] -- continuous; metronidazolei [4] -- 5 days on, 9 days off.

Get the research results you paid for: support Open Access

Love that, Paron! It is especially appropriate with the Supreme Court decision last week.

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Rica PPMSi [19] EDSSi [14] 6.7 at beginning - now 2. Began CAPi [7] Sept, 2004 with Rifampin 150 mg 2xd, Doxyi [3] 100 mg 2xd, added regular pulses Jan 2005. Jan 2006 switched to Doxy, Azith, cont. flagyli [4] total 55 pulses LDNi [5] Rifampin 8/08 again NC USA

 

Now, that's maybe even better, Ron!............Sarah

An Itinerary in Light and Shadow

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