Hi Mark,  Samento is something that I have not seem posted by others active in discussion on this site.  So to stop it now when you are doing the Wheldon Protocol, Nac, Doxy, and Roxi at this point seems like a reasonable trial to omit it for a period of time.

Has she ever been evaluated by and ENT MD? 

Did she not have post nasal drip prior to any of the ME treatments?

Does she have known enlarged tonsils and adenoids by history?

Just a few questions to help you folks think this one trhough.

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Louise  CFSi [9], CPN+/Bb+,Wheldon CAPi [10] 6/07, Cholestyramine 1-2 pks @ HS for Porphyriai [11] & Endotoxinsi [12] PRN, Doxyi [7] 200daily, Roxi 300BID, Tini500BIDx14day pulses,VitD3-10,000IU, Iodoral 25mg, {S.O.D.3/QD[KAL Brand], Pyruvate 3.75G, SAM-e For Energy Support

I have no idea what "hockle" means, but onomatopoeicly I'm going to assume it's similar to the pertussis-like cough that I get when I start secreting "bucket and buckets" of mucous.  The part about it going down the back of the throat  from either the ear or nose is eerily familiar.  

I suffered bouts of something like this for years.  I would get the runny nose and scratchy throat characteristic of a cold or allergies, but then the waterworks  (mucous-works) would turn on and I would feel like I was going to drown.   I had to wad up tissue and plug my nostrils so that it wouldn't drip on my work.  In addition, I would get a sore throat that felt like my eustachian tubes were blocked.  This would go on for ten days to two weeks.  The mucous running down the back of my throat would get hung up and start to tickle and this would make me cough - sometimes hard enough and long enough to make me gag.  

Antihistamines had little effect on this.  One doctor resorted to giving me cortisone shots, but even that would take days to shut off the spigot.  I had always assumed that as fast as it came on, it was provoked by an allergen.   I had read somewhere that Quercetin acted like an antihistamine, so the last time this happened, I took some - 1,000 mg at a time, several times a day.  It was by no means a magic bullet, but it did seem to greatly decrease the mucous flow within about 24 hours and clear everything up in about three days - about seven days faster than the cortisone.    

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CAPi [10] for M.S. since 8/2007. Currently: 100 mg Dox. (2 x day), 250 mg Zithi [13] (3 x week).  Fifteenth pulse metronidazolei [14] + INHi [15] completed 11/22/2008.

Mark -

I had a similar response when taking NACi [1] initally.  Felt like I had a fire hydrant surgically inserted into my nose.  So I definitely empathize with Paula.

If Paula is lying down in bed, she might have gravity working against her and the mucus running down her throat rather than out of her nose.  Don't know if it would help but if she isn't already, maybe propping up in bed with pillows would help it run out nose and not down throat. 

Also, I used a nasal saline rinse, several times per day and that really cleared my problem up faster and made me feel better.  If you are interested I'll give you more details.

Hope this resolves soon !

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Daisy - Husband on CAPi [10] 5/07.  "When Going Thru Hell, Just Keep Going", Winston Churchill

I don't know anything medically, but all I can do is say that this is familiar to me and relate my experience to you.  First, however, I need to tell you that Daisy's suggestion of a nasal saline rinse is, from my experience and what others have told me, unbelievably useful in both giving relief, clearing up blockage, and preventing infection from setting in. 

I read it in the magazine "Prevention" once and tried it, then my sister told me that she knows people with a history of severe nasal problems (needing surgery, etc) and their nasal doctor(whatever they are called) told them to do this saline rinse once (or twice) a day, and as long as they did it, they quit having problems.  Anyway, whatever you do, DON'T go out and buy a nasal saline in a bottle.  According to "Prevention" itself, these premade ones have added ingredients(can't remember what -preservatives or drying agents?) that cause the sinuses to actually become more inflamed and dry if you used the product for very long.  It is not a long term solution. 

According to "Prevention", you need to use sea salt or canning salt (which must be like sea salt?) in warm water and add a pinch of baking soda.  The magazine said how much salt, but I don't remember anymore.  I test it by tasting it and if it seems like saline, that's what I use.  If you use too much, it will burn like mad.  You can use a lesser amount of salt for helping to moisten and clear your sinuses or you can use a little more for prevention of problems (like I think the nasal doctor had told those patients with nasal problems).  I'm sorry I don't know how much, but all I can say is it was in "Prevention" so it probably is a somewhat known thing and may be online somewhere or a doctor might know. 

As for my similar experience, I started my Protocol with NACi [1] AND amoxicillan and my nose started running, my ears hurt and my glands in my throat swelled, and my chest hurt some.  It wasn't as bad as Paula's, as her's sounds profuse, like a bad cold.  My symptoms came and went, but all stopped eventually for awhile. 

 But now I'm at one year on protocol, and I haven't started flagyl yet because of various stupid reasons, and now I'm having extreme sinus inflammation, sinus pressure, swollen glands and a small amount of white stuff running down the back of my throat.  I know it is not a cold because it doesn't follow the usual course of a cold, and it has gone on too long.  And it seems more like inflammation than infection.  So I also am concerned because I don't know if this is good, a sign of more die off, or bad, a sign of inflammation from heat shock protein because I have kept these bugs from eating for so long and haven't killed any of them yet. 

I don't know how you know when something is one sort of die off or another, or heat shock protein inflammation only or something totally different.  Maybe some of the more experienced people here can tell you.  I can only tell you that I take comfort in knowing that so many of us have such similar symptoms, and that my general endurance has gotten better over the year, which is a good sign. 

So I hope for you that hearing about other's similar problems helps you both to not become too freaked out.  And I hope you get some good advice to help weather the symptoms. 

Also thank you for your post because it reminded me that my symptoms ARE probably a normal part of what happens , although I may need to make some changes in my protocol to make things work better, as I feel that going to slowly may have its down side in the long run.

Oh, along with the sinus thing, I also get my muscle inflammation back to some degree off and on, around the same time as the sinus thing starts, and I had jaw pain (that started and then kept getting better).  Sometimes my fatigue increases.  Sound familiar?  I also get recurrence of bowel problems around the same time.  The good thing is that, except for the inflamed sinus thing lately, the other things don't keep getting worse, as they did before.  They come and go, but seem to not be as bad as before, and my fatigue slowly is less.  I can tell.  I think it is a slow process, and you need to follow the protocol and do the stuff you're supposed to do to help your body deal with side effects as best you can. 

Sorry for long length of post.  I post seldom, but seem to make up for it in lengthy posts. 

Reve'

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Memphis,TN - FMSi [17], IBSi [18], rhinitis, depres (~20 yrs) CFSi [9], intestine, bladder, pelvic inflam., red itchy skin, anxiety (~5 yrs). CPni [6] titer 1:256.  CAPi [10] 6-07 Current NAC 2400mg; doxyi [7] 100mg x2, Biaxin 500mg x2, pyruvate, supplementsi [19].

I just thought of something else, maybe insignificant, but it couldn't hurt.  I like the "Traditional Medicine" teas that I get at an Organic Food Store.  I used the Echinacea one and felt like it helped me when I had a cold, and now I'm using the Breathe Easy one that is supposed to promote respiratory health.  I don't know if they really work.  I like to be scientific about these things, but am starting to have a little more faith in old fashioned or non western traditional stuff, even without proof.   I think they might help, and if nothing else, they may be soothing or give one a mental boost if one thinks it is working. 

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Memphis,TN - FMSi [17], IBSi [18], rhinitis, depres (~20 yrs) CFSi [9], intestine, bladder, pelvic inflam., red itchy skin, anxiety (~5 yrs). CPni [6] titer 1:256.  CAPi [10] 6-07 Current NAC 2400mg; doxyi [7] 100mg x2, Biaxin 500mg x2, pyruvate, supplementsi [19].

Thanks Louise.  Paula stopped taking Samento on Monday but as of yet haven't noticed any reduction in "hockle" - but it is early days.

Getting an ENT doc to come out to see her would be a bit of a problem.  It was hard enough getting a dentist out.  Her NHS GP came out to see her early this year and we mentioned the mucas issues.  She couldn't find anything wrong.

Paula says that she used to have terrible tonsils when she was a child.  They would always be swollen, but she put this down to a dairy intollerance (funnily enough, her teeneage daughter has the same tonsil/dairy problem)

She didn't have any post nasal drip (or down throat drip :-) until she started taking the maximum dose of Samento back in July last year.

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UK Carer of bedridden Severe ME/CFS Feb06. Bitten by ticks Summer 04.  CPNi [6] dx. Apr07. Borrelia dx Sept08. Samento 15 drops per day July07.  2400mg 1200mg NAC 200mg. Doxyi [7] Jan08.  75mg Roxyi [8] Nov 26th 08

hdwit, thanks for the info there.

Btw "hockle" is a slang word here in the North East of England for when you cough something up from the back of your throat.

We will give Quercetin a go.  Paula is currently on 500mg twice per day.  She is gonna try to increase it to 1000mg twice per day to see if it helps.

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UK Carer of bedridden Severe ME/CFS Feb06. Bitten by ticks Summer 04.  CPNi [6] dx. Apr07. Borrelia dx Sept08. Samento 15 drops per day July07.  2400mg 1200mg NAC 200mg. Doxyi [7] Jan08.  75mg Roxyi [8] Nov 26th 08

Thanks Daisy and Reve.  If the removal of Samento or the increase of Quercetin doesn't work, I will look into the nasal saline rinse.

This mucas is definately linked to her ears and nose.

There is also Serrapeptase that I bought a month ago which Paula is a bit concerned about taking just yet.

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UK Carer of bedridden Severe ME/CFS Feb06. Bitten by ticks Summer 04.  CPNi [6] dx. Apr07. Borrelia dx Sept08. Samento 15 drops per day July07.  2400mg 1200mg NAC 200mg. Doxyi [7] Jan08.  75mg Roxyi [8] Nov 26th 08