Daisy,  Is this anything like oncomodulin?

Joyce~caregiver-advocate in Dallas for Steve J (SPMSi [7]).  CAPi [6] since August 06, Cpni [8], Mpn, B. burgdorferi, systemic candidiasis, EBVi [9], CMV & other herpes family viral infectionsi [10], elevated heavy metals, gluten+casein sensitivity. 

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Joyce~caregiver-advocate in Dallas for Steve J (SPMSi [7]).  CAPi [6] since August 06, Cpni [8], Mpn, B. burgdorferi, systemic candidiasis, EBVi [9], CMV & other herpes family viral infectionsi [10], elevated heavy metals, gluten+casein sensitivity. 

I'm quite partial to Kombu, I did not know that it could help me grow more brain and nerve cell.   I'll feel even better when eating it...

I'll keep my eye on this, very interesting.

Michèle (UK) GFAi [11]: Wheldon CAPi [6] 1st May 2006. Daily Doxyi [12], Azi MWF, metroi [13] pulse. Zoo keeper for Ella, RRMSi [14], At worse EDSSi [15] 9, 3 months later 7 now 5.5 Wheldon CAP 16th March 2006

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Michèle (UK) GFAi [11]: Wheldon CAPi [6] 1st May 2006. Daily Doxyi [12], Azi MWF, metroi [13] pulse. Zoo keeper for Ella, RRMSi [14], At worse EDSSi [15] 9, 3 months later 7 now 5.5 Wheldon CAP 16th March 2006

Cool links Daisy, I have not used these herbals. I have tried blue green algae to not much good effect, but perhpas it would take a long time to work, like a couple of years. Here [17] is the study on a proprietary version--it was published. I used both the proprietary then a cheaper version. Stem cell therapeutics is using human chorionic gonadotropin and erythropoietin to stimulate nerve growth. This approach is currently in trial for post stroke recovery http://www.marketwire.com/mw/release.do?id=844732 [18] I am also wondering if neupogen (filgrastim) which is given to people as part of ASCT to stimulate stem cell production could be used as a stem cell agent on its own. Apparently the injection causes some very uncomfortable bone pain, maybe not so good for MR Grumpy! A study by Mark Freedman MD in Ottowa on ASCT showed an interesting improvement in function two years after the ASCT. They think that the late improvements are due to the stem cells making differences that showed up after time Here it is [19] Wierd thing about that study is that they claim no patient ever showed signs of the disease again....WHAT THEY MEAN IS no one ever had an enhancing lesion on MRI in he 7 years post ASCT. Several people lost EDSSi [15] score points! Some stabilized and a couple got better edss scores. I do not call this an unequivocal success in saying that MS was stopped. It looks like inflammationi [20] was perhaps stopped, but I am REALLY bothered by dropping edss scores and people mentioning that as an afterthought while touting the clean MRI as if that tells the tale. The final chapter of this story will be interesting marie On CAPi [6] since Sept '05 for MS, RA, Asthmai [21], sciatica. EDSS at start 5.5. Currently on: Doxyi [12] 200, Azith 3x week, Tinii [22] cont. since April '07, all supplementsi [23]. "Color out side the lines!"

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On CAPi [6] since Sept '05 for MSi [2], RAi [24], Asthmai [21], sciatica. EDSSi [15] at start 5.5.(early cane) Now 6 (cane full time) Originally on: Doxyi [12] 200, Azith 3x week, Tinii [22] cont. over summer '07, Revamp of protocol in Summer '08 by Stratton due to functional loss; clarithromy

Marie, The Freedman ASCT link (the last one in your post) comes up Page Not Found. Is this due to the site revamp, or something else??

The difference between what we do and what we are capable of doing would suffice to solve most of the world’s problems. Mohandas Gandhi

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The difference between what we do and what we are capable of doing would suffice to solve most of the world’s problems. Mohandas Gandhi

Dang! Here's a copy of the text Bone marrow treatments restore nerves in multiple sclerosis patients An experiment that went wrong may provide a new way to treat multiple sclerosis, a Canadian researcher said on Tuesday. Patients who got bone marrow stem-cell transplants -- similar to those given to leukemia patients -- have enjoyed a mysterious remission of their disease. And Dr. Mark Freedman of the University of Ottawa is not sure why. "Not a single patient, and it's almost seven years, has ever had a relapse," Freedman said. Multiple sclerosis or MSi [2] affects an estimated 1 million people globally. There is no cure. It can cause mild illness in some people while causing permanent disability in others. Symptoms may include numbness or weakness in one or more limbs, partial or complete loss of vision, and an unsteady gait. Freedman, who specializes in treating MS, wanted to study how the disease unfolds. He set up an experiment in which doctors destroyed the bone marrow and thus the immunei [25] systems of MS patients. Then stem cells known as hematopoeitic stem cells, blood-forming cells taken from the bone marrow, were transplanted back into the patients. "We weren't looking for improvement," Freedman told a stem cell seminar at the U.S. National Institutes of Health. "The actual study was to reboot the immune system." Once MS is diagnosed, Freedman said, "you've already missed the boat. We figured we would reboot the immune system and watch the disease evolve. It failed." STEM CELL REPAIR They had thought that destroying the bone marrow would improve symptoms within a year. After all, MS is believed to be an autoimmune disease, in which immune system cells mistakenly attack the fatty myelini [26] sheath that protects nerve strands. Patients lose the ability to move as the thin strands that connect one nerve cell to another wither. Instead, improvements began two years after treatment. Freedman reported to the seminar about 17 of the patients he has given the transplants to. "We have yet to get the disease to restart," he said. Patients are not developing some of the characteristic brain lesions seen in MS. "But we are seeing this repair." MS patients often have hard-to-predict changes in their symptoms and disease course, so Freedman says his team must study the patients longer before they can say precisely what is going on. "We are trying to find out what is happening and what could possibly be the source of repair," Freedman said. But he has found some hints that may help doctors who treat MS by using drugs to suppress the immune system. "Those with a lot of inflammationi [20] going on were the most likely to benefit (from the treatment)," he said. "We need some degree of inflammation." While inflammation may be the process that destroys myelin, it could be that the body needs some inflammation to make repairs, Freedman said. Immune cells secrete compounds known as cytokinesi [27]. While these are linked with inflammation, they may also direct cells, perhaps even the stem cells, to regenerate. The treatment itself is dangerous -- one patient died when the chemicals used to destroy his bone marrow also badly damaged his liver. Source: Reuters Canada © Thomson Reuters 2008 (07/05/08) On CAPi [6] since Sept '05 for MS, RA, Asthmai [21], sciatica. EDSSi [15] at start 5.5. Currently on: Doxyi [12] 200, Azith 3x week, Tinii [22] cont. since April '07, all supplementsi [23]. "Color out side the lines!"

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On CAPi [6] since Sept '05 for MSi [2], RAi [24], Asthmai [21], sciatica. EDSSi [15] at start 5.5.(early cane) Now 6 (cane full time) Originally on: Doxyi [12] 200, Azith 3x week, Tinii [22] cont. over summer '07, Revamp of protocol in Summer '08 by Stratton due to functional loss; clarithromy

Oh, darn. It's costing me a fortune in postage to send packages on cpni [8] to all these doctors who only need to make one more leap in the logic department.... I'll photocopy it on Monday and send it to him.

 You have to love those unintended discoveries in medical studies!

The difference between what we do and what we are capable of doing would suffice to solve most of the world’s problems. Mohandas Gandhi

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The difference between what we do and what we are capable of doing would suffice to solve most of the world’s problems. Mohandas Gandhi

Yes, the cool thing is that they had actual improvement in function but it took 2 years and this jives with what I know about peripheral nerve injury. My darling saw me trying to cut apart frozen hamburgers and quickly took the knife from me--only to cut his own thumb so deeply it severed the nerve. It took 2 years to come back, but come back it did. IT was numb, then wierdly tingly, then gradually pretty normal. I have a girl friend whose husband broke his back thus injuring the cord (but not severing it), this he was told would also take 2 years to recover normal feeling. He suffered pain for those two years then as predicted at 2 years things began to be normal. He is normal now. I find the few studies on stem cell approaches to be interesting in that they seem to look at shorter timelines than that. I am a little worried that such approaches will be found to be ineffective because they looked at something like 6 months instead of a more reasonable 2 years. I find it also interesting that people who pay for those stem cell transplants in other countries claim far more rapid improvements. Some of that is perhaps related to the idea that stem cells are antiinflammatory on their own. MY guess is that the therapy that would work would be stem cells every 3 months for a couple of years along with aggressive physical therapy. MY idea on getting stems is to harvest the cells from yourself and grow them in the lab for readministration or stimulate them endogenously (like the filgrstim above mentioned) on that regular schedule. Some of us will need regenerative therapy so these issues are really interesting to me. marie On CAPi [6] since Sept '05 for MS, RA, Asthmai [21], sciatica. EDSSi [15] at start 5.5. Currently on: Doxyi [12] 200, Azith 3x week, Tinii [22] cont. since April '07, all supplementsi [23]. "Color out side the lines!"

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On CAPi [6] since Sept '05 for MSi [2], RAi [24], Asthmai [21], sciatica. EDSSi [15] at start 5.5.(early cane) Now 6 (cane full time) Originally on: Doxyi [12] 200, Azith 3x week, Tinii [22] cont. over summer '07, Revamp of protocol in Summer '08 by Stratton due to functional loss; clarithromy

 Cool article from Harvard Research.  ^{Here [28] it is.} 

^{Daisy - Husband on CAPi [6] 5/07.   Roxithromycin, Minocycline, Rifampin, Bactrim DS, Mepron, Prednisone, Novantrone, Doxyi [12], Azithromycin, Flagyli [13], Diflucan}

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Daisy - Husband on CAPi [6] 5/07.  "When Going Thru Hell, Just Keep Going", Winston Churchill

Is it any surprise then that people doing the CAPi [6] can take two years plus to start to get better.

Michèle (UK) GFAi [11]: Wheldon CAP 1st May 2006. Daily Doxyi [12], Azi MWF, metroi [13] pulse. Zoo keeper for Ella, RRMSi [14], At worse EDSSi [15] 9, 3 months later 7 now 5.5 Wheldon CAP 16th March 2006

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Michèle (UK) GFAi [11]: Wheldon CAPi [6] 1st May 2006. Daily Doxyi [12], Azi MWF, metroi [13] pulse. Zoo keeper for Ella, RRMSi [14], At worse EDSSi [15] 9, 3 months later 7 now 5.5 Wheldon CAP 16th March 2006

Good find Daisy, that research is very encouraging. Now all I need is to find a sonic hedgehog ["a protein named sonic hedgho"] among the plenty who visit my garden.

New Forest, UK. Progressive MSi dx 12/06 LDNi [29] 3/07 CAPi [6] 6/07: Wheldon version. Pulses so far #10

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Progressive MSi [2] dx2006. LDNi [29] & CAPi [6]: Wheldon version. All supps. Doxyi [12] 200mg. Zithi [30] 250mg. Metroi [13] 400mg.Pulses #10/16...I can because I think I can.

you are the best,

God Bless

CFIDSi [32]/ME 32 yrs, FMSi [33], IBSi [34], EBVi [9], CMV, Cpni [8], chronic insomnia, Lymes, HME, Natural HRT peri-M, NACi [35] 2.5 gm, 6-07 Doxy 200 mg day pm, Azith 375 mg M/W/Fday, Pulse#10 1000 mg 3 days & 750mg 2 days, 5-17-8

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CFIDSi [32]/ME 32 yrs, FMSi [33], IBSi [34], EBVi [9], CMV, Cpni [8], chronic insomnia, Lymes, HME, Natural HRT peri-M, NAC 3 gm, 6-07 Doxy 200 mg day pm, Azith 375 mg M/W/Fday, Pulse#15 750 mg X 5 days 11-1-08

This link [36] should help you sort out the hedgehogs.

(Yes, the protein is named after a video game character.)

 Even though I have studied an inordinate amount of the human anatomy, I still find structures of the brain somewhat difficult. 

http://www.sylvius.com/ [37] is a very useful website for sorting out brain components and very useful when reading MRI reports and neuroi [38] healing texts.

^{Daisy - Husband on CAPi [6] 5/07.   Roxithromycin, Minocycline, Rifampin, Bactrim DS, Mepron, Prednisone, Novantrone, Doxyi [12], Azithromycin, Flagyli [13], Diflucan}

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Daisy - Husband on CAPi [6] 5/07.  "When Going Thru Hell, Just Keep Going", Winston Churchill