Reactivation of CPn in Cortisone Treated Mice

Reactivation of Chlamydia pneumoniae infection in mice by cortisone treatment.
K Laitinen, A L Laurila, M Leinonen, and P Saikku
National Public Health Institute, Helsinki, Finland.

Reactivation of Chlamydia pneumoniae infection was studied by inducing immunosuppression by cortisone acetate treatment given every other day for 14 days in intranasally infected NIH/s mice. The treatment started 2 or 4 weeks after primary infection, when no C. pneumoniae was detected. C. pneumoniae could be recovered from the lung cultures on days 7 and 9 in 10 and 60% of the mice, respectively, when cortisone treatment was begun 30 days after infection. These results confirm the persistent nature of C. pneumoniae infection.

This research was to give mice CPn, wait til you could not detect it, then give them cortisone and see what happens. The CPn came back, demonstrating persistent infection in spite of being unable to detect it in the pre cortisone phase.
Pretty cool!
Marie

Thanks, Marie. Makes me

Submitted by MacKintosh on Sat, 2008-05-24 19:32.

Thanks, Marie. Makes me glad I haven't had to resort to steroids again since diagnosis. Then again, with full antibiotic treatment, perhaps we aren't subject to these findings?

The difference between what we do and what we are capable of doing would suffice to solve most of the world’s problems. Mohandas Gandhi

In the study below,

Submitted by Jim K on Sat, 2008-05-24 23:22.

In the study below, cortisone combined with antibiotics was more effective in erradicating Cpni [2] than either agent alone. Interestingly, at the right dosage (lower end) cortisone alone had an antichlamydial affect. Dr. Stratton's interpretation is that we are seeing the cortisone as both causing the conversion of cryptic Cpn back to replicating RB's where it becomes susceptible to the antibiotics, and at low dose the anti-inflammatory (rather than immunosuppresive higher dosing) affect is assisting the antibiotic function.

Can't get it to take, so made it it's own forum post:

http://www.cpnhelp.org/glucocorticoids_increase_ [3]

I'd read about the addition

Submitted by Twickle Purple on Sun, 2008-05-25 11:33.

I'd read about the addition of 5mg prednisone (if applicable) and was reassured by that. I took so much steroid topically that I experienced adrenal suppression/insufficiency. I've got to take low dose prednisone from time to time, and the addition of steroid (ingested or applied) was an initial concern. I worried that I would be sabotaging any gains.

I'm hoping that Dr. Stratton's take on it is bang on.

May 2008. NACx1200mg, D3x2000mg, B12x1000mcg. Allergies, chronic inflamation, eczema, long-term steroid use, sinusitis/cysts, BL/TN, FM, CF, arthritis, rosaceai [4].

Don't worry, Dr [5]

Submitted by Sarah on Sun, 2008-05-25 12:00.

Don't worry, Dr Stratton's take is bang on. It is also the take of my husband, Dr Wheldon and many people, especially early in treatment are prescribed low dose steroids along with CAPi [6] for various reasons.............Sarah

An Itinerary in Light and Shadow...........Completed Stratton/Wheldon regime for aggressive secondary progressive MSi [7] in June 2007, after nearly four years, three of which intermittent. Still slowly improving and no exacerbation since starting. EDSSi [8] was 7, now 2, less on a good day.

Could a steroid shot to a

Submitted by Timaca on Sun, 2008-05-25 13:10.

Could a steroid shot to a joint (knee or shoulder) activate a latent Cpni [2] infection? Any articles on this that anyone knows of?

Thanks, Timaca

I had some pretty severe

Submitted by raven on Sun, 2008-05-25 14:00.

I had some pretty severe joint pain and swelling from an EBVi [9] infection in late '06. In Feb '07 I went to see my orthopedic doc for intense shoulder pain. I was unable to lift anything heavy with my right arm so I put a lot of stress on the left shoulder. He injected it with cortisone. The pain in all my joints went away within a few weeks just as he predicted, but I came down with an extreme respiratory infection and had to take Levaquin for a week to get a handle on it. I was afraid that this would happen. But I did get well from the infection and the joint pain went away. I don't think I would take cortisone again unless it was a last resort. Raven CAPi [6] since 8-05 for Cpni [2] and Mycoplasma P for MSi [7] and/or CFSi [10]

Sarah, Thank you. What you

Submitted by Twickle Purple on Sun, 2008-05-25 15:45.

Sarah, Thank you. What you all contribute is priceless.

May 2008. NACx1200mg, D3x2000mg, B12x1000mcg. Allergies, chronic inflamation, eczema, long-term steroid use, sinusitis/cysts, BL/TN, FM, CF, arthritis, rosaceai [4].

I have found relief from a

Submitted by Twickle Purple on Sun, 2008-05-25 15:53.

I have found relief from a torn rotator cuff injury, which calcified, with NIR LLLT. No side effects, it's all good. This is also the only effective treatment of my trigeminal neuralgia (nerve) pain. I use different devices/wavelengths for particular applications. The relief is just as quick as a cortisone shot, and with regular application the benefits are long term. And it is safe. Here's a link [11] to my original device, there are some interesting links as well.

HTH,
Corinna

May 2008. NACx1200mg, D3x2000mg, B12x1000mcg. Allergies, chronic inflamation, eczema, long-term steroid use, sinusitis/cysts, BL/TN, FM, CF, arthritis, rosaceai [4].

Indeed, I did not post it

Submitted by mrhodes40 on Sun, 2008-05-25 17:51.

Indeed, I did not post it to scare folks about cortisone at all! It is proof of cryptic infection after a seemingly "comlpete" eradication of the germ. The low doses of steroid are as noted helpful. Marie On CAPi [6] since Sept '05 for MSi [7], RA, Asthmai [12], sciatica. EDSSi [8] at start 5.5. Currently on: Doxyi [13] 200, Azith 3x week, Tinii [14] cont. since April '07, all supplementsi [15]. "Color out side the lines!"