?

UK Carer of bedridden Severe ME/CFS Feb06. CPNi [2] dx. Apr07. Samento 15 drops per day July07.  2400mg NAC 200mg Doxyi [1] Jan 08.

___________________________________________________________

UK Carer of bedridden Severe CFS Feb06. Tick bites Summer04.  CPNi [2] dx.Apr07. Borrelia dx Sept08. Samento 15 drps daily July07.  200mg Doxyi [1] Jan08.  300mg Roxy Apr08 Stopped abxi [4] Nov/Dec08. Building up on Supps again.

I suggest that she keeps the doxyi [1] dose 100mg twice a day, and take 150mg roxyi [9] once a day for a couple of days to see how she reacts.   Then I would take the roxy  twice a day to in the beginning.   If she is going to have reactions it will give you enough time to hold back on the second dose.   Once that has bedded in you can start playing around with double doses at one go.   I suggest you cut a few tabs in half at one time it will make it easier.  

Michèle (UK) GFAi [10]: Wheldon CAPi [11] 1st May 2006. Daily Doxy, Azi MWF, metroi [12] pulse. Zoo keeper for Ella, RRMSi [13], At worse EDSSi [14] 9, 3 months later 7 now 5.5 Wheldon CAP 16th March 2006

___________________________________________________________

Michèle (UK) GFAi [10]: Wheldon CAPi [11] 1st May 2006. Daily Doxyi [1], Azi MWF, metroi [12] pulse. Zoo keeper for Ella, RRMSi [13], At worse EDSSi [14] 9, 3 months later 7 now 6.5 Wheldon CAP 16th March 2006

Hi Mark here is what I think. 

Paula is a very sensitivity woman from what I hear. 

 May folks do just fine with the full dose at one point during the day. 

From my experience the 200 mg of Doxyi [1] at one time causes more die off for me, I feel it. 

Taken at night may not be so difficult, I am trying it now after 9 months. 

The Roxi I still take twice a day.  It is easy on the stomach and I guess I find it no problem to take it twice a day so have not tried the full does at one time. 

You can take the full dose of both at one time according to the protocol with each of them.   However the comment that is often made is "If you can take it" the die off that is.  

You can get a pill splitter and cut the 300 mg tablets that would work. 

About the Doxy no, do not reduce it to 100mg per day. the protocol is 200mg per day. and she had gotten her dosage there now so not wise to back down at this point.

just my thoughts, sure we will hear some to the contrary .

Louise

CFSi [15]/ME.CPnPositive.BbPositive.WheldonCAPbegan6/24/07. NowNAC,Doxy, Roxi, TiniPulse#4 Ended2/3/08. Cholestyramine at BedtimeforPhorphoria&liposacarideEndotoxinDie-OffExperiences.

___________________________________________________________

Louise  CFSi [15],CPNi [2]+/Bb+(Lyme) Cholestyramine 1-2 pks @ HS for Porphyriai [16] +fattyEndotoxins HS PRN, Wheldon CAPi [11] 6/07,all supps, Doxyi [1] 200QD, Roxi 300BID, Tinidazole 500 BIDx20day Pulses, VitD3-10,000IU,Iodoral25mg,SAM-e100mgQD+B-vits, Pyruvate3.75Gm at 1PM

Thanks Michelle and Louise.

Mark 

UK Carer of bedridden Severe ME/CFS Feb06. CPNi [2] dx. Apr07. Samento 15 drops per day July07.  2400mg NAC 200mg Doxyi [1] Jan 08.

___________________________________________________________

UK Carer of bedridden Severe CFS Feb06. Tick bites Summer04.  CPNi [2] dx.Apr07. Borrelia dx Sept08. Samento 15 drps daily July07.  200mg Doxyi [1] Jan08.  300mg Roxy Apr08 Stopped abxi [4] Nov/Dec08. Building up on Supps again.

Can you take the Doxyi [1] and Roxi at the same time and with food? (Paula does get pretty nauseous if she doesn't take Doxy with a full meal at the min)

Ta very muchly - (Geordie speak for "thank you very much") (a Geordie is someone who was born within the smell of the River Tyne in the North East of England, or more specifically Newcastle Upon Tyne.)

:-)

Mark. 

UK Carer of bedridden Severe ME/CFS Feb06. CPNi [2] dx. Apr07. Samento 15 drops per day July07.  2400mg NAC 200mg Doxy Jan 08.

___________________________________________________________

UK Carer of bedridden Severe CFS Feb06. Tick bites Summer04.  CPNi [2] dx.Apr07. Borrelia dx Sept08. Samento 15 drps daily July07.  200mg Doxyi [1] Jan08.  300mg Roxy Apr08 Stopped abxi [4] Nov/Dec08. Building up on Supps again.

Mark - Yes - you can take the Doxyi [1] and Roxyi [9] together with food.

Doxy is recommend without food for maximum absorption but even the package insert says you can take it with food if you have stomach distress.

 Roxy seems to be super easy on the stomach and can be given with or without food. 

My husband takes both at the same time (plus the Bactrim DS and Rifampin) on an empty stomach with 3 digestive enzymes but we are apparently sadists.   Desperate sadists though

Good luck with the Roxy addition.

^{Daisy - Husband on CAPi [11] 5/07.  Minoi [17], Roxy, Diflucan round two 1-31, Rifampin, Bactrim DS, Prednisone, Novantrone, Doxy, Azithromycin, Flagyli [12]}

___________________________________________________________

Daisy - Husband on CAPi [11] 5/07.  "When Going Thru Hell, Just Keep Going", Winston Churchill

Thanks Daisy.

You are doing a brilliant job by the way.

Mark 

 

UK Carer of bedridden Severe ME/CFS Feb06. CPNi [2] dx. Apr07. Samento 15 drops per day July07.  2400mg NAC 200mg Doxyi [1] Jan 08.

___________________________________________________________

UK Carer of bedridden Severe CFS Feb06. Tick bites Summer04.  CPNi [2] dx.Apr07. Borrelia dx Sept08. Samento 15 drps daily July07.  200mg Doxyi [1] Jan08.  300mg Roxy Apr08 Stopped abxi [4] Nov/Dec08. Building up on Supps again.

Daisy, is that all once a day with all of those meds? 

Guess I would like to ask what is the shedule that you have at the moment.  Surely it would bowl me over but I am curious.  He is at least twice maybe plus my weight so there is more body mass to distribute the meds through. 

Sure wish I had a tough constitution.

Hope today is a better day for you folks.

Louise

CFSi [15]/ME.CPnPositive.BbPositive.WheldonCAPbegan6/24/07. NowNAC,Doxyi [1], Roxi, TiniPulse#4 Ended2/3/08. Cholestyramine at BedtimeforPhorphoria&liposacarideEndotoxinDie-OffExperiences.

___________________________________________________________

Louise  CFSi [15],CPNi [2]+/Bb+(Lyme) Cholestyramine 1-2 pks @ HS for Porphyriai [16] +fattyEndotoxins HS PRN, Wheldon CAPi [11] 6/07,all supps, Doxyi [1] 200QD, Roxi 300BID, Tinidazole 500 BIDx20day Pulses, VitD3-10,000IU,Iodoral25mg,SAM-e100mgQD+B-vits, Pyruvate3.75Gm at 1PM

___________________________________________________________

I am apparently also a sadist -- who knew?

Each a.m., on an empty stomach,  this 110 pounder takes Roxi, Tetra, Bactrim DS, Rifampin and NACi [3]! 

I thought that was normal!

*****

Positive Cpni [2] and Bb dx'd November 2006.  Previously dx'd RRMSi [13] May 2000.  Treated by Lyme MD as of 11/06.  Current regimen is Bactrim DS, Roxithromycin, Rifampin and Tetracycline.  Also NAC, probiotics and a few supplementsi [21]. 47 year old mom of two teenagers. Work at home office with husband/business parter. Rhode Island, USA.

___________________________________________________________

Positive Cpni [2] and Bb dx'd November 2006.  Previously dx'd RRMSi [13] May 2000.  Treated by Lyme MD as of 11/06.  Current regimen is tetracycline, Difllucan and Mepron.

Deborah -

I think you are normal in taking it all together.  Know lots of peeps now who do this.

Louise - On a typical day - my husband takes Rifampin 600mg  at 8 AM and then at 8:30 AM takes Bactrim DS , Roxithromycin 300mg and Minocycline 100mg.  Then at 9 AM breakfast.

 Around 6 pm he gets another round - Bactrim DS , Roxithromycin 300mg and Minocycline 100mg.  Then dinner at 6:30 pm or 7PM.

In between all the supplementsi [21] with and without food, seizure med and prednisone get worked in.

^{Daisy - Husband on CAPi [11] 5/07.  Mino, Roxy, Diflucan round two 1-31, Rifampin, Bactrim DS, Prednisone, Novantrone, Doxyi [1], Azithromycin, Flagyli [12]}

___________________________________________________________

Daisy - Husband on CAPi [11] 5/07.  "When Going Thru Hell, Just Keep Going", Winston Churchill

Daisy, the about 5 - 6 hours later bang.  It that the time for the bunching bag +/-.

Sarah, my comment was primarily for those who have mega unrelenting fatigue as a significant part of their chief complaints.  I WISH that I did not belong to that subset of individuals!

Mark, I think that Paula and I have more in common on some level or other with chronic fatigue high on the list.

Bless you all with your cast iron stomaches!  That is why I chose Roxi and Tinii [23].  I'll try azytho and metronidiazole at some point later.   I admire your sturdy constitutions.

LouiseCFS/ME.CPnPositive.BbPositive.WheldonCAPbegan6/24/07. NowNAC,Doxyi [1], Roxi, TiniPulse#4 Ended2/3/08. Cholestyramine at BedtimeforPhorphoria&liposacarideEndotoxinDie-OffExperiences.

___________________________________________________________

Louise  CFSi [15],CPNi [2]+/Bb+(Lyme) Cholestyramine 1-2 pks @ HS for Porphyriai [16] +fattyEndotoxins HS PRN, Wheldon CAPi [11] 6/07,all supps, Doxyi [1] 200QD, Roxi 300BID, Tinidazole 500 BIDx20day Pulses, VitD3-10,000IU,Iodoral25mg,SAM-e100mgQD+B-vits, Pyruvate3.75Gm at 1PM

 Roxy should be taken on empty stomach or at least 15  minutes before a meal for best absorbtion (=the levels you want to have in your blood). You can read it in the CAPi [11] medication info at the end of the cpni [2]-handbook.

 I take 300 Roxy in the morning on empty stomach and breakfast 30 minutes or more after.

Doxyi [1] is better with lots of water and with food a meal to prevent nausea.

Don't lie down after taking Doxy. I take my 200 doxy in the evening after my evening meal. I have to sit up  at least one hour after (but with  legs on the sofa or coffee-table ). 

"Odhilda" CFS, not able to work or study since 1993. Mekobalamin (B12) injections 10mg x12/month.  Levothyroxine(T4). NAC 1000 mg. Started Doxycyklin 100mg 20/09-07. Roxithromycin. 20/11-07. 200 Doxy 8/1-08. First Metronidazolei [12] pulse 12/3-08.

___________________________________________________________

"Odhilda" CFS, not able to work or study since 1993. Mekobalamin (B12) injections 10mg x12/month. Levothyroxine(T4). NACi [3] 500-850. Started Doxyi [1] Sept-07. Started Roxi Nov-07 first Metroi [12]-pulse March-08. Swedish is my first language.

Well, my bottles of doxyi [1] say no food unless nausea occurs, then a 'small amount of food'. I think we all aim for taking the meds without food, so as not to interfere with absorption, but some are stuck and just have to eat with them. I'm on day twenty-one of flagyli [12] and have only twice felt nausea after taking abxi [4] for 29 months. Suddenly, two days in a row last week, doxy on an empty stomach made me seasick. Taken with food, all was well again. I'm sticking to a few bites of bread with doxy, azith and flagyl til I finish this long pulse, just to be safe, though I know I'm cutting down a bit on absorption.

The difference between what we do and what we are capable of doing would suffice to solve most of the world’s problems.  Mohandas Gandhi

___________________________________________________________

The difference between what we do and what we are capable of doing would suffice to solve most of the world’s problems. Mohandas Gandhi

 MacKintosh, according to FASS (Farmaceutical specialitys in Sweden) for physicians, food affects absorbtion of doxycyclin insignificantly. So why take it without food and risk nausea when you can take it with food.

Lots of other thing does affect Doxy absorbtion and concentration in blood significantly, like iron, magnesium ,calcium , rifampicin and a couple of other meds .

I am sorry I don't have/don't know the english equivalent for FASS, but it is used by all physicians in Sweden when prescribing meds and giving patients information so it really is reliable. 

Day 21 of Flagyl! Sounds scary too me! I thought five days every third week would be enough.

Sorry for writing short but I still don't feel very well and have very little energy.

"Odhilda" CFS, not able to work or study since 1993. Mekobalamin (B12) injections 10mg x12/month.  Levothyroxine(T4). NAC 1000 mg. Started Doxycyklin 100mg 20/09-07. Roxithromycin. 20/11-07. 200 Doxy 8/1-08. First Metronidazolei [12] pulse 12/3-08.

___________________________________________________________

"Odhilda" CFS, not able to work or study since 1993. Mekobalamin (B12) injections 10mg x12/month. Levothyroxine(T4). NACi [3] 500-850. Started Doxyi [1] Sept-07. Started Roxi Nov-07 first Metroi [12]-pulse March-08. Swedish is my first language.

Odhilda, short is better than not at all; you have been missed here! And day 22 finds me with energy enough to work for two hours on construction at my house after working a full day at my job. (But days 16 and 17 were lousy, with no energy to speak of.) My comment was more about the various directions we are all given with our medications. Some receive doxyi [1] and it says okay to take with food or milk. Others get labels that say no food, unless nausea occurs, then a small amount of food. (I remember getting a label at one pharmacy that actually said 'such as a cracker'. I tried to be valiant like Katman and take my abxi [4] separately from food and other vitaminsi [24] and supps, but I'm too lazy to keep track of such a specific schedule, so I usually take my doxy and half of my vitamins and supps in the morning and my azith at night with the other half of the vitamins/supps. Mornings, I rarely get food before leaving for work, so doxy and the whole mix is on an empty stomach most of the time by necessity, not choice. (Someday I will have a kitchen again, I will, I will, I will....) Here's wishing you some improvement - and quickly!

The difference between what we do and what we are capable of doing would suffice to solve most of the world’s problems.  Mohandas Gandhi

___________________________________________________________

The difference between what we do and what we are capable of doing would suffice to solve most of the world’s problems. Mohandas Gandhi

Just for info, Paula took her first Doxyi [1] of the day yesterday with only a small amount of food (half a banana).  She didn't feel nauseous at all, which is good.

Her fatigue and all other CFSi [15] related symptoms were a lot worse yesterday, including irritability.  Maybe it's increased porphyriai [16] symptoms - maybe the Doxy is is being absorbed better without taking as much food with it.

Or maybe she has been doing far too much this past week.  Especially trying to pass cpni [2] related info onto others with CFS via phone calls and text messages on her mob, letter writing, etc.

Sheesh!

I've told her to be selfish and look after herself, not to think about spreading the info to others until she is well enough. - That's my job. :-)

Looks like the Roxi is off the menu again for the time being.

:-(

Mark 

UK Carer of bedridden Severe ME/CFS Feb06. CPN dx. Apr07. Samento 15 drops per day July07.  2400mg NAC 200mg Doxy Jan 08.

___________________________________________________________

UK Carer of bedridden Severe CFS Feb06. Tick bites Summer04.  CPNi [2] dx.Apr07. Borrelia dx Sept08. Samento 15 drps daily July07.  200mg Doxyi [1] Jan08.  300mg Roxy Apr08 Stopped abxi [4] Nov/Dec08. Building up on Supps again.

Mark I would go with a quicker absorption and therefore a a sharper rise in blood level of Doxyi [1].  Personally I do better keeping mine a bit more even.  Also consider how glycemic bananas are causing spikes in insulin and resulting fall in blood sugar as a result for me that means FATIGUE and irritability.

Louise

CFSi [15]/ME.CPnPositive.BbPositive.WheldonCAPbegan6/24/07. NowNAC,Doxy, Roxi, TiniPulse#4 Ended2/3/08. Cholestyramine at BedtimeforPhorphoria&liposacarideEndotoxinDie-OffExperiences.

___________________________________________________________

Louise  CFSi [15],CPNi [2]+/Bb+(Lyme) Cholestyramine 1-2 pks @ HS for Porphyriai [16] +fattyEndotoxins HS PRN, Wheldon CAPi [11] 6/07,all supps, Doxyi [1] 200QD, Roxi 300BID, Tinidazole 500 BIDx20day Pulses, VitD3-10,000IU,Iodoral25mg,SAM-e100mgQD+B-vits, Pyruvate3.75Gm at 1PM

Thanks Louise.

Relating to the banana - Paula takes the doxyi [1] with lots of water now.  She didn't have anything to eat Sunday morning with the doxy and was fine.  She had a main meal about 30 minutes after the doxy.

I agree that some of her symtoms could be better doxy absorbtion, but also her increased activity this past week and she agrees.

Mark 

 

UK Carer of bedridden Severe ME/CFS Feb06. CPNi [2] dx. Apr07. Samento 15 drops per day July07.  2400mg NAC 200mg Doxy Jan 08.

___________________________________________________________

UK Carer of bedridden Severe CFS Feb06. Tick bites Summer04.  CPNi [2] dx.Apr07. Borrelia dx Sept08. Samento 15 drps daily July07.  200mg Doxyi [1] Jan08.  300mg Roxy Apr08 Stopped abxi [4] Nov/Dec08. Building up on Supps again.