I think the Vit D can create die off as well. I get depression with it. I would suggest slowly increasing your vit d, maybe start with 1000 iu, and see how you do for a few days or even a week, and slowly increase. hopefully, some more knowledgable folks will be along shortly to comment.

edit: go put that shivering body of yours under a heating blanket or wrap those cold hands in heating pad..  

Mphs, TN. CFSi [9], hypoT (Hashi), adrenal fatigue, 37 w/hormones of 80,. right arm neuropathy. + cpni [4], myco, EBVi [10], CMV. on NACi [11] 3000mg, doxyi [8] 100-2xday, azith 250 m/w/f/sun, progesterone, synthroid, and pulsing w/flagyli [7], tinii [12].

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Mphs, TN. CFSi [9], hypoT (Hashi), adrenal fatigue, 37 w/hormones of 80, right arm neuropathy. + cpni [4], myco, EBVi [10], CMV. Capi [13] began in 6/07. NACi [11] 2400mg, doxyi [8] 100-bid, biaxin 500mg bid since 7/08, progesterone, synthroid, flagyli [7] pulses

On the positive side, there has been a noticeable decrease in aches and pains in less than a week of adding vitamin Di [3]. I was expecting it to take several weeks to have any effect on that. So, despite shivering more, I'm aching less. I hope that part continues. :)

Asthmai [6], chronic sinusitis/rhinitis, chronic tendonitis, hypothyroid. Jan 9, '08 started Azithromycin 1000mg/week.

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GFAi [5] - asthmai [6], sinusitis/rhinitis, tendonitis, low back pain, hypothyroid. Started azi 1000mg/week Jan 9, '08. Increased azi to 250mg/day, added 20mg Benicar daily Mar 13, '08. First Flagyli [7] pulse started June 30, '08. Added Doxyi [8] 200mg/day Aug 16.

Sharon has a good point about the Vit D, I think. You might drop back and build more slowly unless you can stand some weeks of this. The D combined with the abxi [2] can be wicked apparently sometimes. And stay ahead on the garbage-collectors. Sounds like that crew will be pretty busy.

 

Rica PPMSi [14] EDSSi [15] 6.7 at beginning - now 2. Began CAPi [13] Sept, 2004 with Rifampin 150 mg 2xd, Doxyi [8] 100 mg 2xd, added regular pulses Jan 2005. Jan 2006 switched to Doxy, Azith, cont. flagyli [7] total 49 pulses NC USA

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Rica PPMSi [14] EDSSi [15] 6.7 at beginning - now 2. Began CAPi [13] Sept, 2004 with Rifampin 150 mg 2xd, Doxyi [8] 100 mg 2xd, added regular pulses Jan 2005. Jan 2006 switched to Doxy, Azith, cont. flagyli [7] total 55 pulses LDNi [16] Rifampin 8/08 again NC USA

Hi Sunnivara,

Glad to hear the aches and pains have decreased, but definitely be careful with that Vit D3. It can really pack a die-off/secondary porphyriai [18] punch, particularly when combined with CAPi [13]. And the negative side-effects of the secondary porphyria from, it can build over time if you're not careful...

Hang in there!

On Combined Antibiotic Protocol for Cpni [4] in Rosaceai [19] 01/06 - 07/07, On Vit D3 + NACi [11] since 07/07 and daily FIRi [20] Sauna since 08/07

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Treatment for Rosaceai [19]

• CAPi [13]:  01/06 - 07/07
• High-Dose Vit D3, NACi [11] & FIRi [20] Sauna Only:  07/07 - 11/08
• Intermittent CAP, High-Dose Vit D3:  11/08 - Present

Red, this is the first time I've heard about negative effects from D. I thought it was just supposed to help with energy. I've been taking D and just received a mail-order of D3. What is the skivvy on this stuff?

PPMSi [14]-misdiagnosed 2001-diagnosed 2006. Minocycline 7 mos.- resulting bronchitis 5 months. Talked Hopkins neuroi [21]. into: HRT (estriol and progesterone as neural protectant re Voskuhl,UCLA).Wheldon CAPi [13] 3/2/07 - 200 doxyi [8]; azith MWF. 4 pulses. Rockville,Md. Loo

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PPMSi [14]-misdiagnosed 2001-diagnosed 2006. Also maybe csf and Lyme -- who knows?! Minocycline 7 mos.- resulting bronchitis 5 months. Deserted by Hopkins neurology dept. and going to private md. out-of-plan. Wheldon CAPi [13] 3/2/07 - 200 doxyi [8]; azith MWF. 5 pulses.

Hi Artile,

Vit D3, particularly in higher doses, seems to have some good anti-Cpni [4] effects on its own (probably only killing the intracellulari [23] forms of Cpn via its effects on the intracellular forms' abilities to prevent normal cellular apoptosisi [24]), and combined with the antibioticsi [2] of CAPi [13], Vit D3 has produced some pretty heavy die-off / secondary porphyriai [18] for several of us.

Given its ability to induce our own antimicrobial peptides, or cathelicidins, which are active against many other pathogens, it's probably a great idea to discuss adding Vit D3 to CAP therapy with your doctor, but be careful about adding it too quickly.   It can really pack an unexepected punch! 

 
On Combined Antibiotic Protocol for Cpn in Rosaceai [19] 01/06 - 07/07, On Vit D3 + NACi [11] since 07/07 and daily FIRi [20] Sauna since 08/07

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Treatment for Rosaceai [19]

• CAPi [13]:  01/06 - 07/07
• High-Dose Vit D3, NACi [11] & FIRi [20] Sauna Only:  07/07 - 11/08
• Intermittent CAP, High-Dose Vit D3:  11/08 - Present

Hi Sunni, you should read what David Wheldoni [25] says about Vit D, here [26]. Below is a severely cut extract from that page.

Vitamin Di [3], antibacterial peptides (cathelicidins) and immunomodulation.

In 2004 Wang and colleagues published a study showing that 1,25(OH)2D3 directly induces specific antimicrobial gene expression and activity leading to the production of cathelicidins, small peptides which have marked antimicrobial activity.  Cathelicidins have a very broad spectrum of activity, and promote wound healing and re-epthelialization of breaks in the skin: they are absent in chronic (non-healing) ulcers. 

Cathelicidins have activity against intracellulari [23] bacteria; this has been demonstrated in Mycobacterium tuberculosis.

Cathelicidins are active in the innate defence system of the gut, lining the mucosa and preventing attachment by epithelial-adherent bacterial pathogens.

Cathelicidins are active in vitro against Herpes Simplex Virus and cathelicidin deficiency has been found in persons with eczema herpeticum.

The study of cathelicidins and their potential is clearly just beginning. note that 'cathelicidin peptides have properties of both natural antibioticsi [2] and host stimulatory molecules. The rapid increase in cathelicidin at epithelial interfaces exposed to injury or infection can provide a simultaneous barrier to microbial proliferation and an additional alarm to the host.' 

The actions of vitamin D on the immunei [27] system are reviewed in this paper [van Etten E, Mathieu C. Related Articles, Immunoregulation by 1,25-dihydroxyvitamin D3: basic concepts. J Steroid Biochem Mol Biol. 2005 Oct; 97 (1-2): 93-101.]

Supplementation: what dose?

Supplementation with D3 seems, on this evidence, reasonable and even advisable. What would be a reasonable and advisable daily dose? The safe upper limit of supplementation in adults is officially declared to be 50 micrograms (2,000 iu.) Vieth and colleagues state that 100 micrograms (4000 iu.) may be safely given (and, in older persons may be necessary)  

The authors support their statement with convincing evidence. This paper is recommended reading. Hathcock and colleagues, in a very recent and thorough study, make the comment: 'Collectively, the absence of toxicity in trials conducted in healthy adults that used vitamin D dose > or = 250 microg/d (10,000 IU vitamin D3) supports the confident selection of this value as the UL.'

High dose Vitamin D will be of particular importance to those receiving doxycycline or minocycline, both of which can cause photosensitivity reactions. It is important to take the D3 form.


[Note: Disordered calcium metabolism is frequent in sarcoid, a non-caseating granulomatous condition. Hypercalcaemia may be found in 20% of patients with sarcoid, while hypercalciuria may be even more common, and is of major clinical importance. 

Sarcoid granulomas abound in macrophages; the sarcoid macrophage has been found to to synthesize 1,25(OH)2D3 from its precursor 25(OH)D3, thus by-passing the strict regulation by parathyroid hormone. The excess circulating 1,25(OH)2D3 produced extrarenally causes increased intestinal absorption of calcium, enhanced bone resorption, and resultant hypercalciuria with or without hypercalcaemia. Other diseasesi [28] with granulomatous features may also involve disordered calcium metabolism, albeit less severe; these include a subset of persons with active Crohn's disease

Michèle (UK) GFAi [5]: Wheldon CAPi [13] 1st May 2006. Daily Doxy, Azi MWF, metroi [7] pulse. Zoo keeper for Ella, RRMSi [29], At worse EDSSi [15] 9, 3 months later 7 now 5.5 Wheldon CAP 16th March 2006

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Michèle (UK) GFAi [5]: Wheldon CAPi [13] 1st May 2006. Daily Doxyi [8], Azi MWF, metroi [7] pulse. Zoo keeper for Ella, RRMSi [29], At worse EDSSi [15] 9, 3 months later 7 now 6.5 Wheldon CAP 16th March 2006

I cut back to 2,000 iu of D yesterday and felt a bit better than the day before. Monday was the worst day I've had so far I think. The only way I could get even slightly comfortable that night was with a cup of hot cocoa and a thick pile of blankets. I didn't have to resort to that last night. I'm a bit surprised the reaction was so severe.

Asthmai [6], chronic sinusitis/rhinitis, chronic tendonitis, hypothyroid. Jan 9, '08 started Azithromycin 1000mg/week.

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GFAi [5] - asthmai [6], sinusitis/rhinitis, tendonitis, low back pain, hypothyroid. Started azi 1000mg/week Jan 9, '08. Increased azi to 250mg/day, added 20mg Benicar daily Mar 13, '08. First Flagyli [7] pulse started June 30, '08. Added Doxyi [8] 200mg/day Aug 16.

Glad you're feeling a bit better Sunnivara!   Hang in there... 

On Combined Antibiotic Protocol for Cpni [4] in Rosaceai [19] 01/06 - 07/07, On Vit D3 + NACi [11] since 07/07 and daily FIRi [20] Sauna since 08/07

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Treatment for Rosaceai [19]

• CAPi [13]:  01/06 - 07/07
• High-Dose Vit D3, NACi [11] & FIRi [20] Sauna Only:  07/07 - 11/08
• Intermittent CAP, High-Dose Vit D3:  11/08 - Present

Hey Sunni!

The chills are wicked, when I get cold like that I feel like a popsicle!

Use lots of your moppers & I don't have to tell you...bundle up!

CFIDSi [31]/ME 25yrs, FMSi [32], IBSi [33], EBVi [10], Cpni [4], (insomnia - melatonini [34], GABA, tarazadone, triazolam, novocycloprine, allergy formula, 3 gm tryptophan), Natural HRT peri-M, NACi [11] 2.5 gm, 6-07 Doxy 200 mg day pm, Azith 375 mg M/W/Fday, 2-6-08 7th pulse 2 X 375 mg 2day+

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CFIDSi [31]/ME 32 yrs, FMSi [32], IBSi [33], EBVi [10], CMV, Cpni [4], H1, chronic insomnia, Lymes, HME, Natural HRT peri-M, NAC 3 gm, Full CAP 6-2-08, all supplementsi [35] +Sea Kelp, Chitosan Pulse 16 1-4-09 1gm Flagyli [7]/day-3 days

Sunnivara -  ^Here [36] is a link to thoughts by Dr. Powell on using Niacin for the cold hands and feet endotoxini [37] reaction you have been experiencing.  Hope this helps.

^{Daisy - Husband on CAPi [13] 5/07.  Minoi [38], Roxyi [39], Diflucan round two 1-31, Rifampin, Bactrim DS, Prednisone, Novantrone, Doxyi [8], Azithromycin, Flagyli [7]}

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Daisy - Husband on CAPi [13] 5/07.  "When Going Thru Hell, Just Keep Going", Winston Churchill

 Please note that the Niacini [40] has anti-chlamydial effects too! So don't rush in when you are already overloaded. But a judicious dose could really help warm things. When I was in this phase he used Trental to counter the endotoxini [37]-chill effects. Really helped me.

CAPi [13] for Cpni [4] 11/04. Dx: 25yrs CFSi [9] & FMSi [32]. Protocol: 200mg Doxyi [8], 500mg MWF Azith, Tinii [12] 1000mg/day pulses; Vit D1000 units, INHi [41] 150mg, Magnascent Iodine 20 drps/day, T4 & T3

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CAPi [13] for Cpni [4] 11/04. Dx: 25yrs CFSi [9] & FMSi [32]. Currently: 150mg BID Roxithromycin, Doxycycline 100mg BID, Tinii [12] 1000mg/day pulses; Vit D2000 units, T4 & T3