Pectin, Fiber and Endotoxin

Just skimming some articles about modified citrus pectin and found this: http://tinyurl.com/27yow9u< Been interested in it for chelation purposes but now I find that it can be helpful for endotoxinsi.

Sickness behavior induced by endotoxini can be mitigated by the dietary soluble fiber, pectin, through up-regulation of IL-4 and Th2 polarization

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Christina L. Sherrya, Stephanie S. Kimb, Ryan N. Dilgerc, Laura L. Bauerc, Morgan L. Moona, Richard I. Tappingd, George C. Fahey Jr.a, c, Kelly A. Tappendena, c, e and Gregory G. Freunda, b, c, Corresponding Author Contact Information, E-mail The Corresponding Author a Division of Nutritional Sciences, University of Illinois, Urbana, IL 61801, USA b Department of Pathology, University of Illinois, Urbana, IL 61801, USA c Department of Animal Science, University of Illinois, Urbana, IL 61801, USA d Department of Microbiology, University of Illinois, Urbana, IL 61801, USA e Department of Food Science and Human Nutrition, University of Illinois, Urbana, IL 61801, USA Received 12 October 2009; revised 25 January 2010; accepted 26 January 2010. Available online 6 February 2010.

Abstract

Peripheral activation of the immunei system by infectious agents triggers the brain–cytokine system causing sickness behaviors which profoundly impact well-being. Dietary fiber is a beneficial foodstuff that, from a gastrointestinal tract perspective, exists in both insoluble and soluble forms. We show that a diet rich in soluble fiber protects mice from endotoxin-induced sickness behavior by polarizing mice Th2 when compared to a diet containing only insoluble fiber. Mice fed soluble fiber became less sick and recovered faster from endotoxin-induced sickness behaviors than mice fed insoluble fiber. In response to intraperitoneal endotoxin, mice fed soluble fiber had up-regulated IL-1RA and reduced IL-1β and TNF-α in the brain as compared to mice fed insoluble fiber. Importantly, mice fed soluble fiber had a basal increase in IL-4 in the ileum and spleen which was absent in MyD88 knockout mice. Con-A stimulated splenocytes from mice fed soluble fiber showed increased IL-4 and IL-5 and decreased IL-2, IL-12 and IFN-γ when compared to mice fed insoluble fiber. Likewise, endotoxin-stimulated macrophages from mice fed soluble fiber demonstrated decreased IL-1β, TNF-α, IFN-γ, IL-12 and nitrate and increased IL-1RA, arginase 1 and Ym1 when compared to mice fed insoluble fiber. Finally, the behavioral protection afforded by feeding mice soluble fiber was reduced in IL-4 knockout mice, as was the impact of soluble fiber on Con-A stimulated splenocytes and endotoxin activated macrophages. These data show that a diet rich in soluble fiber protects against endotoxin-induced sickness behavior by polarizing mice Th2 and promoting alternative activation of macrophages.

So what does that mean in plain English? Eat more apples?

Soluble fiber like Modified Citrus Pectin is supposed to mop up endotoxinsi better than insoluble fiber. You can buy capsules of Modified Citrus Pectin. It is also a chelator.

Here is a link about it:

http://www.lef.org/magazine/mag2004/mar2004_report_citrus_01.htm<

I am particularly interested in this reduction of bad side effects from endotoxins and and TNF with the use of soluble fiber. Modified citrus pectin has been "modified" to be more soluble. I thought this article was pretty significant.

 

Raven

Feeling 98% well-going for 100. Very low test for Cpni. CAPi since 8-05 for Cpn/Mycoplasma P.,Lyme, Bartonella, Mold exposure,NACi,BHRT, MethyB12 FIRi Sauna. 1-18-11 begin new treatment plan with naturopath

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