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bile2Submitted by Jim K on Sat, 2008-10-18 21:36. »
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The main pouring of bile
The main pouring of bile occurs when Chyme reaches the upper intestine and the mechanism is mainly hormonal, being mediated by CCK. The presence of digestive products of fats and proteins, ie fatty acids and L-amino acids releases CCK from the upper intestines into the blood. CCK contracts the gall-bladder and relaxes the choledochoduodenum. Both Vagal excitation and secretin augment the action of CCK on the gall-bladder. MgSO contracts the gallbladder and discharges bile into the intestine because it releases CCK. Generally, substances that lead to the pouring of bile into the intestine by contracting the gall-bladder and relaxing the sphincter are called cholagogues.