Naprosyn \ Aleve \ Naproxen \ Anti-Inflammatory

Kim has had questions about whether the ABXi is really working.  She's had a tough time the past month or so.  We've bumped her up to 2gm Chlorella per day and she is still taking charcoal at night.  But, Kim keeps asking me if the ABXi is really helping.  I've been recounting for her how far she's come and how several symptoms are vastly improved, but I can hear in Kim's voice that she's asking in relation to how she feels .... today.  In all my recounting for Kim I realized that I keep using the words "die-off" and "inflammationi".  Kim takes charcoal and chlorella for the die-off, but suddenly, I really paid attention to the word "inflammation".

A few hours of thinking and google and reading here at CPnhelp netted us Naproxen.  I keep this stuff in the house because I have on and off back pain.  When I take them, I go to script levels.  For Kim, I broke the Aleve tablets in half and spread them into Kim's noon and night vitaminsi.  Low dosage.

On day 1, also a day one for Flagyli day, Kim said she felt better than normal for a first day of the pulse.  On day 2, I noticed that some of the red bumps on Kim's face were clearing and she was pretty tolerant of the pulse.  I think it's helping, but it's too early to tell.  I can't believe that I didn't think of this before.

Questions:

1) Who here takes Aleve\Naproxen?

2) How have you found is the best way to take it?

3) I could not find any issues with Naproxen and ABX, but has anyone found problems with this combination?

4) Do you take it daily or just when you take Flagyl or some other schedule?

5) How much do you take? 

I'll have a post up on TIMS in a week or so that will include this.  Thanks for your thoughts, Ken

Ken            

I've also taken Naproxen sodium from time to time.  I haven't felt like it's helped  me much but Kim and others may see more benefits from it then I have.

The way I've taken it is just the standard oral doses.  I think I tried doubling the dosage amount and it didn't seem to make a difference.

I know of no issues with ABXi and Naproxen.  The ABXi we use here is fairly common and I would think that my doctor would have said something.  Alternatively, the label on the Naproxen would have said something and it didn't.

I never too Naproxen on a schedule, just on an as needed basis.  I hope this helps.

best, John

RRMSi/EDSSi was 4.5, 5, 6, 6.5, 6.9999, 6.5 on Wheldon/Stratton Protocol beginning 04/12/2006
naci 4x600 mg/day
doxycycline 2x100mg/day
azithromycin 3x250mg/day MWF
metronidazolei 3x400mg/day then 3x500mg/day

Ken- I've used ibuprophen for the same purpose, and quite often early on. It's one of the signs I've improved that I need it once a week now versus, when I started the CAPi, twice a day all the time. Naproxen is stronger and usually lasts a bit longer than ibuprophen, but always disturbed my stomach where the ibuprophen did not. Both can lead to stomach bleeding if overused, and also have blood thinning effects. Dr. Stratton has said it's perfectly appropriate to use these as needed if they help and there are no other health contraindications. Personally, I think there are benefits to keeping inflammationi under control as I believe it helps avoid tissue damage from inflammation, but that's more a personal non-medical opinion!

 

CAPi for Cpni 11/04. Dxi: 25+yrs CFSi & FMSi. Currently: 250 aithromycin mwf, doxycycline 100mg BIDi, restarted Tinii pulses; Vit D2000 units, T4 & T3, 6mg Iodoral

I take Aleve whenever I injure myself (the hazard of old house restoration) and have had no problems with it. I can feel the relief on inflammationi within 20-30 minutes.

The difference between what we do and what we are capable of doing would suffice to solve most of the world’s problems. Mohandas Gandhi

Ken, to follow on with Jim's non medical opinion, mine is that whenever I felt the need I would take ibuprofen, with a priming dose of up to twice what is recommended on the packet, then back down to what is recommended.

Tell Kim that even Sriram thinks the abxi are working because he told her to stop novantrone..............Sarah

An Itinerary in Light and Shadow

Completed Stratton/Wheldon regime for aggressive secondary progressive MSi in June 2007, after four years, three of which intermittent.   Still improving bit by bit and no relapses since finishing treatment.

Thanks all. 

F.A.W. - we were not able to find any conflicts with any of the ABXi Kim is on either.

Jim - I looked at ibuprophen too.  As a disctectomy survivor, I can tell you Nap is the drug of choice. I agree it is doing something positive and, I don't disagree with the tissue damage thinking, although, I can't find support for the idea - have you?

Mac - I bet Bob Vila uses the stuff too.  My next project is an angel tree topper for Christmas - more on this later.

Sarah - I'm working on a letter to Sriram to preceed Kim's next appointment.  There will be a new post at TIMS soon.  If the positive impacts Kim is having this pulse is from the Nap, dare I say, everyone on ABXi ought to be taking Nap during the pulse week.  No banana slapping this time around!  Seriously, I think the Aleve made the side effects from Flagyli much more tollerable AND made the recovery speedier.  One tiny adjustment, Sriram took Kim Copaxone was optional.  Kim was taken off Novantrone just weeks before we started our "ramped-up" effort to get scripts for ABX in autumn 2007.  

Ken 

In pursuit of ABX<

Don't Allow What You Know To Get In The Way Of What Might Be

Ken           

Excellent feedback!  I'm glad to hear of Kim's progress and I hope this continues unabated!

best, John

RRMSi/EDSSi was 4.5, 5, 6, 6.5, 6.9999, 6.5 on Wheldon/Stratton Protocol beginning 04/12/2006
naci 4x600 mg/day
doxycycline 2x100mg/day
azithromycin 3x250mg/day MWF
metronidazolei 3x400mg/day then 3x500mg/day

http://www.rxlist.com/naprosyn-drug.htm<

 

I found a good bit of info about Naprosyn at the link above.  I wanted to find out if folks took it long term and it sounds like they do.  I also found that Naprosyn is a COX-1 and COX-2 inhibitor, which makes it much more interesting in this anti-CPni/MSi effort.  Ken

In pursuit of ABX<

Don't Allow What You Know To Get In The Way Of What Might Be

Ken           

Thanks for the link and wake up call.  My understanding is that it is a COX-2 and 5-LOX inhibitor, and that it doesn't interrupt COX-1.  I tried to find the information in the link you posted and couldn't find it mixed in with everything else.  Granted, I only did a quick search so maybe it is right out in plain site and I just missed it.  But if you would tell me where on the pages it is, I would be grateful.

best, John

RRMSi/EDSSi was 4.5, 5, 6, 6.5, 6.9999, 6.5 on Wheldon/Stratton Protocol beginning 04/12/2006
naci 4x600 mg/day
doxycycline 2x100mg/day
azithromycin 3x250mg/day MWF
metronidazolei 3x400mg/day then 3x500mg/day

John,

Here's a pretty authoritative source that suggests (in a not so clear way) that the COX-1 pathway may be effected by Naproxen:

Drug Interactions: Nonsteroidal anti-inflammatory agents, including ibuprofen and naproxen, may diminish the cardioprotective effect of aspirin (Catella-Lawson F, 2001; Capone ML, 2005). It is surmised that ibuprofen may exhibit greater affinity than aspirin for the COX-1 site or if dosed regularly (or prior to aspirin), it would gain access to the active site first. In either case, aspirin's inhibition of COX (irreversible) would be limited in favor of ibuprofen inhibition (reversible). Avoid regular use of NSAIDsi (nonselective) if possible. If used occasionally, take after aspirin (immediate release) ingestion.

http://www.merck.com/mmpe/lexicomp/naproxen.html<

Ken

 

In pursuit of ABX<

Don't Allow What You Know To Get In The Way Of What Might Be

Ken            

This sounds like it's in line with what I've read elsewhere that says that Naproxen Sodium inhibits both COX-1 and COX-2 enzymes.  For that reason, I probably wouldn't choose it for regular use since it inhibits both.  Of course, this is information that I only recently came to know and previously was using Naproxen daily.  I'm still on the search to come up with a choice and/or strategy that allows for the use of NSAIDsi without inhibiting vitamin Di but still don't have what I think is a definitive answer about it.

best, John

RRMSi/EDSSi was 4.5, 5, 6, 6.5, 6.9999, 6.5 on Wheldon/Stratton Protocol beginning 04/12/2006
naci 4x600 mg/day
doxycycline 2x100mg/day
azithromycin 3x250mg/day MWF
metronidazolei 3x400mg/day then 3x500mg/day

Sarah,

I was just wondering what a priming dose is and how long you woudl take it.

Ken

In pursuit of ABX<

Don't Allow What You Know To Get In The Way Of What Might Be

Ken you've got an unclosed html in you signature!!! I tried to edit this page but it's not in the formatting

On to the question I use aleve most every day I find it makes a big difference. Dr Stratton told me to do it last May. Sometimes I use enzymes like zyflamend as a natural antiinfammmatory as well when I am not doing as well. I think NSAIDs are pretty hard on my stomach so sometimes I need to back off a little.
marie

On CAPi since Sept '05 for MSi, RAi, Asthmai, sciatica. EDSSi at start 5.5.(early cane) Now 6 (cane full time) Originally on: Doxyi 200, Azith 3x week, Tinii cont. over summer '07, Revamp of protocol in Summer '08 by Stratton due to functional loss; clarithro

Thanks Marie,

I fixed my sig.  I think Farandwide has uncovered some important thoughts about naproxen and I hope we can find out more soon.  For now Kim is using Ipuprofen instead.

Ken

In pursuit of ABX<

Don't Allow What You Know To Get In The Way Of What Might Be

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