Another death on an MSi trial, this time caused by an infection.
http://www.medicalnewstoday.com:80/articles/110437.php
FTY720 is an immunei suppresser called Fingolimod, taken orally and developed from the Chinese fungus, cordyceps..............Sarah
An Itinerary in Light and Shadow...........Completed Stratton/Wheldon regime for aggressive secondary progressive MSi in June 2007, after nearly four years, three of which intermittent. Still slowly improving and no exacerbation since starting. EDSSi was 7, now 2, less on a good day.
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Surely one in 17 deaths is a
Surely one in 17 deaths is a high percentage and must be taken seriously. I've not heard of anyone following a CAPi dying...
Michèle (UK) GFAi: Wheldon CAP 1st May 2006. Daily Doxyi, Azi MWF, metroi pulse. Zoo keeper for Ella, RRMSi, At worse EDSSi 9, 3 months later 7 now 5.5 Wheldon CAP 16th March 2006
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Michèle (UK) GFAi: Wheldon CAPi 1st May 2006. Daily Doxyi, Azi MWF, metroi pulse. Zoo keeper for Ella, RRMSi, At worse EDSSi 9, 3 months later 7 now 5.5 Wheldon CAP 16th March 2006
Or going bankrupt paying
The difference between what we do and what we are capable of doing would suffice to solve most of the world’s problems. Mohandas Gandhi
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The difference between what we do and what we are capable of doing would suffice to solve most of the world’s problems. Mohandas Gandhi
Yes, you'd think they would
Yes, you'd think they would also view 1 in 17 as a high proportion! Instead of backing off though, they want to rush it to market!
Joyce~caregiver-advocate in Dallas for Steve J (SPMSi). CAPi since August 06, Cpni, Mpn, B. burgdorferi, systemic candidiasis, EBVi, CMV & other herpes family viral infectionsi, elevated heavy metals, gluten+casein sensitivity.
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Joyce~caregiver-advocate in Dallas for Steve J (SPMSi). CAPi since August 06, Cpni, Mpn, B. burgdorferi, systemic candidiasis, EBVi, CMV & other herpes family viral infectionsi, elevated heavy metals, gluten+casein sensitivity.
Oh, this was only day
Oh, this was only day one, though. I give them a week before they stop the trial, if only temporarily, like tysabri. Shame no-one has logged on to the infection angle as yet, though............Sarah
An Itinerary in Light and Shadow...........Completed Stratton/Wheldon regime for aggressive secondary progressive MSii in June 2007, after nearly four years, three of which intermittent. Still slowly improving and no exacerbation since starting. EDSSi was 7, now 2, less on a good day.
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Yeah, but with injectable
Yeah, but with injectable M.S. treatments starting around $20,000 a year (the less said about efficacy, the better), there's just too much money to be made with an oral treatment to let a few deaths slow you down.
I'm sure there are more than a few out there whose attitude is that the people who die in these trials don't really count since they were going to end up being crippled anyway.
CAPi for M.S. since 8/2007. Currently: 100 mg Dox. (2 x day), 250 mg Zithi (3 x week) ceased 3/2008, restarted 5/2008,
150 mg Roxi (2 x day)starting 3/2008, ended 5/2008. Ninth pulse metronidazolei completed 6/7/2008.___________________________________________________________
CAPi for M.S. since 8/2007. Currently: 100 mg Dox. (2 x day), 250 mg Zithi (3 x week) ceased 3/2008, restarted 5/2008,
150 mg Roxi (2 x day)starting 3/2008, ended 5/2008. Twelfth pulse metronidazolei & INHi completed 8/28/2008.They've given the drug to
Thomas McPherson Brown, who for decades treated patients with rheumatoid arthritis with antibioticsi, all the while watching the latest 'wonder drugs' appear, have their day, then get revealed as blunder drugs which didn't help in the long run, had a good statement about drugs based on autoimmune theories, which I'll quote approximately as: "There is a lot of room for happy accidents in medical research, but nobody ever found the north pole by going south." It's reasonable to expect fingolimod to fail, too, eventually -- but it hasn't yet done so: one death in a trial isn't enough to constitute failure.
In any case, the trials they're doing are part of an approval process that takes something like a decade; there is no unusual haste involved.
If you are looking at
If you are looking at safety aspects and comparing it to CAPi... it seems pretty significant to me. It seems to make the clear point that its meant to..
CPNi pcri and antibody positive , treating MS, CFSi, TMJ, trigeminal neuralgia, IBS neutropenia, pus found in facial bone, Doxy 100x2, zithro 250x1 alternate days. Metroi pulses each month.
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CPNi pcri and antibody positive , treating MSi,
CFSi, TMJ, trigeminal neuralgia,IBSineutropenia, pus found in facial bone,Doxyi 100x2,Doxy 200x2 zithro 250x1 alternate days. Metroi pulses each month.Looking at the report of
(They're not being complete idiots about this; they did monitor infectionsi as side effects, and indeed found a large increase in upper respiratory infections, among other things.)
Perhaps this new drug is
Perhaps this new drug is opening the way for the CPni (re upper respiratory infectionsi) to harm patient who already have compromised immunity.
CFIDSi/ME 32 yrs, FMSi,
IBSi, EBVi, CMV, Cpn, chronic insomnia, Lymes, HME, Natural HRT peri-M, NACi 2.5 gm, 6-07 Doxy 200 mg day pm, Azith 375 mg M/W/Fday, Pulse#10 1000 mg 3 days & 750mg 2 days, 5-17-8___________________________________________________________
CFIDSi/ME 32 yrs, FMSi,
IBSi, EBVi, CMV, Cpni, chronic insomnia, Lymes, HME, Natural HRT peri-M, NACi 2.5 gm, 6-07 Doxy 200 mg day pm, Azith 375 mg M/W/Fday, Pulse#13 1240 mg X 3 days 8-7-08That sounds likely, and
The difference between what we do and what we are capable of doing would suffice to solve most of the world’s problems. Mohandas Gandhi
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The difference between what we do and what we are capable of doing would suffice to solve most of the world’s problems. Mohandas Gandhi
Norman said, "They're not
Norman said, "They're not being complete idiots about this; they did monitor infectionsi as side effects, and indeed found a large increase in upper respiratory infections, among other things."
This is why I gave then a week to stop the trial, which lots of people won't like. With so much dampening of the immunei system, pre-existing infections can run riot, never mind any new ones which might happen along.............Sarah
An Itinerary in Light and Shadow...........Completed Stratton/Wheldon regime for aggressive secondary progressive MSi in June 2007, after nearly four years, three of which intermittent. Still slowly improving and no exacerbation since starting. EDSSi was 7, now 2, less on a good day.
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Since Cpni parasitizes
In any case, blaming the disease on the patient gives them a license to be nasty to patients, as in: "You have an autoimmune disease, so we're going to have to suppress your immune system in one way or another to solve it. What did you expect from us? We're just doctors, not miracle workers; we cannot make bread without flour, or make wine out of water."
A week is about how long it'd take for them to look into the death and see whether it looked like an ordinary accidental death from infection, or like something more ominous. But even a more ominous sort of death, as happened with Tysabri, didn't stop that drug from being approved.