Melatonin instead of Benzodiazepines - interesting!

Melatonini instead of Benzodiazepines - interesting!

I am taking lorazepam for sleep and want to come away from it. Might be interesting for others how take sleep meds or benzos.

Did anyone took benzodiazepines and melatonin together (for the first few weeks of benzo decrease)?

Regards 

Résumé / AbstractAn open pilot study on the safety and efficacy of melatonin in the treatment of insomniac patients was conducted in 22 subjects (16 females), mean ± S.D. age 60.1 ± 9.5 years. All patients received 3 mg of gelatin melatonin capsules per os daily for 6 months, 30 min before expected sleep time. Twenty of 22 patients were on benzodiazepine treatment and they continued this treatment for part of or for the entire melatonin administration period. Serum concentrations of prolactin, follicle-stimulating hormone (FSH), thyroid-stimulating hormone (TSH), or estradiol were measured by radioimmunoassay (RIA) in morning samples at the beginning and after 6 months of melatonin administration, and standard clinical laboratory tests for blood components were performed. Urinary 6-sulphatoxymelatonin (aMT6s) excretion was measured by RIA before treatment. Serum concentrations of prolactin, FSH, TSH, or estradiol did not exhibit changes after 6 months of melatonin administration, nor were any indications of hematologic or blood biochemistry alteration found. Melatonin augmented significantly the quality and duration of sleep, and decreased sleep latency and the number of awakening episodes, as assessed from sleep logs filled by the patients (first 21 days) and from structured interviews performed by incumbent physicians (up to 6 months). Estimates of next-day function (i.e., alertness in the morning and during the day) also improved significantly during melatonin treatment. The observed effect lasted for the entire period examined (up to 6 months), with 22 out of 22 patients showing improved sleep at the end of treatment. The urinary excretion of aMT6s before starting administration of melatonin correlated negatively and significantly with age, but not with the intensity of sleep the disorder or the outcome of treatment. In 13 of 20 patients taking benzodiazepines together with melatonin, benzodiazepine use could be stopped, and in another four patients, benzodiazepine dose could be decreased to 25-66% of the initial dose. The results of this open, subacute administration trial indicate that melatonin is a safe and useful treatment for sleep disturbances in middle-aged or elderly patients, either by itself or together with benzodiazepines.

I took yesterday evening my first 2 gramms of Melatonini. I couldn t sleep well at all(OK by the way yesterday was fullmoon). But when I woke up this morning it was like an additional not so nice die off feeling. Cold hands, shivering, feeling dizzy. It seems that melatonin boosts the immunsystem. Anyone else experienced the same?
Male 38 years (Germany),CFIDSi, IBSi, Enterovirus, Cpni and Bartonella, Dientamoeba fragilis positive. Started Capi on 02/19/08, Currently taking Bactrim, Flagyli, soon adding Malarone and Clindamycin for suspected protozooa. 

Melatonini is listed as one of the agents that enhance nitric oxide synthesis on a recent handout from my doctor (he is a well known and respected doctor known to many on this site). Increasing nitric oxide is one component of his program to treat chronic fatigue/fibromyalgiai. His handout does report that "increasing nitric oxide levels too quickly can lead to headache and kill virus/bacteria too rapidly leading to unpleasant die-off symptoms". You may need to go slower with your approach. Good luck..

 ____________________________________________________________

CFIDSi 6 years, Cpni, EBVi, CAPi (12 pulses), many supplementsi, MCB protocol. Southwest USA

Diagnosed with cpni, CFSi for 5+ years. Zithro, doxyi, many supplementsi;  1 year full pulses;  methylation cycle protocol;   New Mexico, USA

>Melatonini is listed as one of the agents that enhance nitric oxide synthesis on a recent handout from my doctor

 

Interesting, I'll have to look that up. I've found low dose DHEAi (10mg) seemed to really kick up my NO and did get a decent headache for a couple of days from it. Arginine and Cocoa also increase NO.

Doxyi 100mgx2, Azithromycin 250mg MWF, Probiotics: PB8, JarrowDophilus. CFSi since 2003. Last 5+ years lots of the usual research (Depression, Adrenal Fatigue, HPA, Mercury, Candida, Thyroid, etc.). iherb.com $5 coupon code: HAW103

Biohazard, I take DHEAi (25mg and get no untoward effects but then I am old enough not to have much of it naturally, ie. Post menopausal, maybe it effects those with adaquate levels ie those "younger age bracket" if they take it and it puts them a bit on overdrive?

How are you doing with your research on bringing CAPi into your treatment plan for your CFSi?

Louise

  • CAPi(TiniOnly): 06/07-02/09 for CFSi
  • MethylationProtocolSupplements: Started08/08
  • Intermtnt CAP: 02/09-02/10
  • Full MethylProtocol & LDNi 02/09
  • Off CAP: 02/10, cont LDN & MethlyProtocol support

Cesare, Melatonini never helped me to sleep through the night and getting to sleep was not my problem.  What it did do was cause me to feel hung over.   I do take Clonazapam 0.5 mg 1/2 to 1 hr before sleep for the past 15 months and this get me through my mid sleep cycle wakefulness.  Occasionally I wake to void (urinate) but with the Clonazapam going back to sleep is rarely difficult. I have no need of it during the day.   Clonazapam is a long acting benzo and has deep muscle relaxation effect.  Taking such a small dose once a day seems like a small trade off.  I have tried multiple variations on herbals and this is what is currently working for me.  If you had asked me about such "drastic measures" earlier in my life I would have been very skeptical.  Now I am open to many things such as long term antibioticsi and and my other neutraceutical supports.    I am on the verge of saying I have a life back.  Just a few more logistical pieces to put in place.  For me currently it is part of my treatment package.

I am enjoying your posts.  Well wishes to you .  Louise  

  • CAPi(TiniOnly): 06/07-02/09 for CFSi
  • MethylationProtocolSupplements: Started08/08
  • Intermtnt CAP: 02/09-02/10
  • Full MethylProtocol & LDNi 02/09
  • Off CAP: 02/10, cont LDN & MethlyProtocol support
Cesare- I would not expect that simple substitution will give you a clear indication as you withdrawing the benzo will cause sleeplessness even with melatonini. Your system will have to  adjust to a gradually lowered benzo amount while adding the melatonin. Only after you've completely detoxed on the benzo can you know if the melatonin alone will work for you.

 

CAPi for Cpni 11/04. Dxi: 25+yrs CFSi & FMSi. Currently: 250 aithromycin mwf, doxycycline 100mg BIDi, restarted Tinii pulses; Vit D2000 units, T4 & T3, 6mg Iodoral

I'm finding a lot of evidence that Melatonini decreases Nitric Oxide production:

 

http://www.nature.com/bjp/journal/v151/n2/abs/0707225a.html

http://www.nitricoxideresearch.com/showabstract.php?pmid=7527477&redirec...

 

I would like to see where your Doctor got his information?

 

Doxyi 100mgx2, Azithromycin 250mg MWF, Probiotics: PB8, JarrowDophilus. CFSi since 2003. Last 5+ years lots of the usual research (Depression, Adrenal Fatigue, HPA, Mercury, Candida, Thyroid, etc.). iherb.com $5 coupon code: HAW103

Cesare, I guess my situation is different I get to sleep just fine.  It is staying asleep that is problematice coupled with the real problem for me, not being able to return to sleep.  I am taking a phosphatdylserine Complex formula to modulate my cortisol spike the showed up with salva testing as provided to me by my MD.

Have you done saliva testing of your cortisol levels to see if this is impacting your situation?  Just another aspect to possibly explore around sleep disturbances.  These are so common in CFSlike afflictions. 

I am waking these days spontaneously around 5:30 a.m. before my alarm, just like I did in the anicient times when I had a full life and full energy. 

Wishing you much health and healing,  Louise

  • CAPi(TiniOnly): 06/07-02/09 for CFSi
  • MethylationProtocolSupplements: Started08/08
  • Intermtnt CAP: 02/09-02/10
  • Full MethylProtocol & LDNi 02/09
  • Off CAP: 02/10, cont LDN & MethlyProtocol support

Bio- don't get too singleminded about NO. Using that lens only doesn't appreciate the complexities of the action of a hormone like melatonini. First, the NO suppressive effects in the studies you cite appear to be quite localized and at the same time (another study on the same page as the second link you gave) melatonin in the presence of LPSi activates macrophages and induces the production of other oxygen intermediates (anti-microbial oxidizers). There are also other research abstracts which show direct antichlamydial effects of Cpni:

http://www.cpnhelp.org/?q=serotonin_and_melatonin_n

and it's anti-oxidant neuroprotective effects

http://www.cpnhelp.org/?q=another_reason_to_take_me

 

 

CAPi for Cpni 11/04. Dxi: 25+yrs CFSi & FMSi. Currently: 250 aithromycin mwf, doxycycline 100mg BIDi, restarted Tinii pulses; Vit D2000 units, T4 & T3, 6mg Iodoral

hi louise ! My problem is the same - falling asleep is no problem but the staying asleep. My adrenals were tested and what I have is elevated dheas . It is upregulated because of the stress from the immunei system.  But I talked to my doc today, he said dheas is a precursor of cortisol and told me to give seriphos a try. I still have it here, will try it tonight.  How much do you take?

Thanks a lot!

Male 38 years (Germany),CFIDSi, IBSi, Enterovirus, Cpni and Bartonella, Dientamoeba fragilis positive. Started Capi on 02/19/08, Currently taking Bactrim, Flagyli, soon adding Malarone and Clindamycin for suspected protozooa. 

Cesare, I took it three times a day based on the timing of the Cortisol spikes.  My level was in the normal range at noon time according to my saliva testing results.  I did this for two months this past spring.  The formulation was a "complex" the brand as PhysioLogics - Phosphatidylserine - neuroi PS - 100 mg.  Label mentions aids brain function, sharpens mental focus and helps improve memory.  60 softgel in bottle.  I have been looking for a supplier to continue with this brand which is available to me through his office however the Suggested Retail is $43.89 and that office charged $40 and the first on line source for the same brand is 28.53 for the same 60 number of softgels.  I googled Physiologics phosphatidylserine complex and found a number of possible sources I have not used one yet.  I have been using something that I picked up at the local health food store which is less of a complex and over priced in comparison.   

He was specific that I needed to do the supplement for several months.  Perhaps he will retest me next time I go for a visit.   His instructions for the complex formulation was take one to three gels at each dose for me that was early in my morning, middle of my afternoon and later in the evening before bedtime.  

He is very good in complementary medicine and nutrition (his mother was a nutritionist guess he could not escape the influenceWink.  I was the first person to go to him requesting tx for CPni and since he as tested many more and has found it in others with chronic illnesses.   He was not worried about me taking to much of this.  Of course it is an expense so to take enough but not to much is always best from my point of view.

So anyway now I am taking it just in the evening for now.

I will be interesting in hearing about your experience with this neutraceutical supplement. 

Wishing you many zzzzzzzzz!   Louise

  • CAPi(TiniOnly): 06/07-02/09 for CFSi
  • MethylationProtocolSupplements: Started08/08
  • Intermtnt CAP: 02/09-02/10
  • Full MethylProtocol & LDNi 02/09
  • Off CAP: 02/10, cont LDN & MethlyProtocol support

Wow, you guys make me happy that melatonini was enough to help me reset my sleep cycle. I went to a doctor in 1995 or 96, asking for a sleep med, since I couldn't get to bed (no matter what I tried) before 4a.m. She refused, not realizing I'd reached the end of my rope when I'd finally broken down and gone to see her.

On a friend's recommendation, I ended up taking melatonin, which helped a lot.  I eventually stopped taking it, until I started the Wheldon protocol.  It again pretty much 'fixed' me.  I still take it, though I've noticed I often forget it, yet my sleep schedule and quality is consistently pretty good without taking it as regularly as I used to.  I'll probably start weaning myself from it soon.

The difference between what we do and what we are capable of doing would suffice to solve most of the world’s problems. Mohandas Gandhi

Try onions just out of curiosity. They did wonders for me.

One middle sized onion half an hour before bed time should be enough.

It's not easy for the liver to process too much onion, so using it on a daily basis might be risky. A one day on one off might work.

Tudor

On CAPi from June 2008 to October 9, 2008
Reactive Arthritis, polyuria, infertility, CFSi, CPNi (uncertain)
Now taking: Apple Vinegar - 5 spoons morning and evening, 2 spoons2 x 3 apples a day, Omega 3, Myco Plus, sangre de grado,

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