Macrocytic red blood cells (rbc)

Does anyone know of a link between infectionsi and macrocytic red blood cells?  Before my diagnosis a blood test showed that I had much larger than normal red blood cells which is known as macrocytic.  Apparently this is common in people with MSi. I was just wondering if this had anything to do with the monocytes being infected with Cpni.

Comments

My posts are going all over

My posts are going all over the place!!  Thanks for the recommended Vit B link.  IHerb are great.
Started CAPi April 2005, right leg motor function now worse

And again

Concentrate more on the

Concentrate more on the sublingual B12.  http://store.yahoo.com/iherb/b12advanced.html<  You only need to take one a day of these and they are very small!  They are cherry flavoured.  Red wine in moderation is beneficial  as well.
(Ooh, I'll have a look at that link you just posted!)
Sarah
Completed Stratton/Wheldon regime for aggressive secondary progressive MSi in June 2007, after four years, three of which intermittent.   Still improving bit by bit and no relapses since finishing treatment.

I know this isn't entirely

I know this isn't entirely relevant but it goes to show that some scientific brains think bacteria are causes of macrocytic blood cells as per this link: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15559613&query_hl=2<
Started CAPi April 2005, right leg motor function now worse

oh dear, will have to keep

oh dear, will have to keep chomping the yucky Vit B complex pills!  And maybe a little less red wine. 

 

Thanks for the info.

Started CAPi April 2005, right leg motor function now worse

The association of MS and

The association of MSi and macrocytosis is well known. It is a complex subject. Probably due to low B12 plus cpni interference with mitochondrial membrane, resulting in disorders of haem synthesis. Depletion of antioxidantsi due to chronic infectionsi may aggravate this.  I couldn't find anything about infections, but I did find this in addition to Jim's posting:
"Multiple sclerosis (MS) is occasionally associated with vitamin B12 deficiency. Recent studies have shown an increased risk of macrocytosis, low serum and/or CSF vitamin B12 levels, raised plasma homocysteinei and raised unsaturated R-binder capacity in MS. The aetiology of the vitamin B12 deficiency in MS is often uncertain and a disorder of vitamin B12 binding or transport is suspected. The nature of the association of vitamin B12 deficiency and MS is unclear but is likely to be more than coincidental. There is a remarkable similarity in the epidemiology of MS and pernicious anaemia. Vitamin B12 deficiency should always be looked for in MS. The deficiency may aggravate MS or impair recovery. There is evidence that vitamin B12 is important for myelini synthesis and integrity but further basic studies are required.........."
Aren't they always?
Sarah



Completed Stratton/Wheldon regime for aggressive secondary progressive MSi in June 2007, after four years, three of which intermittent.   Still improving bit by bit and no relapses since finishing treatment.

Alexandra-I don't know if

Alexandra I don't know if this is the same condition exactly, but I found this on the indicated link. It sugggests a B12 deficiency, which we know is common from infectious sources as B12 is a primary detox and antioxidant">i agent. (see section on Porphyriasi in Treatment link) and in Stratton/Vanderbilt protocol.

From:http://www.answers.com/topic/anemia

Macrocytic anemia The most common cause of macrocytic anemia is megaloblastic anemia due to a deficiency of either vitamin B12 or folic acid (or both) due either to inadequate intake or insufficient absorption. Folate">i deficiency normally does not produce neurological symptoms, while B12 deficiency does. Pernicious anemia is an autoimmune condition where the body lacks intrinsic factor, required to absorb vitamin B12 from food. Alcoholism can cause macrocytic anemia. Drugs that inhibit DNA replication, such as methotrexate, can also cause macrocytic anemia. This is the most common etiology in nonalcoholic patients. The treatment for vitamin B12-deficient macrocytic and pernicious anemias was first devised by William Murphy who bled dogs to make them anemic and then fed them various substances to see what (if anything) would make them healthy again. He discovered that ingesting large amounts of liver seemed to cure the disease. George Minot and George Whipple then set about to chemically isolate the curative substance and ultimately were able to isolate the vitamin B12 from the liver. For this, all three shared the 1934 Nobel Prize in Medicine.

On Wheldon/Stratton protocol for Cpni in CFSi/FMSi since December 2004.

 

CAPi for Cpni 11/04. Dxi: 25+yrs CFSi & FMSi. Currently: 250 aithromycin mwf, doxycycline 100mg BIDi, restarted Tinii pulses; Vit D2000 units, T4 & T3, 6mg Iodoral