LymeMD about tinidazole

This is very good news, Lala.  It works well with Cpni as well. I think that Stratton and co. wish it was less expensive in the US...............Sarah

A  Journey through Light and Shadow

Completed Stratton/Wheldon regime for aggressive secondary progressive MSi in June 2007, after four years, three of which intermittent.   Still improving bit by bit and no relapses since finishing treatment.

A fascinating report, Lala. Thanks. It's interesting that penicillin seems to have an effect on Lyme bacteria. The author states that penicillin degrades bacterial RNA. This implies that it also inhibits bacterial protein production.

 And its interesting that tinidazole is effective against the Lyme "cysts". (Perhaps the "cysts" are stressed forms undergoing a stringent response analogous to CPNi.)

D W - [Myalgia and hypertension">i (typically 155/95.) Began (2003) taking doxycycline and macrolide and later adding metronidazolei. No medication now. Morning BP typically 110/75]

David, do you think WP/SP could be enough for lyme, too?

Nord sent me an original study, about which the article speaks:

http://www.dovepress.com/evaluation-of-in-vitro-antibiotic-susceptibilit...<

I also detected another interesting LymeMD input about rifampin.

http://lymemd.blogspot.com/2008/07/why-does-rifampin-work-so-well.html 

If rifa is synergistic with other atb, I speculate, why not. What are your ideas about this?   

 

Stratton/Wheldon protocol 02/2006 - 10/11 for CFSi and many problems 30 years

Lala, Thanks for putting a link to the original article.

I have no personal experience of treating Lyme disease, but I'd speculate, on theoretical grounds, that the combination of bacterial protein synthesis inhibitors (doxycycline, macrolide or rifampicin) plus nitroimidazole (metronidazolei or tinidazole) long-term, should be effective. I had this in mind when Sarah became ill; I believe that Lyme can cause symptoms indistinguishable from MS. As it says in Lymeinfo: "it is important for those diagnosed with Multiple Sclerosis be thoroughly evaluated by a physician skilled at diagnosing Lyme disease". Not that the neurologist arranged this. Sarah's Lyme serologyi (Western Blot) was not remarkable. I talked with a Lyme specialist in Southampton without gaining much in the way of advice. In the end I gave empirical treatment. It worked.

I'd say again, though, that I don't claim any expertise in Lyme, but the bacterium does seem to have a polyphasic habit which likely involves stressed forms which you would expect to be killed by nitroimidazoles: indeed, the paper implies this. The protein synthesis inhibitors would prevent effective repair of the breaks in the bacterial DNA, enhancing antibacterial efficacy. Speculation, but if I had Lyme I'd go for it.

D W - [Myalgia and hypertension">i (typically 155/95.) Began (2003) taking doxycycline and macrolide and later adding metronidazolei. No medication now. Morning BP typically 110/75]

Thank you for your opinion, David.

The problem is the in vitro tests often do not correspond with in vivo efficacy. And the in vivo efficacy is problematic to evaluate when we have no reliable tests!

Stratton/Wheldon protocol 02/2006 - 10/11 for CFSi and many problems 30 years

I found an article about penetration of BBBi. Looks like tinii should be twice as efective as metroi. http://jac.oxfordjournals.org/content/3/3/239.abstract<

Stratton/Wheldon protocol 02/2006 - 10/11 for CFSi and many problems 30 years

Lala you always find so good articles. Yes according to it tinii really looks to be twice as effective as metroi. But for me this information is also important - "The lowest CSF concentrations were several fold higher than those needed to inhibit Bacteroides fragilis in vitro". So at the end tini is as effective as metro. But probably higher dose of metro is needed to reach the needed concentration. And that's why tini should be better but I can only dream of tini as it isn't available in our countries.

 

MSi for more than 30 years, WP since July 08, break Jan 09-March 09. NACi 2x600mg, Doxyi 2x100mg, Roxi 2x150mg, Entizol in pulzes, LDNi, supplementsi.Since May 2013 without abxi.

Evita, are you sure you can’t get it?  Lala is in the Czech Republic and you in Slovakia...................................Sarah

A  Journey through Light and Shadow

Completed Stratton/Wheldon regime for aggressive secondary progressive MSi in June 2007, after four years, three of which intermittent.   Still improving bit by bit and no relapses since finishing treatment.
Yes, I am. I think Lala is getting it on the internet and I am afraid of getting it this way. If it's available in the Czech Republic I would have no problem to get it. But I am afraid it isn't. Also I am afraid the Slovak customs wouldn't allow it. When I get supplementsi from Swanson I can see that the parcel was opened and checked.

MSi for more than 30 years, WP since July 08, break Jan 09-March 09. NACi 2x600mg, Doxyi 2x100mg, Roxi 2x150mg, Entizol in pulzes, LDNi, supplementsi.Since May 2013 without abxi.

Evita, I buy all my meds online from magicpharma except they don't supply Naltrexone which  I buy from riverpharmacy.ca (Canada)  in tablet form & cut into 10mg doses.

All have the same therapeutic effect as those manufactured in UK/Europe

They are all sent from the same place in India in small amounts, foil wrapped, with a layer of thin card each side,  to fit into ordinary envelopes. Although last time they arrived in a lightly padded envelope. It might be worth trying to buy them once to see if your customs don't check letters from abroad. Also ask for them to be in ordinary envelopes not padded. They take a few days to reply to emails. Sometimes the odd tablet is slightly crushed.

Clare

Thanks Clare for the information. It's good to know the way of mailing. I think it shouldn't be a problem with the customs while it is sent as a letter. For the time being as metroi seems to help me I will stay with it. Also I pay nothing for itWink. But if I feel that I should change it I will try.

MSi for more than 30 years, WP since July 08, break Jan 09-March 09. NACi 2x600mg, Doxyi 2x100mg, Roxi 2x150mg, Entizol in pulzes, LDNi, supplementsi.Since May 2013 without abxi.

I do not have tinii from internet, I have it from Russia. It is without prescription there as well as in Ukraine. Since Ukraine is Slovakia's neighbor, it should not be big problem.

Stratton/Wheldon protocol 02/2006 - 10/11 for CFSi and many problems 30 years

Sorry Lala I thought you had tinii from the internet. Well, Ukraine is a neighbour of Slovakia. Maybe my husband or daughter could drive there and bought it but there is again a problem at the customs. Long queues and long waiting times. And our customs officers check everything. That's why it takes so long to get through the customs. And they may not allow any drugs. I have to check it. But I am really seriously thinking about trying tini. Maybe I order from the link Clare gave me. Anyway I want to discuss it with my doc firstly. And she may give me the prescription and it may be useful if I decide to buy it in Ukraine but only because of the customs.

MSi for more than 30 years, WP since July 08, break Jan 09-March 09. NACi 2x600mg, Doxyi 2x100mg, Roxi 2x150mg, Entizol in pulzes, LDNi, supplementsi.Since May 2013 without abxi.

Evita, she might aso give you a prescription which you can use with 1drugstore-online.  You can buy from them either with or without a prescription............................Sarah

A  Journey through Light and Shadow

Completed Stratton/Wheldon regime for aggressive secondary progressive MSi in June 2007, after four years, three of which intermittent.   Still improving bit by bit and no relapses since finishing treatment.

Lala: the Teacher, the Philosopher, and the Scientist,

You are a master of the Socratic Method !!!

(which has nothing to do with the above blogs, but everything to do with one I recently posted on another site) I can find no other way to contact you except this. Otherwise I would have contacted you privately.. 

A thousand thank yous for your astute, sincere questions and comments.

MSmom

.

 

MSMom, Click on her screen name, which will take you to her member page, then click on 'send private message'. ;-)

The difference between what we do and what we are capable of doing would suffice to solve most of the world’s problems. Mohandas Gandhi

Lala, Thanks for sharing these links.  Louise

  • CAPi(TiniOnly): 06/07-02/09 for CFSi<
  • MethylationProtocolSupplements: Started08/08
  • Intermtnt CAP: 02/09-02/10
  • Full MethylProtocol & LDNi 02/09
  • Off CAP: 02/10, cont LDN & MethlyProtocol support
  • <

tinidazole kills the cyst form of giardia which I think I got from brushing my teeth in poisoned water.  I had nausea for 8 years from just drinking water and sulphurous burps.  flagyl/metronidazolei doesn't kill cysts so it would be interesting if it kills spirochete cysts.

I had a really strange reaction when I started it, with severe fog, very slow thinking, trouble speaking, and then later dizziness and balance problems, maybe it was due to the bell's palsy damage and my ears started popping.  maybe it was treating a neuroi infection of some sort.   

Interesting as my ND just gave me some Pleo-Notaquent ( penicillin homeopathic )..... Lins

ampicillin may be a better antibiotic since penicillin is so often prescribed

Why?

The difference between what we do and what we are capable of doing would suffice to solve most of the world’s problems. Mohandas Gandhi

Mac, whhich one of them are you saying 'why' to?  Actually, prrobably to both because I can't think that anything described as a homeopathic antibiotic does anything apart from induce resistance...................Sarah

Completed Stratton/Wheldon regime for aggressive secondary progressive MSi in June 2007, after four years, three of which intermittent.   Still improving bit by bit and no relapses since finishing treatment.

Sorry, Sarah.  Physics was still online and had just posted that comment about taking one antibiotic instead of another, so I thought I'd ask 'why'. 

The difference between what we do and what we are capable of doing would suffice to solve most of the world’s problems. Mohandas Gandhi

Well, I thought 'why' as well, but I am also questioning the homeopathic use of penicillin.  Sorry, I can't use that spelling: it should be 'homoeopathic'....................Sarah

Completed Stratton/Wheldon regime for aggressive secondary progressive MSi in June 2007, after four years, three of which intermittent.   Still improving bit by bit and no relapses since finishing treatment.

I am going for another live blood on Sat. after having taking this penicillium homeopathic - I will report back ok?

ampicillin is more broad spectrum than penicillin and covers some gram negative and gram positive bacteria such as strepB group infectionsi.  I just read about it being used for serious infections.  it has to do with a physical characteristic of the bacterial cell membrane. 

Fine, but since you are taking other things as well, you won't be able to tell what the homeopathic stuff has done.......................Sarah

Completed Stratton/Wheldon regime for aggressive secondary progressive MSi in June 2007, after four years, three of which intermittent.   Still improving bit by bit and no relapses since finishing treatment.

Yes you can from live blood cell /dark something?

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