long term abx with high IgE

I have been on Flagyli (pulsing i week, once per month), Doxyi (100 twice daily) and Zithro (750 mgs per week), for over a year.  I take Dulera (200) two puffs twice daily and a nasal steroid for my sinuses once daily. I am stopping the Flagyl and Doxy for now at my Drs request to see where that goes. I'm a daily NACi user as well.

Three years ago, I contracted this Adult Onset of Asthmai and inflammationi issue out of nowhere. I never had anything at all even as a child. I was wondering if my high IgE count 1047 is telling me something. I still have a respiratory issue (obstruction, inflammation, can't climb stairs without heavy breathing etc.). I fought back a daily battle to a livable situation, but I'd LOVE to finish this battle...

Any ideas, thoughts etc?

BernieM

Surely the high IgE is telling you something...but what?

IgE is not specific for allergies. Your IgE is so high that I would also consider other causes besides allergies, such as parasitic infectionsi. The physiologic function of IgE is fighting parasites.

Did you have a differential blood count test? How high were the eosinophiles? I would also recommend that ECP (eosinophilic cationic protein) is being tested. The problem is that all these parameters can be elevated in allergies OR parasitic infections. And because doctors in the west normally don't know very much about parasites, they say it's caused by allergy. Have you been in countries where parasitic infections are common or are exposed to animals?

Markus:

I've been tested for parasites - NONE were found. Eosinophiles have been high in the past, but I don't know if I've ever had the ECP (eosinophilic cationic protein) tested. What would that indicate? IgE just dropped to 847 30 days after the 1047 where it's been hovering for years...Inflammationi that causes flem and conjestion and respiratory issues has been raging for three years now. It's under control after 18-24 months of Doxyi, Zitro combo and Flagyli pulse once a month. Doc wants me to stop all but Zithro to see what happens...so far it's no change. Still have an air blockage that keeps me from running or climbing stairs etc...

BernieM

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