Lipopolysaccharide Induces Disseminated Endothelial Apoptosis Requiring Ceramide Generation

I'm wondering out loud.  Red, Please help .....  ~8o)

Here's the article:

Lipopolysaccharide Induces Disseminated Endothelial Apoptosis Requiring Ceramide Generation <

Now I understand that it's old.  But, I think this is a pretty solid article.  Interestingly, this ceramide stuff can be induced with D3.  I don't know if that fits in with all the reasons we take D3 or not, but I wonder.

Here's an interesting wonder

Please, anyone, tell me if this makes sense of not - science believes that part of the pathogenesis of MSi is the breaking down of the Blood Brain Barrier which in part is composed of endothelial cells, these are also cells implicated in Atherosclerosis, which we know is a CPni issue. 

Q1) Might LPSi be the mysterious thing that opens the Blood Brain Barrier in MS?

We with MS have been told for a long time that part of what science thinks about MS is that the Blood Brain Barrier got opened up and it's really not supposed to.  One of the touted "benefits" of the IFN drugs, is that they are supposed to help shore up the Blood Brain Barrier (Tysabri too).  But, if you read about Copaxone, guess what?, it's not designated as having any believed impact on the BBBi.  Meaning, if you're on Copaxone, no effort is being made to make the BBB more solid.  Now, in ABXi, I wonder - Does having a more or less open Blood Brain Barrier help the therapy?  Does it help the ABXi get into the CNSi?

Q2) Does D3 help ABX get into the CNS via Endothelial apoptosis?

This makes me wonder.  It's an interesting thought, what you think?  Ken