Lauricidin

I apologize for the wide text spread, but after many attempts at getting rid of it and

having lost this post three times already, I'm going with it as is.  Since the real value of

this post is as a reference list, I don't think the wide text field will matter much (unless

it causes a site problem).

Please read the attachment first for an understanding of why I have posted this

reference list.  I hope it will help you, but please use this information cautiously.

The following is a compilation of resources I've been gathering for the past nine months

on lauric acid/monolaurin/glycerol monolaurate/Lauricidin.

A good place to start is at this webpage, a review in an alternative medicine publication:

     http://www.liebertonline.com/doi/pdf/10.1089/act.2006.12.310?cookieSet=1<

BACTERIA

"Minimum Inhibitory Concentrations Of Herbal Essential Oils And Monolaurin For Gram-Positive and Gram-Negative Bacteria" by Preuss HG, Echard B, Enig M, Brook I, Elliott TB, April 2005.:

     http://www.p-73.com/pdf/StaphResearch2.pdf<

"Glycerol monolaurate inhibits the effects of Gram-positive select agents on eukaryotic cells" by Peterson ML and Schlievert PM, Feb 2006:

     http://pubs.acs.org/cgi-bin/abstract.cgi/bichaw/2006/45/i07/abs/bi051992u.html<

"Coconut: In Support of Good Health in the 21st Century" by Mary G. Enid, PhD. Mention of Chlamydia pneumoniae inre artery disease. "...Some of the pathogenic gram-negative bacteria with an appropriate chelator have been reported to be inactivated or killed by lauric acid and monolaurin as well as capric acid and monocaprin (See above, Bergsson et al 1997 and Thormar et al 1999)." So far I haven't been able to get those two full articles, but I'm pursuing them as well as the one listed below on Mpn.

See p. 9:  http://www.mtmayon.com/Articles/InSupportOfGoodHealth.pdf<

"Effects of monoglycerides on Mycoplasma pneumoniae growth" by RD Fletcher, AC Albers, JN Albertson, JJ Kabara, Journal of the American Oil Chemists' Society , January, 1983 DOI 10.1007/BF02540887 Pages 9-40

     http://www.springerlink.com/content/d4t4731271321670/< (by subscription)

 

"In Vitro Inactivation of Chlamydia trachomatis by Fatty Acids and Monoglycerides" by Bergsson G, Arnfinnsson J, Karlsson SM, Steingrímsson Ó, Thormar H, Antimicrob Agents Chemother. 1998 September:

     http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=105821<

"Antibacterial actions of fatty acids and monoglycerides against Helicobacter pylori" by Sun CQ, O'Connor CJ, Roberton AM, FEMS Immunol Med Microbiol. 2003 May:

     http://www.blackwell-synergy.com/doi/abs/10.1016/S0928-8244(03)00008-7<

"Susceptibility of Helicobacter pylori to bactericidal properties of medium-chain monoglycerides and free fatty acids" by Petschow BW, Batema RP, Ford LL, Antimicrob Agents Chemother. 1996 February.

     http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=163106<

"In Vitro Susceptibilities of Neisseria gonorrhoeae to Fatty Acids and Monoglycerides" by Bergsson G, Steingrímsson Ó, Thormar H, Antimicrob Agents Chemother. 1999 November:

     http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=89562<

"In Vitro and In Vivo Evaluations of the Activities of Lauric Acid Monoester Formulations against Staphylococcus aureus" by Rouse MS, Rotger M, Piper KE, Steckelberg JM, Scholz M, Andrews J, Patel R, Aug 2005:

     http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1196268<

"Equivalence of Lauric Acid and Glycerol Monolaurate as Inhibitors of Signal Transduction in Staphylococcus aureus" by Ruzin A and Novick RP, J Bacteriol. 2000 May:

     http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=111339<

"Glycerol Monolaurate Inhibits Induction of Vancomycin Resistance in Enterococcus faecalis" by Ruzin A, Novick RP, J Bacteriol. 1998 Jan:

     http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=106868<

"Glycerol Monolaurate Inhibits Virulence Factor Production in Bacillus anthracis" by Vetter SM, Schlievert PM, Antimicrob Agents Chemother. 2005 April:

     http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1068626<

"Glycerol monolaurate inhibits the production of beta-lactamase, toxic shock toxin-1, and other staphylococcal exoproteins by interfering with signal transduction" by Projan SJ, Brown-Skrobot S, Schlievert PM, Vandenesch F, Novick RP, J Bacteriol. 1994 July:

     http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=205630<

"Effect of glycerol monolaurate on bacterial growth and toxin production" by Schlievert PM, Deringer JR, Kim MH, Projan SJ, Novick RP, Antimicrob Agents Chemother. 1992 March:

     http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=190568<

"Modulation of immune cell proliferation by glycerol monolaurate" by Witcher KJ, Novick RP, Schlievert PM, Clin Diagn Lab Immunol. 1996 January:

     http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=170240<

"Influence of selected fatty acids upon plaque formation and caries in the rat" by Williams KA, Schemehorn BR, McDonald JL Jr, Stookey GK, Katz S, Arch Oral Biol. 1982;27(12):1027-31:

     http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=6963883&dopt=Citation<

VIRUSES

"Inactivation of enveloped viruses and killing of cells by fatty acids and monoglycerides" by Thormar H, Isaacs CE, Brown HR, Barshatzky MR, Pessolano T, Antimicrob Agents Chemother. 1987 January:

     http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=3032090&dopt=Abstract<

"Effect of antimicrobial factors in human milk on rhinoviruses and milk-borne cytomegalovirus in vitro" by Clarke NM, May JT, J Med Microbiol, 2000 Aug:

     http://jmm.sgmjournals.org/cgi/content/short/49/8/719<

HIV/AIDS

Website supportive of lauric acid research, focused on benefit to the HIV/AIDS community:

     http://www.lauric.org/<

"Canadian AIDS Treatment Information Exchange...Fact Sheet" on monolaurin: 

     http://www.catie.ca/pdf/supple-e/mono.pdf<

"Rays of Hope: Managing HIV/AIDS in Africa", a treatment handbook by the Jesuits and Caritas Internationalis. This is a very interesting document.

     Go to Appendix 8 on p. 130: http://www.caritas.org/Upload/R/RaysofHope.doc<

CANDIDA ALBICANS

"In Vitro Killing of Candida albicans by Fatty Acids and Monoglycerides" by Bergsson G, Arnfinnsson J, Steingrímsson Ó, Thormar H, Antimicrob Agents Chemother. 2001 Nov:

     http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=90807<

PBS ISSUES

"Peer reviewed research on coconut oil," a collection of abstracts in re to cholesterol, triglycerides, weight, insulin, etc.:

     http://www.prosperityorganicfoods.com/pdfs/abstract_coconut_oil.pdf<

AUTISM

"A Comprehensive Guide to Managing Autism", by Willis S. Langford, another very interesting document. Dr. X treatments seems to follow this school of thought in treating autism, MS, and other chronic inflammatory diseases. The introduction touches on genetically based underproduction of metallothionein, the factor he thinks underlies and generates all the other factors either directly or indirectly.

     Go to p. 83-84 for monolaurin/Lauricidin: http://www.cancertutor.com/Autism/ComprehensiveGuide.doc<

LAURICIDIN

Lauricidin technical data: http://www.lauricidin.com/tech_data.htm<

Antimicrobial properties of mother's milk, history of use as an antiseptic:

     http://www.lauricidin.com/mothers_milk.htm<

Clarification and comparison of related substances, more technical data:

     http://www.lauricidin.com/lauricidin_coconut.htm<

Dosage, side effects ("herxing" caution):

     http://www.lauricidin.com/dosing.htm<

A list of the microbes inactivated:

     http://www.lauricidin.com/micro.htm<

Frequently asked questions: http://www.lauricidin.com/faq.htm<

Kabara's credentials/resume: http://www.lauricidin.com/kabara.htm<

Kabara's research, papers, citations: http://www.lauricidin.com/references.htm< 

Cypriane~caregiver/advocate for Steve (SPMSi) - Cpni indicated by reactions; Mpn, EBVi, CMV positive; elevated heavy metals; gluten+casein sensitive - Wheldon CAPi since Aug.06; antivirals; chelation; LDNi; GF/CF diet.

Cypriane (self)~"Generally Falling Aparti" profile: chronic Cpn infection indicated by reactions and by positive testing, elevated heavy metals, PBSer, borderline diabetic, high cholesterol/triglycerides, HBP, elevated liver enzyme/calcium/iron/RBC/thyroid counts, chronic respiratory infections (before starting the supplementsi<i< recommended on the CAP), arthritis, DISH, ARD, dry eyes/dry mouth/dry skin, developing cataracts, macular granulation/retinal inflammation, carpal tunnel syndrome, fibrocystic breasts, history of fibroid tumors ending with hysterectomy, fatigue, tinnitus, significantly impaired a.m. balance/cognitive function/coordination. There's probably more, but I can't think of anything else right now...that's enough anyway.

AttachmentSize
Lauricidin_notes.doc30 KB

Comments

Jeanne and Louise...I thank

Jeanne and Louise...I thank you both for bringing my attention to the  Lauricidin debate and papers. I am about to fly overseas in the next few days and probably cannot do the papers justice. I understand that the adjunct is not a replacement for Capi protocol. I will revisit this research upon my return in a few weeks, and will hopefully be better placed in a few weeks to even consider adjuncts. Thanks for your advanced searches Jeanne..it is always best to try and stay up with the research- I appreciate all your effort and the informed debate. Suzanne
FMSi/ME dxi 2001. Started Wheldon Protocol 16 Jan. '10. Mino 100mg q 24 h. Roxyi 150mg q 12h. Cholestyramine, LDNi 0.75mg q 24 h. prophylactic migraine-topamax 75mg q 24h. migraines, headache, fatigue, sleep problems, body aches

Jeanneroz, It is a very odd

Jeanneroz, It is a very odd situation indeed and it has happened multiply times over multiple posts. 

It simply no longer feels safe to me to be locked and denied access to my current comments in posts. 

A mystery it seems to be. But it is happening none the less and it is very curious and I do not appreciate it either that it is happening.  

I actually have asked about it and could get no clear answer except that the moderator addressed was not involved.  There are a number of people who have had moderating access added for various reasons.  And thread where the edit has been turned off and then further along in the postings I can edit my post again.  I have seen it over time.  Since I tend to make lots of typos I correct spelling, sometime I notice after someone else has posted and I happen to see it often I go back and in this thread I could not go back still cannot.  That is what it is.

  • CAPi(TiniOnly): 06/07-02/09 for CFSi<
  • MethylationProtocolSupplements: Started08/08
  • Intermtnt CAP: 02/09-02/10
  • Full MethylProtocol & LDNi 02/09
  • Off CAP: 02/10, cont LDN & MethlyProtocol support
  • <

Louise, Yes, it is weird,

Louise, Yes, it is weird, but  how could one possibily have any idea that another person is trying to edit a post? I resented the acusation that I was sitting there deviously waiting/timing my deletions/editing.  

I, as I am sure others, would be interested in knowing who the moderators are since Jim isn't around much.  I  know Michele and MackIntosh are but who else?

Also as a courtesy to Cypriane's (Joyce) blog perhaps one of the moderators could delete the irrelevant comments (your's and mine) that do not pertain to this topic... if you are agreeable to that.  This is just nonsensical bantering IMOi that doesn't add value to this topic or the Forum.

JeanneRoz

JeanneRoz ~ DXi'd w/ CPNi 4/2007; 6/07 -"officially" dx'd w/CFIDSi/FM; also: HHV6, EBVi, IBSi-C, 100 Doxyi:BIDi<; 500 mg Biaxin BIDi; Tindamax Pulses, B12 shots, ERFA Dessicated Thyroid,Cortef, Iodoral 25 mg, Vit D-6,000 uni

There you go you did it

There you go you did it again but you changed your comment to the ~.  I suspect that you are editing my ability to edit my own postings.  I have seen it before and likely will again and will call it again if it happens again.

 

  • CAPi(TiniOnly): 06/07-02/09 for CFSi<
  • MethylationProtocolSupplements: Started08/08
  • Intermtnt CAP: 02/09-02/10
  • Full MethylProtocol & LDNi 02/09
  • Off CAP: 02/10, cont LDN & MethlyProtocol support
  • <

Louise, you are being

Louise, you are being acusatory of something that I have no control over.  I did nothing but change my post.... how it affects your ability and the timing, is coincidential.  I thank you if you believe I am smart enough to figure something like that out....

 Perhaps Jim, or one of the moderators should publicly address why/how this happens as you are implying that I am doing something intentional and I am  not and I do not appreciate it!

JeanneRoz

JeanneRoz ~ DXi'd w/ CPNi 4/2007; 6/07 -"officially" dx'd w/CFIDSi/FM; also: HHV6, EBVi, IBSi-C, 100 Doxyi:BIDi<; 500 mg Biaxin BIDi; Tindamax Pulses, B12 shots, ERFA Dessicated Thyroid,Cortef, Iodoral 25 mg, Vit D-6,000 uni

Guess with the holiday

Guess with the holiday festivities I didn't see the link in Raven's 12/26/09 blog I am interested that you find that interesting.   Thiis blog does seem like an informational blog post and blogs do make comebacks and thanks again for reviving it.     Sometimes I read avidly as you do and sometimes I do not, guess that is the case for many readers here.  Interesting that my ability to edit my previous comment has been instantly shut off again after a post made by you....   food for thought again....

Have a great day!

  • CAPi(TiniOnly): 06/07-02/09 for CFSi<
  • MethylationProtocolSupplements: Started08/08
  • Intermtnt CAP: 02/09-02/10
  • Full MethylProtocol & LDNi 02/09
  • Off CAP: 02/10, cont LDN & MethlyProtocol support
  • <

You, too!! 

You, too!!  Wink

JeanneRoz ~ DXi'd w/ CPNi 4/2007; 6/07 -"officially" dx'd w/CFIDSi/FM; also: HHV6, EBVi, IBSi-C, 100 Doxyi:BIDi<; 500 mg Biaxin BIDi; Tindamax Pulses, B12 shots, ERFA Dessicated Thyroid,Cortef, Iodoral 25 mg, Vit D-6,000 uni

Thanks Jeanneroz for

Thanks Jeanneroz for reviving this May 5, 2007 blog today January 21, 2010.

This is certainly the kind of info Suzanne was asking for regarding Lauricidin.

I wonder if the book that I ordered along with my oder for my Lauricidin will have and more references beyond what Joyce posted.

Did you happen to find any other discussion posted by Joyce on this topic in your archival searching?  I have been considering Lauricidin since Raven posted about it but just recently approached my doctor and got approval for it's use.

I was not aware of this blog as it was posted before I was dxi with CPni in May 2007!  

  • CAPi(TiniOnly): 06/07-02/09 for CFSi<
  • MethylationProtocolSupplements: Started08/08
  • Intermtnt CAP: 02/09-02/10
  • Full MethylProtocol & LDNi 02/09
  • Off CAP: 02/10, cont LDN & MethlyProtocol support
  • <

 Louise, re: "I was not

 Louise, re: "I was not aware of this blog as it was posted before I was dxi<i< with CPni<i< in May 2007!"  

Interesting, in that you are such an avid reader/responder here..........I don't see how you missed it, in that this link was just brought back upon 12/26/2009  under a forum topic posted by Raven re her use of “An Interesting Trio of Agents”    http://cpnhelp.org/an_interesting_trio_agent< 

Don't want to hijack this blog anymore than we have..... :)  and yes, I posted it so Suzanne and others would have the information previously discussed as there was quite a bit.  Many have been using monolaurin and/or Lauricidin for quite some time, so it's really not a new topic,  per se.

Thanks for keeping everything bookmarked and linked.

 

 

JeanneRoz ~ DXi'd w/ CPNi 4/2007; 6/07 -"officially" dx'd w/CFIDSi/FM; also: HHV6, EBVi, IBSi-C, 100 Doxyi:BIDi<; 500 mg Biaxin BIDi; Tindamax Pulses, B12 shots, ERFA Dessicated Thyroid,Cortef, Iodoral 25 mg, Vit D-6,000 uni

JeanneRoz ~ DXi'd w/ CPNi 4/2007; 6/07 -"officially" dx'd w/CFIDSi/FM; also: HHV6, EBVi, IBSi-C, 100 Doxyi:BIDi<; 500 mg Biaxin BIDi; Tindamax Pulses, B12 shots, ERFA Dessicated Thyroid,Cortef, Iodoral 25 mg, Vit D-6,000 uni

Lauricidin, Extensive

Lauricidin, Extensive Research done by member Cypriane 5/5/2007.

JeanneRoz ~ DXi'd w/ CPNi 4/2007; 6/07 -"officially" dx'd w/CFIDSi/FM; also: HHV6, EBVi, IBSi-C, 100 Doxyi:BIDi<; 500 mg Biaxin BIDi; Tindamax Pulses, B12 shots, ERFA Dessicated Thyroid,Cortef, Iodoral 25 mg, Vit D-6,000 uni

John,  Thanks for the link

John,  Thanks for the link to retrieve dead webpages.  Actually, on the subject of monolaurin/Lauricidin, the link to her comments on the onibasu thread revealed more than the link to her summary of the DAN conference. 

I have already unearthed information from the DAN conference and elsewhere on the importance of the proper zinc/copper balance, metallothionein, and a protocol (Pfeiffer) to promote it (my other subjects of interest).  This has to do with why some people develop chronic infections when others who are exposed to the same pathogens do not.  When I've collected enough resources on those subjects, I expect to post on that also.  A genetic tendency to produce too little metallothionein may prove to be the originating factor for a large percentage of people with chronic inflammatory illnesses.  

Roughly, here's the theory:  Since metallothionein is the chief agent for clearing heavy metals from the body, the under-production of it allows heavy metal accumulation.  That leads to depletion of glutathione, another important agent for clearing heavy metals (and toxins), and thus, to a greater degree of heavy metal accumulation, which results in even deeper glutathione depletion. If you haven't read-up on glutathione, please do.  It's vital in this way and many other ways for proper function.  Anyway, the presence of the heavy metals causes different metabolic processes to go awry by showing up and winning out over the proper metals, like iron, for instance.  Some researchers think this vicious cycle leads to an even broader vicious and intensifying cycle of inflammation, immune system dysfunction, gut problems, sensitivities and allergies, poor sleep, etc., but most importantly to us, it leads to vulnerability to chronic infections like Chlamydia pneumoniae.  Also, stressors contribute to making people more vulnerable to acute and chronic infections, whether they are caught up in that vicious cycle or not.  Of course, once all the other factors have developed, we know that they have to be addressed, even if the originating factor is corrected...deep-seated infections are not going to resolve that way, and neither is a lifetime's accumulation of heavy metals.

The thinking is that 100 years ago and more, this genetic trait of lessened metallothionein production in some people didn't matter much, but that now, in our modern world of greater exposure to environmental toxins and heavy metals, it matters very much.  They think these are people who end up with a variety of chronic inflammatory illnesses.  To the extent of my investigation, it appears that research and study related to CSF have traced the vicious cycle back to the problem of glutathione depletion.  The DAN group is following research that traces the cycle back beyond glutathione depletion to the genetic trait of lessened metallothionein production.  Both communities are also taking a look into another area of research and treatment that's on my "dig" list---methylation. 

The DAN group has the type of attitude about treating autism that we have about treating the illnesses addressed on cpnhelp.org.  Their kids have a very short window of opportunity for proper development.  After that window closes, incremental stage by incremental stage, the misdirected development of the CNSi in their brains becomes "hard-wired," and reversal is limited.  So their parents and physicians are very aggressive and not willing to wait decades for the standard procedures normally required for a sea change.  There are many more in that group than there are in ours, and society is more supportive of tackling kids' illnesses.  That's why we should keep an eye on DAN's attention to whichever items of cutting edge research and the treatments they embrace.  Some of it will cross-over, some of it won't.  I just wonder when they are going to figure out that some of those kids have Cpni.

You might notice that I haven't provided a single link---that was purposeful. I intend to enter a post similar in structure to this post.  I'm hoping someone else will beat me to the punch (open invitation to anyone reading...hint, hint).  I encourage anyone and everyone to dig up the pieces of this puzzle and post on it.  Make a liar or an idiot out me for blabbing about this with no references, or reveal something very meaningful to this community. 

Key words:  metallothionein, metalloproteins, glutathione, heavy metals, mercury, lead, cadmium, zinc and copper, Pfeiffer Protocol, toxins, autism, DAN, Rich Van Konyenburg, Alzheimer's, chronic fatigue, fibromyalgia, multiple sclerosis, etc.

Happy googling and thanks for taking the time to read this long blog.

Joyce~caregiver-advocate in Dallas for Steve J (SPMSi) / Cpn indicated by reactions; Mpn, EBVi, CMV positive; elevated heavy metals; gluten+casein sensitive / Wheldon CAPi since Aug. '06 - doxycycline+azithromycin+flagyl pulses; antivirals; chelation; LDNi.

Joyce~caregiver-advocate in Dallas for Steve J (SPMSi).  CAPi since August 06, Cpni, Mpn, B. burgdorferi, systemic candidiasis, EBVi, CMV & other herpes family viral infectionsi, elevated heavy metals, gluten+casein sensitivity. 

Hi John,  See the "Dosage

Hi John,  See the "Dosage Information" and the "Lauricidin vs. Coconut Oil" pages on www.lauricidin.com< for information on this.  You can also find discussion of this by Dr. J. McCandless in this thread< in at least a couple of places (read bottom to top).  Steve and I have worked up to 3g doses 3 times a day.  That's 9g per day.  A jar lasts one person about 28 days.  You can do the rest of the googling and math for a cost differential.  To the best of my knowledge, the only sources for Lauricidin are Med-Chem Labs and Canada Drug Superstore.

By the way, I hope you had a chance to read the link I provided Sunday night to Dr. McCandless' summary of the DAN conference, because the page expired that same evening.  If you did and happened to save it in any way, I'd appreciate your help recovering it.  There were other topics on it that interested me greatly.

Joyce~caregiver-advocate in Dallas for Steve J (SPMSi) / Cpni indicated by reactions; Mpn, EBVi, CMV positive; elevated heavy metals; gluten+casein sensitive / Wheldon CAPi since Aug. '06 - doxycycline+azithromycin+flagyl pulses; antivirals; chelation; LDNi.

Joyce~caregiver-advocate in Dallas for Steve J (SPMSi).  CAPi since August 06, Cpni, Mpn, B. burgdorferi, systemic candidiasis, EBVi, CMV & other herpes family viral infectionsi, elevated heavy metals, gluten+casein sensitivity. 

Hi Joyce      Thanks

Hi Joyce     

Thanks for getting back to me on this.  I did not find any other sources for Lauricidin but there are a few for monolaurin, which brings me to my question about what differentiates Lauricidin from monolaurin.  The answer from what I've read is that it is more pure and it manufactured without add-ins or fillers.  Thus, one wouldn't get the inosine or calcium phophate some manufacturers of monolaurin might include in the manufacturing process for monolaurin. 

I was not able to find the post from Dr. J. McCandless in what you posted.  I don't believe I saw it earlier before it expired.  If you know the web address for it, it might be possible to get a coffee from www.archive.org< ...maybe.

all my best

John

RRMSi/EDSSi was 4.5, now 4.??? on Wheldon Protocol (naci, doxycycline, azithromycin, metronidazolei) since 04/12/2006

best, John

RRMSi/EDSSi was 4.5, 5, 6, 6.5, 6.9999, 6.5 on Wheldon/Stratton Protocol beginning 04/12/2006
naci 4x600 mg/day
doxycycline 2x100mg/day
azithromycin 3x250mg/day MWF
metronidazolei 3x400mg/day then 3x500mg/day

Joyce         Thank

Joyce        

Thank you for posting this information, it's quite informative.  However, I have one or two questions.

First, why do you say that Lauricidin is different from other types of monolaurin, such as those in capsule form.  What distinguishes it as different?

Second, I did a search for Lauricidin from a couple of vitamin sources and it didn't turn up.  Is the only source for it the source you list in your original post? 

all my best

John

RRMSi/EDSSi was 4.5, now 4.??? on Wheldon Protocol (naci, doxycycline, azithromycin, metronidazolei) since 04/12/2006

best, John

RRMSi/EDSSi was 4.5, 5, 6, 6.5, 6.9999, 6.5 on Wheldon/Stratton Protocol beginning 04/12/2006
naci 4x600 mg/day
doxycycline 2x100mg/day
azithromycin 3x250mg/day MWF
metronidazolei 3x400mg/day then 3x500mg/day

Thanks everyone for your

Thanks everyone for your comments.  Jim's concern about not getting confused about Lauricidin and a CAPi was also one of my concerns and one of the main reasons I have taken so long to discuss it.  I was afraid that a newcomer might see it and think "great, I'll just do this instead."  For those who didn't take the time to read the attachment, I likened an attempt to treat chronic infections in an inflammatory illness with Lauricidin as a stand-alone treatment to showing up at a fire with a water pistol.  I believe it has potential, but the potentialities I hope will be explored do not include using it as a stand-alone treatment.  Again, I ask anyone who has an interest in this thread to please read the attachment.  If you don't, you'll miss the point entirely.  As the purpose of this post is mainly to provide a reference list, I didn't want to stick a lot of text at the front of it.  That's why I made the attachment.  Now I wonder if I made the best choice.

I refer to our CAP prescribing physician as Dr. X.  Lauricidin is on his list of recommended supplementsi, and he is the one who recommended that I use it after I expressed my concern of reinfecting Steve with Cpni and a few of my own health problems.  He's also the doc who advised the peri-pulse abstinence to reduce the killing effect of flagyl.  That's one doctor----here's another who mentions its use in her treatment of autistic kids (see 2nd & 4th page)<.  She follows the DAN (Defeat Autism Now) line of treatments.  DAN is a progressive/aggressive group that is forging ahead and grappling with that problematic illness much like we are doing here.  So what does the autism community have to do with us?  Just like the HIV/AIDS community and our community, the autistic are all riddled with chronic infections of various sorts. 

Anyone interested to satisfy themselves that there are actually other people out there using Lauricidin/monolaurin and to what benefit need only do a little googling on it in connection with HIV/AIDS or autism.  I did run across one comment by a woman with CFSi who said it did nothing to change her condition.  I suspect that was one of those water pistol scenarios and/or that it involved using the weaker capsule form.

(Edited May 15, 2007 to revise link to McCandless document)

Joyce~caregiver-advocate in Dallas for Steve J (SPMSi) / Cpn indicated by reactions; Mpn, EBVi, CMV positive; elevated heavy metals; gluten+casein sensitive / Wheldon CAP since Aug. '06 - doxycycline+azithromycin+flagyl pulses; antivirals; chelation; LDNi.

Joyce~caregiver-advocate in Dallas for Steve J (SPMSi).  CAPi since August 06, Cpni, Mpn, B. burgdorferi, systemic candidiasis, EBVi, CMV & other herpes family viral infectionsi, elevated heavy metals, gluten+casein sensitivity. 

The liver filtering I was

The liver filtering I was referring to is done on the contents of the hepatic portal vein, which goes from the gut to the liver, carrying all the newly absorbed food, so that the liver can transform it and detoxify it before it gets to the rest of the body. Compounds don't have to pass through that filtering, in order to be effective against organisms living in the gut. They do, however, need to pass through it to get to the rest of the body.

I agree that one has to be

I agree that one has to be careful jumping from in vitro studies to in vivo effects. I would note that a lot of fatty acid substances get by the liver just fine: caprylic (fatty) acid, undecyclinic acid, both I've used for yeast problems and get definitive affect in my gut. As a number of folks have multiple pathogens to deal with, these kinds of things are at least worth a look, and maybe a try by those of us doing our own personal chemistry experiments! Just have to not confuse it with the CAP itself. 

CAP for Chlamydia pneumonia since 11/04. 25yrs CFSi & FMSi- Currently: 150mg INHi, 200 Doxycycline, 500mg MWF Azithromycin, 1000mg Flagyli daily (Continuous protocol)

 

CAPi for Cpni 11/04. Dxi: 25+yrs CFSi & FMSi. Currently: 250 aithromycin mwf, doxycycline 100mg BIDi, restarted Tinii pulses; Vit D2000 units, T4 & T3, 6mg Iodoral

Joyce,many thanks for your

Joyce,

many thanks for your hard work. My experience is that when I first got overt symptoms of a respiratory tract infection I tried any and every natural thing out there. Hardly anything worked.

One of the few things that did seem to help was Lauricidin. It didn't give me any die-off symptoms but what it did seem to do was hold the CPni in check.

Its certainly something I will try again in the future.

DW's comments about membrane properties & the host/pathogen realtionship are very interesting to say the least.

garcia.

____________________________________________________________

CFSi since 2001. Infected CPn Jan 2006. Dxi'd March 2007. Started CAPi March 2007. Currently taking: Azith 250mg MWF, 100mg doxyi every other day.

Hunter: Don't think - experiment

Joyce, Thank you for the

Joyce, Thank you for the info. Very interesting read. Best, Chris CAPi since 11/06 for CFSi. Cpni, Myco P, CMV, HHV-6 infectionsi. Zithi 500 mg Tues, Thurs/Doxyi 200mg MWF. All supplementsi.
CAPi since 11/06 for Cpni, Lyme, Bartonella, Babesia, Myco P, CMV, HHV-6 infectionsi. Rifampin 600mg daily, Zithromax 500mg daily. NACi 2250mg daily. All other supplementsi. Now Bicillin LA 2.4 mil injection weekly.

Joyce, I didn't see much to

Joyce, I didn't see much to comment on, as regards your personal experiences. That it has made you and your husband feel worse isn't much of a recommendation, by itself. The ear infection being relieved is more promising, but if it happened to me I'd still wonder whether it was just chance.

The paper DW mentions is indeed interesting; it talks about effects present at very small concentrations -- micromolar or less. But could even those concentrations get past the liver? (The liver normally sits astride blood coming from the gut, and rearranges the incoming lipids to its own liking, stripping fatty acids from glycerol and/or adding them back.)

Joyce, Pretty cool info. As

Joyce,

Pretty cool info. As one who enjoys poisoning my husband with strange "natural" concoctions (artemesinin,samento), monolaurin seems a perfect candidate.

Thanks for sharing all this info with us. And certainly not expensive at all!

Lexy

--------------- "Chance favors the prepared mind." --Louis Pasteur Husband treating MSi with CAPi

I think this is

I think this is fascinating, Joyce; thank you for all your hard work. It's a subject about which I know little. Monolaurin is a surfactant, and thus likely to have an effect on membranes. You have cited a very interesting paper: [Witcher KJ, Novick RP, Schlievert PM. Modulation of immunei cell proliferation by glycerol monolaurate. Clin Diagn Lab Immunol. 1996 Jan;3(1):10-3.] Even minor alterations of membrane properties can have a profound effect on the host / pathogen relationship, particularly if the latter is intracellulari. There may be parallels with N-acetyl cysteine, which has membrane-altering potentiality which is apparently slight but enough to abort or ameliorate infection with influenza A virus. Certainly your own experience with Lauricidin is food for thought.

D W - [Myalgia and hypertension">i (typically 155/95.) Began (2003) taking doxycycline and macrolide and later adding metronidazolei. Now on intermittent treatment. Normotensive.

D W - [Myalgia and hypertension">i (typically 155/95.) Began (2003) taking doxycycline and macrolide and later adding metronidazolei. No medication now. Morning BP typically 110/75]

Thank you both for reading

Thank you both for reading this, as I have spent considerable time and effort to bring you this information.  Norman, thanks for the chemistry lesson.  Now, please read the attachment for an understanding of why I posted this information and for what I think is its potential usefulness.  Janice, thank you for sharing about a source of monolaurin capsules.  Lauricidin is not exactly the same as the capsule version.  There is a reason why it is specifically recommended as opposed to "generic" monolaurin.  It is much more potent (and cheaper).  As Dr. Kabara (PhD) was quoted in the link on autism, “Lauricidin® is the only monolaurin clinically tested. The dosage is somewhat critical..."   

And the answer in NO, I'm not selling this stuff.

Joyce~caregiver-advocate in Dallas for Steve J (SPMSi) / Cpni indicated by reactions; Mpn, EBVi, CMV positive; elevated heavy metals; gluten+casein sensitive / Wheldon CAP since Aug. '06 - doxycycline+azithromycin+flagyli pulses; antivirals; chelation; LDNi.

Joyce~caregiver-advocate in Dallas for Steve J (SPMSi).  CAPi since August 06, Cpni, Mpn, B. burgdorferi, systemic candidiasis, EBVi, CMV & other herpes family viral infectionsi, elevated heavy metals, gluten+casein sensitivity. 

Hi Joyce   Thanks for

Hi Joyce

   Thanks for this. I read it last night and found it very interesting.

Diana

Ecological Gardens makes a

Ecological Gardens makes a good brand of Monolaurin. Combined Antibiotic Protocol for chlamydia pneumoniae in fibromyalgiai, interstitial cystitisi, sinus: minocycline, Zithromycin, Flagyli. infrared, D3

minocycline, azithromycine, metronidazolei 2007-2009, chelation for lead poisoning, muscle pain, insomnia, interstitial cystitisi (almost well), sinus, dry eyes, stiff neck, veins, hypothyroid, TMJ, hip joints (no longer hurt)

If you're going to be

If you're going to be reading this sort of stuff, you should learn a little chemistry -- enough, at least, to be able to interpret what they're saying about concentrations. I only looked at a couple of those papers, but those were talking about rather high concentrations of those fatty acid compounds (10 millimolar or thereabouts) being needed for a bacteriocidal effect. One of the papers< states "The bacteria were therefore about 2.5 times more sensitive to the lipid than the host cells", which almost certainly means it is useless as something to root out deep infection. The use they're suggesting it for is as a component of condom lubricants and the like, to prevent initial infection with Chlamydia trachomatis.

Anyway, today's chemistry lesson is what molarity means<. It assumes you already know what a mole is; if you don't know, this< is a decent explanation.

In any case, people in the drug industry commonly turn up their noses< at compounds active at micromolar levels, as not being potent enough. Millimolar is a thousand times worse. These fatty acids have an advantage over drug-company type compounds, in that they are foods and thus can be eaten in large quantities -- capric acid, the fatty acid found to be most effective in the above-linked paper, is named for its presence in goats' milk -- but to get a millimolar concentration of this particular capric acid compound, in your blood or tissues, is most unlikely to be something you can accomplish by eating goat cheese.