Interesting Perspective Article on Vit D3 and Septicemia
Here's an interesting perspective article on the potential for Vit D3 to reduce the risk of septicemia. It's well worth a read since it discusses the anti-endotoxini effects of Vit D3, an area we have discussed on the site before, but not in much detail:
"A review of the epidemiological features
associated with septicemia and UVB doses in the United States
indicates that vitamin D variations may explain much of the epidemiology
of septicemia in the United States. The hypothesis examined
here is that vitamin D, through induction by 1,25-dihydroxyvitamin
D [(1,25(OH)2D)] of human cathelicidin, LL-37, reduces the
risk of septicemia. LL-37 is the cleaved antimicrobial
37-residue, COOH-terminal peptide of hCAP18 (human cationic antimicrobial
protein with a molecular mass of 18 kD).15 1,25(OH)2D is directly
correlated with serum 25(OH)D levels,16 and 25(OH)D levels are
directly related to vitamin D from both oral intake and photoproduction
caused by UVB irradiance.
Mookherjee et al.,17 reviewed cathelicidin’s antisepticemia properties.
They ascribed some benefit to the anti-infective properties
of cathelicidins. Although vitamin D provides immunei protection
against Mycobacterium tuberculosis,18 the mechanisms of action have
only recently been uncovered.19 Vitamin D also offers protection
against respiratory diseasesi caused by viral infectionsi.20,21 They
attributed the primary effect in reducing the risk of septicemia to
other effects of cathelicidins, including lower endotoxin and proinflammatory
cytokinei tumor necrosisi factor α levels in plasma, as well
as reduced endotoxic shock and death.22"
Also, a summary of the Mookherjee article sited above can be found here:Cathelicidins and functional analogues as antisepsis molecules.