Interesting Perspective Article on Vit D3 and Septicemia

Here's an interesting perspective article on the potential for Vit D3 to reduce the risk of septicemia.   It's well worth a read since it discusses the anti-endotoxini effects of Vit D3, an area we have discussed on the site before, but not in much detail:

Perspective: Solar ultraviolet-B irradiance and vitamin D may reduce the risk of septicemia

"A review of the epidemiological features
associated with septicemia and UVB doses in the United States
indicates that vitamin D variations may explain much of the epidemiology
of septicemia in the United States. The hypothesis examined
here is that vitamin D, through induction by 1,25-dihydroxyvitamin
D [(1,25(OH)2D)] of human cathelicidin, LL-37, reduces the
risk of septicemia. LL-37 is the cleaved antimicrobial
37-residue, COOH-terminal peptide of hCAP18 (human cationic antimicrobial
protein with a molecular mass of 18 kD).15 1,25(OH)2D is directly
correlated with serum 25(OH)D levels,16 and 25(OH)D levels are
directly related to vitamin D from both oral intake and photoproduction
caused by UVB irradiance.


Mookherjee et al.,17 reviewed cathelicidin’s antisepticemia properties.
They ascribed some benefit to the anti-infective properties
of cathelicidins. Although vitamin D provides immunei protection
against Mycobacterium tuberculosis,18 the mechanisms of action have
only recently been uncovered.19 Vitamin D also offers protection
against respiratory diseasesi caused by viral infectionsi.20,21 They
attributed the primary effect in reducing the risk of septicemia to
other effects of cathelicidins, including lower endotoxin and proinflammatory
cytokinei tumor necrosisi factor α levels in plasma, as well
as reduced endotoxic shock and death.22"

 

Also, a summary of the Mookherjee article sited above can be found here:

Cathelicidins and functional analogues as antisepsis molecules.


 

 

Red- this article, although focused on septicemia, actually has a good review of the impact of Vit D on a number of health conditions. Really worth downloading and reading. The anti-endotoxini aspects are also of note. Thanks.

 

CAPi for Cpni 11/04. Dxi: 25+yrs CFSi & FMSi. Currently: 250 aithromycin mwf, doxycycline 100mg BIDi, restarted Tinii pulses; Vit D2000 units, T4 & T3, 6mg Iodoral

Thought the 2nd link Red posted above was worth pasting directly. Very interesting stuff.

Cathelicidins and functional analogues as antisepsis molecules

The emergence of antibiotic-resistant bacteria together with the limited success of sepsis therapeutics has lead to an urgent need for the development of alternative strategies for the treatment of systemic inflammatory response syndrome and related disorders.

Immunomodulatory compounds that do not target the pathogen directly (therefore limiting the development of pathogen resistance), and target multiple inflammatory mediators, are attractive candidates as novel therapeutics.

Cationic host defence peptides such as cathelicidins have been demonstrated to be selectively immunomodulatory in that they can confer anti-infective immunity and modulate the inflammatory cascade through multiple points of intervention. The human cathelicidin LL-37, for example, has modest direct antimicrobial activity under physiological conditions, but has been demonstrated to have potent antiendotoxin activity in animal models, as well as the ability to resolve certain bacterial infectionsi.

A novel synthetic immunomodulatory peptide, IDR-1, built on this same theme has no direct antimicrobial activity, but is effective in restricting many types of infection, while limiting pro-inflammatory responses. The ability of these peptides to selectively suppress harmful pro-inflammatory responses, while maintaining beneficial infection-fighting components of host innate defences makes them a good model for antisepsis therapies that merit further investigation.

Hunter: Don't think - experiment

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