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Started CAPii April 2005, right leg motor function now worse
INH, Rifampicin, Amoxicillin
Submitted by Alexandra Gibbs on Wed, 2006-01-18 12:11. I've been on isoniazid (INHi), rifampicin and amoxicillini for about 2 weeks now and my walking has over the last 2 days felt very malcoordinated and lacking strength. I hardly dare use the gym. My left foot burn is also quite bad and has been since the last dose of flagyli which I had just before starting the new protocol of INH, rifampicin and amoxicillin. Has anyone else experienced a deterioration in neurological symptoms when starting the INH/rifampicin pills?
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Alex, I have no experience
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 Yes Alex i
Yes Alex i have experienced a deterioration in neurological symptoms when starting the INHi/rifampicin pills..
started abxi on 06-06-2004
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On CAPi's protocol for Cpni in PPMSi since June 2004 - Currently: Doxyi 100mgx2/day - Roxyi 150mgx2/day - Flagyli 500mgx3/day (Continuous protocol since sept.2006)
Oh dear and oh good at the
Oh dear and oh good at the same time!!! It's good to hear that others have suffered worsening neurological deficits with INHi and rifampicin and also bad to hear that since I've got another 5 and a half months on it. At least. Oh well, onwards through the fog...
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Started CAPi April 2005, right leg motor function now worse
Alex, check my blog
Alex, check my blog entry from late Nov. '05. You will see that I suffered terribly as well. Rifampicin and I do not get along well-[lol!] But, the improvements with the long term therapy are worth it!
Hang in there, you're among birds of a feather. :)
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Wheldon Protocol for rrmsi since Oct '05. Added LDN 4.5mg qhs Oct '07. All supp's. Positive IGGi's for Lyme Disease,Babesia, & Erlichiosis Sept. 2008. Currently: Mepron 750mg bid and Azithromycin 250mg qdi for Babesia.
You all know that I have to
You all know that I have to get my little thing in here, too- I have taken Rifampin from the beginning Sept. 2004- 300 mg, 2xd, Doxyi also, then added Zithi last summer and 17 pulses of Flagyli. Since I was so foggy and had no sites of commiseration, I didn't know it made for worse coordination. Couldn't walk anyway but a few feet so I didn't NEED to be coordinated!
Rica
Ignorance is voluntary bad luck. Lauritz S. A true Viking
If you come to a fork in the road, take it. Yogi Berra
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3/9 Symptoms returning. Began 5 abxi protocol 5/9 Rifampin 600, Amoxicillini 1000, Doxyi 200, MWF Azith 250, flagyli 1000. Caffeine pills with AM abxi Began Sept 04 PPMSi EDSSi 6.7 Now good days EDSS 1
INHi and rifampicin both
INHi and rifampicin both appear to be stronger antichlamydial agents with greater tissue penetration than the other agents used. I recall our Dr. A in the expert interview speaking of patients "getting hammered" by rifampicin. It also has the best neuroi penetration, so not surprising you are having more neuro symptoms-- the question being how much is too much. I just started INH and even a half tab gave me significant inflammatory pain... everywhere. This after being on the full protocol for a year. And I'm still taking Doxyi and Azith, both of which have some immunomodulatory effect.
So, I think you are taking the biggest hitters possible, which means that they may be hitting you too hard. Dr. Powell suggests backing off the dosages for a few days if you are getting hit too hard (see Cera's blogs on this).
So now you have the full range of advice: from Sarah's saying she wouldn't take the INH herself, to kitkat2's 'forge on,' to my caution about hitting it too hard! At least you won't lack encouragement from somebody herer, whatever path you decide!
On Wheldon/Stratton protocol for Cpni in CFSi/FMSi since December 2004.
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CAPi for Cpni 11/04. Dxi: 25yrs CFSi & FMSi. Currently: 250 aithromycin mwf, doxycycline 100mg BIDi, Tinii 1000mg/day pulses; Vit D2000 units, T4 & T3, 12mg Iodoral
...and IÂ like to
...and I like to occasionally encourage anyone out there who might have *no* exacerbation reactions to abxi, as I've never had any short-term reaction of any kind to any of the abxi I've relied on during my recovery over the last 14 months of combo abx use. I was deeply anxious about this "herx deficiency" before my disabling CFSi started to recede, and I thought I might never improve on treatment, but I am now around 95% improved. That's just one persons experience - not a data set, but a data point. And while my recovery during treatment could be coincidental, I dont consider that very likely.
Recently I have used 300 mg /day isoniazid for 10 days - as expected, I have no reaction to it.
Eric- You aren't alone in
Eric- You aren't alone in this. David reports at least one patient with no reactions to meds other than improvement for over a year of treatment. Go figure! We are all envious of your "herx deficiency!"
On Wheldon/Stratton protocol for Cpni in CFSi/FMSi since December 2004.
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CAPi for Cpni 11/04. Dxi: 25yrs CFSi & FMSi. Currently: 250 aithromycin mwf, doxycycline 100mg BIDi, Tinii 1000mg/day pulses; Vit D2000 units, T4 & T3, 12mg Iodoral
OOOOOOH! I just read the
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Started CAPi April 2005, right leg motor function now worse
Alex, as far as I am aware,
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oooh thank you - sometimes
oooh thank you - sometimes I get a bit confused!
I'm glad not to take yet another pill!!
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Started CAPi April 2005, right leg motor function now worse