Influence of CPn infection on aortic stiffness in healthy young men

Influence of Chlamydia pneumoniae infection on aortic stiffness in healthy young men.

Tasaki N, Nakajima M, Yamamoto H, Imazu M, Okimoto T, Otsuka M, Shimizu Y, Kohno N.

Department of Molecular and Internal Medicine, Graduate School of Biomedical Sciences, Hiroshima University, 1-2-3 Kasumi Minami-ku, Hiroshima 734-8551, Japan. ntasaki@hiroshima-u.ac.jp

Though Chlamydia pneumoniae infection has been implicated in the pathogenesis of atherosclerosis, its role in early atherogenesis has not been well elucidated. To clarify whether C. pneumoniae infection was related to early atherogenesis, we evaluated the association between serological detection of C. pneumoniae antibodies and aortic stiffness in 102 healthy young male volunteers (mean age 27.1+/-0.4 years). Serum C. pneumoniae IgA and IgG antibodies were measured by the enzyme-linked immunosorbent assay (ELISA). Aortic stiffness was estimated using the brachial-ankle pulse wave velocity (PWV). No significant differences were observed between IgA seropositive and seronegative groups with regard to conventional cardiovascular risk factors. However, the mean PWV value was significantly higher in the IgA seropositive group than the seronegative group. Analyses of subgroups according to C-reactive protein (CRP) level showed that those subjects with IgA seropositivity and a high CRP level (>0.17 mg/l) had the highest PWV values. Multivariate logistic regression analysis revealed that a combination of C. pneumoniae IgA seropositivity and a high CRP level was an independent predictor of high values of PWV. These results suggest that C. pneumoniae infection might contribute to early atherogenesis, which might be associated with chronic inflammation.

Publication Types:
Evaluation Studies

PMID: 14642413 [PubMed - indexed for MEDLINE]

Comments

Fo several years before I started the antibiotic protocol, I could see my abdominal artery pulsing through the skin.

minocycline, azithromycine, metronidazolei 2007-2009, chelation for lead poisoning, muscle pain, insomnia, interstitial cystitisi (almost well), sinus, dry eyes, stiff neck, veins, hypothyroid, TMJ, hip joints (no longer hurt)

Yes Janice, and I could hear David's heart beating away at night in a hard and somewhat erratic way.  I didn't need to hold his neck to test his pulse, just listen.  It was way to fast for someone fast asleep.  About six years ago he had an operation which required a line in.  The blood clotted around it straight away.  When he eventually took it out himself, because there was no nurse available, a single, thick dark brown glob of blood came out.   Two years ago he started the abxi for CPni: he did register as having a slightly higher load than me.  Very quickly the heart became softer and regular, pulse dropped, blood pressure dropped.  Gradually, after that, the hardness in the vein softened and now it is as pliable as any other.  If he cuts himself, the blood is bright red and free flowing.  If I wake in the night, I don't worry about him......Sarah
Completed Stratton/Wheldon regime for aggressive secondary progressive MSi in June 2007, after four years, three of which intermittent.   Still improving bit by bit and no relapses since finishing treatment.

Recently I noticed that I now bleed when I cut myself. Before I didn't. One time years ago I went in for blood work, and the nurse never got any blood out. Other times my blood would clot before they got the tube filled.

The last blood test since starting antibioticsi, the report came back that my blood was turbid.

minocycline, azithromycine, metronidazolei 2007-2009, chelation for lead poisoning, muscle pain, insomnia, interstitial cystitisi (almost well), sinus, dry eyes, stiff neck, veins, hypothyroid, TMJ, hip joints (no longer hurt)

Good find, Marie! Especially for us CFSer's. One of the main markers for CFS is 'infiltration cardiomyopathy', where the arteries/heart are too stiff to fill properly. Further, we know about the association between C.Pn. and abdominal aortic aneurism. And blood pressure. And transplant failures. And cardiomyopathies of all sorts.

What a picture is filling in!

 

Ron

On Stratton protocol for CFS starting 01/06 (NE Ohio, USA).

Ron

On CAPi for CFSi starting 01/06 (NE Ohio, USA)

Began rifampin trial 1/14/09

Currently: on intermittent

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