Recent studies suggest the importance of Vitamin D3 in immunity, and indeed, vitamin D3 deficiency has been linked to multiple sclerosis, rheumatoid arthritis, hypertensioni, heart diseasei, depression, diabetes, chronic pain, osteoporosis and many other illnesses:
Vitamin D3 has also been shown to play an important role in host defense against pathogens by promoting the production of the human antimicrobial peptides, cathelicidins (LL-37). These cathelicidins have been found to have broad spectrum antimicrobial activity, showing activity against the following microbes, among others:
- C. albicans
- C. trachomatis
- Bacillus species (Several members)
- B. burgdorferi (Lyme Disease)
- E. coli
- H. pylori
- M. tuberculosis
- Cytomegalovirus
- M. furfur & Dermatophyes (Seborrheic dermatitis and tinea infections)
- P. aeruginosa, S. aureus, S. epidermidis, Herpes simplex virus type 1, and Adenovirus
- Streptococcus species (Group A)
While cathelicidins (LL-37) have been shown to have little or no direct effect against C. pnuemoniae, Vitamin D3 has been shown to disrupt the mechanism that the intracellulari forms of C. pneumoniae use to prevent normal celluar apoptosisi, and it is believed that Vitamin D3 is active against the intracellular forms of C. pneumoniae through this mechanism. The resulting die-off effects from Vitamin D3 can be quite large, and symptoms of secondary pophryia can also be dramatically increased. Vitamin D3 levels should therefore be increased very slowly when treating a C. pneumoniae infection!
There is much controversy surrounding the optimum levels of Vitamin D3 supplementation, and while the currently established safe upper limit for Vitamin D3 is listed as 2000 IU per day for adults and children over the age of 12 months, many experts are now questioning this level and calling for the upper limit to be increased to levels as high as 10,000 IU:
Another method to obtain adequate levels of Vitamin D3 is through approximately 15-20 minutes of near full body exposure to the sun at peak sun times during the summer. In this amount of time at peak sun during peak sun months, our skin produces between 10,000 and 20,000 IU of Vitamin D3. No additional Vitamin D3 is produced in longer exposure, and peak levels are produced prior to any sunburn pinkness.
However, the time of the day, the season of the year, and the latitude you live in alter the the amount of UVB rays (the Vitamin D3 producing rays) you are exposed to as the following study from India points out:
UVA and UVB in sunlight, Optimal Utilization of UV rays in Sunlight for phototherapy
Even at high noon, UVB exposure varies so much by season, that you may have trouble getting enough Vitamin D3 in the near winter and winter months depending on your latitude as the diagrams of UVB exposure in various US cities by month in the following article show:
vitamin D
UV exposure in the USAVitamin D3 supplementation may be contraindicated in certain diseasesi including sarcoidosis, so please talk to your doctor before taking high level supplements of Vitamin D3.
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On Combined Antibiotic Protocol for Cpnii in Rosaceaii 01/06 - 07/07, On Vit D3 + NACi since 07/07 and daily FIRii Sauna since 08/07
Red, thanks for making this
Red, thanks for making this post and pulling all this information together.
Louise
CFSi/ME.CPnPositive.BbPositive.WheldonCAPbegan6/24/07. NowNAC,Doxyi, Roxi, Full TiniPulses. Cholestyramine at BedtimeforPhorphoria&liposacarideEndotoxinDie-OffExperiences.
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Louise-CFSi, CPN+/Bb+ Wheldon CAPi 6/07, Cholestyramine1-2pksHSforPorphoria& Endotoxinsi, Doxy100daily,Roxi300BID,Tini500mgBIDpulses,VitD3-4000IU,MagnascentIodine,{S.O.D.3/QD[KAL Brand],+Pyruvate3.75G+SAM-eForEnergy}
Thanks for this Red. In my
Thanks for this Red. In my Canadian news there was a small segment of a study of women with breast cancer. Many of them were very deficient in vit. D. some of these breast cancer survivors are popping the Vit. D (I hope it is the D3)
CFIDSi/ME 26yrs, FMSi,
IBSi, EBVi, CMV, Cpni, chronic insomnia, Lymes, HME, Natural HRT peri-M, NACi 2.5 gm, 6-07 Doxy 200 mg day pm, Azith 375 mg M/W/Fday, Pulse#9 750mg 5.5 day, 4-25-8___________________________________________________________
CFIDSi/ME 32 yrs, FMSi,
IBSi, EBVi, CMV, Cpni, chronic insomnia, Lymes, HME, Natural HRT peri-M, NACi 2.5 gm, 6-07 Doxy 200 mg day pm, Azith 375 mg M/W/Fday, Pulse#13 1240 mg X 3 days 8-7-08Ok Red, we've been
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--------------- "Chance favors the prepared mind." --Louis Pasteur Husband treating MSi with CAPi
Another great video on
Another great video on Vitamin D3. Includes a very good discussion on Vit D pathways...
Vitamin D: It's Not Just For Bones Anymore, presented by David Feldman, MD, professor of medicine at Stanford
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On Combined Antibiotic Protocol for Cpni in Rosaceai 01/06 - 07/07, On Vit D3 + NACi since 07/07 and daily FIRi Sauna since 08/07
Red - I really appreciate
Red - I really appreciate your posts. This one (as usual) is excellent !
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Daisy - Husband on CAPi 5/07. "When Going Thru Hell, Just Keep Going", Winston Churchill
A couple of other important
A couple of other important and apparently previously unrecognized functions of of the cathelicidins (LL-37) upregulated by Vitamin D3:
The human host defence peptide LL-37 prevents bacterial biofilm formation.
Neutrophil secondary necrosis is induced by LL-37 derived from cathelicidin.
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On Combined Antibiotic Protocol for Cpni in Rosaceai 01/06 - 07/07, On Vit D3 + NACi since 07/07 and daily FIRi Sauna since 08/07
Some other important areas
Some other important areas of discussion related to Vitamin D3 can also be found at the following threads:
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On Combined Antibiotic Protocol for Cpni in Rosaceai 01/06 - 07/07, On Vit D3 + NACi since 07/07 and daily FIRi Sauna since 08/07
I'm sure it's no
I'm sure it's no coincidence that up here in the Northwest where we see the least amount of sun we have the highest rate of MSi. And the greedy suncreen manufacturers' campaign to scare everyone into wearing suncreen 24/7 is only making things worse. I've seen ads telling people to wear sunscreen just to drive to work because that little bit of sun hitting your left arm through the tinted car window is still "dangerous"! So now people I know even in sunny Southern California are probably not getting enough D because they've become so afraid of the sun they cover up or slather on the sunscreen just to get the newspaper off the front porch. The way the advertisers talk about the sun you'd think sunlight was some relatively recent toxic pollutant humans are not accustomed to and even a moment's exposure is harmful. Get real. The sun has been shining on Earth for billions of years. We are not allergic to it. We need it to live like all life does. Don't fear it. Just don't get stupid with it and you're fine.
Although, since so many here have to avoid the sun because of doxyi side effects it's especially important to take D supplementsi.
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GFAi - asthmai, sinusitis/rhinitis, tendonitis, low back pain, hypothyroid. Started azi 1000mg/week Jan 9, '08. Increased azi to 250mg/day, added 20mg Benicar daily Mar 13, '08. First Flagyli pulse started June 30, '08. Added Doxyi 200mg/day Aug 16.
Some more threads pointing
Some more threads pointing to important studies on Vitamin D3 related topics:
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On Combined Antibiotic Protocol for Cpni in Rosaceai 01/06 - 07/07, On Vit D3 + NACi since 07/07 and daily FIRi Sauna since 08/07
And a few more threads
And a few more threads pointing to important studies on Vitamin D3 related topics:
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On Combined Antibiotic Protocol for Cpni in Rosaceai 01/06 - 07/07, On Vit D3 + NACi since 07/07 and daily FIRi Sauna since 08/07
Wow! Red this is a
Wow! Red this is a terrific! You have been busy and we all benefit so much from it! Thank you. I know it will take me a bit to read them all right now but I am quite excited to dig in.
Many thanks!
Corinna
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Corinna | GFAi. Wheldon Protocol: 4 – 8/08. Stepping back to recoup. Prednisone, Tramadol, Probiotics.
Vitamin D Deficiency -
Vitamin D Deficiency - 'A Disease of Neglect' and Its Unrecognized Toll
ImmuneSupport.com
07-25-2008
The above link has some key points from Dr M Holick's fascinating video presentation - “The Vitamin D Pandemic and Its Health Consequences” such as:
Can you make any vitamin D in winter?
Little or none, if you live above the 35th latitude north or south of the equator. That's only slightly north of such 'southern' cities as Atlanta, Georgia, which is at 33 north. In a study, subjects exposed to sunlight in Boston (42.19 north) were able to make “zero vitamin D” from November through February. To check the latitude where you live:
Latitude-Longitude of World Cities - click on link on top of page for US Cities
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NACi 2400 mg, Zithi 250mg/MWF, minoi 100mg/BID, Tinii 500mg/BID pulses, Iodoral 25mg, Supps, CFIDSi/FMSi, Hashimoto's, Psoriasis, PA, IBSi, Secondary Addisons
Don't believe everything you think!My husband and I live in
My husband and I live in the Pacific Northwest near Seattle. We're at 47.6º latitude. We average only 58 sunny days a year, mostly around June-Aug I'd say. My husband has a "Dr. Dumb" for a physician. In Feb he went in for his annual blood tests and I told him to ask his doctor to do a Vit D test, which they don't normally do. She almost refused arguing that, because he worked in the yard on Saturdays, "getting outside regularly", he would not need to worry about it. When he told me that my jaw hit the floor. Feb, in Seattle, outside one day a week covered from head to foot in warm clothing, and this dumber-than-dumb doc thinks he gets enough sunlight to provide sufficient vitamin Di?!! That does not take a brain surgeon to figure out there's no sun exposure there. What the *BLEEP* was she thinking?
Well, he got her to give him the Vit D test, despite her know-it-all objections, and it was only 21 (normal 30-150) and, can you believe, no apology, no admission of surprise even. She had the audacity to scold and lecture him for not taking enough vitamin supplementsi! He had, actually, been taking a multi vitamin with the min 400iu D daily for quite some time. Obviously not enough.
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GFAi - asthmai, sinusitis/rhinitis, tendonitis, low back pain, hypothyroid. Started azi 1000mg/week Jan 9, '08. Increased azi to 250mg/day, added 20mg Benicar daily Mar 13, '08. First Flagyli pulse started June 30, '08. Added Doxyi 200mg/day Aug 16.
Sunni- When in doubt, blame
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CAPi for Cpni 11/04. Dx: 25yrs CFSi & FMSi. Currently: 150mg BID Roxithromycin, Doxycycline 100mg BID, Tinii 1000mg/day pulses; Vit D2000 units, T4 & T3
Wow, Red this thread is a
Wow, Red this thread is a gem and a half. Great work and wonderful effort getting all this combined in a single page.
Sunni, that is hilarious.... No wonder medicine is in such a tail spin.
marie
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On CAPi since Sept '05 for MSi, RAi, Asthmai, sciatica. EDSSi at start 5.5.(early cane) Now 6 (cane full time) Currently on: Doxyi 200, Azith 3x week, Tinii cont. over summer '07, back to pulses of flagyli winter '08 all supplementsi. "Color out side the lines