High Dose Niacinamide for Nerve Repair

Found this interesting article about high dose Niacinamide for Alzheimers. Note with amusement the author commenting about media saying "don't try this at home". Well, I have used niacinamide in the past at high doses-- 3000mgs a day split into two doses. This was a part of Cpni therapy my doctor recommended for many months. I experienced healing of nerve pain and generally found it it well tolerated.

So I will definitely be going back to this dose starting today.I use SourceNaturals 1500 mg tabs.

http://www.orthomolecular.org/resources/omns/v04n25.shtml <

Raven

Just read ahead to the news releases and almost all of them prove uncertainty all around. What you have posted is perhaps more beneficial I suppose if one has alzheimers disease but that's about it - my opinion.Believe that I am not adverse, however, unconvinced.

There is much more proof in Wheldon protocol, however, I continue to suffer but not cognitively!

diagnosed MSi Jan.2000 ,  chronic neurological lyme disease Nov.2002.

doxyi 100 mg. 1BID. roxyi.150 mg.? BIDi,adding rifampin soon, pulsed tinii. every 3 weeks, as of oct.17/08, rifampin,naltrexone (LDNi),NACi, nystatin, major wheldon supplemrnts daily,

Raven, is niacinamide substitute for INHi in the capi? That is how I understood it. Or is there any other effect, except that it repairs nerves? I think it kills replicating cpni when you reach some dose. Am I right?

Stratton/Wheldon protocol 02/2006 - 10/11 for CFSi and many problems 30 years

Cpni bacteria is implicated in alzheimers aswell isnt it ? Niacinamide in those dosages kills replicating cpn as i understand it, so it seems logical it would help. But its good if it helps with repairs too....I remember reading about a swedish couple drinking alot of coconutoil to try and fight off alzheimers and it worked well for them.
Treating PPMSi with Azithromycin 250 mg every other day, Doxyi 100 mg BiDi, Coconut oil 4 times daily,  five flagyli pulses. Been sick since June 2009. Having good success and very few symptoms.

My doctor seemed to think it was worth trying to kill Cpni at the dose of 3000mgs a day. I did this for six months while taking NACi and doing Flagyli pulses every two weeks. I felt good improvement. Had die off from the pulses. I can't recall why he switched me but yes I was taking INHi before that and it might have been because of elevated liver enzymes.

Loulou, the article just points up that the news media tells everyone about these discoveries but then says "don't try try at home". I like to find the root scientific articles and send them to my doctor. He is well aware that high dose Niacinamide heals nerves. And all I was saying was, yes, I was on it for an extended period. Suffered no ill effects and definite benefits. But this is just my own personal experience and everyone else will have to make up their own minds.

As for the CAPi, the combo of doxyi, Azith and Tinii seems to have worked the best for me. But I am at a point where it may be time to change things around again. Will know more after I talk to him next week. All I know is that Tini is still killing, but I am uncertain if doxy and azith are holding the line when I am not pulsing. May need a different combo of anti-replicants.

Do you see a Lyme doc?

Raven

Feeling 98% well-going for 100. Very low test for Cpni. CAPi since 8-05 for Cpn/Mycoplasma P.,Lyme, Bartonella, Mold exposure,NACi,BHRT, MethyB12 FIRi Sauna. 1-18-11 begin new treatment plan with naturopath

Yes, I am strongly suspicious that my Dad had Cpni infection. He died of heart failure but had all the signs of Cpn. Earlier in his life he suffered from very bad peridonital disease, severe hemorrhoids, respiratory infectionsi, bowel problems and then Alzheimers. Raven

Feeling 98% well-going for 100. Very low test for Cpni. CAPi since 8-05 for Cpn/Mycoplasma P.,Lyme, Bartonella, Mold exposure,NACi,BHRT, MethyB12 FIRi Sauna. 1-18-11 begin new treatment plan with naturopath

So, you did not take doxyi nor azi when taking niacinamide, flagyli and naci? I tried niacinamide along with doxy, azi, rifa and nac and got such a horrible flush reaction, that I stopped it immediately. I tried niacin already before, only with doxy, azi and nac and reaction was by far so not bad.

Stratton/Wheldon protocol 02/2006 - 10/11 for CFSi and many problems 30 years

I first started with minocycline and azithromyacin and later added Flagyli pulses. For some reason my doctor switched me to Cuprimine and INHi with Flagyl pulses. Then he told me to take 3,000 mgs of niacinamide with Flagyl pulses. I have also been on Rifamfin for 6 months. Can't recall which combo that was a part of. I should go through my old blog posts and try to reconstruct what I did.

What I would like to know is if there is any way to kill off all of this bug. At this point I am doubtful.

Where is our silver bullet???

Raven

Feeling 98% well-going for 100. Very low test for Cpni. CAPi since 8-05 for Cpn/Mycoplasma P.,Lyme, Bartonella, Mold exposure,NACi,BHRT, MethyB12 FIRi Sauna. 1-18-11 begin new treatment plan with naturopath

Yes, Raven I see a lyme doc and have seen 7 of them since being diagnosed in 2002.4  in the US and 3 in Canada - all unique in approaches and beliefs.I seem to be so sorry that I became involved and I did listening to each one. Neurology took a back seat and I am just worse. I am still following Wheldon protocol but not making glimmers of improvement on most days.

Depressing, I know.I seem to get further depressed when rereading what I have just typed, so I'll stop.

I should begin another tinii pulse but I'm even afraid of that.

diagnosed MSi Jan.2000 ,  chronic neurological lyme disease Nov.2002.

doxyi 100 mg. 1BID. roxyi.150 mg.? BIDi,adding rifampin soon, pulsed tinii. every 3 weeks, as of oct.17/08, rifampin,naltrexone (LDNi),NACi, nystatin, major wheldon supplemrnts daily,

Loulou, your signature says you pulse every 3 weeks. Is it possible to go to every two weeks? Give the monsters less time to regroup their forces? Raven

Feeling 98% well-going for 100. Very low test for Cpni. CAPi since 8-05 for Cpn/Mycoplasma P.,Lyme, Bartonella, Mold exposure,NACi,BHRT, MethyB12 FIRi Sauna. 1-18-11 begin new treatment plan with naturopath

Yes, Raven I think I should go to two weeks for pulsing.

I do have a lot on my plate without any sort of emotional support.

I should start pulse, if not this week, then next.

diagnosed MSi Jan.2000 ,  chronic neurological lyme disease Nov.2002.

doxyi 100 mg. 1BID. roxyi.150 mg.? BIDi,adding rifampin soon, pulsed tinii. every 3 weeks, as of oct.17/08, rifampin,naltrexone (LDNi),NACi, nystatin, major wheldon supplemrnts daily,

Raven, Re "our silver bullet"

My UK specialist GP, who also has a research facility, just told me that XMRV allows other bugs [can't think of the right word] to affect us; that it's only a matter of time before government will allow treatment for it.

He's been right about so many other things, so I'm trusting him on this one.

 

Isn't the niacinamide the form of niacin that can cause liver problems? Our livers are so burdened already I'd be leery of taking high dose niacinamide.
Yes, it can cause liver enzymes going up, but that is usually harmless, as I understand.

Stratton/Wheldon protocol 02/2006 - 10/11 for CFSi and many problems 30 years

No, niacinamide isn't the liver-damage form of niacin; that's slow-release niacin. Niacinamide isn't completely worry-free as regards liver damage, but it's not notorious for it, either. Slow-release niacin, the notorious stuff, is chemically niacin, just in a pill that releases it slowly rather than all at once. Niacinamide is a different molecule.

Slow release niacin">i is even harder on the liver, but both forms can increase liver enzymes.

see http://www.ncbi.nlm.nih.gov/pubmed/11126400<

"High-dose nicotinamide should still, however, be considered as a drug with toxic potential at adult doses in excess of 3 gm/day and unsupervised use should be discouraged."

I guess, that is why, people here were recommended to take no more than 3000mg daily by their doctor. 

Stratton/Wheldon protocol 02/2006 - 10/11 for CFSi and many problems 30 years

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