Hi all,
Here's a great review article on Vitamin Di:
Back to the future: a new look at 'old' vitamin D.
R Chun, Dept. of Orthopaedic Surgery, UCLA-Orthopaedic Hospital, Los Angeles, United States.
Our perception of the vitamin D system continues to evolve. Recent studies have re-evaluated the parameters for adequate vitamin D status in humans, revealing a high prevalence of insufficiency in many populations throughout the world. Other reports have highlighted the potential consequences of vitamin D insufficiency beyond established effects on bone homeostasis. Most notably there is now strong evidence of a role for vitamin D in modulating innate and adaptive immunity, with insufficiency being linked to infectious disease and other immunei disorders. To date, signaling pathways for these new responses to vitamin D have been based on established endocrine models for active 1,25-dihydroxyvitamin D, despite current evidence for more localized, intracrine modes of action. In the following review, we provide a fresh perspective on vitamin D signaling in non-classical target cells such as macrophages by highlighting novel factors associated with the transport and action of this pluripotent seco-steroid.
PMID: 18495944 [PubMed - as supplied by publisher]
Here's a link to the full article:
Back to the future: a new look at 'old' vitamin D.
___________________________________________________________
On Combined Antibiotic Protocol for Cpnii in Rosaceaii 01/06 - 07/07, On Vit D3 + NACi since 07/07 and daily FIRii Sauna since 08/07
The article above discusses
The article above discusses Vitamin Di binding to Heat Shock Proteins, and I didn't know much about this myself, so for anyone interested, the wiki on Heat Shock Proteins gives some good info on HSPs:
Heat shock protein
Click on the link for HSP 70 toward the bottom of the wiki page for specific information on it...
On Combined Antibiotic Protocol for Cpni in Rosaceai 01/06 - 07/07, On Vit D3 + NACi since 07/07 and daily FIR Sauna since 08/07
___________________________________________________________
On Combined Antibiotic Protocol for Cpni in Rosaceai 01/06 - 07/07, On Vit D3 + NACi since 07/07 and daily FIRi Sauna since 08/07
Hi Red- Haven't gotten
Hi Red- Haven't gotten through the article yet, but it looks to be a good one. Scanning the authors I found this one of related interest:
Ann N Y Acad Sci. 2007 Nov;1117:94-105. Epub 2007 Jul 26.Click here to read Links
Vitamin Di in defense of the human immunei response.
Adams JS, Liu PT, Chun R, Modlin RL, Hewison M.
Division of Endocrinology, Diabetes and Metabolism, Burns and Allen Research Institute, Cedars-Sinai Medical Center, 8700 Beverly Boulevard, Room B-131, Los Angeles, CA 90048, USA. adamsj@cshs.org
Defensin is a generic name reserved for an endogenously synthesized antimicrobial agent. The purpose of this review is to describe a series of discoveries that led to the proposal that 25-hydroxylated metabolites of vitamin D are key, intracellulari regulators of the synthesis and action of naturally occurring defensin molecules against bacterial antigens. The discussion will (1) highlight the basic elements of human immune response that is responsive to vitamin D, (2) recount work relevant to the extrarenal expression of the vitamin D-1-hydroxlase (CYP27b1) in the macrophage as an initiator of the innate immune response, and (3) describe recent work on the relevance of the vitamin D intracrine-autocrine-paracrine system in a model of a common and devastating human disease, tuberculosis.
Full article pdf link.
http://www.annalsnyas.org/cgi/rapidpdf/annals.1402.036v1
CAPi for Cpni 11/04. Dx: 25yrs CFSi & FMSi. Protocol: 200mg Doxyi, 300mg Roxithromycin, Tinii 1000mg/day pulses; Vit D1000 units, Iodoral 50mg, T4 & T3
___________________________________________________________
CAPi for Cpni 11/04. Dx: 25yrs CFSi & FMSi. Currently: 150mg BID Roxithromycin, Doxycycline 100mg BID, Tinii 1000mg/day pulses; Vit D2000 units, T4 & T3
Great article, Jim.
Great article, Jim. Thanks!
Great Sunday morning, coffee-time ready for a nerd like me.
On Combined Antibiotic Protocol for Cpn in Rosaceai 01/06 - 07/07, On Vit D3 + NACi since 07/07 and daily FIRi Sauna since 08/07
___________________________________________________________
On Combined Antibiotic Protocol for Cpni in Rosaceai 01/06 - 07/07, On Vit D3 + NACi since 07/07 and daily FIRi Sauna since 08/07
Red, I so appreciate your
Red,
I so appreciate your presence at this site! You always post some of the best research !
Daisy - Husband on CAPi 5/07. Roxyi, Diflucan, Rifampin, Bactrim DS, Mepron 4-6,
Prednisone,Novantrone, Doxyi, Azithromycin, Flagyli,Minoi___________________________________________________________
Daisy - Husband on CAPi 5/07. "When Going Thru Hell, Just Keep Going", Winston Churchill
Daisy- Agreed! It's nerds
Daisy- Agreed! It's nerds like Red that help us understand more of what we are dealing with here, and of the resources we need to, as Dr. Powell says, "Make yourself a bad host!"
CAPi for Cpni 11/04. Dx: 25yrs CFSi & FMSi. Protocol: 200mg Doxyi, 300mg Roxithromycin, Tinii 1000mg/day pulses; Vit D1000 units, Iodoral 50mg, T4 & T3
___________________________________________________________
CAPi for Cpni 11/04. Dx: 25yrs CFSi & FMSi. Currently: 150mg BID Roxithromycin, Doxycycline 100mg BID, Tinii 1000mg/day pulses; Vit D2000 units, T4 & T3
Dan, Thanks so much for
Dan, Thanks so much for this. I have to admit, I was too tired to try to understand the really nerdy bits of the text, so I scanned for the tidbits of "meat" in it. Very cool theories on the history of D and the genetic alterations/adaptations~geography and complexion. Thanks too for the link on HSPs---lots of fodder for pondering there.
Joyce~caregiver-advocate in Dallas for Steve J (SPMSi). CAPi since August 06, Cpni, Mpn, B. burgdorferi, systemic candidiasis, EBVi, CMV & other herpes family viral infectionsi, elevated heavy metals, gluten+casein sensitivity.
___________________________________________________________
Joyce~caregiver-advocate in Dallas for Steve J (SPMSi). CAPi since August 06, Cpni, Mpn, B. burgdorferi, systemic candidiasis, EBVi, CMV & other herpes family viral infectionsi, elevated heavy metals, gluten+casein sensitivity.
Hi Red, I can't post a new
Hi Red, I can't post a new forum topic for this because of the site change, so I hope you don't mind that I added to your excellent thread.
Those with low vitamin D twice as likely to die
The title of the article is a sure attention grabber.
Here's one more:
Vitamin D may prevent heart attacks in men
Study: Those with lower levels were 2 1/2 times more likely to have attack
___________________________________________________________
Corinna | GFAi. Wheldon Protocol: 4–8/08. Can't kill the yeast.
Hi Corinna, Thanks.
Hi Corinna,
Thanks. Interesting (and scary) studies!
Here's the abstract for the first study for anyone interested, btw:
Independent Association of Low Serum 25-Hydroxyvitamin D and 1,25-Dihydroxyvitamin D Levels With All-Cause and Cardiovascular Mortality
___________________________________________________________
On Combined Antibiotic Protocol for Cpni in Rosaceai 01/06 - 07/07, On Vit D3 + NACi since 07/07 and daily FIRi Sauna since 08/07