Cpnhelp.org - Chlamydia Pneumoniae Treatment

Daisy, and Ella, as well. Reading Michele's blog for Ella was truly scary at the beginning, too, but look how it's resolved! You two have certainly been through the mill, but you've made huge strides in knowledge and resources. More has been accomplished than is evident, but that doesn't mean you haven't come a long way.

The difference between what we do and what we are capable of doing would suffice to solve most of the world’s problems.  Mohandas Gandhi

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The difference between what we do and what we are capable of doing would suffice to solve most of the world’s problems. Mohandas Gandhi

thanks for the update Daisy!

I am soo happy you have found a new doctor that is helpful & has actually talked to Dr. Stratton, that is very encouraging.

As I was reading about your increased Flagyl pulse it got me thinking; I know, it doesn't happen often, that my experience with my first teeny weeny pulse I had a delayed reaction over a week later, YAAA, I know.... I was shocked tooo.

Anyway, your husband is in capable hands, you are the best!

God Bless you on your journey!

Ruth

CFIDSi/ME 25yrs, FMSi, IBSi, EBVi, Cpni, (insomnia - melatonini, GABA, tarazadone, temazepam, novocyclopine, allergy formula, 2 gm tryptophan), Natural HRT peri-M, NACi 2.5 gm, 6-07 Doxy 200 mg day pm, Azith 375 mg M/W/Fday, 8-21-07 1st pulse 1 X 250 mg Metroi

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CFIDSi/ME 32 yrs, FMSi, IBSi, EBVi, CMV, Cpni, chronic insomnia, Lymes, HME, Natural HRT peri-M, NACi 2.5 gm, 6-07 Doxy 200 mg day pm, Azith 375 mg M/W/Fday, Pulse#11 1000 mg 5 days 6-14-08

Mac's right it was a long time before we could say that Ella had made some real improvements and up to a year into the treatment there were constant set backs, especially once we started the flagyli.   But today she is jumping out of a plane.  

She is bright and organised, keeping a stable weight, able to get around with a stick.   She is setting herself a goal of two stick free days a week.   We have not seen great improvements in her walking ability and her strength and balance, at times, seem a little erractic. But she has some good days when she feels she is making real physical progress.  A post CAPi deficit in her right hand has made a complete recovery, here pupils react to light almost normally from a point where her left pupil did not react at all, and her disturbed vision is a thing of the past.

But an appreciation of music indicates progress, something that was lost has returned.  That is how it starts, with small some would say insignificant improvements.

You have enough scientific knowledge to understand the possible effects of the different drugs, so I won't say be careful with Rifampicin.   Whoops I've said it.   Dr Stratton said somewhere I think that it is very effective against Cpni, but apart from the close scrutiny of liver function you have to be aware of possibly strong die off reactions... 

Michele (UK) GFAi: Wheldon CAP1st May 2006 . Daily Doxyi, Azi MWF, Flagyl at 400mg for 7 days prior to 5 day pulses at 1200mg three weeks cycle. Spokesperson for Ella, RRMS Wheldon CAP 16th March 2006

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Michèle (UK) GFAi: Wheldon CAPi 1st May 2006. Daily Doxyi, Azi MWF, metroi pulse. Zoo keeper for Ella, RRMS, At worse EDSS 9, 3 months later 7 now 5.5 Wheldon CAP 16th March 2006

Daisy - It is interesting to me that your husband had the genomics testing looking at the genesi for nuerotransmitters and detox pathways and found that he is a poor methylator and does not have the genes to produce glutathione.  This is an area that I have been researching with my limited scientific abilities.  It is a subject that has been brought up on a CFSi discussion group I belong to and it interests me greatly because a lack of glutathione seems to be one of the key problems in my immunei dysfunction.  A man named Rich Van Konynenburg who is a researcher and has CFS has researched in this area for over 10 years.  After determining the importance of glutathione in the immune system he found many people who were researching this area and was lead to the DAN project for Autistic children and to the work of Amy Yasko.  Rich used to post regularly on the CFS site and shared his findings. Now he is very busy answering questions for CFS patients using Dr. Yasko's Protocol. Dr. Yasko uses the gene testing you spoke of and then has a very specific supplement program she uses to correct the methylation pathway that is blocked.  A few CFS patients tried this and started a discussion board to support people with CFS doing this, but Rich found that most CFS patients could not afford the gene testing and then also were too sick to handle the entire Yasko protocol.  So he developed a simplified Yasko approach which only has 5 supplementsi and is relatively cheap to use and does not do the testing.  It just assumes you have the methylation block and if it doesn't work for you, then you know you don't lack those genes. He then started another discussion group for CFS patients using the modified Yasko Protocol. When CFS patients started using this, they had amazing results.  This protocol can unblock the methylation pathways in as little as a few days.  People who were hypothyroid became hyperthyroid and had to adjust or stop their thryroid meds and he has reported that the 2 CFS patients that had developed Diabetus Insipidus as a result of the CFS( a rare occurence)that started this protocol were able to stop taking Vasopressin(anti-diuretic hormone) without a return of the increased thirst, extremely large urine output and dehydration problems. Many other CFS problems have been relieved also but no one has been on this program long enough to know long term effects.  Of course this interested me greatly because my DI is a great problem for me.  I wrote Rich about me starting the modified program as he and I had discussed in the past how my DI and Lyme disease and CPn were effected by the glutathione problem.  He wrote me back that the protocol has die-off effects because it allows the immune system to start functioning normally and immediately starts clearing toxins, bacterias and viruses from the body.  He was concerned that using the Modified Yasko protocol along with the CAPi could cause too much  die-off for me to handle with all the problems I have.  I was hoping I could use them both and normalize my immune system and have a better chance of completely irradicating the Lyme which seems to be a major problem from what I have researched.

I am probably giving you some info that you may already have since you had your husband tested for those specific genes.  I know that Joyce has referenced the methylation block and production of glutathione before and even put up a site to read one of Rich's papers. It involves the use of specific types of B-12 and folate and some other things.  I know Joyce mentioned it to Odhilla when she started giving info on the importance of B-12.  Here is another site that gives a paper that he presented to a CFS conference in January that explains his research. I don't know if this is the direction you are speaking of in experimenting in some areas with your husband, but I would be very interested in knowing if it is the same or if you have found a different way to stop the methylation block.  I think this is an important area to explore because I have CPn, chronic acitve EBVi and CMV as well as Lyme and who knows what other lurking infectionsi.  There is a reason my immune system and most every one else's on this site has allowed these infections to remain chronic and make us very sick when a  huge percent of the general population carries most of these dormant in their bodies and don't get sick at all.

Lynda- ME/CFS, Fibro, IBSi, Hypothyroid, Lyme, CPN, Diabetus Insipidus(DI).  Stratton Protocol 8-06; Daily: NAC 2250mg, Doxy 200mg, Flagyli pulses 1500mg for 5 days 500 mg- 2 days, Azith 250 mg MWF,LDN,Armour Thyroid, Klonopin, Vasopressin

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Lynda- ME/CFSi, Fibro, IBSi, Hypothyroid, Lyme, Cpni, Diabetus Insipidus(DI).  Stratton Protocol 8-06; Daily: NAC 2250mg, Doxy 200mg, Flagyli pulses   1500mg- 5days, Azith 250 mg MWF,Armour Thyroid, Klonopin, Desmopressin, supplementsi.

 Thanks for this, Lynda. A good description of this can be found at http://phoenix-cfs.org/GSH%20Methylation%20Treatment%20Konynenburg.htm

CAPi for Chlamydia pneumonia since 11/04. 25yrs CFS & FMSi- Currently: 300mg INHi, 200 Doxycycline, 500mg MWF Azithromycin, 1000mg Tinii daily (Taking a break from continuous protocol)

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CAPi for Cpni 11/04. Dx: 25yrs CFSi & FMSi. Currently: 150mg BID Roxithromycin, Doxycycline 100mg BID, Tinii 1000mg/day pulses; Vit D2000 units, T4 & T3

Thanks Jim, for posting that info.  I had not read that particular report from Rich.  I Have a 17 page e-mail that he posted in July that explained the simplified Yasko Protocol but is much more positive in that he had gotten responses from well over 60 people, he lost count after that, who had tried it and though had die-off reactions had some very significant good responses.  He also had changed the protocol to 5 supplementsi rather than 7.  Some people who had been sick for a long time were able to tolerate the treatment.  He explained in the e-mail that his initial report which is on the site you posted was not very positive about persons trying the modified version because he had no experience to go on.  Now he is encouraged that more people can be helped by the simplified version than he thought.  He did report a few adverse effects and so recommends that anyone trying this approach do so under the supervision of a doctor who has researched this protocol and understands it.  He also gave several suggestions to make the protocol work better and what to watch for.  I wanted to post this info but all I have is the e-mail which is very long.   It probably wouldn't be very helpful to those of us on this site as we are all on abxi.  But it is something to think about for those who are close to finishing this protocol to try to make sure the immunei systems are working properly to keep the bacterias and viruses from returning instead of having to go on intermittent abx therapy.  Just a thought.

Lynda- ME/CFSi, Fibro, IBSi, Hypothyroid, Lyme, CPNi, Diabetus Insipidus(DI).  Stratton Protocol 8-06; Daily: NAC 2250mg, Doxy 200mg, Flagyli pulses 1500mg for 5 days 500 mg- 2 days, Azith 250 mg MWF,LDN,Armour Thyroid, Klonopin, Vasopressin

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Lynda- ME/CFSi, Fibro, IBSi, Hypothyroid, Lyme, Cpni, Diabetus Insipidus(DI).  Stratton Protocol 8-06; Daily: NAC 2250mg, Doxy 200mg, Flagyli pulses   1500mg- 5days, Azith 250 mg MWF,Armour Thyroid, Klonopin, Desmopressin, supplementsi.

At every turn it seems that NACi is the most important supplement we take. It is with good reason that we should start with that, if it mobilises the metabolism as well as support the liver and kill EBs and moulds. What more will it be shown to do for us in the future?

It strikes me that Rich Van Konynenburg empirical protocol for kick starting the metabolism contains many of the vitamins and supplementsi we already take.  Here is is with some notes about prices that I have added:

 

Protocol: The simplified approach would involve giving the following oral supplementsi daily, all of which are available from Dr. Yasko’s supplement website at http://www.holisticheal.com
 
    *¼ tablet (200 micrograms) Folapro (Folapro is 5-methyl tetrahydrofolate, an active form of folate, which is sold by Metagenics with a license from Merck, which holds the patent on synthesis). evitalhealth.com $17.49 for 60
 
    * ¼ tablet Intrinsi B12/folate (This includes 200 micrograms of folate as a combination of folic acid, 5-methyl tetrahydrofolate, and 5-formyl tetrahydrofolate, aka folinic acid or leucovorin (another active form of folate), 125 micrograms of vitamin B12 as cyanocobalamin, 22.5 milligrams of calcium, 17.25 milligrams of phosphorus, and 5 milligrams of intrinsic factor) evitalhealth.com $16.45 for 60
 
    * (up to) 2 tablets (It’s best to start with ¼ tablet and work up as tolerated) complete vitamin and ultra-antioxidanti from Holistic Health Consultants (This is a multivitamin, multimineral supplement with some additional ingredients. It does not contain iron or copper, and it has a high ratio of magnesium to calcium. It contains antioxidants, some trimethylglycine, some nucleotides, and several supplements to support the sulfur metabolism.) 
 
    * 1 softgel capsule Phosphatidyl Serine Complex (This includes the phospholipids and some fatty acids) iherb $24.19 for 60 is cheaper than holisticheal
 
    * 1 sublingual lozenge Perque B12 (2,000 micrograms hydroxocobalamin with some mannitol, sucanat, magnesium and cherry extract) wellnessworks.net $24for 100
 
    * 1 capsule SAMe (200 mg S-adenosylmethionine) I herb $20.98 for 60
 
   * 1/3 dropper, 2X/day Methylation Support Nutriswitch Formula (This is an RNA mixture designed to help the methylation cycle. It is not essential, but is reported to be helpful.) 

 

Does anyone see any advantage in taking the supplements he recommends in the link that Jim posted above over those that we benefit from by taking our supplements.   A couple of them are b12 variations, maybe they work better than the ones we take?    

The only completely new/different supplement I see on the list is  Phosphatidyl Serine Complex.

Michele (UK) GFAi: Wheldon CAP1st May 2006 . Daily Doxyi, Azi MWF, Flagyli at 400mg for 7 days prior to 5 day pulses at 1200mg three weeks cycle. Spokesperson for Ella, RRMS Wheldon CAP 16th March 2006

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Michèle (UK) GFAi: Wheldon CAPi 1st May 2006. Daily Doxyi, Azi MWF, metroi pulse. Zoo keeper for Ella, RRMS, At worse EDSS 9, 3 months later 7 now 5.5 Wheldon CAP 16th March 2006

Daisy and Joyce - thank you for giving such a positive response to this info.  It is a complicated issue, particularly for those of us already taking the abxi.  Like Joyce I wished I had found this info before I started the abxi also because I think it would have been better to improve the immunei system first and my endrocrine problems and then had a easier time of using the abx.  But now it seems that it could be difficult to use the program and the abx together because of increased die-off.  Although Rich did tell me that he had not had any experience with anyone doing both at the same time.  So he is giving his best educated guess.  He is not a physician, so is hesitant to give out advice.  He can only suggest from his best educated guess and experience from people using his simplified version and reporting to him.  Daisy, You are in a better position with your huband since you have already done the testing and know exactly what his problems are.  The question is do you risk adding this to his abx.  I have wondered if I should discontinue the CAPi temporarily and try the 5 supplementsi in his simplified protocol which are the first five listed in the site Jim listed.  If I don't respond by improving my DI and thyroid then I will know I don't have the methylation block and then just go back to the CAP.  But I hate to stop the abx now when I am finally reaching the tissues where the bacteria is and killing it as evidenced by me finally having definite die-off reactions.  I may just wait until I am not reacting as bad and do a short trial with very small doses of the treatment supplementsi and see how I do.

Michelle - I had my nutrtionist look at the program and she said the supplements are in very different forms than what I was taking and modified my supplements for me to add this protocol into them.  That was before Rich wrote me with his cautions.  The supplements Dr. Yasko uses are very different in the forms that they are in from what are recommended on this site.  For example she uses a very special formulated Folate and we use Folic acid.  Also there are things like intrinsic factor added in and the Multi vitamin is very specific to the needs of this protocol.  It is the only thing that you have to order from her website because she designed it.  The other products are made by Metagenics and can be ordered anywhere Metagenics products are sold, though I noticed most of the prices are exactly the same at her site as the site you mentioned.  One thing that I learned from my nutrtionist is that the form of the supplement is very improtant.  I was taking the wrong kind of Vit C and when I went back to the type she wanted me on I did much better.  This protocol and the types of supplements listed is very specific for unblocking the methylation cycle if a person has that problem.  Rich's simplified protocol assumes you have that block.  It is basically her step 2 of her program and is the step that unblocks the methylation cycle.  Rich gains nothing from all the work he has done to try to help CFSi patients and take Dr. yasko's program and make it workable for those who can't afford the testing and the entire Yasko Protocol.

Joyce or anyone else- I have tried to find the link to the specific e-mail that Rich submitted to the CFS site so I can give it here, but I don't know how to do that.  It is 17 pages long and has a lot of good info.  If anyone can tell me how to do that I would appreciate it.  The CFS/ME/Fibro site is a Yahoo discussion page. I have looked through his papers and can't find it anywhere else.  It was written in July and  is much more updated then the one he wrote in Jan. that Jim posted the site for.

There is a Yahoo discussion group that has been established for CFS patients who want to try the simplified Yasko Protocol.  It is http://health.groups.yahoo.com/group/simplified_protocol_support/  I haven't gone there yet, most of my functional time of typing and reading has been spent here.  But I plan to and maybe can find someone who is trying it and taking abx at the same time.  You obviously don't have to be a CFS patient to have this methylation block because Autistic kids have it and Daisy's huband who has MS has it.  So I think it would be applicable for anyone with an illness that has greatly affected their immune systems like all of us have.

Lynda- ME/CFS, Fibro, IBSi, Hypothyroid, Lyme, CPNi, Diabetus Insipidus(DI).  Stratton Protocol 8-06; Daily: NAC 2250mg, Doxy 200mg, Flagyli pulses 1500mg for 5 days 500 mg- 2 days, Azith 250 mg MWF,LDN,Armour Thyroid, Klonopin, Vasopressin

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Lynda- ME/CFSi, Fibro, IBSi, Hypothyroid, Lyme, Cpni, Diabetus Insipidus(DI).  Stratton Protocol 8-06; Daily: NAC 2250mg, Doxy 200mg, Flagyli pulses   1500mg- 5days, Azith 250 mg MWF,Armour Thyroid, Klonopin, Desmopressin, supplementsi.

Thanks for that information Lynda, I will do a bit more research on that. I actually have Autism: Effective biomedical Treatment and this is what alerted me to the importance of what you are saying. I would never describe Ella as autistic, certainly not in the same way as the mildly autistic children I have worked with, but certain things in the description of their early years rang a bell with me. Particularly the collic and the fact that she would only feed once in 24 hours, at night. Later the neurological events and the thyroid problems are also tell tale.   So I shall do some more investigation...

Michele (UK) GFAi: Wheldon CAP1st May 2006 . Daily Doxyi, Azi MWF, Flagyli at 400mg for 7 days prior to 5 day pulses at 1200mg three weeks cycle. Spokesperson for Ella, RRMS Wheldon CAP 16th March 2006

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Michèle (UK) GFAi: Wheldon CAPi 1st May 2006. Daily Doxyi, Azi MWF, metroi pulse. Zoo keeper for Ella, RRMS, At worse EDSS 9, 3 months later 7 now 5.5 Wheldon CAP 16th March 2006

Lynda,  I haven't had a chance yet to thoroughly read your links, but for what it's worth, Steve's doc has had him on a rx methylated B-complex since beginning his treatment last year (a few weeks before starting the abxi).  It's called Metanx, and I have no idea why it's a rx medicine.  The only thing I do know about buying this methylated B-complex as a rx med is that it's CHEAP!

Joyce~caregiver-advocate in Dallas for Steve J (SPMS).  CAPi since August 06, antivirals, heavy metals chelation, LDN, Metanx, Lunesta, GF/CF diet, Lauricidin, oral IgGi/lactoferrin/IGF-1 booster, astaxanthin, gamma oryzanol.

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Joyce~caregiver-advocate in Dallas for Steve J (SPMS).  CAPi since August 06, Cpni, Mpn, B. burgdorferi, systemic candidiasis, EBVi, CMV & other herpes family viral infectionsi, elevated heavy metals, gluten+casein sensitivity. 

For those who are curious about this geneticsi testing - here are a few examples  from my husbands.  This is  an excerpt from a PM message I sent someone on this site a while ago.

This is all genomics testing.

1) Tested postive for IL-1B chromosome 2-31C-T gene which slightly increases IL-B1 production leading to increased inflammationii and suppressing hydrochloric acid in the stomach which rips up the mucosal lining and sets you up for leaky guy, dysbiosis, food sensitivities and further inflammation.

2) Tested positive for 5,10 methltetrahydrofolate reductase methylation.  This is a gene that has a 40% higher positive affinity in Italians.  This genotype puts you at risk for elevated homocysteineii AND S-adenosylhomocysteine (SAH).  If SAH is elevated you get disrupted neurotransmitter metabolism (possibly explaining  wierd neurotransmitter results) and disrupted synthesis of DNA, carnitine and coenzyme Q10.   The non methylated B's are probably not being processed.

3) positive for catechol-o-methltransferase (COMT)methylation gene.  This regulates neurotransmitters and if you have moderately deceased activity you also have - ta da - IMPAIRED METHYLATION

4) Absence of gene for Glutathione S-Transferase (GST) mu-1 Detoxification.   GST as you know is responsible for Phase 2 detox of products of oxidative stress.  This probably greatly reduces your ability to detox .  

5)  Glutathione S-transferase Pi-1 1105V gene- (GSTP) Detoxification.  GTSP1 is located primarily in the BRAIN and lungs.  Also responsible for phase 2 detox of xenobiotics, carcinogens and products of oxidative stress!.

6) Superoxide Dismutase-2 (SOD) A16V gene - Detoxification. Sod converts reactive oxygen species (ROSii) into less reactive H2O2.  Located within cellular mitochondria and uses manganese as cofactor. Adequate SOD protects the cells from products of oxidative stress.    Some doctors give IM injections to cancer and cardiac patients of SOD.

I don't know if this will help anyone but I thought I would share a couple of the results that are applicable to this discussion.

The question of course becomes, how do you use this information to enhance health and the clearance of infectionsi?

Daisy-Caregiver- Balo's Concentric Sclerosis. Began CAPi 5/10/07. Doxyi 200 mg, Mino 100 BID 9/1/07, AZI 250mg QD 9/10/07, NACi 1200 mg, HD Flagyli Pulses, Novantrone, Prednisone & daily lb of supplementsi.

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Daisy - Husband on CAPi 5/07.  Roxithromycin, Rifampin, Bactrim DS, Tindamax 6-23, Tetracycline 7-3

Daisy, does your husband have any idea what is going on and what you are doing? Once in a while I think of the parents of the young fellow Lorenzo ______, to compare you to. That is as close as I can come except for David Wheldoni. Our world, especially this little one, if filled with heroes.

 

Rica PPMS EDSS 6.7 at beginning - now 2. Began CAPi Sept, 2004 with Rifampin 150 mg 2xd, Doxyi 100 mg 2xd, added regular pulses Jan 2005. Jan 2006 switched to Doxy, Azith, cont. flagyli total 44 pulses NC USA

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Rica PPMS EDSS 6.7 at beginning - now 2. Began CAPi Sept, 2004 with Rifampin 150 mg 2xd, Doxyi 100 mg 2xd, added regular pulses Jan 2005. Jan 2006 switched to Doxy, Azith, cont. flagyli total 51 pulses NC USA

Rica - It would be my greatest pleasure some day to show my husband this blog and to have him read it and to really understand everything in it.

I don't feel like a hero.  Just a person backed into a corner who is  fighting for her life.

Daisy-Caregiver- Balo's Concentric Sclerosis. Began CAPi 5/10/07. Doxyi 200 mg, Minoi 100 BID 9/1/07, AZI 250mg QD 9/10/07, NACi 1800 mg QD, HD Flagyli Pulses, Novantrone, Prednisone & daily lb of supplementsi.

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Daisy - Husband on CAPi 5/07.  Roxithromycin, Rifampin, Bactrim DS, Tindamax 6-23, Tetracycline 7-3

From the Townsend Letter (2006) on Methylation by Amy Yasko. From everything I understand Amy Yasko has some huge fans and some equally strong detractors.

 Here is the link.  Here is also a copy of an article that she wrote for  Annals NY.

Interesting excerpt from the Townsend letter article

Methylation and the Immunei System

 

 

Daisy-Caregiver- Balo's Concentric Sclerosis. Began CAPi 5/10/07. Doxyi 200 mg, Minoi 100 BID 9/1/07, AZI 250mg QD 9/10/07, NACi 1800 mg QD, HD Flagyli Pulses, Novantrone, Prednisone & daily lb of supplementsi.

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Daisy - Husband on CAPi 5/07.  Roxithromycin, Rifampin, Bactrim DS, Tindamax 6-23, Tetracycline 7-3

This is certainly worth persuing for me daughter in particular, and I am going to give Rich Van Konynenburg modified Yasko protocol a try with caution to see if it brings any improvement in Ella's thyroid condition in particular.   I'm hoping that starting with small doses of some of the supplementsi with be mild enough not to cause too many difficulties.   I'm particularly looking at the different B12 substances, as currently the B12 does not seem to make much difference to her condition. (she ran out of them for a few weeks and there was no difference in how she felt on or off them)

Michele (UK) GFAi: Wheldon CAP1st May 2006 . Daily Doxyi, Azi MWF, Flagyli at 400mg for 7 days prior to 5 day pulses at 1200mg three weeks cycle. Spokesperson for Ella, RRMS Wheldon CAP 16th March 2006

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Michèle (UK) GFAi: Wheldon CAPi 1st May 2006. Daily Doxyi, Azi MWF, metroi pulse. Zoo keeper for Ella, RRMS, At worse EDSS 9, 3 months later 7 now 5.5 Wheldon CAP 16th March 2006

I am not sure if it is the B12 specifically, but, sometimes my muscles get all cranky & tie up in knots.  It seems those are the days when I may have missed a round of B12.  I am going to have to keep a closer eye on it.

blessings

r

CFIDSi/ME 25yrs, FMSi, IBSi, EBVi, Cpni, (insomnia - melatonini, GABA, tarazadone, temazepam, novocyclopine, allergy formula, 2 gm tryptophan), Natural HRT peri-M, NACi 2.5 gm, 6-07 Doxy 200 mg day pm, Azith 375 mg M/W/Fday, 8-21-07 1st pulse 1 X 250 mg Metroi

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CFIDSi/ME 32 yrs, FMSi, IBSi, EBVi, CMV, Cpni, chronic insomnia, Lymes, HME, Natural HRT peri-M, NACi 2.5 gm, 6-07 Doxy 200 mg day pm, Azith 375 mg M/W/Fday, Pulse#11 1000 mg 5 days 6-14-08

Resurfacing this methylation thread to ask how folks are doing on either the Yasko or simplified Yasko (via Konynenburg) methylation protocol in addition to CAPi treatment for Cpni. Thanks for any updates/thoughts you can share.

I'm about to order the supplementsi outlined in the thread here for the simplified Yasko plan: the Folapro, Intrinsi B12/Folatei, Phosphatidylserine complex, SAMe, and Perque B12. I planned to skip the optional RNA supplement and the multivitamin in hopes I had those covered or could do without them.

I've read discussion that you can feel sick at first on the methylation supplementsi (if they're working to clear a methyl block I understood), and I also read recommendations not to start them while on the CAP (perhaps because of adding to the body burden while the block clears?). Has anyone gone ahead with them while on CAP, or did you stop the CAP temporarily to get on the methylation protocol?

I also read that if they don't work, Konynenburg then recommends proceeding with the costly Yasko testing to figure out how to fine-tune the program to fit your needs. I wondered how you knew if they weren't working.

My guess is if they work, you'll feel sick at first and then see improvement after getting over the hump. If they don't work I suppose you'd feel no change. Does that sound right?

Thanks a bunch,

Marysia

NACi 2400mg/dy, Doryx 200mg/dy, ramping up on protocol. CDC +Lyme FMSi 02/06; Cpn, HHV6, and EBVi + 03/08. 2 yrs slow improvement on variations of long-term antibioticsi for Lyme. Currently slowly resuming treatment and changing to newly discovered (for me) Cpn protocol after a severe porphyria attack 09/07 on Diflucan.

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NACi 2400mg/dy, Doryx 200mg/dy, ramping up on CAPi for both Cpni and Lyme. CDC+ Lyme FMSi 02/06; Cpn, HHV6, and EBVi+ 03/08. 2 yrs slow improvement on variations of long-term antibioticsi for Lyme. Now slowly resuming treatment after severe porphyria att