Dianna's CAP: GERD, Migraines and CPn -- Smooth muscle?

I'm reporting Dianna's results with the CAPi. She started it for a variety of complaints, and because we live together she's probably carrying some load. Her Ig tests were mildly elevated.

Three of her complaints - mild rosaceai, GERDi, and migraines - have improved markedly since she started. The asthmai seems unchanged, and her hypertension">i had disappeared before she started the CAP. At this point, she's done 3 weeks of Doxyi, and 2 weeks of Azithromycin. She'll start Flagyli next week, if all goes well.

I hesitated to list the migraines; she didn't start the abxi with any notion that the migraines would improve. Still, they have, and we can't think of any other changes that would account for the improvement.

It made me think about the diagrams and photos in The Potbelly Syndrome. CPni apparently loves to live in smooth muscle. I think these diseasesi may share a common cause -- the weakened, disorganized muscle cells can't close sphincters or reliably adjust the size of blood vessels.

Could rosacea">i, GERD, migraines (sometimes), and even CFSi/ME be considered as "smooth muscle diseases"?

Ron 

 

Here's my sig block:

Ron

On CAPi for CFSi starting 01/06 (NE Ohio, USA)

Currently: doxyi & zithi -- continous; metronidazolei -- 4days on, 7 days off.

Ron

On CAPi for CFSi starting 01/06 (NE Ohio, USA)

Began rifampin trial 1/14/09

Currently: on intermittent

Ron, if the migraines are a major problem, you may well want to look into bruxism and myofascial trigger points. I've posted some very interesting stuff on this over the last 2 weeks at yahoo infectionandinflammation2. I hope to learn more about the subject in the near future.

It might be, Eric, but it seems that Dianna's may have been a result of damage to the mitochondria. They started when the other troubles began, and increased in severity and frequency until she started on the CAPi. She's doing her first pulse right now (2 days is the target) and she has a migraine and GERDi.

 Here's a couple abstracts I thought might be pertinent:

 
 
The second one is especially interesting: they know that there are DNA changes in migraine sufferers, but they don't appear to originate in the genome of the person (if I'm reading it right.) Sounds reminiscent of Kerr's work on CFIDSi/ME to me.
 
Ron 

On CAP for CFSi starting 01/06 (NE Ohio, USA)

Currently: doxyi & zithi -- continous; metronidazolei -- 4days on, 7 days off.

Ron

On CAPi for CFSi starting 01/06 (NE Ohio, USA)

Began rifampin trial 1/14/09

Currently: on intermittent

On GERDi, there's this: Mitochondrian, 2004, September, Gastrointestinal complications of mitochondrial disease. , Hom & Levine<

 Thin, but intriguing: on the level of a rumor about someone passing pictures of a smoking gun? It's not an area where there's much activity: most research seems to be focused on the mechanics of GERD. It is more intuitive, certainly.

Ron 

On CAPi for CFSi starting 01/06 (NE Ohio, USA)

Currently: doxyi & zithi -- continous; metronidazolei -- 4days on, 7 days off.

Ron

On CAPi for CFSi starting 01/06 (NE Ohio, USA)

Began rifampin trial 1/14/09

Currently: on intermittent

Dianna finished her 2-day "pulsette" with colors flying. She told me this afternoon, "Hey, I can breathe through both sides of my nose at once! I don't remember the last time I could do that."

Ron


On CAPi for CFSi starting 01/06 (NE Ohio, USA)

Currently: doxyi & zithi -- continous; metronidazolei -- 4days on, 7 days off.

Ron

On CAPi for CFSi starting 01/06 (NE Ohio, USA)

Began rifampin trial 1/14/09

Currently: on intermittent

Ron,  I'm very excited for Dianna, and I'm watching your reports of her progress closely as well as Michele's and Rica's Richard.  I hope to follow in their footsteps and in David's early next year for my own varied Cpni-related health problems.  As a matter of curiosity, what type of doctor is prescribing the CAPi for Dianna?

Joyce~caregiver-advocate in Dallas for Steve J (SPMSi) / Cpn indicated by reactions; Mpn, EBVi, CMV positive; elevated heavy metals; gluten+casein sensitive / Wheldon CAP since Aug. '06 - doxycycline+azithromycin+flagyli pulses; antivirals; chel

Joyce~caregiver-advocate in Dallas for Steve J (SPMSi).  CAPi since August 06, Cpni, Mpn, B. burgdorferi, systemic candidiasis, EBVi, CMV & other herpes family viral infectionsi, elevated heavy metals, gluten+casein sensitivity. 

Hi Ron and Diana,

Both my oesophagitis and my pharyngitis problems have improved over the past 7 months, even though I was not expecting it to happen.   It appears as if all the minor ailments that have been bothering me in the past 10 to 15 years have improved.   It is great of course to feel better by gradually getting rid of these minor problems and right too I supposed that they should improve before the big stuff does.   Hypertension">i still the same, IBSi may be slightly better, but it is so unplredictable that at times I feel its as bad as it ever was, and sometimes I catch myself feeling good.   The peripheral neuropathy in my feet seems intimately linked with was goes on in my gut.

My crowning glory is a success story though. 

So I hope it works for Diana too. 

Michele:  on Wheldon protocol since 1st May 2006 for a variety of long standing ailments including IBS, sinusitis, alopecia">i, asthmai, peripheral neuropathy, also spokesperson for Ella started Wheldon CAPi 16th March 2006 for RRMSi<

Michèle (UK) GFAi: Wheldon CAPi 1st May 2006. Daily Doxyi, Azi MWF, metroi pulse.

Joyce-- Dianna and I are both under the care of a physiatrist for the CAPi. He kind of came into knowledge of the protocol through the back door -- he has FMA himself, that's why he went into physiatry. Since he's well known in the FMA world, he sees a fair number of CFIDSi/ME patients as well. I went to him and asked if he'd consider this protocol for me, and he contacted Stratton. He now has "several" patients on CAP.

Michele -- we asked for Dianna to do a CAP on the thinnest of rationales, I suppose. The rosaceai was relatively mild, and the other problems that we hoped the CAP might improve were only linked by suspicion to CPni. Her hypertension">i had improved with exercise, and she had had a hysterectomy for the fibroidsi that sprang into existence concurrently with the rosacea">i, dry eye, GERDi, etc.

However, I could find strong links to an asthmai/CPn connection (large majority) and links to GERD/asthma (again, well over 50%), so I knew there had to be at least some overlap. That, and the other comorbid conditions were the reasons we pursued the CAP for her. She also lives with me, so has been continuously exposed for many, many years.

Her migraines had increased in severity and frequency over the last three years to the point that she was having 2 or 3 every week. Within two weeks of adding the doxyi to the protocol (no Flagyl at that time) she was down to one or none per week. She had a migraine, GERD, sweaty rosacea, and rumbly tummy the first day of her pulse, but she's back eating holiday goodies now with the only worry being her waistline. No digestive problems at all, now.

When her migraines went away, I started suspecting that the CPn just generally damages smooth muscles, and that the blood vessels in the brain were haywire the same way the esophagus was. When Eric asked me, I did a little more googling, and broadened the concept to mitochondrial damage. That line of inquiry looks promising, at least.

I loved the pictures of your hair! If Dianna's usually abundant hair increases like yours has, she'll be able to cut topiary sculptures in it -- or donate a wig to some bald husband or someone. 

Ron

On CAP for CFSi starting 01/06 (NE Ohio, USA)

Currently: doxy & zithi -- continous; metronidazolei -- 4days on, 7 days off.

Ron

On CAPi for CFSi starting 01/06 (NE Ohio, USA)

Began rifampin trial 1/14/09

Currently: on intermittent

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