Daisy and Michele have brought up a subject of general interest which I thought deserved its own thread.
Fungal sinusitis, or eosinophilic sinusitis is very distant from my patch but it’s becoming increasingly recognised as an entity. Fungi are found in most people’s noses (and on most people’s skins) and something seems to happen to make them turn bad. The eosinophils in eosinophilic rhinitis and sinusitis may represent an exaggerated host reaction to the fungi; fungal antigens cause the eosinophils to loose their granules, thus beginning a destructive inflammatory process. There’s evidence that chronic C. pneumoniae infection both damages the immune system and makes it hyperreactive to foreign antigens. If this is so, then the control of the C. pneumoniae infection should return the situation to a more peaceful modus vivendi where fungus and mucosa live harmoniously. I’ve certainly experienced a clearness of my nasal passages unknown since I was a teenager. (Evidence that chronic C. pneumoniae infections make for hyperreactivity against foreign antigens can be seen in the exaggerated reaction to mosquito bites. In some people they can cause huge blisters several centimetres in diameter; with treatment this subsides.) In MSi an acute attack of sinusitis can be a prodrome for a relapse; this has been known for decades. Incidentally, eosinophils can do immense damage in allergic asthma - we used to look for them in the sputa of chest clinic patients.
N-acetyl cysteine may be useful in inactivating fungal toxins (gliotoxins) which are pernicious in their destruction of antioxidants.
Another thing I’ve noticed, since starting treatment, is that a dermatophyte infection of my foot has come under control. Previously it was painful, unpleasant and weeping. Clotrimazole powder would make it go for a month or so but it would quickly return. (I often used to wonder why athlete’s foot used to clear up quickly in childhood but not in latter years. I hated it when I got it as a boy, because the authorities would stop you from swimming, which I love.) The dermatophyte hasn’t gone; it’s just barely detectable.
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D W - [Myalgia and hypertensioni (typically 155/95.) Began (2003) taking doxycycline and macrolide and later adding metronidazoleii. No medication now; just supplementsii and IR sauna. Morning BP typically 105/75]
That makes sense to me.
That makes sense to me. Cpni infects my sinus and aggravates fungi... So unless you eliminate either or both you are going to have a chronic infection.
Michele (UK) GFAi: Wheldon CAP1st May 2006 . Daily Doxyi, Azi MWF, Flagyli at 400mg for 7 days prior to 5 day pulses at 1200mg three weeks cycle. Spokesperson for Ella, RRMSi Wheldon CAP 16th March 2006
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Michèle (UK) GFAi: Wheldon CAPi 1st May 2006. Daily Doxyi, Azi MWF, metroi pulse.
Thanks for the further
Thanks for the further explanation, DW. This makes perfect sense to me too, and it seems to explain well my sinus related issues that also seemed to clear up with treatment.
Also, I've battled frequent recurrent tinea infectionsi for over 20 years, but haven't had any recurrence since very early on in CAPi. And while I didn't keep very good notes on my mostly scalp related seb derm (and from what I understand, most would generally consider malessizia yeasts to be implicated in this condition), as I remember, it seemed to start clearing up in early CAP, and disappeared completely when I added in the Vit D3. I haven't had any real signs of it in months.
One odd sinus-related issue I have noticed while now on Vit D3 + NACi + Firi sauna is that when I hit it too hard, by taking a larger dose of Vit D3 or staying in the sauna too long (or turning up the heat setting too high), I get a really awful night's sleep with lots of night sweats and tossing and turning combined with a day or so (if I cut back) of stuffy sinuses and popping ears, generaly lung congestion etc. I got this same result yesterday / last night by adding in a 2 mile run in the heat to my normal regimine.
Again, now for me this is very apparent because normally my sinuses / ears and lungs are completely clear at this point. Could some of this congestion / stuffiness be related to an allergic type response to the endotoxinsi released in a Cpni die-off as well?
On Combined Antibiotic Protocol for Cpn in Rosaceai 01/06 - 07/07, On Vit D3 + NAC since 07/07 and daily FIR Sauna since 08/07
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Treatment for Rosaceai
Thanks for the
Thanks for the insight...
The past few weeks my sinuses have been more active & as well, I have been having problems with my voice box, crackly & have not been able to sing my usual range. Having to do lots of throat clearing. In my 20's I had laringitis a few times for a week at a time? Yes, it was very quiet!!
My husband has had a recurring cough for many years, as soon as he gets run down it takes hold & quickly moves into his chest. He doesn't take good care of himself which totally ticks me off as I have to do overkill on the complete opposite of that spectrum! MEN!!!
Anyway, he is going to be on the NACi soon as his cough settles a bit again. I will take that as a window of opportunity to start & hope my hubby takes his vitaminsi!
Peace
Ruth
CFIDSi/ME 25yrs, FMSi, IBSi, EBVi, Cpni, (insomnia - melatonini, GABA, tarazadone, temazepam, novocyclopine, allergy formula, 2 gm tryptophan), Natural HRT peri-M, NAC 2.5 gm, 6-07 Doxy 200 mg day pm, Azith 375 mg M/W/Fday, 8-21-07 1st pulse 1 X 250 mg Metroi
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CFIDSi/ME, FMSi, MCS, IBSi, EBVi, CMV, Cpni, H1, chronic insomnia, Chronic Lyme, HME, Babesia, Natural HRT-menopause, NAC 2.4 gm,Full CAP 6-2-07, all supplementsi+Iodorol, Inositol-depression, ultra Chitosan, L lysine Pulse#27 04-19-10 1gm Flagyli/day-5 days<
Since starting CAP about
Since starting CAPi about 10 weeks ago, I have noticed an increase in smell. Before hand (since I was a teenager), I have poor olfactory senses. I never knew how bad Lantana's (garden plant) smelt until now.
Mphs, TN. adrenal fatigue and CFSi. 6/26/07- CPNi Titer 1:256 (normal 1:16); 6/27/07-started NACi; 7/2/07-started doxycycline 100 mg twice daily; 7/19/07 started Biaxin 250mg per day. 9/7/07-stopped Biaxin and started on Azithromycin 500 mg every other
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Mphs, TN. CFSi, hypoT (Hashi), adrenal fatigue-almost resolved, severe hormonal inbalance-resolved, right arm neuropathy-getting better. cpni, myco, EBVi, CMV. Capi began in 6/07. NACi 3000mg, minoi 100mg bidi, biaxin 500mg bidi. cytomel, tinii pulses
Nice, Sharon! I call them
Rica PPMSi EDSSi 6.7 at beginning - now 2. Began CAPi Sept, 2004 with Rifampin 150 mg 2xd, Doxyi 100 mg 2xd, added regular pulses Jan 2005. Jan 2006 switched to Doxy, Azith, cont. flagyli total 44 pulses NC USA
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3/9 Symptoms returning. Began 5 abxi protocol 5/9 Rifampin 600, Amoxicillini 1000, Doxyi 200, MWF Azith 250, flagyli 1000. Caffeine pills with AM abxi Began Sept 04 PPMSi EDSSi 6.7 Now good days EDSS 1
David - Excellent reasoning
David -
Excellent reasoning as usual! CPNi or mold to me is a chicken or egg situation? Or I guess to be more precise, is CPN predominantly the "cause" or the "catalyst" of all the various ills we discuss on this site?
Here and Here are two quick bits of information on the original Mayo study and patent on fungal and bacterial sinusitis.
I especially love this quote - "However, patients diagnosed with Chronic RhinoSinusitis (CRS) have an immunologic response to the fungi causing activated white blood cells (eosinophils) to enter their mucus. The activated eosinophils release a major basic protein -- a toxic protein -- into the mucus, which attacks and kills the fungi but damages the nose and sinus membranes. The major basic protein also injures the epithelium, which allows bacteria to infect the tissues."
So in theory if you are already CPN infected, your infected immunei system will travel to the site of the fungal infection and set up permanent house keeping... Otherwise, you in theory are a sitting duck with a fungal infection for picking up all sorts of other bacterium which are also implicated in chronic sinusitis.
The plot thickens... or should I say the mucus thickens...
htmDaisy-Caregiver- Balo's Concentric Sclerosis. Began CAPi 5/10/07.
Doxyi 200 mg, Minoi 100 BIDi 9/1/07, AZI 250mg QDi 9/10/07, NACi 1800 mg QD, HD Flagyli Pulses,Novantrone, Prednisone & daily lb of supplementsi.___________________________________________________________
Daisy - Husband on CAPi 5/07. "When Going Thru Hell, Just Keep Going", Winston Churchill
Oh Daisy, I'm afraid my
Oh Daisy, I'm afraid my predilection for horrid puns may be infectious given your "thickening" comment. Or perhaps the disease has already been well rooted in you. I've not found it curable. In fact it's quite clear that flagyli, or any attempts at treatment make it worse.
David- You've given us a very useful reference point here, which I think will help many with diverse diseasesi but common overlapping co-conditions. In my recent attempts to collate last years survey, the most common diagnosis along with the main complaint has been sinusitusi. Those of us with "immunei deficiency" such as CFSi often assume this is just one more burden brought about by our central condition, that we don't fight these things off, whereas others may never connect their main diagnosed disease with their sinus complaints. Why should MSi and sinusitis have anything in common? Even more so for something like hypertensioni. At least on the surface.
CAPi for Chlamydia pneumonia since 11/04. 25yrs CFS & FMSi- Currently: 300mg INHi, 200 Doxycycline, 500mg MWF Azithromycin,
1000mg Tinii daily(Taking a break from continuous protocol)___________________________________________________________
CAPi for Cpni 11/04. Dxi: 25yrs CFSi & FMSi. Currently: 250 aithromycin mwf, doxycycline 100mg BIDi, Tinii 1000mg/day pulses; Vit D2000 units, T4 & T3, 12mg Iodoral
Here is an interesting
Here is an interesting series of abstracts that trace the recent history of research into CRS. Reading about all the research being done you wonder how these are being funded. Is there a lot of money to be made from curing sinusitis?
The second abstract postulates that CRS is the result of a combination of pathogens, which may vary from region to region and from patient to patient. Fungus is one of them, but they think not the only one.
Michele (UK) GFAi: Wheldon CAP1st May 2006 . Daily Doxyi, Azi MWF, Flagyli at 400mg for 7 days prior to 5 day pulses at 1200mg three weeks cycle. Spokesperson for Ella, RRMSi Wheldon CAP 16th March 2006
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Michèle (UK) GFAi: Wheldon CAPi 1st May 2006. Daily Doxyi, Azi MWF, metroi pulse.