Cpnhelp.org

Timaca       

Doxyi alone is not enough as you may be aware of; however, flagyl is not the next antibiotic to add at this point.  At this point, you are should be targeting two of the three stages of Cpni - the EBi (elementary body) and RB (reticulating body) stages. 

For the EB stage, you should be taking either NACi (n-acetyl cysteine) or amoxicillini.  There are related alternative antibioticsi that can be used instead but that is generally the most common and favored one I've seen used.  If you take NAC, you get a similar result without the impact on your intestinal flora plus you get liver protecting benefits.  That is not true with amoxicillin.

For the RB stage, you should be taking 2 bacteriostatic antibiotics.  Azithromycin is one and Doxycylcine in another.  Roxithromycin and Rifampin are still other options as well.  By taking two of these, you help to prevent resistance from emerging in the Cpn you're fighting off.  Without taking two, you're at greater risk of that happening so you need to add another bacteriostatic antibiotic.  Flagyl is not one of them, it is used for the third stage of Cpn.

The third state is the CB (cryptic body) stage.  This is the stage where the Cpn bacteria has hunkered down to survive either bacteriostatic antibiotics or you body's immunei system.  It becomes anerobic so the normal, bacteriostatic antibiotics do not affect it in this stage.  A bacteriocidal antibiotic that kills anerobic bacteria is needed.  That means Flagyl (metronidazolei) or Tinii (tinidazole).

Generally, flagyl is used after you have started treating the first two stages and have down so for a period of time such as 3 months.  Doing so ensures that you can tolerate the treatment and have a baseline for how you feel and what to expect.  So, definitely add another bacteriostatic antibiotic first and then add flagyl later once you know how things are going.

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all my best

John

RRMSi/EDSSi was 4.5, 5, now 6 on Wheldon Protocol (naci, doxycycline, azithromycin, metronidazolei) since 04/12/2006. Added Rifampin 2x150mg/daily 08/19/2007. Added INHi 300mg/daily 03/17/2008 stopped 05/08

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Rica PPMSi EDSSi 6.7 at beginning - now 2. Began CAPi Sept, 2004 with Rifampin 150 mg 2xd, Doxyi 100 mg 2xd, added regular pulses Jan 2005. Jan 2006 switched to Doxy, Azith, cont. flagyli total 55 pulses LDNi Rifampin 8/08 again NC USA

farandwide~  I appreciate your detailed explanation.   Thank you.

katman~   I take Florastor once a day (a beneficial yeast--saccharomyces boulardii) and I rotate 4 different brands of probiotics (taking one each day, to get the greatest variety of beneficial bacteria).    I, unfortunately, am the queen of probiotics (due to being the queen of toilet paper and stool cultures in the past).   Thanks for the reminder to all to take the probiotics.

Best,    Timaca

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Diagnosed with lyme disease 3/05. Diagnosed with chronic HHV-6, EBVi, VZV, and HSV1 6/07. Diagnosed with CPni 5/08. On antibioticsi for 2+ years, Valcyte (antiviral drug) for 9 months. Currently on 100 mg doxyi bid for Cpn and acyclovir for viruses.

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Michèle (UK) GFAi: Wheldon CAPi 1st May 2006. Daily Doxyi, Azi MWF, metroi pulse. Zoo keeper for Ella, RRMSi, At worse EDSSi 9, 3 months later 7 now 6.5 Wheldon CAP 16th March 2006