Flagyl (metronidazole) versus Tinidazole (Tinactin): differential responses?

As we have more people on the CAPi protocolsi longer, our community is accruing clincal priceless experience with the different medications used and course of improvement and diffficulties on the CAP. One of these areas for observation and discussion has been use of Tinidazole versus Flagyli, and it's effect on treatment and course of recovery. There has been another thread discussing these, but I thought it was time to restart the discussion now that a number of people have experienced switching back and forth between these meds. So my own comments (posted on Rica's blog also) below.

Tini vs Flagyl-- interesting questions.

I have to say, after doing Tini since pulse 3 and then trying Flagyl again for my last pulse (pulse 16) they do have different effects. Not just different side effects. It is possible, as our clinical experience accumulates, that there could even be good reason to do courses of both, or alternate them for pulses.

I had felt I'd reached, if not a plateau, at least a slowed rate of improvement in my major symptoms: brain fog, fatigue, flares of inflammationi. The Flagyl pulse made for a significant improvement in brain fog and fatigue-- at least during the pulse (I got a stomach virus right after, so can't yet assess post-pulse baseline).

Although we know that Tini has longer half life and better minimum kill concentration than Flagyl, these are general blood levels. How they concentrate in different organ tissues is not at all clear.

It's also my impression, from reading reactions of people earlier in the protocol, that while Tini is easier to take (that's why i switched) and gentler in side effects during the pulse, people may have longer post-pulse reactions from it. So the notion that there is a "behind the scenes" process going on could be from it's longer action, as well as lack of clarity about improvements on multiple, closely spaced pulses with Tini, ie if you are still getting reactions by the time you pulse next, you may not be seeing improvements as your system doesn't get to repair (or at least not in a way you can discern). 

So, if we hypothesize a situation where Tini & Flagyl get at Cpni better in different tissues, one from another, and that the concentrations and post-pulse profiles are different, there may be value in alternating. Clearly, for most of us it would be easier to start with Tini (although more costly). But worth trying a course of Flagyl after the bacterial loadi is down enough to see if it has some differential effect.

Let's keep gathering info on this. I'll post this on it's own thread to accumulate observations there, so we don't highjack Rica's.  

Combined Antibiotic Protocol for Chlamydia pneumonia in Chronic Fatigue Syndromei & Fibromyalgiai- Currently: 150mg INHi, Doxycycline/Zithromycin, Tinidazole pulses. Northern Ohio, USA

I started with metroi, first pulse (full pulse, except first day) I did not feel many reaction. Some depression or bad mood, which dissapeared relatively quickly and few days after pulse I felt some pain in my "bad places" in the body. But it was not extremely strong and I recovered quickly. I started second pulse and during the pulse I had some cardio problems and felt pain in my heart, but again not so strong, mostly intermitent. But few days after pulse it hit me really hard. From hour to hour I came down with terrible depression, strong pain started in my neck, shoulders, back, I got strong migraine,  pain in my abdomen worsened and felt like having flu for couple of days. I was recovering very slowly, more than month I still felt consequences of pulse. And my depression lasted and lasted for weeks. Before third pulse I was really afraid about what metro brings, so I switched to tinii and took 2x500mg for five days. It was very different from metro. I had much more energy during pulse and no negative feelings. After pulse I felt again some pain in my "bad places", but it was manageable. No negative mental changes (I continued with medc against depression, which I started after second pulse). After this third pulse something happened in my body, I felt positive change in my worst place- in my abdomen, pain decresed significantly. It was first time I felt something like this and was happy. This positive change is still lasting, so I hope it will continue. Next pulse I plan again tini, but I am short of it, so will have to swich to metro after. We can compare it after more experiences. It seems to me like good idea starting with tini and then switching to metro more prepared with lower cpni load.

Prague, The Czech Republic, On Wheldon protocol for Cpn and Mycoplasma since 02/18/2006.

Stratton/Wheldon protocol 02/2006 - 10/11 for CFSi and many problems 30 years

Lala

If this had been available at my beginning I may have done the same.    I am happy that you are started on the next part and look forward to a better, healthier future for you and wish you great success. 

Rica        EDSSi 6.7 at beginning - now 2
Ignorance is voluntary bad luck.  Lauritz S.   A true Viking
If you come to a fork in the road, take it. Yogi Berra

3/9 Symptoms returning. Began 5 abxi protocol 5/9 Rifampin 600, Amox 1000, Doxyi 200, MWF Azith 250, flagyli 1000 daily. Began Sept 04 PPMSi EDSSi 6.7 Now good days EDSS 1 Mind, like parachute, work only when open. Charlie Chan  In for the duration.&am

I am currently in the middle of my first Tinii pulse (Day 3) after doing 5 "pulses" (not all full 5 day pulses & only 500 mg each day) of Flagyli. So far. I have noticed a HUGE difference in the 2 AB's! My reactions to Flagyl were very strong...In fact the last pulse was pretty nasty...symptoms included nausea, decreased appetite, depression, fatigue & evening anxiety on Days 3-6. So far, the side effects of Tini have been mild.

There have been a few changes to my supplementsi tho' & the addition of Provigil for combatting my extreme fatigue, so it's difficult to know if I can really compare the 2 types of pulses accurately. But I imagine that if I was to have a strong reaction to the Tini, it would happen anyway.

My new supps/ changes are: upped doseage of Acetyl-L-Carnitine to 1,000mg daily, upped Boron doseage to 9mg daily, upped NACi doseage to 2400mg daily, added Entrox (Perilla Seed Extract), added Indole-3-Carbinol, & added Curcumin. The new supps are supposed to help with Endotoxini-related symptoms, energy, mental clarity & hormonal issues. So, either they ARE helping or the Tini is easier for my body to tolerate...or it's a little of both!

I will post again after I've finished this Tini pulse & have let a few days go by post-pulse. I'm certainly hoping the mild symptoms continue!

BTW, the Provigil totally eliminated my severe Fatigue Attacks! I was hesitant to take a stimulant medication, but desperate times call for desperate measures. I only took 1/4 of a pill in the A.M. After about 5 days; I actually felt  slightly "hyper", so I'm taking a break from the Provigil to see how long I can go without the severe fatigue returning. Without those fatigue crashes 2-3 times a day, I feel so much more close to "normal"! (Something I haven't felt in 13+ years!) It wasn't until I had fatigue/ crash-free days that I could really think clearly about the progress I have made on the CAPi! I am optimistic that I'm improving enough to really feel inspired to continue on the protocol! Amazing what a boost energy can be to one's outlook! Wink (Even if it is drug-induced!)

More later...

Hugs,

Annie 

Primary Dxi:FM x 13+ years, On Dr.Powell's Cpni Protocol since 1/06, Currently taking NAC/Azithromycin/Tini/Oodles of Supps, Northern California.

Day 3 Post Tinii Pulse....

Hi again! Well, my first Tini pulse was a breeze compared to the previous Flagyli pulses! I took 1 Tini in the A.M.'s on Days 1-3 of the pulse. I was feeling so terrific that I upped the dose on Days 4 & 5 to twice a day. No problem!

Here's what I have experienced so far...

During the Tini pulse, I felt great! I was energized with an amount of energy that I haven't felt in many, many years. At first, I thought that I was feeling wide awake from taking a low dose of Provigil for 4 days prior to the pulse. But I discontinued the Provigil & the energy remained! The only explanations I came up with for going from MAJOR Fatigue Attacks daily to high energy were: 1) A miracle 2) Provigil had an effect on my brain/ body which somehow lasted 3) Doubling my doseage of Acetyl-L-Carnitine/ alpha lipoic Acid">i helped and/or 4)the Tini has an energy-enhancing effect? I'm baffled. Any guesses? Instead of trying to figure it out, I've decided to simply rejoice & enjoy my newfound energy!

Other Tini pulse symptoms were: bladder irritationi/ pain, felt "yeasty", so I took Diflucan, & an increase in muscle/ joint pain.

Since Day 5 of the pulse, I've been having multiple, loose BM's (sorry), which is not typical for me. Yesterday I had some mild, transient nausea & the return of a Fatigue Attack (just one). Today it's more GI rumbling/ action & joint/muscle pain, but nothing terrible.

My reaction to low dose Flagyl was much stronger than the Tini. (So far) During my last Flagyl pulse, I had depression, anxiety, nausea, fatigue, lots of tingling, & increased muscle/joint pain. It was nasty.

So, I guess time will tell if the Tini pulses continue to be gentler on my body & mind.Hopefully it's still killing off the Cpni! It is interesting that some people here have had the reverse reactions...More symptoms from the Tini vs. the Flagyl.

Well, that's my story so far. If things change drastically, I'll update this.

Blessings,

Annie

Primary Dxi:FM, On CAPi since 1/06, Dr.Powell's Protocol, Currently on NACi/Azithromycin/Tini/Oodles of Supps,Northern CA.

 


 I noticed a pretty big difference in flagyl/metronidazoles generic versus brand name side effect wise when I took them for a different infection. The brand name was easier on me nausea and metallic taste wise.

 Its possible different brands may cause different hardships side effect and kill off wise.

CAPi- zithro, flagyli, plaquenil - CPNi +, fibromyalgiai, endometriosis, b12 deficiency

Wow, glad you "bumped" this post! Guess I should really update this as my Tinii pulse experiences sure did change! My first pulse was easier for me than the previous 5 Flagyli pulses. The next 2 Tini pulses were NOT so kind!...I blogged this on another post:

Symptoms During Tini Pulses: 

Increased Pain 3/3 pulses, Urinary Bladder Pain 2/3, Irritability 2/3, Fatigue 2/3, Headaches 2/3, Tinglys 1/3, Decreased appetite 1/3, Slight Anxiety 1/3, Major Depression 1/3 (during pulse that was 500mg twice a day), Increased TMJ pain 1/3, Dry eyes 1/3, Nausea 1/3, Migraines 1/3, Body itchiness 1/3

Symptoms Immediately Following Tini Pulses:

Increased Pain 3/3, Fatigue 3/3, Decreased Appetite 3/3, Nausea 2/3, Body Itchiness 2/3, Dry Mouth 2/3, Very Low Energy 2/3, Tingly Head 2/3, Low Blood Pressure/ Light Headedness 2/3 {e.g. BP : 74/46!}, Meunstrual Spotting at weird time of cycle 2/3, Stomach Pain 1/3, Vomitting 1/3, Excessive Intestinal Gurgling in lower right intestine 1/3

Sounds like fun/ a good time , huh?!!!

So, as you can see; I experienced pretty nasty symptoms during and after the Tini pulses. I am currently on a CAPi "vacation". (Instructed to do so by Dr.P's office.) My stomach/ intestinal problems have subsided since I am not swallowing 80 pills a day. Yesterday, I started back with taking NACi. This time; I'm going to take it SLOWLY! I am going to add back Azithromycin, Niacinamide, Curcumin, Lutimax & Tini pulses...I am planning on adding one at a time, spaced out by at least a week each time. This way, I'll be able to tell what exactly my body is reacting to! All I know is that before my "vacation", my bod was on overload!

Blessings,

Annie

Primary Dxi:FM, On CAP since1/06, On Dr.Powell's protocol, Currently taking: NAC, Northern CA.

Hi Annie, my last tinii pulse (4th of tini) also hit me hard. I experienced pain completely in all my body. As you wrote- lower right intestine-it is place, where I feel pain constantly for years. And gurgling every day. Anybody else? It is also place of appendix, where lots of immunei cells is concentrated. So maybe, that is why we have problems here..infected immune cells in our right lower intestine- only idea..

Prague, The Czech Republic, On Wheldon protocol for Cpni and Mycoplasma since 02/18/2006.

Stratton/Wheldon protocol 02/2006 - 10/11 for CFSi and many problems 30 years

Lala, How interesting that you also experience the right- sided intestinal gurgling! I know it's not my Appendix as I had mine removed due to acute Appendicitis 17 years ago!

I have been trying to figure out this excessive gurgling over the past month. It started at the end of August & got extreme right after my last Tinii pulse. From 9/11 to just a few days ago, I was having major rumbling/ gurgling...mostly right where the stomach empties into the intestines. (Just above where my Appendix scar is.) The gurgling is so loud, others nearby can hear it! I was running a low fever for over a week & thought I better not just assume that these were pulse-associated symptoms! My new GP was a little befuddled...Told me it could be viral or a flare up of IBSi & my chronic Gastritis...Eventually, things have settled down a bit & the fever isn't happening.

One thing I have remembered throughout this is that last September, I experienced the same type of stomach pain/ intestinal rumblings! I had a consultation with the head Dr. at UCSF's GI clinic last September...without reading all my history & without examining me, he diagnosed me with "severe IBS"! His answer...take an antidepressant & go into psychotherapy to find out why I was so stressed out to cause the IBS! (BTW, I didn't do either!) He told me IBS often occurs with Fibro & that my body was simply overreacting to normal bodily functions.(Perceiving normal GI movement as discomfort/ pain.) OK, whatever!...a huge waste of time/ effort! (Wouldn't go back there again!)

Anyway, I have had a general inflammatory period since August...Increased Arthritis pain, muscle pain, Tendinitis pain, Gastritis, intestinal problems, Post Nasal/ Seasonal allergy symptoms...It is difficult to pinpoint WHY?! I theorize that this time of the year (wine harvest season here!) is rough for my body(the inflammationi happens every fall for me) & doing the Tini pulse at the beginning of Sept. really pushed me over the edge!

Anyone else experience the major intestinal rumblings? I think I remember Jim mentioning it in a recent post. Maybe our GI systems are loaded with Cpni & pulsing/ the protocol flare things up?

Hugs,

Annie 
Primary Dxi:FM, On CAPi since1/06, On Dr.Powell's protocol, Currently taking a CAP/supp "vacation", only taking NACi/a few supps & meds, Northern CA.

Annie, I also had my appendix removed 11 years ago and since that I have had problems till know. Pain in right intestinal and big painful cramps after main or bigger meal. During the operation they cut through my normal gut by mistake and then I had big inflamation in my abdomen. I was on second reooperation, but they did not find anything unusual. It seemed to me, that inflammationi continued for years. Now I have cramps only occasionaly, my digestion improved greatly and I feel big activity in this place constantly, much worse always after pulse. They also told me it is "psychic"- which is nonsense. I am not suprised, that we had problems with appendix, if infected immunei cells concentrated in our appendix realeased many EBs, everything seems to be logic.

Prague, The Czech Republic, On Wheldon protocol for Cpni and Mycoplasma since 02/18/2006.

Stratton/Wheldon protocol 02/2006 - 10/11 for CFSi and many problems 30 years

> gurgling every day. Anybody else?

It was fairly mild in degree, but I had it going all day every day, every 5-15 seconds. It would still be going when I'd wake up (which was 7-15x per night). All cleared up nowadays.

Yes me too, gurgling and pain everyday..

Prague, The Czech Republic, On Wheldon protocol for Cpni and Mycoplasma since 02/18/2006.

Stratton/Wheldon protocol 02/2006 - 10/11 for CFSi and many problems 30 years

> gurgling every day. Anybody else?

During a pulse and immediately after (2-5 days post-pulse)

Ron

On Stratton protocol for CFSi starting 01/06 (NE Ohio, USA) Currently: doxyi, zithi, Flagyli; 4days on, 7 days off.

Ron

On CAPi for CFSi starting 01/06 (NE Ohio, USA)

Began rifampin trial 1/14/09

Currently: on intermittent

lala,

 It could be adhesions from surgery? Scar tissue basically. But when they get removed it frees up things and feels much better. Problem is any abdominal surgery can lead to adhesions, even the surgery to remove them. Wonder if the cpni gathers in adhesions as well.

CAPi- zithro, flagyli, plaquenil - CPNi +, fibromyalgiai, endometriosis, b12 deficiency

Looking for reasons to convince my doc for Flagyl I found this thread.  This is really funny. I have this gurgling so extreme, that I have let a laparoscopy be done. They loosened adhesions, but gurgling remained. It disappears with antibioticsi and I still cannot imagine what this may be. I asked for maybe a lot of fibrine, but they said that they saw nothing which would been worth to mention. Very strange.

Anyway, is there a place where the effect of metronidazolei is mentioned in detail? I know it is supposed to work on the cryptic formi, but how? I may need some further information. My doc was very interested in NACi and maybe he is open for all the suggestions. But he goes into detail and won't spend much time in reading. I would have to have it in short terms.

gitta, Germany 

Postinfectious arthritis, CFSi, Asthmai, Hypertension">i, Zithi since 20th Sept 06 -  first 3/7 500 mg, since Nov 06 reduced to 3/7 250 mg. Doxyi since Nov 06 - 200 mg per day, NAC 600-1200 per day

gitta, Germany 

Postinfectious arthritis, CFSi, Asthmai, Hypertension">i, Zithi since 20th Sept 06 -  3/7 500 mg. Doxyi since Nov 06 - 200 mg per day, NACi 600-1200 per day

gitta, your doctor may think this page is "just right"; concise and professional.

http://www.cpnhelp.org/?q=wheldon<

I like the graphic approach: look at http://www.cpnhelp.org/?q=simple< and print the picture that is just after #4 on the page for your doctor.

Ron

On Stratton protocol for CFSi starting 01/06 (NE Ohio, USA)

Currently: doxyi & zithi -- continous; metronidazolei -- 4days on, 7 days off.

Ron

On CAPi for CFSi starting 01/06 (NE Ohio, USA)

Began rifampin trial 1/14/09

Currently: on intermittent

Here< is a good comparison review from Medscape on Tindamax and Flagyl. 

Several posters here have remarked that Tindamax is better tolerated than Flagyl - makes me wonder if Flagyl may hit people harder with porphyriai Vs Tindamax due to P450 metabolism. 

The data seems to be conflicting on how each drug is metabolized. 

This review from Medscape says "In an in vitro study, tinidazole was not observed to inhibit hepatic cytochrome P450 enzymes. " 

From Tindamax PI labeling,  "Tinidazole is biotransformed mainly by CYP3A4. In an in vitro metabolic drug interaction study, tinidazole concentrations of up to 75 [micro ]g/mL did not inhibit the enzyme activities of CYP1A2, CYP2B6, CYP2C9, CYP2D6, CYP2E1 and CYP3A4. "

From March 2007, The Annals of Pharmacotherapy on Flagyl - Link<

Elevated plasma concentrations and toxicities have been reported for a number of CYP3A substrates including amiodarone, carbamazepine, quinidine, tacrolimus, and cyclosporine when administered with metronidazolei. This has led to the widespread belief that metronidazole is a significant inhibitor of CYP3A4. However, 4 pharmacokinetic studies conducted in humans showed that metronidazole did not increase plasma concentrations of the CYP3A substrates midazolam, erythromycin, cyclosporine, and alprazolam, thereby refuting the suggestion that metronidazole is a CYP3A4/5 inhibitor.  

Either way, we start Tindamax tomorrow.  Perhaps less porphyria???

Daisy - Husband on CAP 5/07.   Roxithromycin, Minocycline, Rifampin, Bactrim DS, Mepron, Prednisone, Novantrone, Doxyi, Azithromycin, Flagyl, Diflucan

Daisy - Husband on CAPi 5/07.  Husband died from Acute Myelogenous Leukemia Secondary to the Infusion of Novantrone.  Ie - the treatment with the conventional MSi drugs killed him.

Daisy on her own CAP 11/2012. 

I'm going to miss it when I don't have CPni causing secondary porphyriai or the antibioticsi poisoning me with endotoxinsi because I won't have any more excuses for being a pain in peoples' backside. 

CAPi for M.S. since 8/2007. Currently: 100 mg Dox. (2 x day), 250 mg Zithi (3 x week) ceased 3/2008, restarted 5/2008, 150 mg Roxi (2 x day) starting 3/2008, ended 5/2008. Ninth pulse metronidazolei completed 6/7/2008.

CAPi for M.S. 8/2007 - 3/2009.  Twentieth pulse metronidazolei + INHi completed 3/12/2009.  Intermittent treatment thereafter until 11/20/2009.  

 Ah, HD, there's an old saying: "So, did you mean to be rude, or is it just your way?"

Daisy- I've always wondered about the differences in response to these agents. This might explain why early on I couldn't tolerate Flagyli at all, because of porphyriai and probably liver Cpni, and now I can though it makes me depressed! I still prefer Tinii. Always more to learn.

CAPi for Cpn 11/04. Dxi: 25yrs CFSi & FMSi. Currently: 300mg BIDi Roxithromycin, Bactrim DS 2x/day, Tini 1000mg/day pulses; Vit D2000 units, T4 & T3

 

CAPi for Cpni 11/04. Dxi: 25+yrs CFSi & FMSi. Currently: 250 aithromycin mwf, doxycycline 100mg BIDi, restarted Tinii pulses; Vit D2000 units, T4 & T3, 6mg Iodoral

Thanks Daisy, I will be waiting and hoping that the Tinii makes a difference with your husband's secondary porphoria.   I look forward to any more posts you have to add to this topic and do want to be sure to log in now to follow it.

Louise USA.CFSi.CPn Positive.BbPositive.WheldonCAP6/24/07.NACi,Doxyi,Roxi, Tinidazole Pulses. VitD-3,4000IU. Intermittent Cholestyramine 1-2 packets atbedtimewithpulses&asneeded forporphoria&endotoxinsi

  • CAPi(TiniOnly): 06/07-02/09 for CFSi<
  • MethylationProtocolSupplements: Started08/08
  • Intermtnt CAP: 02/09-02/10
  • Full MethylProtocol & LDNi 02/09
  • Off CAP: 02/10, cont LDN & MethlyProtocol support
  • <
"So, did you mean to be rude, or is it just your way?" Thank you for that quote, Jim, I must carry it around in my mind, to respond to relevant people at all times e.g. consultants M.E./CFSi 20 years, intermittent.  Wheldon Protocol - Started NACi and supplementsi Sept 2007. Doxyi and Roxy full dose by Dec '07.  First Flagyli pulse January 2008.
M.E./CFSi 20 years, intermittent.  Wheldon Protocol - Started NACi and supplementsi Sept 2007. Doxyi and Roxy full dose by Dec '07.  First Flagyli pulse January 2008.  Changed to Tinii in December 2008.  Stopped CAPi in February 2009 at pulse 16.
Metronidazolei made me vomit the first year on CAPi. Tinii didn't make me vomit, but it was much more expensive. Combined Antibiotic Protocol minocycline, azithromycin, metronidazole for muscle pain, insomnia, interstitial cystitisi, sinus, disphonia, dry eyes, stiff neck, veins, thyroid, TMJ.

minocycline, azithromycine, metronidazolei 2007-2009, chelation for lead poisoning, muscle pain, insomnia, interstitial cystitisi (almost well), sinus, dry eyes, stiff neck, veins, hypothyroid, TMJ, hip joints (no longer hurt)

I get the gurgles too and I'm not pulsing yet. Must be one of the other abxi.

Berkshire, UK. Diagnosed RRMSi Feb 4th 2008.

NACi 2400mg. All supplementsi. Doxyi 200mg. Zithi 250mg M/W/F.
No GP/Neuroi support. Self medicating with help from David Wheldoni.
Started CAPi 20th April 2008.

Berkshire, UK. Diagnosed RRMSi Feb 4th 2008.

NACi 2400mg. All supps. Doxyi 200mg. Zithi 250mg. Metroi 400mg.
No GP/Neuroi support. Self medicating with help from David Wheldoni.
Started CAPi 20th April

I did my 1st tinii pulse about 2 months ago: 3- 500 mg pills over 2 days. The first one was a breeze. I slept for two days, had a bit of a headache and then was fine. This 2nd pulse produced sinus pain, aches and tinglies in my legs (especially the broken ankle) and tiredness but not sleep. About 3 days after the last pill I beame weak, sleepy, extremely depressed, unable to limp as well as before, and now, 2 weeks later, my sinuses hurt from the top of my head down to the glands under my jaw. And I am tired and weak.

Still, it's better than flagyli!

PPMSi-misdiagnosed 2001-diagnosed 2006. Probably caught cpni in birth canal but it didn't pass BBBi until my 40s. Minocycline 7 mos.- resulting bronchitis 5 months.Go to private m.d. out-of-plan. Wheldon CAPi 3/2/07 Stopped 12/12; resumed 12/13

I finished the primary 4 beginning years of the treatment. These years showed me that the protocol made me feel like a non-human as there is such a tremendous level of the inflammationi, that after these beginning 4 years of my treatment, I can say that I have hardly managed it.

Now the protocol is more managable for me and I even added a high quantity of vitamin Di.

My body still feels completely rottened but at least I can manage this regimen without so much pain.

I hope I could eventualy get rid of this dramatic disease witin 12 years.

CFSi, Severe Peripheral neuropathy, Insomnia, Azitromycine/Clarithromycine/Roxytromycine, Doxycycline 2x100mg, Caffeine every day, Tinidazol for pulsing, ACC 2 x 600 mg -  treatment duration: 24 months

how is rifampin, I heard it can damage your liver so I'm going to take NACi?  I had a granuloma in my lung and my mom had TB so I'm going to try isoniazid too.  I just can't exhale at all after taking amycin for 6 weeks. 

I think I had a stroke after years of asthmai, sleep disorders and low oxygen.  I can't pronounce words, lost some hearing and my vision is blurry and of course terrible brain fog.
tried azithromycin 6wks, couldn't exhale after
tinidazole

Crippled, please read my reply on your last post and act upon it........................Sarah

Completed Stratton/Wheldon regime for aggressive secondary progressive MSi in June 2007, after four years, three of which intermittent.   Still improving bit by bit and no relapses since finishing treatment.

I think my condition is an emergency, I can't work because of the severe brain fog and exhaustion and I was having tachycardia of 125.  what kind of reaction could I have to rifampacin and isoniazid?  it's the standard treatment for TB? 

I have read your liver can be damaged on rifampacin, but maybe I could try short courses

is there a CPNi or Lyme's doctor in NY I could go to? 

I think I had a stroke after years of asthmai, sleep disorders and low oxygen.  I can't pronounce words, lost some hearing and my vision is blurry and of course terrible brain fog.
tried azithromycin 6wks, couldn't exhale after
tinidazole

You are damned right about an emergency, so go and see a doctor! Rifampicin and INHi are standard treatment for TB, but not for a short period.  Once you start on rifampicin you have to stick with it.  If you are in New York, there are doctors everywhere.  I thought you were in Indonesia or somewhere so where are you?...........................Sarah

Completed Stratton/Wheldon regime for aggressive secondary progressive MSi in June 2007, after four years, three of which intermittent.   Still improving bit by bit and no relapses since finishing treatment.

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