Antimicrob Agents Chemother. 2005 Sep;49(9):3959-62.Click here to read Click here to read Links
Effect of simvastatin, an established lipid-lowering drug, on pulmonary Chlamydia pneumoniae infection in mice.
* Erkkila L,
* Jauhiainen M,
* Laitinen K,
* Haasio K,
* Tiirola T,
* Saikku P,
* Leinonen M.
National Public Health Institute, Department of Viral Diseasesi and Immunology, P.O. Box 310, 90101 Oulu, Finland. leena.erkkila@ktl.fi
The effects of simvastatin treatment on Chlamydia pneumoniae lung infection, inflammation, and serum lipids in mouse model were studied. Simvastatin decreased viable chlamydial counts and increased inflammatory cell infiltrates in the lung tissue, suggesting that simvastatin treatment had both antichlamydial and immunomodulatory effects during an acute C. pneumoniae infection.
PMID: 16127082 [PubMed - indexed for MEDLINE]
This is interesting if considered as there is a considerable amount of information suggesting the statins may be of help in many inflammatory conditions. Atherosclerosis is both frequently associated with CPn and positvely affected by statins while in the field of MSi statins are just beginning to show promise and we also have early evidence that infection is likewise possibly causing the inflammation.
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On CAPii since Sept '05 for MSi, RAii, Asthmaii, sciatica. EDSSii at start 5.5.(early cane) Now 6 (cane full time) Originally on: Doxyi 200, Azith 3x week, Tinii cont. over summer '07, Revamp of protocol in Summer '08 by Stratton due to functional loss; clarithromy
This is interesting
This is interesting reading, even though it does not give us any definite answers in the case of a chronic infection, this evidence together with the empirical evidence would suggest that statins have a beneficial effect in the treatment of Cpni. I include the link here, as it seems to have disappeared from Marie's post.
Thanks Marie for all this new and updated information you have posted.
Michele: Wheldon CAP1st May 2006 for ailments including IBSi, sinusitis, alopeciai, asthmai, peripheral neuropathy. Spokesperson for Ella started Wheldon CAP 16th March 2006 for RRMSi. Sussex UK
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Michèle (UK) GFAi: Wheldon CAPi 1st May 2006. Daily Doxyi, Azi MWF, metroi pulse. Zoo keeper for Ella, RRMSi, At worse EDSSi 9, 3 months later 7 now 6.5 Wheldon CAP 16th March 2006