Cpnhelp.org

I got the same problem and I'm getting no answers at ebvⁱ.org.

My titres:

EBV VCA IgM = 5,1 (reference < 9)
EBV VCA IgGⁱ = 49,5 (reference < 9)
EBNA1 IgG > 50 (reference < 9)

HHV6 IgG 1:64 (reference 1:16)
HHV6 IgM 1:16 (reference 1:16)

What do these figures tell???

A

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Male(44).Germany.Immuneⁱ defficiency.Cpnⁱ+.CAP08/2008-12/2009.Q10,NACⁱ.Diagnosis:CVID.

That means not much.  Just about everyone has had or has EBVⁱ.  My EBNA are over 600 with the blood test only going to 600 in range and 18 or below negative.  My I.D. said that info is not enough for active EBV, she takes additional to confirm.  IgM is one marker for active EBV but yours is not high.  The only for sure is you have been exposed to EBV and HHV-6, so has everyone just about.  If you are concerned at those levels take a MONO SPOT test too but I would not worry much you have low values.

Take the Cpnⁱ IgGⁱ, IgM, IgA panel and a Tetanus Anti-Toxoid test for general immuneⁱ system activity, a good marker used by my docs for an overactive immune system.  Do not forget the NACⁱ test.

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Cpnⁱ, Mycoplasma, Chronic EBVⁱ, M.S.(MRI, Spinal Tap-greater than 5 oligoclonal bands and VEP), PANDAS(OCD). Wheldon CAPⁱ (started 12/08), Azithromycin/Clarithromycin(12/09), Lithium, Lamictal, NACⁱ(2.4g/day), D3(12,000IU/day)

Thank you, moxy. You helped me out a lot.

What's the NACⁱ test? (I'm in month 15 of the Wheldon scheme and Cpnⁱ titres are down.)

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Male(44).Germany.Immuneⁱ defficiency.Cpnⁱ+.CAP08/2008-12/2009.Q10,NACⁱ.Diagnosis:CVID.

Here is a link to an article about chronic EBVⁱ infection:

http://www3.interscience.wiley.com/cgi-bin/fulltext/111088889/PDFSTART

These authors find EBV VCA IgGⁱ of >=1:640 and EA of >=1:160 in patients with chronic active EBV infection (CAEBV).

This link gives additional info:

http://www.vicd.info/testing.html

Dr. Montoya's criteria for participation in his recent research is at this link:

http://clinicaltrials.gov/ct/show/NCT00478465?order=1

The criteria he used is:

 Patients with "high" antibody titers against HHV-6 IgG ≥ 640, EBV VCA IgG ≥ 640 and detectable EA Ab at 1:160 or HHV-6 IgG ≥ 320 if EBV VCA IgG ≥ 1280 and has detectable EA Ab at 1:160 (measured by the average of a minimum of two time points obtained during screening at least 3 weeks apart).

These reference ranges are different than the reference ranges of the lab you were tested at.  

JJ, I've had CMV and Parvo tested with a reference range like your EBV.  My results are similar to yours and the doctors are not concerned.   My EBV testing has a reference range like what I posted above:  1:5120, etc.   To be sure, you could try to get an EBV panel done at Focus Diagnostics Lab, which includes the EA.   

 http://www.focusdx.com/focus/1-reference_laboratory/search_frame.asp?searchOptionScope=2&S1=1&S2=1&test=&sp=2420&Keyword=2420#an_2420 

Andreas~  Your values do look high.  Since you live in Germany I don't know what to suggest, except see if there is also an EA test in your country.  

There are some videos on EBV on the HHV-6 website:  http://www.scivee.tv/node/7965/video  

Best, Timaca

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Dx  lyme disease 3/05. Dx HHV-6, EBVⁱ, VZV, and HSV1 6/07. Dx with CPnⁱ 5/08 and enterovirus 2/09. On antibioticsⁱ for 2+ years, Valcyte (antiviral drug) for 9 months. On 100 mg doxyⁱ bidⁱ for Cpn, acyclovir for viruses, oxymatrine for enterovirus

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Male(44).Germany.Immuneⁱ defficiency.Cpnⁱ+.CAP08/2008-12/2009.Q10,NACⁱ.Diagnosis:CVID.

Thanks Timaca.

 My CMV IgGⁱ ratio was 2.7, for whatever that's worth.

The one that seemed to concern my doc the most (which still wasn't a lot) was the Streptozyme titer of 1:100.

 No Cpnⁱ results to report yet, as I hadn't found this site when the initial blood work was done. We were thinking "chronic infection" but she just scattershot on the bloodwork.

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CAPⁱ started 10/09 - Doxyⁱ 200mg, Azith 250 MWF, 1 Flagylⁱ pulse. Empirical CAP on suspicion of CPnⁱ or tick-borne infection. Primary symptoms are chronic sore throat, muscle pain (jaw, neck, trapezius, all on right side), rosaceaⁱ, joint pain.

Just found this and believe it applies to the test that was run on my blood (still doesn't say whether it's a potential problem, or just previous exposure).

REFERENCE RANGE
Negative: I.V. less than or equal to 0.90 Note: I.V. = Index Value
Equivocal: I.V. 0.91 to 0.99
Positive: I.V. equal to or greater than 1.00

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CAPⁱ started 10/09 - Doxyⁱ 200mg, Azith 250 MWF, 1 Flagylⁱ pulse. Empirical CAP on suspicion of CPnⁱ or tick-borne infection. Primary symptoms are chronic sore throat, muscle pain (jaw, neck, trapezius, all on right side), rosaceaⁱ, joint pain.

The parameters listed on the blood test and their results are what matters.  You cannot swap indexes from one test to another for the most part, labs and tests vary greatly.

The strep issue may be of concern as strep is a very active germ and can do a great amount of damage quickly although it is also very common and most of the time does not.  Dr. Stratton has said that any infection on the body can elevate Cpnⁱ levels so this may apply.  If the levels are high in the blood then you have to find out where it is on the body with a tissue culture, a good one.  My g.p. has told me there are four common areas for low grade infection to hide:  tonsils, teeth, nasal tissue and a female's vaginal tissue.  If the infection is positive for any of these areas and then after antibioticsⁱ fail to kill it the infected tissue must be removed.

http://www.mc.vanderbilt.edu/reporter/index.html?ID=779

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Cpnⁱ, Mycoplasma, Chronic EBVⁱ, M.S.(MRI, Spinal Tap-greater than 5 oligoclonal bands and VEP), PANDAS(OCD). Wheldon CAPⁱ (started 12/08), Azithromycin/Clarithromycin(12/09), Lithium, Lamictal, NACⁱ(2.4g/day), D3(12,000IU/day)