Doxycycline Questions - Capsules vs Tablets, Mono vs Hyclate

I recently had a discussion with someone about doing CAPi and possibly switching to doxycycline in the future to save some money and lo and behold when I did a price check in my rx mail order there are FOUR different possibilities I could get each with its own price. 

Ok, now the price isn't even that much of an issue (not much difference) but if I don't get the "right" information on the rx, it's a nightmare to try to change or fill with the mail order service.  

So, which do you all use?  Here are the 4 types available in 100 mg strength generics:

Doxycycline  monohydrate tablets

Doxycycline monohydrate capsules

Doxycycline hyclate tablets

Doxycycline hyclate capsules 

I have taken the hyclate version in tabs or caps and can't say I have noticed any difference.   I'm not sure whether the hyclate or monohydrate have much of a difference either although this question was asked here before and one person commented on it.

Michèle (UK) GFAi: Wheldon CAPi 1st May 2006. Daily Doxyi, Azi MWF, metroi pulse.

Hi Reenie

I take 100mg Doxycyline Hydrochloride pelletised capsules (called Doryx) here in Australia - works much better for me than tabs like Vibramycin; not sure why but it feels like I'm getting better penetration.

Overlap syndrome: lupus, RAi, MCTD/Scleroderma. Wheldon CAPi Oct 03-Nov 04; Pulsed abxi for 3.5 years. Restarted Wheldon CAP Nov 08. ABXi daily: 200mgs Doxyi, 300mgs Biaxsig, monthly 7-day Flagyli pulses 1200mgs; Daily supps: CoQ10,  B Complex &  B12, Vit D

Hi All,

I'm bumping this up in case my questions weren't clear or you didn't have an answer on the differences of the doxyi types.  I would appreciate all feedback on your type of doxy, whatever you can share.  I think this will be a good thread to refer to in the future if everyone replies. Smile

Would you please post which type of doxycycline you are taking?  If you don't know whether or not it's hyclate or monohydrate would you please post whether you are using tablets or capsules and maybe the name of the manufacturer? 

Since the basics of CAP include doxy, I would think I would have alot of feedback to help me decide which type to ask my Dr for when I switch from minoi.  

Thanks in advance.  Smile

NACi 2.4g, Zithi 250mg/MWF, minoi 200mg, Tinii 5day/1g/5 pulses, Valcyte
Supplementsi, CFIDSi/FMSi, Hashimoto's, Psoriasis, PA, IBSi, Sec Addisons

Don't believe everything you think!  

Hi Reenie, Doryx has been recommended to me by Lyme aquantances as being easy to take.  Unfortunately my insurance would need my MD to specifically order the brand name to get it and it is expensive here in USofA.

Currently I have Doxycycline Hyclate tablets. 

I took Capsules for a year and find the tablets less gastric irritating for me.  Finally this fall I talked to the pharmacist and specifically asked for tablets.  Since my script was written for 3 months at a time I got whole closed bottles, therefore I can tell you that the tablets are hyclate.  The capsules I do not know specifically which they were, they were filled in relabeled Rx bottles.

Louise

  • CAPi(TiniOnly): 06/07-02/09 for CFSi
  • MethylationProtocolSupplements: Started08/08
  • Intermtnt CAP: 02/09-02/10
  • Full MethylProtocol & LDNi 02/09
  • Off CAP: 02/10, cont LDN & MethlyProtocol support

Louise, 

Thanks for your reply.  Hopefully there will be more.  I had no idea there were so many different variations of doxyiSmile

NACi 2.4g, Zithi 250mg/MWF, minoi 200mg, Tinii 5day/1g/5 pulses, Valcyte
Supplementsi, CFIDSi/FMSi, Hashimoto's, Psoriasis, PA, IBSi, Sec Addisons

Don't believe everything you think!  
I take capsules (oblong-aqua blue). The label doesn't say anything else.

Mary Ann

SPMSi. Dxi 1991. EDSSi 6.0, 6.5, 6.9; Weldon CAPi. started 3/08.  All supps, NACi, Doxyi, Azrith, 13 flagy pulses, 5th tini pulse 11/13/09, 19 total pulses, no improvements, worsening condition 

Doxycyline Hyclate - slow release pellets versua regular

 Reenie,

As mentioned above I take 'Doryx' pelletised capsules - this is what the manufactuer says is the difference - it's a special delayed release version - so gets absorbed in the small intestine and not the stomach. I notice a real difference in effectiveness compared to when I take Vibramycin tabs for example, which are also a hyclate. I've not tried the monohydrate but i understand they are meant to be easier on the stomach than the regular hyclate - see previous thread on this site below

http://www.wcrx.com/products/doryx/

http://www.cpnhelp.org/doxycycline_monohydrate_a

kind regards
Gill

Overlap syndrome: lupus, RAi, MCTD/Scleroderma. Wheldon CAPi Oct 03-Nov 04; Pulsed abxi for 3.5 years. Restarted Wheldon CAP Nov 08. ABXi daily: 200mgs Doxyi, 300mgs Biaxsig, monthly 7-day Flagyli pulses 1200mgs; Daily supps: CoQ10,  B Complex &  B12, Vit D

Hi Reenie

I'm taking Doxycycline monohydrate tablets, pretty much as this is all that's prescribed here. On that basis, I have made an online order for the same. But, to be honests, I have no knowledge of which type is better or not.

Bob

 

 

Symptoms: Very run down/malaise etc. Breathless, CFSi. heavy limbs. Irritated nerve feelings. Severe pelvic discomfort. Oct 08 - all Supps + 2400mg NACi. Dec 08 - 200mg Doxyi + 250mg Azith.Clarithro M.W.F.

Hi Gill,

Are you saying you think the tabs or the caps are more effective?  What are you measuring effectiveness by? 

I'm curious since both types of hyclate (tabs/caps) are both supposedly time released.  

Also, how many people are taking their doses once a day?  It seems with the hyclate variety once a day dosing is all that is required according to the link from Doryx Gill provided. 

Hi Bob, 

I'm not sure I ever saw anywhere that there was any specific typing of the doxycycline referred to on this site or in any of the literature I read.  Where did you see that the monohydrate was rx'd or were you referring to your Dr?  

NACi 2.4g, Zithi 250mg/MWF, minoi 200mg, Tinii 5day/1g/5 pulses, Valcyte
Supplementsi, CFIDSi/FMSi, Hashimoto's, Psoriasis, PA, IBSi, Sec Addisons

Don't believe everything you think!  

Hi Reenie,it was a discussion before about doxyi. If I remember correctly it was better to take it twice a day. But seams like most here take it once a day because its easier.

Best Wishes,Maria

Cpni since sep 2006. Autoimmune thyroid,hypofunction.levaxin,b12+folic acid">i.All classic cpn,porphyriai and toxinsymtoms.Not able to work.Selftreating cpninfection with AllicinMax(garlic), NACi, high vitamin D3. CAPi for over 3 years. Back to work and life

Maria,

I can see it would definitely be better to take the monohydrate type 2/day because it's not time released but so far not many folks have answered which type of doxyi they are using.

If folks are taking doxy only 1/day, I would wonder if more people are taking the hyclate variety as it's time released.  

These varieties may be making it easier or more difficult for people to tolerate CAPi and I would like to see more of the old timers chime in with what they are taking!  Hopefully, during the week more people will post!  Smile

NACi 2.4g, Zithi 250mg/MWF, minoi 200mg, Tinii 5day/1g/5 pulses, Valcyte
Supplementsi, CFIDSi/FMSi, Hashimoto's, Psoriasis, PA, IBSi, Sec Addisons

Don't believe everything you think!  

I thought I would check to see if there was any difference for pricing between the mono and hyclate and this is what I found which didn't make much sense to me really... 

Both the mono and hyclate tabs are the highest priced while the capsules of either are the cheaper priced thru my mail order pharmacy.

All of the doxycycline is much less expensive than the minocycline I'm now on though, so any would be fine. I just would like to take the easiest one to tolerate and the most effective.  Smile

NACi 2.4g, Zithi 250mg/MWF, minoi 200mg, Tinii 5day/1g/5 pulses, Valcyte
Supplementsi, CFIDSi/FMSi, Hashimoto's, Psoriasis, PA, IBSi, Sec Addisons

Don't believe everything you think!  

I think most just take it once a day because it is easier to fit in the daily program with all the abxi,supplementsi, medicins and more.

I dont remember any discussion about timerealesed form.

Hope you can sort things out so you can chose the best doxyi for you!

Cpni since sep 2006. Autoimmune thyroid,hypofunction.levaxin,b12+folic acid">i.All classic cpn,porphyriai and toxinsymtoms.Not able to work.Selftreating cpninfection with AllicinMax(garlic), NACi, high vitamin D3. CAPi for over 3 years. Back to work and life

I initially started the CAPi with a prescription from David Wheldoni and it was just "Doxycycline" on it, generic I guess so cheaper. I currently have Doxycycline hyclate capsules from the pharmacist. I started by using a divided dose but soon combined the dosage, so I now take 200mg first thing in the morning - because it is easier to manage.

If David didn't distinguish the version of Doxycycline then then I would assume that there is no difference.

speedbird

Doxyi monohydrate (vibramycin N) is kinder to the stomach. I feel I can take it any time (on an empty stomach for eg) without getting heartburn. I even lie down almost as soon as I have taken it without trouble. I don't know whether the hyclate or the monohydrate are more or less effective though. Nelly (long time infected with several bacterial things)
Nelly (France-neuroLyme and ????)

Nelly,

Are you using tablets or capsules?  

Speedbird, 

Did you start off with tabs or caps?  All of the doxyi variations I've listed are generic forms of it.  Nothing seems to be easy, does it?  Can you imagine if we added in brands and manufacturers?  

NACi 2.4g, Zithi 250mg/MWF, minoi 200mg, Tinii 5day/1g/5 pulses, Valcyte
Supplementsi, CFIDSi/FMSi, Hashimoto's, Psoriasis, PA, IBSi, Sec Addisons

Don't believe everything you think!  

Reenie

 Unfortunately it was a subjective judgement only that made me feel  that Doryx works better. I was on Vibramycin tabs for about a month and as soon as I switched back to the Doryx pellitisd capsules my fingers became less stiff - it felt like it was clearing the tissues more effectively; felt like something was happening again, where the month on Vibramycin felt like nothing much of anything was happening. Not very scientific I know. sorry - just my personal perception of the drug's activity. And as for capsules, i find them easier than tablets to get down. I take them all in one dose too - per DW's original advice at the time in 2004.

Overlap syndrome: lupus, RAi, MCTD/Scleroderma. Wheldon CAPi Oct 03-Nov 04; Pulsed abxi for 3.5 years. Restarted Wheldon CAP Nov 08. ABXi daily: 200mgs Doxyi, 300mgs Biaxsig, monthly 7-day Flagyli pulses 1200mgs; Daily supps: CoQ10,  B Complex &  B12, Vit D
I have only ever taken capsules - that's what is dispensed by the pharmacist. I would think that tablets would be harder to swallow, but then that's just me and my experience with metrodiazole!

speedbird

Hi all,

I would really appreciate it if more of you would kindly reply with what type of doxycycline you are taking and if it's caps or tabs.  

Thank you in advance.  Smile

NACi 2.4g, Zithi 250mg/MWF, minoi 200mg, Tinii 5day/1g/5 pulses, Valcyte
Supplementsi, CFIDSi/FMSi, Hashimoto's, Psoriasis, PA, IBSi, Sec Addisons

Don't believe everything you think!  
(Prescription) Doxycycline 100mg capsules, aqua blue oblong capsules imprinted with 'Westward' and '3142', which is what I've been taking since 06 Oct 2005.

The difference between what we do and what we are capable of doing would suffice to solve most of the world’s problems. Mohandas Gandhi

I've taken little light-orange colored tablets, and now the generic I'm given is blue capsules. I believe both are Hyclate form. I find the capsules more likely to give me heartburn, even with food sometimes, and I never had this with the tablets, although I always got nauseated if I didn't take them with food.

 

CAPi for Cpni 11/04. Dxi: 25+yrs CFSi & FMSi. Currently: 250 aithromycin mwf, doxycycline 100mg BIDi, restarted Tinii pulses; Vit D2000 units, T4 & T3, 6mg Iodoral

Now so long out of patent, doxycycline hyclate, which is what I took is available in tablet or capsule in any colour under the sun.  I normally took capsules in either aqua green or two tone, yellow and brown.  Also tablets as described by Jim......................Sarah

An Itinerary in Light and Shadow

Completed Stratton/Wheldon regime for aggressive secondary progressive MSi in June 2007, after four years, three of which intermittent.   Still improving bit by bit and no relapses since finishing treatment.

Started Wheldon CAPi 6 weeks ago with Azithromycin (250mg;M,W,F) and NACi (2.4g/d) and the only symptom was the watery nose that begin after one week or so and is still there somewhat less though. 

Started the 100mg Doxycycline Hyclate Capsules (morning) three weeks ago, Aqua in color and it says DAN 5440 on the capsule if that means anything.  I will go to one 100mg in the morning and one at night in a few days.  Two days into the Doxy kidney and bladder irritationi started and it has been continuous although up and down a bit.  Both symptoms are what I was hoping for, watery nose and the kidney and/or bladder irritation, I was quite sure that is where the bugs are and have been for a very long time, the meds back that up.  They are on the run now for the first time.

Anyway, the meds are working very well for me with really no bad side effects, except more fatigue, although I have always tolerated meds very well. 

Hope this helps.

 

Cpni, Mycoplasma, Chronic EBVi, M.S.(MRI, Spinal Tap-greater than 5 oligoclonal bands and VEP), PANDAS(OCD). Wheldon CAPi (started 12/08), Azithromycin/Clarithromycin(12/09), Lithium, Lamictal, NACi(2.4g/day), D3(15,000IU/day)

HERE are pages of pics of doxycycline.  Yes, I see the blue caps are hyclate. 

From reading most of your replies, it seems like tabs are easier on the stomach regardless of whether they are hyclate or mono.  

Does anyone have any other suggestions or comments?  It looks like I'd be able to get an rx for any of these 4 from the mail order pharmacy, when I'm ready to switch from minoi.  

 

NACi 2.4g, Zithi 250mg/MWF, minoi 200mg, Tinii 5day/1g/5 pulses, Valcyte
Supplementsi, CFIDSi/FMSi, Hashimoto's, Psoriasis, PA, IBSi, Sec Addisons

Don't believe everything you think!  
I take Doxycycline hyclate Strength(s) 100 MG Imprint(s) 3626 Z Manufacturer / Distributor Ivax Pharm Rugby DRx PD-Rx Pharm I take 400 mgs/day and Dr switched me from caps to tabs as he said too many caps hard on esophagus (? Spelling)

5oo mgs Ceftin 2 x/day, 500 mgs Zithromax, 500 mgs 2 x tinii pulses,100 mg diflucan, 4.5 ldni; Wheldon protocol for MSi April, 2006 to May 2008. 2008 MRI shows NO NEW DISEASE ACTIVITY, 2012 MRI no new disease activity.

Hyclate Capsules.   Always took them just before eating, so no irritation...

Treatment for Rosaceai

  • CAPi:  01/06-07/07
  • High-Dose Vit D3, NACi:  07/07-11/08
  • Intermtnt CAP, HDose Vit D3:  11/08-01/09
  • HDose Vit D3, Mg, Zn: 01/09-

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