Hi all, I ran across the following article on a new study today, suggesting that MMP-9 without accompanying TIMP-1, might be very important in cancer angiogenesis:
This reminded me of a study I had read earlier about C. pneumoniae's potential involvement in MSi which found that infection of microglial cells with C. pneumoniae induced MMP-9 without TIMP-1:
Note the following quote from the study above:
"As shown in Fig. 4, infection of microglial cells with C. pneumoniae induced MMP-9 mRNA at 24 h after infection but not MMP-2 and TIMP-1, although both were inducible in the cells by treatment with a non-specific stimulator PMA during the infection forup to 72 h. Thus infection of the microglia with C. pneumoniae selectively induced MMP-9, an important MMP implicated in neurological diseasesi, including MS (Rosenberg, 2002b). However, other MMPs, such as MMP-2, and TIMP-1, which plays a critical role in controlling MMP activity in tissues, were not altered. Control studies showed that heat-killed C. pneumoniae induced minimal, if any, alterations in the level of the MMPs, suggesting that the stimulatory effect was not due merely to active stimulation by some bacterial products such as chlamydial lipopolysaccharidei (data not shown). The selective induction of MMP-9 by C. pneumoniae infection in microglial cells revealed in this study is consistent with previous findings that C. pneumoniae infection of human peripheral blood monocytes and mouse peritoneal macrophages induced secretion of MMP-9 (Kol et al., 1998; Rupp et al., 2004; Vehmaan-Kreula et al., 2001), and a selective expression of MMPs, including gelatinase B (MMP-9), was evident in the tissue of MS patients (Bar-Or et al., 1999). In addition, TNF-{alpha} and MMP are thought to have together a critical role in MS pathophysiology, such as damage of the myelini sheath (Bar-Or et al., 1999). Therefore, the marked production of TNF-{alpha} and the selective induction of MMP-9 by C. pneumoniae infection in the microglia in vitro as shown in this study may provide valuable information on the possible involvement of C. pneumoniae infection in neurological diseases such as MS (Sriram et al., 1999)."
Potentially this might be how C. pneumoniae could contribute to the growth of, if not initiate to begin with, cancer?
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To be honest, this went 'way
To be honest, this went 'way over my head'. So, what I'm about to say may mean the samething. I apologize if it does. My doc says CPNi has been linked to breast cancer due to CPN being very inflammatory. As I have stated in a previous post, I had prophylactic double mastectomies last year for lobular carcinoma insitu (LCIS). the report from my lumpectomy showed fibrosis, cysts, apocrine metaplasia, ductal ectasia, periductal mastitis, focal intraductal hyperplasia and LCIS. The report also said breast with foreign body inflammatory reaction and fibrocystic changes.
I'm just in constant awe on how we are at the forefront of all of this. I cant wait for another 10 or 20 years to see how medical community recognizes CPN and it's ramifications.
Mphs, TN. CFSi, hypoT, weak adrenals, 37 w/hormones of 80 yo. right arm neuropathy. 6/26/07- CPN Titer 1:256 (normal 1:16); 6/27/07- NACi; 7/2/07- doxyi 100, 2xday; 7/19/07-9/7/07- Biaxin. 9/8/07-azith 250 mg m/w/f. 10/18/07-1st flagyli pulse
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Mphs, TN. CFSi, hypoT (Hashi), adrenal fatigue-almost resolved, severe hormonal inbalance-resolved, right arm neuropathy-getting better. cpni, myco, EBVi, CMV. Capi began in 6/07. NACi 3000mg, minoi 100mg bidi, biaxin 500mg bidi. cytomel, tinii pulses
Sharon- Your doc may know
Sharon- Your doc may know of this, but iodine at much higher supplementation than we get in table salt has been significant in preventing and countering cystic breast disease and breast cancer. One summary: http://www.lewrockwell.com/miller/miller20.html .
Red- you may be particularly interested in a quote from that link:
CAPi for Cpni 11/04. Dxi: 25yrs CFSi & FMSi. Protocol: 200mg Doxyi, 500mg MWF Azith, Tinii 1000mg/day pulses; Vit D1000 units, Cytotec 100mg, Plaquenil 100mg, Magnascent Iodine 12 drps/day, T4 & T3
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CAPi for Cpni 11/04. Dxi: 25yrs CFSi & FMSi. Currently: 250 aithromycin mwf, doxycycline 100mg BIDi, Tinii 1000mg/day pulses; Vit D2000 units, T4 & T3, 12mg Iodoral
another reason to take the
another reason to take the iodine supplement. going to gnc this weekend.
Mphs, TN. CFSi, hypoT, weak adrenals, 37 w/hormones of 80 yo. right arm neuropathy. 6/26/07- CPNi Titer 1:256 (normal 1:16); 6/27/07- NACi; 7/2/07- doxyi 100, 2xday; 7/19/07-9/7/07- Biaxin. 9/8/07-azith 250 mg m/w/f. 10/18/07-1st flagyli pulse
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Mphs, TN. CFSi, hypoT (Hashi), adrenal fatigue-almost resolved, severe hormonal inbalance-resolved, right arm neuropathy-getting better. cpni, myco, EBVi, CMV. Capi began in 6/07. NACi 3000mg, minoi 100mg bidi, biaxin 500mg bidi. cytomel, tinii pulses
Sharon- you might look
Sharon- you might look into this a bit more. The most recommended supplement is Iodoral because it is well absorbed and formulated to help avoid stomach distress (which I guess can occur from regular iodine supplementsi). I take a different form that I've been able to tolerate better. Neither one is available at GNC.
CAPi for Cpni 11/04. Dxi: 25yrs CFSi & FMSi. Protocol: 200mg Doxyi, 500mg MWF Azith, Tinii 1000mg/day pulses; Vit D1000 units, Cytotec 100mg, Plaquenil 100mg, Magnascent Iodine 12 drps/day, T4 & T3
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CAPi for Cpni 11/04. Dxi: 25yrs CFSi & FMSi. Currently: 250 aithromycin mwf, doxycycline 100mg BIDi, Tinii 1000mg/day pulses; Vit D2000 units, T4 & T3, 12mg Iodoral