I got very excited when I read David's notation in Farandwide's thread on Porphyriai: http://www.cpnhelp.org/porphyria
Kim's been having die-off reactions and I came here first. She's been taking about 2500mg of charcoal at night, I haven't figured out how to decipher Oregano Oil, and then I came across David's post - Thank you David.
I added a link to the paper David referenced and info on the dosage for Tagamet. I'm still not sure of the dosage and timing for cimetidine and I found some more info here that I thought ought to be in a single post to make it easier to find.
I was surprised to read Louise's post that notes that Flagyl says to consult your doctor before taking Flagyl with Tagamet: http://www.cpnhelp.org/metronidazole_flagyl_pati
I also found Jim K's post of a portion of the Stratton/Mitchell patent that recommends 400mg of Tagamet/Cimetidine once or twice a day: http://www.cpnhelp.org/secondary_porphyria_in_cp
Thank you Jim K for your post, it was very helpful!
So, Question 1 is, is anyone taking Tagamet and if so, how do you work it around the Flagyl? Do you need to work it around Rifampin and Azithromycin too?
I suppose I don't know what question 2 is ... maybe more generally how's it working for you? Should Kim try this? Ken
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Oh, yeah, the real question
Hi Ken, You could check this
Hi Ken, You could check this out. And here is a link that I think answers another of your questions...
Michèle (UK) GFAi: Wheldon CAPi 1st May 2006. Daily Doxyi, Azi MWF, metroi pulse. Zoo keeper for Ella, RRMS, At worse EDSSi 9, 3 months later 7 now 5.5 Wheldon CAP 16th March 2006
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Michèle (UK) GFAi: Wheldon CAPi 1st May 2006. Daily Doxyi, Azi MWF, metroi pulse. Zoo keeper for Ella, RRMS, At worse EDSSi 9, 3 months later 7 now 5.5 Wheldon CAP 16th March 2006
Thank you Michele! So the
I'm not the best person to
I'm not the best person to answer these questions... I know not a lot about science of things. Someone the other day when talking about the action of Rifampin that its action on antibioticsi was not an issue as there was a wide margin of effectiveness factored into the dosage. Maybe the same applies to Tagamet.
Here is another link that gives information about it, maybe you can PM Basil about it.
Michèle (UK) GFAi: Wheldon CAPi 1st May 2006. Daily Doxyi, Azi MWF, metroi pulse. Zoo keeper for Ella, RRMS, At worse EDSSi 9, 3 months later 7 now 5.5 Wheldon CAP 16th March 2006
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Michèle (UK) GFAi: Wheldon CAPi 1st May 2006. Daily Doxyi, Azi MWF, metroi pulse. Zoo keeper for Ella, RRMS, At worse EDSSi 9, 3 months later 7 now 5.5 Wheldon CAP 16th March 2006
The only time I took
The only time I took cimetidine was at a time when porphyria was making me so ill that none of the other measures worked. I'm not sure whether my method would be recommended but for a week I stopped all antibiotics and supplementsi while I took the cimetidine alone.
Now, my recovery on this occasion could have been due to taking the full dose of cimetidine for a week or it may have been from stopping the abxi and therefore slowing down the porphyrin release from die off .....who knows, I can't explain the science but it worked for me at a time when when nothing else would.
Elinor ..... from England on CAPi, doxyi/roxi/tini for ME/CFSi/lyme borreliosis, positive Cpni and borrelia. Started Aug05, stopped Jan06, started again Sept 06.
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Elinor ..... from England on CAPi, doxyi/roxi/tini for ME/CFSi/lyme borreliosis, positive Cpni and borrelia. Started Aug05, stopped Jan06, started again Sept 06.
Stopped Tagamet ------ I
Stopped Tagamet
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I e-mailed Dr. Sriram and Wheldon to ask about Tagamet. Neither Dr. Sriram or Dr. Wheldon recommended continuing with it for porphyriai. I ran out and bought Kim a bottle of Glucose tablets at CVS. I think we noticed (with Tagamet) a slight improvement in comfort during the pulse, but we would rather not risk anything that might compromise the effectiveness of the Flagyli. Ken