CHronic intraocular CHlamydophila felis, non - reactive to WP - HELP

So after years of Wheldon Protocol with Rifampicin and my sight worsening anyway, i had a PCRi analysis of the aqueous humour and the result is - an intraocular infection by Chlamydophila felis. These bugs clearly had only fun on all the treatments until now.  Veterinary medicine uses  Enrofloxacin to eradicate this pathogen; i was told there a 100% eracication in six weeks in cats. But then again, im not a cat and my infection is very chronic. DOctor put me on Ciprofloxacin for now, but i wonder, if that enough. Should I possibly add Metronidazolei? Not sure about Penetration of Metronidazole into the eye (of course, i will sort it out with doctors, too, but i wonder about anyones experiences). I nearly didnt do Metronidazole because of horrible herxes.

My condition is extremely rare and extremely serious. By now, im nearly blind. But the OCT in my left eye looks perfext, so the oculists say, if i get rid of the inflammationi, this eye should be relatively ok again. The question is, how to get rid of the infection. Anyone has any recommendation? Thanks.....

Comments

For inflammationi there is

For inflammationi there is Plaquenil, but that is hard on the eyes. Best to go to a naturopath for help with inflammation or you can write me - I will help as best I can. It seems that you were on Metroi? Or Tinidazole is well - tolerated instead. GET OFF CIPRO - it is poison, truly! xo

thank you luckypenny, for

thank you luckypenny, for your offer, i wrote to you already. , but i cannot gat off Cipro now. it is probably the only option for me, alongside Levofloxacin, no matter jow poisonous it is. the macrolides didnt help me at all and only gave me intracranial hypertension">i in the end. dont forget that ive git a little different bug in my eyes.

but i promise to detix well and protect my liver and kidneys asm mcuh as i can. and i will not be on it forever.also, if i should get poisoned in the course of regaining my vision, well, i might get poisoned. i dont care for staying alive, if i cannot see - sounds horroble, but this is how it is, i have noone to help me, cannot work, willl get no sick pay, my family has had enough of me an my sicknesses. if i do not get my vision back in some months, i can only beg in the streets and not survive the first week of winter. 

es and im planning to get to a chimnese medicine doctor for halp. it will just probably take some fundraising, i thiink about going to Youcaring.com or something.

m worst fear is that NO atbx will work for this.

Euchrid, really!  You have

Euchrid, really!  You have been on the treatment for years, but you have never taken metronidazolei?  There is your answer, so forget about the 'horrible herxes' and get on with it.......................Sarah

Completed Stratton/Wheldon regime for aggressive secondary progressive MSi in June 2007, after four years, three of which intermittent.   Still improving bit by bit and no relapses since finishing treatment.

Oh Saeah, but i did Metroi,

Oh Saeah, but i did Metroi, but not all the time. just in the beginning. the herxes made me unable to work, which meant no money for the treatment. noww im unable to work anyway....

and my sight, i think, was deteriorating even at those times when i was doing Matro pulses.... though it had accelerated later, when i was not doing that.

Do you possibly know, what is the penetration of the Metro into the aqueous humour? All articles i faund on the internet are locked.

thank you!

Euchrid, might I ask you what

Euchrid, might I ask you what is your illness?  C pn  is just the cause of the illness which comes out in people in many different ways.

When you started metronidazolei did you start several months after starting the bacteristatics and did you then build up gradually?  Were you taking rifampicin at the same time as pulsing metronidazole and have you ever thought about using tinidazole?

As for the aqueous humour, one would assume that if it can get into the brain it can also get in the aqueous humour, and besides several people, my husband included have seen refractive improvements hilst on the treatment.

How long ago did you start taing the treatment?..............................Sarah

Completed Stratton/Wheldon regime for aggressive secondary progressive MSi in June 2007, after four years, three of which intermittent.   Still improving bit by bit and no relapses since finishing treatment.

hi Sarah,mybug is

hi Sarah,

mybug is Chlamydophila felis. It is a different species of chlamydia, which mightt not react to macrolides, and my clearly didnt. It didnt even react to Rifa. MY infection is intraocular, very chronic  and very serious. 

I was on WP for several years.... getting worse i didnt take Rifa at the same time as the Metroi and I got much worse whilst on it. i thought abou Tinii many times, but it is impossible to get it in my country; it might not even get through customs.

Ill write more later, as im very sick at this moment...

Euchrid, I have spent my

Euchrid, I have spent my lunch break reading up on enrofloxacin and since it is a fluoroquinalone, if I were you, I would avoid it if you value your tendons.

All I can really say is to carry on with the treatment but avoid rifampicin which is too hard on many people.  If you attempt any pulses of metroi, keep the short, but do take the bacteristatics every day at full dose: if you are able to get it, change azithromycin for roxithromycin, which is what I took and is very gentle.

Next, do try biotin.  I have a friend from up north taking it mainly for her eyes: she suffers from glaucoma and the doctors are very amazed that this seems now not to be getting any worse.  Maybe she should tell them what she is taking.  You can get some Pure-Clinica tablets in a flat pack from Amazon, which goes easily through the letterbox.  If you are in an EU country, you ought to be able to get a flat pack sent without customs difficulty.........................Sarah

Completed Stratton/Wheldon regime for aggressive secondary progressive MSi in June 2007, after four years, three of which intermittent.   Still improving bit by bit and no relapses since finishing treatment.

Thank you Sarah, The problem

Thank you Sarah, The problem is that i had the treatment you recommend for years and i went nearly blind while on it :-( It helped with chronic fatigue syndromei and asthmai, but the eye infection and inflammationi and damage were only accelerating; for my sight, i could have as well taken sugar water with probably the same result :-( 

are there any other options? seem the fluoroquinolones are the last one, no matter what the risk to my tendons (btw, im not really in the risk group, not over sixty, not on steroids - only for 3 days in the beginning of this year; no renal failure). i know Achilles rupture is a very bad thing, but going blind is even worse. Believe me, since the last year, when it got so bad i had to quit my job, ive comtemplated ending my life quite often :-( 

my wiesr fear is that NO antibiotic treatment can help me. tthough this infection is considered treatable, i might be a kinda exception. 

and yes, ive been doing high dose biotin since the beginning of this year. my sight still getting worse and worse, biotin or not :-( my bugs seem to be very determined :-(

its my 9th day on Cipro now. My sight is kinda stromy, but the horrible bright pirple flashes in my peripheral vision... i havent seen them in days. i wonder if its a sighn of something better.... but only time can tell and im not very optimistic already....

taking lotd of vit C and going for some collagen supllement to protect my tendons.

considering Clindamycin, but not sure if its  of nay use to me. Ive read it penetrates the CNSi very well. not sure about the eye. i just know i has a Clindamycin preparation for my acne and it didnt help a bit.....

Right, so the treatment has

Right, so the treatment has helped your chronic fatigue syndromei and your asthmai, but not yet whatever is wrong with your eyes: maybe it isn't caused by an infection at all, so maybe you should be looking at what else it might be, rather than making things orwse by taking a fluoroquinolone......................Sarah

Completed Stratton/Wheldon regime for aggressive secondary progressive MSi in June 2007, after four years, three of which intermittent.   Still improving bit by bit and no relapses since finishing treatment.

hi Sarah, but it is 100% sure

hi Sarah, but it is 100% sure ive git this bug; it was proven by Real Time PCRi from the intraocular fluid and there is no mistake. it also got much worsened after steroids adminitration, which only happens when there is an infection present. nevertheless, it seems to be buried so deep ni meds could reach it so far. im seeing my cotro this friday and will try to sort out the treament. i need something that reaches the retina; Doxyi doesnt, ive read some studies on it. 

Im also contacting a the best veterinary ophtalmologist in my country, i think he might have some idea.

thank you :-)

Euchrid, I have just looked up Langford Vetinary Services

Euchrid, I have just looked up Langford Vetinary Services, part of Bristol University and where David once assisted with the post mortem of a beautiful horse who died whilst running in the Derby.  There small animal department there treat chlamydia felis by using doxycycline for four weeks:

http://www.langfordvets.co.uk/diagnostic-laboratories/diagnostic-laboratories/pcr-acarus/chlamydia-felis< ........................Sarah

Completed Stratton/Wheldon regime for aggressive secondary progressive MSi in June 2007, after four years, three of which intermittent.   Still improving bit by bit and no relapses since finishing treatment.

Also Euchrid, this treatment

Also Euchrid, this treatment definitely reached David's retina and that of one of David's patients who saw the same opthalmologist.  The deterioration of David's vision stopped dead when he started the treatment and hasn't needed stronger lenses since then.........................Sarah

Completed Stratton/Wheldon regime for aggressive secondary progressive MSi in June 2007, after four years, three of which intermittent.   Still improving bit by bit and no relapses since finishing treatment.

Than you Sarah. I know about

Than you Sarah. I know about that Doxyi used fot Chlamydophila felis in cats, but in cats, these problem are always superficial. I spoke to the best veterinary ophtalmologist yesterday. But for Chl. Felis, he always uses a combination of Doxy and quinolones. I was told that there ane many strains of Chlamydophila felis now, which are Doxy - resistant. 

I must say i also treat my kitties with Doxy for the same bug and rwo have responded well and the third on - not.

What was the treatment that helped David and his patient? was it Doxy alsone? or some combination? i took Doxy, Azi, Rifa. No resultd. My chlamydias had only fun of it. Ibe got a little bit different species....

David used doxyi,

David used doxyi, azithromycin and pulses of metronidazolei. His ophthalmologist was astonished but then you are obviously much worse. I hope the treatment of the man you saw yesterday works...........,...,Sarah 

Completed Stratton/Wheldon regime for aggressive secondary progressive MSi in June 2007, after four years, three of which intermittent.   Still improving bit by bit and no relapses since finishing treatment.

thank you, Sarah. i really

thank you, Sarah. i really think you might have hit it whem yuou said that shirking the Metroi might have been the part of my problem. Also that i have a little sifferent bug which might react differently to different medications. The veterinary ophtalmologist has cinfirmed the quinolons as a first choice drug rfo this, but im looking for some other options. ive also spoke to a lady i know who had the sane problem as me. ahe used quinolons topically, as eye drpps, but i dont know yet if she had infectet as deep eye structures as me. i know she was blind for nearly a year and her sight came back.

i see some slight changes in my vision, not for better of worse, very subtle now. but yeah. im very chronic. this has been going on for years, slowly getting worse....