Cholestyramine (koe leh STYE rah meen) - Questran- Questran Light

Cholestyramine Light

Generic Name: cholestyramine (koe leh STYE rah meen)
Brand Names: Cholestyramine Light, Locholest, Locholest Light, Prevalite, Questran, Questran Light

Source: http://www.drugs.com/mtm/cholestyramine-light.html<

 What is Cholestyramine Light (cholestyramine)?

Cholestyramine is a drug that lowers cholesteroli (a type of fat).

Cholestyramine is used to lower high levels of cholesterol in the blood. Cholestyramine is especially good at lowering levels of low-density lipoprotein (LDL) ("bad" cholesterol). A rise in triglycerides (another type of fat) may occur.

Lowering high cholesterol levels is an important part of preventing heart diseasei and arteriosclerosis (hardening of the arteries).

Cholestyramine has also been used to treat the itching that is associated with a blockage of the biliary tract.

Although not approved by the FDA for these purposes, cholestyramine has also been used to help treat certain types of diarrhea and to bind to other drugs in overdose situations (e.g., overdoses of digoxin and thyroid hormone).

Cholestyramine may also be used for purposes other than those listed in this medication guide.

 

What is the most important information I should know about Cholestyramine Light (cholestyramine)?

Follow any diet or exercise plan outlined by your doctor. Diet and exercise are very important factors in controlling cholesterol.

Avoid ingesting or breathing in the dry powder. Taken dry, the powder can cause a severe adverse reaction.

Increase the amount of fluid in your diet to prevent constipation. Drink at least six to eight full glasses (8 ounces) of fluid daily. Talk to your doctor if constipation becomes a problem.

Take other medications at least 1 hour before or 4 to 6 hours after taking a dose of cholestyramine. Cholestyramine can decrease the effectiveness of many other drugs if they are taken too close to one another.

 

Who should not take Cholestyramine Light (cholestyramine)?

Do not take cholestyramine if you have a complete blockage of your biliary or gastrointestinal (stomach) tract.

Before taking this medication, tell your doctor if you

  • have an underactive thyroid gland (hypothyroidism),

  • have diabetes,

  • have kidney disease,
  • have liver disease, or
  • suffer from constipation or hemorrhoids.

You may not be able to take cholestyramine, or you may require a lower dose or special monitoring during treatment if you have any of the conditions listed above.

Before taking any "light" formulation of cholestyramine (Cholestyramine Light, Prevalite, Locholest Light, Questran Light), tell your doctor if you have phenylketonuria. These products contain phenylalanine.

Cholestyramine is in the FDA pregnancy category C. This means that it is not known whether cholestyramine will harm an unborn baby. Since the medication is not absorbed through the stomach, it is not believed to be dangerous during pregnancy. Do not take cholestyramine without first talking to your doctor if you are pregnant. Cholestyramine decreases the absorption of certain vitaminsi. This could become a problem during breast-feeding. Do not take cholestyramine without first talking to your doctor if you are breast-feeding a baby.

 

How should I take Cholestyramine Light (cholestyramine)?

Take cholestyramine exactly as directed by your doctor. If you do not understand these instructions, ask your pharmacist, nurse, or doctor to explain them to you.

Mix the powder with a noncarbonated beverage, soup, cereal, or pulpy fruit such as applesauce or crushed pineapple.

Cholestyramine may be taken one to six times a day. It is usually taken before a meal. Follow your doctor's instructions.

Avoid ingesting or breathing in the dry powder. Consuming the dry powder could cause a severe adverse reaction. Increase the amount of fluid in your diet to prevent constipation. Drink at least six to eight full glasses (8 ounces) of fluid daily.

Take other medications at least 1 hour before or 4 to 6 hours after taking a dose of cholestyramine. Cholestyramine can decrease the effectiveness of many other drugs.

Store cholestyramine at room temperature away from moisture and heat.

 

What happens if I miss a dose?

Take the missed dose as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and take only your next regularly scheduled dose. Do not take a double dose of this medication.

 

What happens if I overdose?

Seek emergency medical attention.

Symptoms of a cholestyramine overdose are unknown, but an intestinal blockage leading to abdominal pain might be expected.

 

What should I avoid while taking Cholestyramine Light (cholestyramine)?

Avoid ingesting or breathing in the dry powder. Doing so could cause a severe adverse reaction.

Take other medications at least 1 hour before or 4 to 6 hours after taking a dose of cholestyramine. Cholestyramine can decrease the effectiveness of many other drugs.

 

Cholestyramine Light (cholestyramine) side effects

If you experience any of the following serious side effects, stop taking cholestyramine and seek emergency medical attention:

  • an allergic reaction (difficulty breathing; closing of your throat; swelling of your lips, tongue, or face; or hives);

  • an increased heart rate or chest pain;

  • black, bloody, or tarry stools; or

  • unusual bleeding or bruising.

Other, less serious side effects may be more likely to occur. Continue to take cholestyramine and talk to your doctor if you experience

  • constipation;

  • abdominal pain, cramps, bloating, or flatulence;

  • nausea, vomiting, diarrhea, indigestion, heartburn, or decreased appetite;

  • hiccups or a sour taste in your mouth;

  • headache; or

  • dizziness or drowsiness.

Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome.

 

What other drugs will affect Cholestyramine Light (cholestyramine)?

The absorption of many drugs may be decreased when they are taken with cholestyramine. Take all other medications at least 1 hour before or 4 to 6 hours after taking a dose of cholestyramine. The following list includes some, but not all, of the drugs that may have decreased effects when taken with cholestyramine:

  • pain, fever, and inflammationi reducers such as aspirin, ibuprofen (Motrin, Advil, Nuprin), indomethacin (Indocin), ketoprofen (Orudis, Orudis KT, Oruvail), naproxen (Aleve, Anaprox, Naprosyn), and others;

  • antibioticsi such as penicillins (Amoxil, Augmentin, Pen VK, Veetids, others), tetracyclines (Sumycin, Achromycin, Minocin, Doryx, Doxyi, Vibramycin, others), and clindamycin (Cleocin);

  • heart medicines such as digoxin (Lanoxin, Lanoxicaps), propranolol (Inderal), methyldopa (Aldomet), furosemide (Lasix), hydrochlorothiazide (HCTZ, HydroDiuril), chlorothiazide (Diuril), metolazone (Mykrox, Zaroxolyn), indapamide (Lozol), and others;

  • diabetes medications such as glipizide (Glucotrol), tolbutamide (Orinase), and others;

  • anticoagulants (blood thinners) such as warfarin (Coumadin);

  • other cholesterol treatments such as gemfibrozil (Lopid), clofibrate (Atromid-S), and nicotinic acid (niacin">i);

  • thyroid hormones such as levothyroxine (Synthroid, Levoxyl, Levothroid);

  • medicines used to treat depression, such as imipramine (Tofranil);

  • gallstone medications such as ursodiol (Actigall);

  • seizure medicines such as phenytoin (Dilantin) and phenobarbital (Luminal, Solfoton);

  • estrogen and progesterone hormones such as Premarin, Premphase, Prempro, Estraderm, Ogen, Menest, Estratest, Estratab, Provera, and others;

  • fat-soluble vitamins such as vitamins A, D, E, and K (you may require vitamin supplementsi); and

  • steroid drugs such as hydrocortisone (Cortef, Hydrocortone).

Drugs other than those listed here may also interact with cholestyramine. Talk to your doctor and pharmacist before taking any prescription or over-the-counter medicines.

 

Where can I get more information?

  • Your pharmacist has more information about cholestyramine written for health professionals that you may read.

What does my medication look like?

Cholestyramine is available with a prescription generically and under the brand names Questran, Questran Light, Locholest, Locholest Light, and Prevalite in a powder formulation. Other brand or generic formulations may also be available. Ask your pharmacist any questions you have about this medication, especially if it is new to you.

  • Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
  • Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

Copyright 1996-2006 Cerner Multum, Inc. Version: 4.05. Revision Date: 2/13/04 3:58:57 PM.;

 Thanks Louise. Helpful to have this available on-site. Worth noting that it may lessen the impact of some meds, including CAPi meds, so should best be taken not at the same time. Haven't completely gotten around the charcoal inconvenience completely!

CAP for Chlamydia pneumonia since 11/04. 25yrs CFSi & FMSi- Currently: 200 Doxycycline, 500mg MWF Azithromycin, Tinii pulses.

A motto, not an aspiration: "Anything worth doing is worth overdoing."

 

CAPi for Cpni 11/04. Dxi: 25+yrs CFSi & FMSi. Currently: 250 aithromycin mwf, doxycycline 100mg BIDi, restarted Tinii pulses; Vit D2000 units, T4 & T3, 6mg Iodoral

Yes Jim,K.  Several are need to know facts that are important to know.  Again a window of time is needed and lots of dilution by high fluid intake at the time of taking it suggested with meals and

Particularly the taking of medications one hour prior or 4 - 6 hours after it's ingestion.   If absorbs fat soluable vits such D and E etc as well as tetraycyclines (Doxyi) and Thyroid medications and of course cholesteroli

At the source site referenced there is more technical data for them that want to read and comprehend it.

Thanks for sharing the possibility of it's use as an alternative approach to the endo/cytok/porhp challenge. 

Louise CFSi. CPn posititve, Bb(Borrelia B.)positive. CAP 6/24/07 Initial Doxy and NACi started.

10/31/07 Macrolide Abxi. added to Doxy and NAC.

11/3/07 Doxy 100mg BIDi, Macrolide 150mg BIDi, NAC600mg BID

  • CAPi(TiniOnly): 06/07-02/09 for CFSi<
  • MethylationProtocolSupplements: Started08/08
  • Intermtnt CAP: 02/09-02/10
  • Full MethylProtocol & LDNi 02/09
  • Off CAP: 02/10, cont LDN & MethlyProtocol support
  • <

Cholestyramine information available as on www.drugstore.com<

Cholestyramine, generic

Entire Monograph

 

Adult Dosing

Dosage forms: 4 g/scoop pwdr; 4 g pwdr pkt

Special Note

formulation clarification

Info: 1 scoop/pkt regular formulation = 9 g powder = 4 g cholestyramine; 1 scoop/pkt sugar-free formulation = 5 g powder = 4 g cholestyramine; dosing presented in g cholestyramine

hypercholesterolemia

4-8 g PO bidi

Start: 4 g PO qdi-bidi, may incr. dose by 4 g/day q4wk; Max: 24 g/day; Info: give before meals; may dose 1-6x/day

*pruritus

4-8 g PO bid

Start: 4 g PO qd-bid, may incr. dose by 4 g/day q4wk; Max: 16 g/day; Info: give before meals; may dose 1-6x/day; for pruritus assoc. w/ cholestasis, uremia, polycythemia vera

*pseudomembranous colitis, adjunct tx

2-4 g PO bid-qid

Max: 16 g/day; Info: give before meals; may dose 1-6x/day; not for severe diarrhea

renal dosing

no adjustment

HD/CAPD: no supplement

hepatic dosing

not defined

 

Peds Dosing

Dosage forms: 4 g/scoop pwdr; 4 g pwdr pkt

Special Note

formulation clarification

Info: 1 scoop/pkt regular formulation = 9 g powder = 4 g cholestyramine; 1 scoop/pkt sugar-free formulation = 5 g powder = 4 g cholestyramine; dosing presented in g cholestyramine

*hypercholesterolemia

6-12 yo

Dose: 80 mg/kg PO tid; Alt: 2-4 g PO bid; Max: 8 g/day; Info: give before meals; may dose 1-6x/day

adolescents

Dose: 4 g PO bid; Alt: 80 mg/kg PO tid; Max: 8 g/day; Info: give before meals; may dose 1-6x/day

renal dosing

see Adult Dosing

renal impairment: dose adjustment may be required although specific pediatric dosing adjustments not defined; see adult renal dosing for guidance

hepatic dosing

not defined

 

Contraindications/Cautions

hypersens. to drug/class/compon.

biliary obstruction

caution if constipation

caution if CAD

caution if renal dysfxn

caution if volume depletion

caution if >60 yo

caution if PKU (sugar-free forms)

 

Drug Interactions

Avoid/Use Alternative

 

amiodarone

leflunomide

meloxicam

raloxifene

sodium phosphate

thyroid hormones

ursodiol

warfarin

Monitor/Modify Tx

 

A2R blocker/HCTZ combos

ACE inhibitor/HCTZ combos

alendronate/cholecalciferol

aliskiren/hydrochlorothiazide

amiloride/hydrochlorothiazide

amlodipine/atorvastatin

atropine/hyoscyamine/phenobarbital/scopolamine

beta blocker/thiazide combos

bismuth subcitrate potassium/metronidazolei/tetracycline

bismuth subsalicylate/metronidazole/tetracycline

contraceptives, oral combo

contraceptives, oral progestin

digoxin

diuretics, thiazide

ezetimibe

ezetimibe/simvastatin

fat-soluble vitaminsi

fibric acid derivatives

folic acid

HRT, estrogen

HRT, estrogen/progestin combo

HRT, progestin

hydrochlorothiazide/spironolactone

hydrochlorothiazide/triamterene

metronidazole

mycophenolate mofetil

mycophenolic acid

niacin">i

niacin/lovastatin

niacin/simvastatin

phenobarbital

phosphate supplementsi

statins, all

tetracyclines

tinidazole

valproic acid derivatives

Caution Advised

 

carbidopa/levodopa/entacapone

corticosteroids, systemic

entacapone

gotu kola

spironolactone

 

Adverse Reactions

Serious Reactions

fecal impaction

intestinal obstruction

metabolic acidosis

fat-soluble vitamin deficiency

folate">i levels decreased

osteoporosis (long-term use)

Common Reactions

constipation

abdominal pain

flatulence

nausea

vomiting

dyspepsia

eructation

anorexia

steatorrhea

bleeding

rash

urticaria

fatigue

fecal impaction

 

Safety Monitoring

Pregnancy: C

Lactation: Safe

Monitoring Parameters

no routine tests recommended

Look/Sound-Alike Drug Names

[from www.usp.org]

cholestyramine confused with: chlorpheniramine

 

Pharmacology

Metabolism: none; CYP450: none; Info: no systemic absorption

Excretion: feces; Half-life: unknown

Class: Cholesterol Lowering

Mechanism of Action

binds intestinal bile acids

 

Manufacturer/Pricing

Manufacturer: generic

DEA/FDA: Rx

Approximate Retail Price

from www.drugstore.com<

powder:

4 gm/dose (1 can, 378 gm): $37.00

powder:

4 gm/dose (1 can, 210 gm): $50.00

 

Patient Education - English

Show Spanish

Generic Name: cholestyramine

Pronounced: koe le STYE ra meen

Brand Names: Cholestyramine Light, Locholest, Locholest Light, Prevalite, Questran, Questran Light

What is the most important information I should know about cholestyramine?

You should not take this medication if you are allergic to cholestyramine, or if you have a blockage in your stomach or intestines.

Before taking cholestyramine, tell your doctor if you have a thyroid disorder, diabetes, kidney or liver disease, or chronic constipation.

Avoid taking other medications at the same time you take cholestyramine. Wait at least 4 to 6 hours after taking cholestyramine before you take any other medications.

What is cholestyramine?

Cholestyramine helps reduce cholesterol (fatty acids) in the blood. High cholesterol is associated with an increased risk of heart diseasei and atherosclerosis (clogged arteries).

Cholestyramine is used to lower high levels of cholesterol in the blood, especially low-density lipoprotein (LDL) ("bad" cholesterol).

Cholestyramine powder is also used to treat itching caused by a blockage in the bile ducts of the gallbladder.

Cholestyramine may also be used for other purposes not listed in this medication guide.

What should I discuss with my healthcare provider before taking cholestyramine?

You should not take this medication if you are allergic to cholestyramine, or if you have a blockage in your stomach or intestines.

Before taking this medication, tell your doctor if you are allergic to any drugs, or if you have:

a thyroid disorder;

diabetes,

kidney disease,

liver disease, or

chronic constipation.

If you have any of these conditions, you may need a dose adjustment or special tests to safely take cholestyramine.

FDA pregnancy category C. This medication may be harmful to an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant during treatment.

Taking cholestyramine can make it harder for your body to absorb certain vitamins your body needs while you are nursing a baby. Do not take cholestyramine without telling your doctor if you are breast-feeding.

This medication may contain phenylalanine. Talk to your doctor before using cholestyramine if you have phenylketonuria (PKU).

How should I take cholestyramine?

Take this medication exactly as it was prescribed for you. Do not take the medication in larger amounts or for longer than recommended by your doctor. Follow the directions on your prescription label.

Cholestyramine is sometimes taken up to 6 times per day. Follow your doctor's instructions.

Take cholestyramine with meals unless your doctor tells you otherwise.

Mix the cholestyramine powder with 2 to 6 ounces of water or other non-carbonated beverage. You may also mix the powder with a brothy soup, crushed pineapple, or applesauce. Measure the powder using the scoop provided with your medication. Do not use any other scoop or measuring cup to measure your cholestyramine dose.

Drink extra fluids to prevent constipation while you are taking cholestyramine.

It is important to take cholestyramine regularly to get the most benefit.

Cholestyramine is only part of a complete program of treatment that may also include diet, exercise, and weight control. Follow your diet, medication, and exercise routines very closely.

To be sure this medication is helping your condition, your blood may need to be tested on a regular basis. Do not miss any scheduled appointments.

Store cholestyramine at room temperature away from moisture and heat.

What happens if I miss a dose?

Take the missed dose as soon as you remember. If it is almost time for your next dose, wait until then to take the medicine and skip the missed dose. Do not take extra medicine to make up the missed dose.

What happens if I overdose?

Seek emergency medical attention if you think you have used too much of this medicine.

Overdose symptoms may include severe stomach pain or constipation.

What should I avoid while taking cholestyramine?

Avoid taking other medications at the same time you take cholestyramine. Wait at least 4 to 6 hours after taking cholestyramine before you take any other medications.

What are the possible side effects of cholestyramine?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have a serious side effect such as:

blood in your urine;

severe stomach pain;

ongoing constipation;

feeling short of breath;

black, bloody, or tarry stools; or

easy bruising or bleeding.

Less serious side effects may include:

mild constipation, diarrhea;

stomach pain, nausea, loss of appetite, weight changes;

bloating or gas;

hiccups or a sour taste in your mouth;

skin rash or itching;

irritation of your tongue;

itching or irritation around your rectal area;

muscle or joint pain; or

dizziness, spinning sensation; ringing in your ears.

This is not a complete list of side effects and others may occur. Tell your doctor about any unusual or bothersome side effect.

What other drugs will affect cholestyramine?

Cholestyramine can make it harder for your body to absorb other medications, such as:

a blood thinner such as warfarin (Coumadin);

digoxin (digitalis, Lanoxin);

propranolol (Inderal);

a diuretic (water pill);

thyroid hormones such as levothyroxine (Synthroid, Levoxyl, Levothroid);

birth control pills or hormone replacement;

seizure medicines such as phenytoin (Dilantin) and phenobarbital (Luminal, Solfoton); or

an antibiotic such as amoxicillini (Amoxil, Trimox, others), doxycycline (Adoxa, Doryx, Oracea, Vibramycin), minocycline (Dynacin, Minocin, Solodyn, Vectrin), penicillin (BeePen-VK, Pen-Vee K, Veetids, others), tetracycline (Brodspec, Panmycin, Sumycin, Tetracap).

This list is not complete and there may be other drugs that can interact with cholestyramine. Tell your doctor about all your prescription and over-the-counter medications, vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start a new medication without telling your doctor.

Where can I get more information?

Your pharmacist can provide more information about cholestyramine.

 

 

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise.

Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides.

The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

Pill Pictures

 

cholestyramine (generic) 4 g/5 g

cholestyramine (generic) 4 g/5 g

 

cholestyramine (generic) 4 g/9 g

CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of your healthcare professional. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you. You should consult your healthcare professional before taking any drug, changing your diet or commencing or discontinuing any course of treatment.

  • CAPi(TiniOnly): 06/07-02/09 for CFSi<
  • MethylationProtocolSupplements: Started08/08
  • Intermtnt CAP: 02/09-02/10
  • Full MethylProtocol & LDNi 02/09
  • Off CAP: 02/10, cont LDN & MethlyProtocol support
  • <

Cholestyramine, generic   as available at www.drugstore.com< website

Entire Monograph

 

Adult DosingDosage forms:  

4 g/scoop pwdr; 4 g pwdr pkt

 

Special Note

formulation clarification

Info: 1 scoop/pkt regular formulation = 9 g powder = 4 g cholestyramine; 1 scoop/pkt sugar-free formulation = 5 g powder = 4 g cholestyramine; dosing presented in g cholestyramine

 

Hypercholesterolemia

4-8 g PO bidi

Start: 4 g PO qdi-bidi, may incr. dose by 4 g/day q4wk; Max: 24 g/day; Info: give before meals; may dose 1-6x/day

 *pruritus

4-8 g PO bid

Start: 4 g PO qd-bid, may incr. dose by 4 g/day q4wk; Max: 16 g/day; Info: give before meals; may dose 1-6x/day; for pruritus assoc. w/ cholestasis, uremia, polycythemia vera

 

*pseudomembranous colitis, adjunct tx

2-4 g PO bid-qid Max: 16 g/day; Info: give before meals; may dose 1-6x/day; not for severe diarrhea

 

renal dosing

no adjustment

HD/CAPD: no supplement

 

hepatic dosing

not defined



Peds Dosing

Dosage forms:  4 g/scoop pwdr; 4 g pwdr pkt

Special Note

formulation clarification

Info: 1 scoop/pkt regular formulation = 9 g powder = 4 g cholestyramine; 1 scoop/pkt sugar-free formulation = 5 g powder = 4 g cholestyramine; dosing presented in g cholestyramine

*hypercholesterolemia

6-12 yo

Dose: 80 mg/kg PO tid; Alt: 2-4 g PO bid; Max: 8 g/day; Info: give before meals; may dose 1-6x/day

adolescents

Dose: 4 g PO bid; Alt: 80 mg/kg PO tid; Max: 8 g/day; Info: give before meals; may dose 1-6x/day

 

renal dosing

see Adult Dosing

renal impairment: dose adjustment may be required although specific pediatric dosing adjustments not defined; see adult renal dosing for guidance

 

hepatic dosing

not defined

 

Contraindications/Cautions

  • hypersens. to drug/class/compon.
  • biliary obstruction
  • caution if constipation
  • caution if CAD
  • caution if renal dysfxn
  • caution if volume depletion
  • caution if >60 yo
  • caution if PKU (sugar-free forms)
 

Drug Interactions

Avoid/Use Alternative

Monitor/Modify Tx

Caution Advised

 

Adverse Reactions

 

Serious Reactions

  • fecal impaction
  • intestinal obstruction
  • metabolic acidosis
  • fat-soluble vitamin deficiency
  • folate">i levels decreased
  • osteoporosis (long-term use)

Common Reactions

  • constipation
  • abdominal pain
  • flatulence
  • nausea
  • vomiting
  • dyspepsia
  • eructation
  • anorexia
  • steatorrhea
  • bleeding
  • rash
  • urticaria
  • fatigue
  • fecal impaction
 

Safety Monitoring

Pregnancy: C<

Lactation: Safe<

Monitoring Parameters
no routine tests recommended

 

Look/Sound-Alike Drug Names
[from www.usp.org]
cholestyramine confused with: chlorpheniramine

 

Pharmacology

Metabolism: none;

CYP450: none;

Info: no systemic absorption

Excretion: feces; Half-life: unknown

Class: Cholesterol Lowering<

 

Mechanism of Action
binds intestinal bile acids

 

Manufacturer/Pricing

Manufacturer: generic

 DEA/FDA: Rx< 

Approximate Retail Price

from  www.drugstore.com< 

powder:

  • 4 gm/dose (1 can, 378 gm): $37.00

powder:

  • 4 gm/dose (1 can, 210 gm): $50.00

Patient Education - English

Show Spanish<

  • Generic Name: cholestyramine
  • Pronounced: koe le STYE ra meen
  • Brand Names: Cholestyramine Light, Locholest, Locholest Light, Prevalite, Questran, Questran Light

What is the most important information I should know about cholestyramine?

  • You should not take this medication if you are allergic to cholestyramine, or if you have a blockage in your stomach or intestines.
  • Before taking cholestyramine, tell your doctor if you have a thyroid disorder, diabetes, kidney or liver disease, or chronic constipation.
  • Avoid taking other medications at the same time you take cholestyramine. Wait at least 4 to 6 hours after taking cholestyramine before you take any other medications.
  •  

What is cholestyramine?

  • Cholestyramine helps reduce cholesterol (fatty acids) in the blood. High cholesterol is associated with an increased risk of heart diseasei and atherosclerosis (clogged arteries).
  • Cholestyramine is used to lower high levels of cholesterol in the blood, especially low-density lipoprotein (LDL) ("bad" cholesterol).
  • Cholestyramine powder is also used to treat itching caused by a blockage in the bile ducts of the gallbladder.
  • Cholestyramine may also be used for other purposes not listed in this medication guide.
  

What should I discuss with my healthcare provider before taking cholestyramine?

 
  • You should not take this medication if you are allergic to cholestyramine, or if you have a blockage in your stomach or intestines.
  • Before taking this medication, tell your doctor if you are allergic to any drugs, or if you have:
    • a thyroid disorder;
    • diabetes,kidney disease,
    • liver disease, or
    • chronic constipation.
 

If you have any of these conditions, you may need a dose adjustment or special tests to safely take cholestyramine.

 

FDA pregnancy category C. This medication may be harmful to an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant during treatment.

 

Taking cholestyramine can make it harder for your body to absorb certain vitamins your body needs while you are nursing a baby. Do not take cholestyramine without telling your doctor if you are breast-feeding.

This medication may contain phenylalanine. Talk to your doctor before using cholestyramine if you have phenylketonuria (PKU)

.

How should I take cholestyramine?

Take this medication exactly as it was prescribed for you. Do not take the medication in larger amounts or for longer than recommended by your doctor. Follow the directions on your prescription label.

Cholestyramine is sometimes taken up to 6 times per day. Follow your doctor's instructions.

 

Take cholestyramine with meals unless your doctor tells you otherwise.

Mix the cholestyramine powder with 2 to 6 ounces of water or other non-carbonated beverage. You may also mix the powder with a brothy soup, crushed pineapple, or applesauce. Measure the powder using the scoop provided with your medication. Do not use any other scoop or measuring cup to measure your cholestyramine dose.

 

Drink extra fluids to prevent constipation while you are taking cholestyramine.

It is important to take cholestyramine regularly to get the most benefit.

Cholestyramine is only part of a complete program of treatment that may also include diet, exercise, and weight control. Follow your diet, medication, and exercise routines very closely.

To be sure this medication is helping your condition, your blood may need to be tested on a regular basis. Do not miss any scheduled appointments.

Store cholestyramine at room temperature away from moisture and heat.

 

What happens if I miss a dose?

Take the missed dose as soon as you remember. If it is almost time for your next dose, wait until then to take the medicine and skip the missed dose. Do not take extra medicine to make up the missed dose.

 

What happens if I overdose?

Seek emergency medical attention if you think you have used too much of this medicine.

Overdose symptoms may include severe stomach pain or constipation.

 

What should I avoid while taking cholestyramine?

 

Avoid taking other medications at the same time you take cholestyramine. Wait at least 4 to 6 hours after taking cholestyramine before you take any other medications.

 

What are the possible side effects of cholestyramine?

 

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

 

Call your doctor at once if you have a serious side effect such as:

  • blood in your urine;
  • severe stomach pain;
  • ongoing constipation;
  • feeling short of breath;
  • black, bloody, or tarry stools; or
  • easy bruising or bleeding.

Less serious side effects may include:

  • mild constipation, diarrhea;
  • stomach pain, nausea, loss of appetite, weight changes;
  • bloating or gas;
  • hiccups or a sour taste in your mouth;
  • skin rash or itching;
  • irritation of your tongue;
  • itching or irritation around your rectal area;
  • muscle or joint pain; or
  • dizziness, spinning sensation; ringing in your ears.

This is not a complete list of side effects and others may occur. Tell your doctor about any unusual or bothersome side effect.

 

What other drugs will affect cholestyramine?

 

Cholestyramine can make it harder for your body to absorb other medications, such as:

  • a blood thinner such as warfarin (Coumadin);
  • digoxin (digitalis, Lanoxin);
  • propranolol (Inderal);
  • a diuretic (water pill);
  • thyroid hormones such as levothyroxine (Synthroid, Levoxyl, Levothroid);
  • birth control pills or hormone replacement;
  • seizure medicines such as phenytoin (Dilantin) and phenobarbital (Luminal, Solfoton); or
  • an antibiotic such as amoxicillini (Amoxil, Trimox, others), doxycycline (Adoxa, Doryx, Oracea, Vibramycin), minocycline (Dynacin, Minocin, Solodyn, Vectrin), penicillin (BeePen-VK, Pen-Vee K, Veetids, others), tetracycline (Brodspec, Panmycin, Sumycin, Tetracap).

This list is not complete and there may be other drugs that can interact with cholestyramine. Tell your doctor about all your prescription and over-the-counter medications, vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start a new medication without telling your doctor.

 

Where can I get more information?

Your pharmacist can provide more information about cholestyramine.

 

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise.

Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides.

The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of your healthcare professional. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you. You should consult your healthcare professional before taking any drug, changing your diet or commencing or discontinuing any course of treatment.
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